Mutagenetix > Incidental Mutation

Incidental Mutation 'R9785:Vmn2r104'

734304

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

R9785 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20249687-20268467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20268409 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 20 (T20I)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably benign
Transcript: ENSMUST00000168050
AA Change: T20I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: T20I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts14	T	C	10: 61,049,427 (GRCm39)	E634G	possibly damaging	Het
Adgre1	T	C	17: 57,785,930 (GRCm39)	L892P	probably damaging	Het
Adgrl1	A	T	8: 84,665,168 (GRCm39)	N1285I	probably damaging	Het
Alpk1	A	T	3: 127,473,594 (GRCm39)	M803K	probably benign	Het
Armt1	T	A	10: 4,389,606 (GRCm39)	W88R	probably damaging	Het
Cacna1d	A	T	14: 29,824,300 (GRCm39)		probably null	Het
Cd27	G	A	6: 125,213,945 (GRCm39)		probably benign	Het
Cebpb	A	G	2: 167,531,663 (GRCm39)	D241G	probably damaging	Het
Clec3b	T	A	9: 122,985,997 (GRCm39)	W132R	probably damaging	Het
Cracd	A	T	5: 77,015,028 (GRCm39)	S1185C	unknown	Het
Csn2	A	T	5: 87,842,502 (GRCm39)	V175D	possibly damaging	Het
Dnm1	A	T	2: 32,223,089 (GRCm39)	C442S	possibly damaging	Het
Dstyk	C	T	1: 132,381,038 (GRCm39)	T511I	probably damaging	Het
Gabra5	C	T	7: 57,140,584 (GRCm39)	V38I	probably benign	Het
Gjd2	A	T	2: 113,841,747 (GRCm39)	Y243*	probably null	Het
Gtf2b	AATCATC	AATC	3: 142,477,178 (GRCm39)		probably benign	Het
Hrnr	G	A	3: 93,238,861 (GRCm39)	R3033H	unknown	Het
Ivd	G	T	2: 118,710,970 (GRCm39)	R393L	probably damaging	Het
Jam2	T	C	16: 84,571,397 (GRCm39)	L8P	unknown	Het
Klhdc7b	G	T	15: 89,272,621 (GRCm39)	D510Y	probably damaging	Het
Lgals8	A	T	13: 12,462,051 (GRCm39)	F260I	probably damaging	Het
Lrrd1	T	C	5: 3,908,708 (GRCm39)	I660T	probably damaging	Het
Mcm5	C	T	8: 75,844,168 (GRCm39)	S313F	probably benign	Het
Npc1l1	C	T	11: 6,180,090 (GRCm39)	A12T	unknown	Het
Or10j7	C	T	1: 173,011,458 (GRCm39)	R181H	probably benign	Het
Or5d47	T	C	2: 87,804,245 (GRCm39)	T255A	possibly damaging	Het
Rprm	C	T	2: 53,975,238 (GRCm39)	V27M	probably benign	Het
Scg3	G	T	9: 75,589,322 (GRCm39)	D110E	probably damaging	Het
Selenon	C	T	4: 134,270,374 (GRCm39)	G326D	probably damaging	Het
Sh3gl2	T	A	4: 85,273,618 (GRCm39)	Y57N	probably damaging	Het
Skint6	A	T	4: 112,740,884 (GRCm39)	L807M	possibly damaging	Het
Srl	A	G	16: 4,314,718 (GRCm39)	V308A	probably benign	Het
Tcf7	T	A	11: 52,173,773 (GRCm39)		probably benign	Het
Trdv2-2	A	T	14: 54,198,489 (GRCm39)	T14S	probably benign	Het
Usf3	A	G	16: 44,041,970 (GRCm39)	E2150G	probably benign	Het
Wnt1	G	T	15: 98,688,752 (GRCm39)	V38L	probably benign	Het
Zbtb17	C	T	4: 141,194,271 (GRCm39)	T740M	possibly damaging	Het
Zdhhc6	T	C	19: 55,300,203 (GRCm39)	M125V	probably damaging	Het
Zfp202	A	G	9: 40,120,233 (GRCm39)	M225V	probably benign	Het
Zfp592	G	T	7: 80,673,245 (GRCm39)	V70F	probably damaging	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,258,501 (GRCm39)	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20,268,358 (GRCm39)	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20,263,055 (GRCm39)	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20,263,158 (GRCm39)	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20,260,930 (GRCm39)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,250,187 (GRCm39)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,262,056 (GRCm39)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,263,118 (GRCm39)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,263,048 (GRCm39)	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20,263,083 (GRCm39)	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20,249,866 (GRCm39)	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20,262,075 (GRCm39)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,250,069 (GRCm39)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,249,889 (GRCm39)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,268,264 (GRCm39)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,263,166 (GRCm39)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,262,987 (GRCm39)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,262,477 (GRCm39)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,262,497 (GRCm39)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,261,031 (GRCm39)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,262,313 (GRCm39)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,268,455 (GRCm39)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,249,818 (GRCm39)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,250,183 (GRCm39)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,250,147 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,262,503 (GRCm39)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,268,443 (GRCm39)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,261,030 (GRCm39)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,250,288 (GRCm39)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,258,528 (GRCm39)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,262,146 (GRCm39)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,250,163 (GRCm39)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,250,450 (GRCm39)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,250,343 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,260,981 (GRCm39)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,250,544 (GRCm39)	missense	possibly damaging	0.89
R5795:Vmn2r104	UTSW	17	20,250,372 (GRCm39)	missense	probably benign	0.02
R5970:Vmn2r104	UTSW	17	20,249,733 (GRCm39)	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20,261,970 (GRCm39)	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20,249,747 (GRCm39)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,258,573 (GRCm39)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,261,909 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,250,507 (GRCm39)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,261,829 (GRCm39)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,249,848 (GRCm39)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,262,487 (GRCm39)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,250,358 (GRCm39)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,261,088 (GRCm39)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,249,737 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,249,791 (GRCm39)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,261,971 (GRCm39)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,263,048 (GRCm39)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,250,483 (GRCm39)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,250,465 (GRCm39)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,261,040 (GRCm39)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,262,110 (GRCm39)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,261,924 (GRCm39)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,249,968 (GRCm39)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,262,097 (GRCm39)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,261,098 (GRCm39)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,268,433 (GRCm39)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,250,250 (GRCm39)	missense	probably damaging	0.99
RF007:Vmn2r104	UTSW	17	20,268,302 (GRCm39)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,250,051 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTTTCCCCAAGTGAGGAAAATAATC -3'
(R):5'- TGTGTGACAGACTGAGTCATG -3'

Sequencing Primer
(F):5'- ATACACACACAAATTTTAGTGACAAC -3'
(R):5'- GACAGACTGAGTCATGAACAAATTC -3'

Posted On

2022-11-14