Incidental Mutation 'IGL01306:Wnt16'
ID 73450
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wnt16
Ensembl Gene ENSMUSG00000029671
Gene Name wingless-type MMTV integration site family, member 16
Synonyms E130309I19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01306
Quality Score
Chromosome 6
Chromosomal Location 22288226-22298521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 22297934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 267 (R267C)
Ref Sequence ENSEMBL: ENSMUSP00000031681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031681] [ENSMUST00000128245] [ENSMUST00000148639]
AlphaFold Q9QYS1
Predicted Effect probably damaging
Transcript: ENSMUST00000031681
AA Change: R267C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000031681
Gene: ENSMUSG00000029671
AA Change: R267C

signal peptide 1 29 N/A INTRINSIC
WNT1 48 364 1.13e-146 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000128245
SMART Domains Protein: ENSMUSP00000134822
Gene: ENSMUSG00000029671

signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.04e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148639
SMART Domains Protein: ENSMUSP00000135016
Gene: ENSMUSG00000029671

signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.61e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176681
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12b G A 12: 70,215,822 (GRCm39) G88S probably damaging Het
Acot10 A G 15: 20,666,051 (GRCm39) F230S probably benign Het
Ago4 T C 4: 126,409,677 (GRCm39) probably null Het
Akap12 G T 10: 4,303,273 (GRCm39) A28S probably benign Het
Anks1 C A 17: 28,205,227 (GRCm39) T262K probably damaging Het
Arfgap3 A G 15: 83,197,710 (GRCm39) Y349H possibly damaging Het
Bltp1 T C 3: 37,059,162 (GRCm39) probably benign Het
Camsap2 T A 1: 136,225,528 (GRCm39) E199D probably benign Het
Ccdc13 A T 9: 121,656,429 (GRCm39) M128K probably benign Het
Ccdc38 T C 10: 93,405,797 (GRCm39) probably null Het
Cep95 G A 11: 106,704,641 (GRCm39) V499I probably benign Het
Cpne6 A T 14: 55,752,706 (GRCm39) I299F probably damaging Het
Cse1l T A 2: 166,769,428 (GRCm39) Y278* probably null Het
Dip2c A G 13: 9,625,179 (GRCm39) N558D possibly damaging Het
Edar A T 10: 58,464,460 (GRCm39) C60S probably damaging Het
Fat2 T C 11: 55,201,698 (GRCm39) N459D probably benign Het
Fbxw8 C T 5: 118,251,785 (GRCm39) V243M possibly damaging Het
Fem1b G A 9: 62,704,810 (GRCm39) A150V possibly damaging Het
Gal3st1 A G 11: 3,948,405 (GRCm39) Y204C probably damaging Het
Gm5422 A T 10: 31,125,432 (GRCm39) noncoding transcript Het
Grin2c T C 11: 115,147,020 (GRCm39) T392A probably benign Het
Itpk1 T C 12: 102,572,362 (GRCm39) E117G probably damaging Het
Kif12 G T 4: 63,084,121 (GRCm39) P627Q probably damaging Het
Krtap15-1 T A 16: 88,626,255 (GRCm39) F88L probably benign Het
Mlh1 T C 9: 111,081,980 (GRCm39) N248D possibly damaging Het
Or2i1 T C 17: 37,507,833 (GRCm39) N342S probably benign Het
Or4k15 A G 14: 50,364,039 (GRCm39) N2D probably benign Het
Or52z12 T C 7: 103,233,900 (GRCm39) Y224H probably damaging Het
Per2 T C 1: 91,376,555 (GRCm39) H106R probably damaging Het
Pfkl T A 10: 77,827,229 (GRCm39) T486S probably benign Het
Prkdc T C 16: 15,485,595 (GRCm39) V474A possibly damaging Het
Scamp4 C A 10: 80,445,256 (GRCm39) Q34K probably damaging Het
Serpinb3b A G 1: 107,082,395 (GRCm39) Y290H probably damaging Het
Sft2d2 G T 1: 165,011,564 (GRCm39) A110E probably benign Het
Siglecf T A 7: 43,001,377 (GRCm39) L115* probably null Het
Slc6a11 C T 6: 114,111,626 (GRCm39) T103M probably damaging Het
Slco1a1 T A 6: 141,892,313 (GRCm39) K18* probably null Het
Spata1 A T 3: 146,193,154 (GRCm39) Y112* probably null Het
Tbc1d32 G A 10: 56,056,620 (GRCm39) T440I probably benign Het
Vmn2r111 T A 17: 22,787,965 (GRCm39) E462V probably damaging Het
Xylt1 A C 7: 117,148,125 (GRCm39) S230R probably benign Het
Other mutations in Wnt16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Wnt16 APN 6 22,291,012 (GRCm39) missense probably damaging 1.00
IGL02297:Wnt16 APN 6 22,297,990 (GRCm39) nonsense probably null
ANU23:Wnt16 UTSW 6 22,297,934 (GRCm39) missense probably damaging 0.99
R0320:Wnt16 UTSW 6 22,297,992 (GRCm39) missense possibly damaging 0.68
R1671:Wnt16 UTSW 6 22,298,178 (GRCm39) missense probably damaging 1.00
R2342:Wnt16 UTSW 6 22,288,923 (GRCm39) missense probably damaging 1.00
R3437:Wnt16 UTSW 6 22,298,133 (GRCm39) missense probably damaging 0.99
R3786:Wnt16 UTSW 6 22,298,021 (GRCm39) missense probably benign
R5301:Wnt16 UTSW 6 22,297,848 (GRCm39) missense probably damaging 0.99
R5357:Wnt16 UTSW 6 22,291,231 (GRCm39) intron probably benign
R5468:Wnt16 UTSW 6 22,291,160 (GRCm39) missense probably benign 0.00
R5843:Wnt16 UTSW 6 22,290,947 (GRCm39) missense probably damaging 0.99
R6655:Wnt16 UTSW 6 22,290,965 (GRCm39) missense probably damaging 1.00
R6731:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R6988:Wnt16 UTSW 6 22,288,510 (GRCm39) missense probably damaging 1.00
R7437:Wnt16 UTSW 6 22,288,560 (GRCm39) missense probably benign 0.17
R7904:Wnt16 UTSW 6 22,297,989 (GRCm39) missense probably damaging 1.00
R7919:Wnt16 UTSW 6 22,291,049 (GRCm39) missense probably benign 0.01
R7940:Wnt16 UTSW 6 22,291,188 (GRCm39) missense possibly damaging 0.78
R8071:Wnt16 UTSW 6 22,288,997 (GRCm39) missense probably benign
R9057:Wnt16 UTSW 6 22,288,823 (GRCm39) missense probably damaging 1.00
R9195:Wnt16 UTSW 6 22,297,932 (GRCm39) missense probably benign 0.00
R9618:Wnt16 UTSW 6 22,297,892 (GRCm39) nonsense probably null
R9618:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R9781:Wnt16 UTSW 6 22,291,114 (GRCm39) missense probably damaging 1.00
Z1177:Wnt16 UTSW 6 22,288,587 (GRCm39) missense probably benign 0.01
Posted On 2013-10-07