Incidental Mutation 'R9785:Trdv2-2'
ID 734298
Institutional Source Beutler Lab
Gene Symbol Trdv2-2
Ensembl Gene ENSMUSG00000076866
Gene Name T cell receptor delta variable 2-2
Synonyms Gm17015
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R9785 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 54198450-54199059 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 54198489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 14 (T14S)
Ref Sequence ENSEMBL: ENSMUSP00000100455 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103678]
AlphaFold Q5R1A4
Predicted Effect probably benign
Transcript: ENSMUST00000103678
AA Change: T14S

PolyPhen 2 Score 0.355 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000100455
Gene: ENSMUSG00000076866
AA Change: T14S

DomainStartEndE-ValueType
IGv 38 113 6.65e-9 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T C 10: 61,049,427 (GRCm39) E634G possibly damaging Het
Adgre1 T C 17: 57,785,930 (GRCm39) L892P probably damaging Het
Adgrl1 A T 8: 84,665,168 (GRCm39) N1285I probably damaging Het
Alpk1 A T 3: 127,473,594 (GRCm39) M803K probably benign Het
Armt1 T A 10: 4,389,606 (GRCm39) W88R probably damaging Het
Cacna1d A T 14: 29,824,300 (GRCm39) probably null Het
Cd27 G A 6: 125,213,945 (GRCm39) probably benign Het
Cebpb A G 2: 167,531,663 (GRCm39) D241G probably damaging Het
Clec3b T A 9: 122,985,997 (GRCm39) W132R probably damaging Het
Cracd A T 5: 77,015,028 (GRCm39) S1185C unknown Het
Csn2 A T 5: 87,842,502 (GRCm39) V175D possibly damaging Het
Dnm1 A T 2: 32,223,089 (GRCm39) C442S possibly damaging Het
Dstyk C T 1: 132,381,038 (GRCm39) T511I probably damaging Het
Gabra5 C T 7: 57,140,584 (GRCm39) V38I probably benign Het
Gjd2 A T 2: 113,841,747 (GRCm39) Y243* probably null Het
Gtf2b AATCATC AATC 3: 142,477,178 (GRCm39) probably benign Het
Hrnr G A 3: 93,238,861 (GRCm39) R3033H unknown Het
Ivd G T 2: 118,710,970 (GRCm39) R393L probably damaging Het
Jam2 T C 16: 84,571,397 (GRCm39) L8P unknown Het
Klhdc7b G T 15: 89,272,621 (GRCm39) D510Y probably damaging Het
Lgals8 A T 13: 12,462,051 (GRCm39) F260I probably damaging Het
Lrrd1 T C 5: 3,908,708 (GRCm39) I660T probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Npc1l1 C T 11: 6,180,090 (GRCm39) A12T unknown Het
Or10j7 C T 1: 173,011,458 (GRCm39) R181H probably benign Het
Or5d47 T C 2: 87,804,245 (GRCm39) T255A possibly damaging Het
Rprm C T 2: 53,975,238 (GRCm39) V27M probably benign Het
Scg3 G T 9: 75,589,322 (GRCm39) D110E probably damaging Het
Selenon C T 4: 134,270,374 (GRCm39) G326D probably damaging Het
Sh3gl2 T A 4: 85,273,618 (GRCm39) Y57N probably damaging Het
Skint6 A T 4: 112,740,884 (GRCm39) L807M possibly damaging Het
Srl A G 16: 4,314,718 (GRCm39) V308A probably benign Het
Tcf7 T A 11: 52,173,773 (GRCm39) probably benign Het
Usf3 A G 16: 44,041,970 (GRCm39) E2150G probably benign Het
Vmn2r104 G A 17: 20,268,409 (GRCm39) T20I probably benign Het
Wnt1 G T 15: 98,688,752 (GRCm39) V38L probably benign Het
Zbtb17 C T 4: 141,194,271 (GRCm39) T740M possibly damaging Het
Zdhhc6 T C 19: 55,300,203 (GRCm39) M125V probably damaging Het
Zfp202 A G 9: 40,120,233 (GRCm39) M225V probably benign Het
Zfp592 G T 7: 80,673,245 (GRCm39) V70F probably damaging Het
Other mutations in Trdv2-2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02691:Trdv2-2 APN 14 54,199,039 (GRCm39) missense possibly damaging 0.58
R5034:Trdv2-2 UTSW 14 54,198,882 (GRCm39) nonsense probably null
R5927:Trdv2-2 UTSW 14 54,198,998 (GRCm39) missense probably damaging 1.00
R6144:Trdv2-2 UTSW 14 54,198,761 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- AGAGAACATTTGGTCCTGACTG -3'
(R):5'- AATGACTCCCTTGTGGCTTCTG -3'

Sequencing Primer
(F):5'- TCTGAAGAGAAAGATAAACACCTTG -3'
(R):5'- GGCTTCTGTCAGAATTAGGAATAGAC -3'
Posted On 2022-11-14