Incidental Mutation 'R9785:Tcf7'
ID 734295
Institutional Source Beutler Lab
Gene Symbol Tcf7
Ensembl Gene ENSMUSG00000000782
Gene Name transcription factor 7, T cell specific
Synonyms TCF-1, T cell factor-1, T-cell factor 1, Tcf1
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.882) question?
Stock # R9785 (G1)
Quality Score 217.009
Status Not validated
Chromosome 11
Chromosomal Location 52143198-52174158 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to A at 52173773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086844] [ENSMUST00000109071]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000086844
SMART Domains Protein: ENSMUSP00000084055
Gene: ENSMUSG00000000782

DomainStartEndE-ValueType
Pfam:CTNNB1_binding 1 100 2.2e-23 PFAM
low complexity region 119 130 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
HMG 187 257 2.86e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109071
SMART Domains Protein: ENSMUSP00000104699
Gene: ENSMUSG00000000782

DomainStartEndE-ValueType
Pfam:CTNNB1_binding 1 100 5.3e-23 PFAM
low complexity region 119 130 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
HMG 187 257 2.86e-22 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T C 10: 61,049,427 (GRCm39) E634G possibly damaging Het
Adgre1 T C 17: 57,785,930 (GRCm39) L892P probably damaging Het
Adgrl1 A T 8: 84,665,168 (GRCm39) N1285I probably damaging Het
Alpk1 A T 3: 127,473,594 (GRCm39) M803K probably benign Het
Armt1 T A 10: 4,389,606 (GRCm39) W88R probably damaging Het
Cacna1d A T 14: 29,824,300 (GRCm39) probably null Het
Cd27 G A 6: 125,213,945 (GRCm39) probably benign Het
Cebpb A G 2: 167,531,663 (GRCm39) D241G probably damaging Het
Clec3b T A 9: 122,985,997 (GRCm39) W132R probably damaging Het
Cracd A T 5: 77,015,028 (GRCm39) S1185C unknown Het
Csn2 A T 5: 87,842,502 (GRCm39) V175D possibly damaging Het
Dnm1 A T 2: 32,223,089 (GRCm39) C442S possibly damaging Het
Dstyk C T 1: 132,381,038 (GRCm39) T511I probably damaging Het
Gabra5 C T 7: 57,140,584 (GRCm39) V38I probably benign Het
Gjd2 A T 2: 113,841,747 (GRCm39) Y243* probably null Het
Gtf2b AATCATC AATC 3: 142,477,178 (GRCm39) probably benign Het
Hrnr G A 3: 93,238,861 (GRCm39) R3033H unknown Het
Ivd G T 2: 118,710,970 (GRCm39) R393L probably damaging Het
Jam2 T C 16: 84,571,397 (GRCm39) L8P unknown Het
Klhdc7b G T 15: 89,272,621 (GRCm39) D510Y probably damaging Het
Lgals8 A T 13: 12,462,051 (GRCm39) F260I probably damaging Het
Lrrd1 T C 5: 3,908,708 (GRCm39) I660T probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Npc1l1 C T 11: 6,180,090 (GRCm39) A12T unknown Het
Or10j7 C T 1: 173,011,458 (GRCm39) R181H probably benign Het
Or5d47 T C 2: 87,804,245 (GRCm39) T255A possibly damaging Het
Rprm C T 2: 53,975,238 (GRCm39) V27M probably benign Het
Scg3 G T 9: 75,589,322 (GRCm39) D110E probably damaging Het
Selenon C T 4: 134,270,374 (GRCm39) G326D probably damaging Het
Sh3gl2 T A 4: 85,273,618 (GRCm39) Y57N probably damaging Het
Skint6 A T 4: 112,740,884 (GRCm39) L807M possibly damaging Het
Srl A G 16: 4,314,718 (GRCm39) V308A probably benign Het
Trdv2-2 A T 14: 54,198,489 (GRCm39) T14S probably benign Het
Usf3 A G 16: 44,041,970 (GRCm39) E2150G probably benign Het
Vmn2r104 G A 17: 20,268,409 (GRCm39) T20I probably benign Het
Wnt1 G T 15: 98,688,752 (GRCm39) V38L probably benign Het
Zbtb17 C T 4: 141,194,271 (GRCm39) T740M possibly damaging Het
Zdhhc6 T C 19: 55,300,203 (GRCm39) M125V probably damaging Het
Zfp202 A G 9: 40,120,233 (GRCm39) M225V probably benign Het
Zfp592 G T 7: 80,673,245 (GRCm39) V70F probably damaging Het
Other mutations in Tcf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01673:Tcf7 APN 11 52,147,823 (GRCm39) missense probably damaging 1.00
IGL02558:Tcf7 APN 11 52,144,797 (GRCm39) splice site probably benign
R1854:Tcf7 UTSW 11 52,147,891 (GRCm39) missense probably benign 0.00
R2937:Tcf7 UTSW 11 52,173,610 (GRCm39) splice site probably null
R2938:Tcf7 UTSW 11 52,173,610 (GRCm39) splice site probably null
R3911:Tcf7 UTSW 11 52,173,793 (GRCm39) start gained probably benign
R4433:Tcf7 UTSW 11 52,152,442 (GRCm39) missense probably benign
R5796:Tcf7 UTSW 11 52,152,354 (GRCm39) missense probably benign 0.31
R6443:Tcf7 UTSW 11 52,144,765 (GRCm39) missense probably benign 0.00
R8798:Tcf7 UTSW 11 52,151,421 (GRCm39) missense probably damaging 0.96
R9787:Tcf7 UTSW 11 52,173,773 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AGTCTCTGCGAAGTGTGCTC -3'
(R):5'- GGTGCCTTTGATGTTCCGAC -3'

Sequencing Primer
(F):5'- AAGTGTGCTCCCGTCCCAG -3'
(R):5'- TCCCAAAGCTGCTGTGC -3'
Posted On 2022-11-14