Incidental Mutation 'R9787:Tcf7'
ID 734411
Institutional Source Beutler Lab
Gene Symbol Tcf7
Ensembl Gene ENSMUSG00000000782
Gene Name transcription factor 7, T cell specific
Synonyms TCF-1, T cell factor-1, T-cell factor 1, Tcf1
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.882) question?
Stock # R9787 (G1)
Quality Score 94.0077
Status Not validated
Chromosome 11
Chromosomal Location 52143198-52174158 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to A at 52173773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086844] [ENSMUST00000109071]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000086844
SMART Domains Protein: ENSMUSP00000084055
Gene: ENSMUSG00000000782

DomainStartEndE-ValueType
Pfam:CTNNB1_binding 1 100 2.2e-23 PFAM
low complexity region 119 130 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
HMG 187 257 2.86e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109071
SMART Domains Protein: ENSMUSP00000104699
Gene: ENSMUSG00000000782

DomainStartEndE-ValueType
Pfam:CTNNB1_binding 1 100 5.3e-23 PFAM
low complexity region 119 130 N/A INTRINSIC
low complexity region 142 157 N/A INTRINSIC
HMG 187 257 2.86e-22 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik T C 7: 43,150,695 (GRCm39) T26A probably benign Het
Arhgap27 A G 11: 103,230,048 (GRCm39) S239P possibly damaging Het
Bambi T C 18: 3,511,515 (GRCm39) V112A possibly damaging Het
BC034090 T A 1: 155,117,955 (GRCm39) E54D possibly damaging Het
Cdin1 T A 2: 115,505,236 (GRCm39) L169Q probably damaging Het
Chst13 C T 6: 90,286,074 (GRCm39) R296H probably benign Het
Clip2 C T 5: 134,533,616 (GRCm39) R487Q probably benign Het
Ctbs T A 3: 146,160,109 (GRCm39) V46E probably damaging Het
Cyp2b9 A G 7: 25,900,259 (GRCm39) I356V probably benign Het
Dot1l A G 10: 80,600,472 (GRCm39) T40A probably benign Het
Dst C T 1: 34,219,524 (GRCm39) T1988M probably benign Het
Fam184a T A 10: 53,626,864 (GRCm39) D38V possibly damaging Het
Fank1 T A 7: 133,463,887 (GRCm39) F83I probably damaging Het
Fto T A 8: 92,211,886 (GRCm39) W404R probably damaging Het
Gabra4 T A 5: 71,791,004 (GRCm39) R279S possibly damaging Het
Garem2 C T 5: 30,319,219 (GRCm39) P227L probably damaging Het
Gfra4 C A 2: 130,884,600 (GRCm39) M1I probably null Het
Gin1 T A 1: 97,703,211 (GRCm39) H11Q probably damaging Het
Gli3 G A 13: 15,900,386 (GRCm39) G1258R probably damaging Het
Gsx1 T C 5: 147,126,677 (GRCm39) S167P probably damaging Het
Gtf2b AATCATC AATC 3: 142,477,178 (GRCm39) probably benign Het
Il7 G A 3: 7,641,171 (GRCm39) R82C probably damaging Het
Lair1 A T 7: 4,013,794 (GRCm39) V151E probably damaging Het
Lpar1 T C 4: 58,437,349 (GRCm39) D360G probably benign Het
Malrd1 T A 2: 15,625,401 (GRCm39) N345K unknown Het
Mbnl1 T A 3: 60,503,086 (GRCm39) N82K probably damaging Het
Mtdh C A 15: 34,123,844 (GRCm39) T357N probably benign Het
Muc6 T A 7: 141,227,748 (GRCm39) K1306* probably null Het
Nsd1 T A 13: 55,461,518 (GRCm39) C2685S probably benign Het
Optn T A 2: 5,036,150 (GRCm39) Q444L probably damaging Het
Or6a2 A T 7: 106,600,899 (GRCm39) L56H probably damaging Het
Pan2 T A 10: 128,144,223 (GRCm39) D157E probably benign Het
Pole G A 5: 110,465,866 (GRCm39) probably null Het
Stau2 A T 1: 16,530,595 (GRCm39) I108N unknown Het
Sugp2 A G 8: 70,695,428 (GRCm39) K134E probably benign Het
Tcaf3 C T 6: 42,574,024 (GRCm39) V63I probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Tubb2b T C 13: 34,312,409 (GRCm39) D128G probably benign Het
Umodl1 A T 17: 31,178,324 (GRCm39) Q100L probably damaging Het
Unc79 T A 12: 103,112,620 (GRCm39) N2230K probably benign Het
Zc3hav1l T C 6: 38,272,101 (GRCm39) T223A probably benign Het
Zfhx4 G A 3: 5,455,506 (GRCm39) D1167N possibly damaging Het
Zfp36 A T 7: 28,077,344 (GRCm39) L200Q probably damaging Het
Zswim9 T A 7: 12,994,205 (GRCm39) L650F probably damaging Het
Other mutations in Tcf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01673:Tcf7 APN 11 52,147,823 (GRCm39) missense probably damaging 1.00
IGL02558:Tcf7 APN 11 52,144,797 (GRCm39) splice site probably benign
R1854:Tcf7 UTSW 11 52,147,891 (GRCm39) missense probably benign 0.00
R2937:Tcf7 UTSW 11 52,173,610 (GRCm39) splice site probably null
R2938:Tcf7 UTSW 11 52,173,610 (GRCm39) splice site probably null
R3911:Tcf7 UTSW 11 52,173,793 (GRCm39) start gained probably benign
R4433:Tcf7 UTSW 11 52,152,442 (GRCm39) missense probably benign
R5796:Tcf7 UTSW 11 52,152,354 (GRCm39) missense probably benign 0.31
R6443:Tcf7 UTSW 11 52,144,765 (GRCm39) missense probably benign 0.00
R8798:Tcf7 UTSW 11 52,151,421 (GRCm39) missense probably damaging 0.96
R9785:Tcf7 UTSW 11 52,173,773 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AAAGTCTCTGCGAAGTGTGCTC -3'
(R):5'- GGTGCCTTTGATGTTCCGAC -3'

Sequencing Primer
(F):5'- AAGTGTGCTCCCGTCCCAG -3'
(R):5'- TCCCAAAGCTGCTGTGC -3'
Posted On 2022-11-14