Incidental Mutation 'R9789:Cnot1'
| ID |
734533 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cnot1
|
| Ensembl Gene |
ENSMUSG00000036550 |
| Gene Name |
CCR4-NOT transcription complex, subunit 1 |
| Synonyms |
6030411K04Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9789 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 96455772 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 1995
(E1995G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063565
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000068452
AA Change: E1995G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000063565
Gene: ENSMUSG00000036550
AA Change: E1995G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
|
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
|
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
|
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
|
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098473
AA Change: E2000G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000096073
Gene: ENSMUSG00000036550
AA Change: E2000G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
|
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
|
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
|
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000211887
AA Change: E1993G
PolyPhen 2
Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212415
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213006
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.5%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
A |
12: 71,231,357 (GRCm39) |
S1038R |
probably benign |
Het |
| Aar2 |
T |
C |
2: 156,392,745 (GRCm39) |
F45L |
probably damaging |
Het |
| Abcg2 |
A |
G |
6: 58,641,533 (GRCm39) |
Y122C |
probably damaging |
Het |
| Arfgef1 |
A |
T |
1: 10,243,427 (GRCm39) |
W1041R |
probably damaging |
Het |
| Ash1l |
A |
G |
3: 88,873,373 (GRCm39) |
N52S |
probably benign |
Het |
| Asrgl1 |
T |
A |
19: 9,093,974 (GRCm39) |
T185S |
probably damaging |
Het |
| Astl |
T |
A |
2: 127,192,146 (GRCm39) |
S234T |
probably damaging |
Het |
| Atp5mf |
T |
C |
5: 145,120,656 (GRCm39) |
Y87C |
probably damaging |
Het |
| Atxn7l1 |
A |
T |
12: 33,396,062 (GRCm39) |
R264W |
probably damaging |
Het |
| Axin2 |
T |
C |
11: 108,840,180 (GRCm39) |
Y828H |
probably damaging |
Het |
| Bnipl |
T |
C |
3: 95,153,140 (GRCm39) |
D145G |
possibly damaging |
Het |
| C8b |
A |
T |
4: 104,640,191 (GRCm39) |
M165L |
probably benign |
Het |
| Cd109 |
T |
C |
9: 78,541,944 (GRCm39) |
L87P |
possibly damaging |
Het |
| Cdk17 |
C |
T |
10: 93,060,891 (GRCm39) |
P232S |
probably damaging |
Het |
| Csf2rb2 |
G |
A |
15: 78,169,196 (GRCm39) |
A653V |
probably benign |
Het |
| Cutc |
A |
G |
19: 43,756,699 (GRCm39) |
N264D |
probably benign |
Het |
| Cxcr4 |
C |
T |
1: 128,516,884 (GRCm39) |
W259* |
probably null |
Het |
| Dnah8 |
T |
C |
17: 30,980,104 (GRCm39) |
|
probably null |
Het |
| Dsp |
T |
C |
13: 38,367,937 (GRCm39) |
I652T |
probably benign |
Het |
| Dstyk |
A |
T |
1: 132,381,859 (GRCm39) |
M538L |
probably benign |
Het |
| Eppk1 |
T |
A |
15: 75,993,219 (GRCm39) |
I1221F |
probably benign |
Het |
| Ern2 |
T |
A |
7: 121,769,485 (GRCm39) |
Y847F |
probably damaging |
Het |
| Exosc7 |
T |
A |
9: 122,959,990 (GRCm39) |
V197D |
probably damaging |
Het |
| Gabra1 |
T |
C |
11: 42,024,352 (GRCm39) |
Y441C |
probably damaging |
Het |
| Garem1 |
G |
A |
18: 21,262,985 (GRCm39) |
P610S |
possibly damaging |
Het |
| Garem2 |
T |
A |
5: 30,319,330 (GRCm39) |
V264E |
probably damaging |
Het |
| Gata2 |
G |
A |
6: 88,177,272 (GRCm39) |
G101S |
probably benign |
Het |
| Gcnt4 |
A |
G |
13: 97,083,429 (GRCm39) |
T242A |
probably benign |
Het |
| Ghitm |
A |
C |
14: 36,852,719 (GRCm39) |
Y120* |
probably null |
Het |
| Gimap7 |
A |
G |
6: 48,700,470 (GRCm39) |
S19G |
probably damaging |
Het |
| Gm5475 |
G |
A |
15: 100,324,881 (GRCm39) |
G103E |
unknown |
Het |
| Gstcd |
A |
T |
3: 132,790,357 (GRCm39) |
C137S |
probably damaging |
Het |
| Gtf2b |
AATCATC |
AATC |
3: 142,477,178 (GRCm39) |
|
probably benign |
Het |
| Hfm1 |
T |
C |
5: 107,065,346 (GRCm39) |
D111G |
probably benign |
Het |
| Ighg2b |
A |
G |
12: 113,270,304 (GRCm39) |
I238T |
|
Het |
| Il2ra |
A |
C |
2: 11,685,161 (GRCm39) |
M166L |
probably benign |
Het |
| Itga1 |
A |
T |
13: 115,171,820 (GRCm39) |
L95* |
probably null |
Het |
| Itpr3 |
A |
G |
17: 27,308,915 (GRCm39) |
T373A |
probably benign |
Het |
| Klhl28 |
A |
G |
12: 64,996,871 (GRCm39) |
V490A |
probably damaging |
Het |
| Kntc1 |
A |
T |
5: 123,898,706 (GRCm39) |
N200I |
possibly damaging |
Het |
| L3mbtl4 |
A |
G |
17: 68,766,794 (GRCm39) |
K167R |
probably benign |
Het |
| Lgals1 |
A |
T |
15: 78,813,930 (GRCm39) |
T63S |
probably benign |
Het |
| Lnpep |
C |
A |
17: 17,795,596 (GRCm39) |
C305F |
probably damaging |
Het |
| Mcm5 |
C |
T |
8: 75,844,168 (GRCm39) |
S313F |
probably benign |
Het |
| Mcmbp |
A |
G |
7: 128,311,583 (GRCm39) |
I310T |
possibly damaging |
Het |
| Mical2 |
G |
A |
7: 111,945,996 (GRCm39) |
R986H |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,415,330 (GRCm39) |
S2759C |
possibly damaging |
Het |
| Myh7 |
A |
G |
14: 55,229,384 (GRCm39) |
V138A |
possibly damaging |
Het |
| Ncr1 |
T |
G |
7: 4,344,300 (GRCm39) |
|
probably null |
Het |
| Ndufa10 |
A |
T |
1: 92,397,610 (GRCm39) |
D145E |
possibly damaging |
Het |
| Neo1 |
T |
A |
9: 58,801,307 (GRCm39) |
|
probably null |
Het |
| Ninl |
A |
T |
2: 150,791,701 (GRCm39) |
S941T |
probably benign |
Het |
| Nrm |
T |
A |
17: 36,172,411 (GRCm39) |
|
probably null |
Het |
| Nup214 |
T |
C |
2: 31,907,227 (GRCm39) |
V1018A |
possibly damaging |
Het |
| Odf1 |
A |
G |
15: 38,219,716 (GRCm39) |
I15V |
probably benign |
Het |
| Or10al2 |
T |
A |
17: 37,983,059 (GRCm39) |
N48K |
probably damaging |
Het |
| Or10j7 |
C |
T |
1: 173,011,458 (GRCm39) |
R181H |
probably benign |
Het |
| Or1e1c |
A |
T |
11: 73,265,710 (GRCm39) |
N48I |
probably damaging |
Het |
| Or4b1d |
T |
A |
2: 89,969,004 (GRCm39) |
T160S |
probably benign |
Het |
| Or52e18 |
A |
T |
7: 104,609,657 (GRCm39) |
I94N |
probably damaging |
Het |
| Or5m10 |
C |
T |
2: 85,717,338 (GRCm39) |
H65Y |
probably damaging |
Het |
| Or5p66 |
A |
T |
7: 107,885,898 (GRCm39) |
V145D |
probably benign |
Het |
| Or7g32 |
C |
A |
9: 19,389,382 (GRCm39) |
D55Y |
probably benign |
Het |
| Osgin2 |
A |
T |
4: 15,998,957 (GRCm39) |
Y222N |
probably damaging |
Het |
| Pcdhga10 |
T |
C |
18: 37,882,363 (GRCm39) |
V708A |
probably benign |
Het |
| Pfn3 |
T |
C |
13: 55,562,900 (GRCm39) |
D27G |
possibly damaging |
Het |
| Plch2 |
A |
G |
4: 155,095,322 (GRCm39) |
|
probably null |
Het |
| Plin2 |
C |
A |
4: 86,576,914 (GRCm39) |
Q270H |
probably damaging |
Het |
| Polk |
A |
G |
13: 96,630,403 (GRCm39) |
F386S |
probably damaging |
Het |
| Prkar1a |
G |
A |
11: 109,556,778 (GRCm39) |
G286E |
probably damaging |
Het |
| Prodh |
A |
T |
16: 17,898,049 (GRCm39) |
L276Q |
probably damaging |
Het |
| Ranbp10 |
T |
C |
8: 106,513,306 (GRCm39) |
N202S |
probably damaging |
Het |
| Rapgef6 |
C |
A |
11: 54,540,097 (GRCm39) |
T724K |
probably benign |
Het |
| Rnf144a |
T |
A |
12: 26,377,574 (GRCm39) |
K56N |
probably benign |
Het |
| Rpa1 |
T |
A |
11: 75,203,938 (GRCm39) |
K303I |
probably damaging |
Het |
| Slc16a9 |
A |
C |
10: 70,118,340 (GRCm39) |
N220H |
possibly damaging |
Het |
| Slc28a3 |
T |
C |
13: 58,724,664 (GRCm39) |
I197V |
probably benign |
Het |
| Slc35d1 |
A |
T |
4: 103,071,946 (GRCm39) |
F19I |
|
Het |
| Sohlh2 |
A |
T |
3: 55,099,721 (GRCm39) |
E164D |
probably damaging |
Het |
| Sord |
A |
T |
2: 122,093,765 (GRCm39) |
K295* |
probably null |
Het |
| Spata31d1b |
A |
G |
13: 59,860,196 (GRCm39) |
Y23C |
probably benign |
Het |
| Stard9 |
T |
A |
2: 120,510,417 (GRCm39) |
Y333N |
probably damaging |
Het |
| Tas2r107 |
A |
G |
6: 131,636,753 (GRCm39) |
F99L |
probably damaging |
Het |
| Thap12 |
C |
T |
7: 98,352,592 (GRCm39) |
|
probably benign |
Het |
| Tmprss9 |
A |
T |
10: 80,730,993 (GRCm39) |
T840S |
probably benign |
Het |
| Trim16 |
T |
A |
11: 62,720,026 (GRCm39) |
|
probably null |
Het |
| Ttc16 |
C |
T |
2: 32,664,805 (GRCm39) |
|
probably null |
Het |
| Ttn |
C |
T |
2: 76,715,357 (GRCm39) |
E7912K |
unknown |
Het |
| Unc80 |
A |
T |
1: 66,651,371 (GRCm39) |
Y1572F |
possibly damaging |
Het |
| Usp42 |
G |
T |
5: 143,706,060 (GRCm39) |
A320D |
possibly damaging |
Het |
| Vmn2r94 |
T |
C |
17: 18,464,038 (GRCm39) |
T751A |
probably damaging |
Het |
| Zbtb41 |
C |
T |
1: 139,368,084 (GRCm39) |
L591F |
probably damaging |
Het |
| Zdhhc5 |
T |
A |
2: 84,524,662 (GRCm39) |
E219D |
probably damaging |
Het |
| Zfp248 |
A |
T |
6: 118,406,012 (GRCm39) |
F526I |
probably damaging |
Het |
| Zfp322a |
T |
C |
13: 23,540,558 (GRCm39) |
K395E |
possibly damaging |
Het |
| Zfp423 |
G |
A |
8: 88,506,877 (GRCm39) |
P1156S |
probably benign |
Het |
| Zfp644 |
T |
C |
5: 106,786,131 (GRCm39) |
T139A |
possibly damaging |
Het |
|
| Other mutations in Cnot1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1902:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATCCCAGCACAACCTCTG -3'
(R):5'- GGGCCTAGGTTCAATCCAAGAC -3'
Sequencing Primer
(F):5'- CAACTCTTGGACGCTCGAATTGG -3'
(R):5'- TAGGTTCAATCCAAGACACAGG -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation