Incidental Mutation 'IGL01305:Tmem168'
ID 73416
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem168
Ensembl Gene ENSMUSG00000029569
Gene Name transmembrane protein 168
Synonyms 8430437G11Rik, 5730526F17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL01305
Quality Score
Status
Chromosome 6
Chromosomal Location 13580688-13608097 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13583045 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 612 (V612E)
Ref Sequence ENSEMBL: ENSMUSP00000031554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031554] [ENSMUST00000149123]
AlphaFold Q91VX9
Predicted Effect probably damaging
Transcript: ENSMUST00000031554
AA Change: V612E

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000031554
Gene: ENSMUSG00000029569
AA Change: V612E

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 92 109 N/A INTRINSIC
low complexity region 152 163 N/A INTRINSIC
transmembrane domain 170 192 N/A INTRINSIC
transmembrane domain 199 216 N/A INTRINSIC
transmembrane domain 226 248 N/A INTRINSIC
transmembrane domain 261 283 N/A INTRINSIC
transmembrane domain 298 320 N/A INTRINSIC
transmembrane domain 359 378 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000149123
AA Change: V228E

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000145372
Gene: ENSMUSG00000029569
AA Change: V228E

DomainStartEndE-ValueType
SCOP:d1jxqa_ 29 167 8e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco2 A G 15: 81,797,915 (GRCm39) E663G possibly damaging Het
Adam29 T A 8: 56,324,879 (GRCm39) H525L probably benign Het
Adamts6 T A 13: 104,526,590 (GRCm39) V506E probably damaging Het
Ankfy1 G A 11: 72,655,617 (GRCm39) E1101K probably damaging Het
Arap3 C T 18: 38,124,380 (GRCm39) probably null Het
Asxl3 T A 18: 22,649,503 (GRCm39) H497Q probably benign Het
Caln1 A G 5: 130,698,392 (GRCm39) E96G probably damaging Het
Cdh23 T C 10: 60,148,403 (GRCm39) T2653A probably damaging Het
Cdk5rap2 T A 4: 70,298,472 (GRCm39) I87F possibly damaging Het
Chi3l1 A G 1: 134,110,554 (GRCm39) probably benign Het
Col27a1 A G 4: 63,218,978 (GRCm39) probably benign Het
Crybg3 T A 16: 59,349,590 (GRCm39) H934L probably damaging Het
Cyp2d22 G A 15: 82,255,869 (GRCm39) T461I probably damaging Het
Dhcr24 T C 4: 106,429,475 (GRCm39) F183L possibly damaging Het
Dnajc13 T C 9: 104,107,836 (GRCm39) probably null Het
Dusp16 A T 6: 134,695,824 (GRCm39) S336T probably benign Het
F930017D23Rik T G 10: 43,480,371 (GRCm39) noncoding transcript Het
Fasl A G 1: 161,609,407 (GRCm39) V193A probably damaging Het
Fgf5 T C 5: 98,423,175 (GRCm39) Y187H probably damaging Het
Focad C A 4: 88,311,784 (GRCm39) Q1423K probably benign Het
Gabrp T C 11: 33,505,055 (GRCm39) T249A probably damaging Het
Galnt5 A T 2: 57,915,354 (GRCm39) K637* probably null Het
Gm20479 G A 7: 27,056,812 (GRCm39) R2525* probably null Het
Grm6 A T 11: 50,750,346 (GRCm39) D503V probably benign Het
Hmg20a A T 9: 56,394,934 (GRCm39) D216V probably damaging Het
Lyst C T 13: 13,852,641 (GRCm39) R2214C probably benign Het
Micu2 T A 14: 58,181,082 (GRCm39) D184V probably damaging Het
Nabp2 T A 10: 128,244,631 (GRCm39) I52F probably damaging Het
Nat8f7 A T 6: 85,684,570 (GRCm39) L90* probably null Het
Or2z2 A T 11: 58,346,088 (GRCm39) M229K probably damaging Het
Or4k47 T C 2: 111,451,546 (GRCm39) N291S probably damaging Het
Pphln1 A G 15: 93,386,985 (GRCm39) E273G probably damaging Het
Ppil1 C A 17: 29,482,862 (GRCm39) V14F possibly damaging Het
Relt A T 7: 100,500,905 (GRCm39) L28Q probably damaging Het
Rpl21 A G 5: 146,770,996 (GRCm39) probably benign Het
Rrp36 A T 17: 46,979,017 (GRCm39) probably benign Het
Skic8 C A 9: 54,635,470 (GRCm39) V44L probably damaging Het
St8sia5 G A 18: 77,342,358 (GRCm39) G320D probably damaging Het
Taf2 T C 15: 54,911,670 (GRCm39) E582G probably damaging Het
Tas2r116 T A 6: 132,832,406 (GRCm39) N2K probably benign Het
Unc79 A G 12: 102,968,130 (GRCm39) S119G probably damaging Het
Washc5 T A 15: 59,227,688 (GRCm39) K425* probably null Het
Wtap G T 17: 13,186,782 (GRCm39) T255K probably benign Het
Zfp148 T C 16: 33,277,313 (GRCm39) V134A probably benign Het
Other mutations in Tmem168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00786:Tmem168 APN 6 13,602,674 (GRCm39) missense probably benign 0.06
IGL01843:Tmem168 APN 6 13,582,940 (GRCm39) missense probably damaging 1.00
IGL02742:Tmem168 APN 6 13,603,261 (GRCm39) missense probably benign 0.04
IGL02863:Tmem168 APN 6 13,582,917 (GRCm39) missense probably damaging 0.98
ANU22:Tmem168 UTSW 6 13,583,045 (GRCm39) missense probably damaging 1.00
R0193:Tmem168 UTSW 6 13,583,312 (GRCm39) missense possibly damaging 0.81
R0537:Tmem168 UTSW 6 13,603,360 (GRCm39) missense probably damaging 1.00
R0630:Tmem168 UTSW 6 13,583,064 (GRCm39) missense probably benign
R0890:Tmem168 UTSW 6 13,603,271 (GRCm39) missense probably damaging 1.00
R1416:Tmem168 UTSW 6 13,591,400 (GRCm39) missense probably damaging 0.96
R1900:Tmem168 UTSW 6 13,583,070 (GRCm39) missense probably benign 0.02
R3947:Tmem168 UTSW 6 13,583,051 (GRCm39) missense probably damaging 1.00
R4362:Tmem168 UTSW 6 13,595,072 (GRCm39) missense probably benign 0.31
R4620:Tmem168 UTSW 6 13,594,952 (GRCm39) missense probably benign 0.03
R5693:Tmem168 UTSW 6 13,602,320 (GRCm39) missense probably benign 0.01
R6142:Tmem168 UTSW 6 13,591,368 (GRCm39) missense probably benign
R6328:Tmem168 UTSW 6 13,602,710 (GRCm39) missense probably benign
R6438:Tmem168 UTSW 6 13,602,673 (GRCm39) missense probably benign 0.06
R6711:Tmem168 UTSW 6 13,603,120 (GRCm39) missense probably damaging 1.00
R6827:Tmem168 UTSW 6 13,582,837 (GRCm39) missense probably damaging 0.99
R6987:Tmem168 UTSW 6 13,591,476 (GRCm39) missense possibly damaging 0.82
R7696:Tmem168 UTSW 6 13,602,937 (GRCm39) missense probably benign 0.01
R8295:Tmem168 UTSW 6 13,602,850 (GRCm39) missense probably damaging 0.99
R8344:Tmem168 UTSW 6 13,583,324 (GRCm39) missense probably benign
R8432:Tmem168 UTSW 6 13,602,535 (GRCm39) missense probably benign 0.30
R8992:Tmem168 UTSW 6 13,602,849 (GRCm39) missense possibly damaging 0.72
R9003:Tmem168 UTSW 6 13,591,446 (GRCm39) missense probably benign 0.06
R9325:Tmem168 UTSW 6 13,583,253 (GRCm39) missense probably benign
Posted On 2013-10-07