Incidental Mutation 'R9789:Cdk17'
ID 734541
Institutional Source Beutler Lab
Gene Symbol Cdk17
Ensembl Gene ENSMUSG00000020015
Gene Name cyclin dependent kinase 17
Synonyms Pctk2, 6430598J10Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # R9789 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 92996492-93086956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 93060891 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 232 (P232S)
Ref Sequence ENSEMBL: ENSMUSP00000070355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]
AlphaFold Q8K0D0
Predicted Effect probably damaging
Transcript: ENSMUST00000069965
AA Change: P232S

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015
AA Change: P232S

DomainStartEndE-ValueType
S_TKc 192 473 4.67e-97 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215286
AA Change: P199S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,231,357 (GRCm39) S1038R probably benign Het
Aar2 T C 2: 156,392,745 (GRCm39) F45L probably damaging Het
Abcg2 A G 6: 58,641,533 (GRCm39) Y122C probably damaging Het
Arfgef1 A T 1: 10,243,427 (GRCm39) W1041R probably damaging Het
Ash1l A G 3: 88,873,373 (GRCm39) N52S probably benign Het
Asrgl1 T A 19: 9,093,974 (GRCm39) T185S probably damaging Het
Astl T A 2: 127,192,146 (GRCm39) S234T probably damaging Het
Atp5mf T C 5: 145,120,656 (GRCm39) Y87C probably damaging Het
Atxn7l1 A T 12: 33,396,062 (GRCm39) R264W probably damaging Het
Axin2 T C 11: 108,840,180 (GRCm39) Y828H probably damaging Het
Bnipl T C 3: 95,153,140 (GRCm39) D145G possibly damaging Het
C8b A T 4: 104,640,191 (GRCm39) M165L probably benign Het
Cd109 T C 9: 78,541,944 (GRCm39) L87P possibly damaging Het
Cnot1 T C 8: 96,455,772 (GRCm39) E1995G probably damaging Het
Csf2rb2 G A 15: 78,169,196 (GRCm39) A653V probably benign Het
Cutc A G 19: 43,756,699 (GRCm39) N264D probably benign Het
Cxcr4 C T 1: 128,516,884 (GRCm39) W259* probably null Het
Dnah8 T C 17: 30,980,104 (GRCm39) probably null Het
Dsp T C 13: 38,367,937 (GRCm39) I652T probably benign Het
Dstyk A T 1: 132,381,859 (GRCm39) M538L probably benign Het
Eppk1 T A 15: 75,993,219 (GRCm39) I1221F probably benign Het
Ern2 T A 7: 121,769,485 (GRCm39) Y847F probably damaging Het
Exosc7 T A 9: 122,959,990 (GRCm39) V197D probably damaging Het
Gabra1 T C 11: 42,024,352 (GRCm39) Y441C probably damaging Het
Garem1 G A 18: 21,262,985 (GRCm39) P610S possibly damaging Het
Garem2 T A 5: 30,319,330 (GRCm39) V264E probably damaging Het
Gata2 G A 6: 88,177,272 (GRCm39) G101S probably benign Het
Gcnt4 A G 13: 97,083,429 (GRCm39) T242A probably benign Het
Ghitm A C 14: 36,852,719 (GRCm39) Y120* probably null Het
Gimap7 A G 6: 48,700,470 (GRCm39) S19G probably damaging Het
Gm5475 G A 15: 100,324,881 (GRCm39) G103E unknown Het
Gstcd A T 3: 132,790,357 (GRCm39) C137S probably damaging Het
Gtf2b AATCATC AATC 3: 142,477,178 (GRCm39) probably benign Het
Hfm1 T C 5: 107,065,346 (GRCm39) D111G probably benign Het
Ighg2b A G 12: 113,270,304 (GRCm39) I238T Het
Il2ra A C 2: 11,685,161 (GRCm39) M166L probably benign Het
Itga1 A T 13: 115,171,820 (GRCm39) L95* probably null Het
Itpr3 A G 17: 27,308,915 (GRCm39) T373A probably benign Het
Klhl28 A G 12: 64,996,871 (GRCm39) V490A probably damaging Het
Kntc1 A T 5: 123,898,706 (GRCm39) N200I possibly damaging Het
L3mbtl4 A G 17: 68,766,794 (GRCm39) K167R probably benign Het
Lgals1 A T 15: 78,813,930 (GRCm39) T63S probably benign Het
Lnpep C A 17: 17,795,596 (GRCm39) C305F probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Mcmbp A G 7: 128,311,583 (GRCm39) I310T possibly damaging Het
Mical2 G A 7: 111,945,996 (GRCm39) R986H probably damaging Het
Muc5b A T 7: 141,415,330 (GRCm39) S2759C possibly damaging Het
Myh7 A G 14: 55,229,384 (GRCm39) V138A possibly damaging Het
Ncr1 T G 7: 4,344,300 (GRCm39) probably null Het
Ndufa10 A T 1: 92,397,610 (GRCm39) D145E possibly damaging Het
Neo1 T A 9: 58,801,307 (GRCm39) probably null Het
Ninl A T 2: 150,791,701 (GRCm39) S941T probably benign Het
Nrm T A 17: 36,172,411 (GRCm39) probably null Het
Nup214 T C 2: 31,907,227 (GRCm39) V1018A possibly damaging Het
Odf1 A G 15: 38,219,716 (GRCm39) I15V probably benign Het
Or10al2 T A 17: 37,983,059 (GRCm39) N48K probably damaging Het
Or10j7 C T 1: 173,011,458 (GRCm39) R181H probably benign Het
Or1e1c A T 11: 73,265,710 (GRCm39) N48I probably damaging Het
Or4b1d T A 2: 89,969,004 (GRCm39) T160S probably benign Het
Or52e18 A T 7: 104,609,657 (GRCm39) I94N probably damaging Het
Or5m10 C T 2: 85,717,338 (GRCm39) H65Y probably damaging Het
Or5p66 A T 7: 107,885,898 (GRCm39) V145D probably benign Het
Or7g32 C A 9: 19,389,382 (GRCm39) D55Y probably benign Het
Osgin2 A T 4: 15,998,957 (GRCm39) Y222N probably damaging Het
Pcdhga10 T C 18: 37,882,363 (GRCm39) V708A probably benign Het
Pfn3 T C 13: 55,562,900 (GRCm39) D27G possibly damaging Het
Plch2 A G 4: 155,095,322 (GRCm39) probably null Het
Plin2 C A 4: 86,576,914 (GRCm39) Q270H probably damaging Het
Polk A G 13: 96,630,403 (GRCm39) F386S probably damaging Het
Prkar1a G A 11: 109,556,778 (GRCm39) G286E probably damaging Het
Prodh A T 16: 17,898,049 (GRCm39) L276Q probably damaging Het
Ranbp10 T C 8: 106,513,306 (GRCm39) N202S probably damaging Het
Rapgef6 C A 11: 54,540,097 (GRCm39) T724K probably benign Het
Rnf144a T A 12: 26,377,574 (GRCm39) K56N probably benign Het
Rpa1 T A 11: 75,203,938 (GRCm39) K303I probably damaging Het
Slc16a9 A C 10: 70,118,340 (GRCm39) N220H possibly damaging Het
Slc28a3 T C 13: 58,724,664 (GRCm39) I197V probably benign Het
Slc35d1 A T 4: 103,071,946 (GRCm39) F19I Het
Sohlh2 A T 3: 55,099,721 (GRCm39) E164D probably damaging Het
Sord A T 2: 122,093,765 (GRCm39) K295* probably null Het
Spata31d1b A G 13: 59,860,196 (GRCm39) Y23C probably benign Het
Stard9 T A 2: 120,510,417 (GRCm39) Y333N probably damaging Het
Tas2r107 A G 6: 131,636,753 (GRCm39) F99L probably damaging Het
Thap12 C T 7: 98,352,592 (GRCm39) probably benign Het
Tmprss9 A T 10: 80,730,993 (GRCm39) T840S probably benign Het
Trim16 T A 11: 62,720,026 (GRCm39) probably null Het
Ttc16 C T 2: 32,664,805 (GRCm39) probably null Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Unc80 A T 1: 66,651,371 (GRCm39) Y1572F possibly damaging Het
Usp42 G T 5: 143,706,060 (GRCm39) A320D possibly damaging Het
Vmn2r94 T C 17: 18,464,038 (GRCm39) T751A probably damaging Het
Zbtb41 C T 1: 139,368,084 (GRCm39) L591F probably damaging Het
Zdhhc5 T A 2: 84,524,662 (GRCm39) E219D probably damaging Het
Zfp248 A T 6: 118,406,012 (GRCm39) F526I probably damaging Het
Zfp322a T C 13: 23,540,558 (GRCm39) K395E possibly damaging Het
Zfp423 G A 8: 88,506,877 (GRCm39) P1156S probably benign Het
Zfp644 T C 5: 106,786,131 (GRCm39) T139A possibly damaging Het
Other mutations in Cdk17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Cdk17 APN 10 93,062,633 (GRCm39) missense probably damaging 1.00
IGL00781:Cdk17 APN 10 93,068,278 (GRCm39) missense probably damaging 1.00
IGL01622:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01623:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01732:Cdk17 APN 10 93,053,907 (GRCm39) missense probably benign 0.01
IGL01768:Cdk17 APN 10 93,044,123 (GRCm39) missense probably damaging 0.99
IGL02942:Cdk17 APN 10 93,074,830 (GRCm39) missense probably benign
IGL03308:Cdk17 APN 10 93,057,506 (GRCm39) critical splice donor site probably null
delude UTSW 10 93,053,823 (GRCm39) splice site probably null
Imagine UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
Magician UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
prestidigitator UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R4436_Cdk17_536 UTSW 10 93,047,758 (GRCm39) splice site probably null
R0039:Cdk17 UTSW 10 93,062,640 (GRCm39) splice site probably benign
R0398:Cdk17 UTSW 10 93,073,702 (GRCm39) missense probably benign 0.01
R0432:Cdk17 UTSW 10 93,073,652 (GRCm39) unclassified probably benign
R0609:Cdk17 UTSW 10 93,052,334 (GRCm39) missense probably benign
R0781:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1110:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1604:Cdk17 UTSW 10 93,068,360 (GRCm39) missense probably damaging 1.00
R1674:Cdk17 UTSW 10 93,057,492 (GRCm39) missense probably benign 0.21
R1758:Cdk17 UTSW 10 93,044,112 (GRCm39) missense probably damaging 1.00
R1797:Cdk17 UTSW 10 93,044,114 (GRCm39) missense possibly damaging 0.76
R1864:Cdk17 UTSW 10 93,061,967 (GRCm39) missense probably damaging 1.00
R1924:Cdk17 UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R1929:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R2143:Cdk17 UTSW 10 93,053,881 (GRCm39) missense probably damaging 1.00
R2207:Cdk17 UTSW 10 93,064,624 (GRCm39) missense probably damaging 1.00
R2261:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R2262:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R3737:Cdk17 UTSW 10 93,057,506 (GRCm39) critical splice donor site probably null
R3883:Cdk17 UTSW 10 93,047,939 (GRCm39) critical splice donor site probably null
R4436:Cdk17 UTSW 10 93,047,758 (GRCm39) splice site probably null
R5372:Cdk17 UTSW 10 93,061,901 (GRCm39) missense probably benign 0.03
R5444:Cdk17 UTSW 10 93,053,823 (GRCm39) splice site probably null
R5488:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5489:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5815:Cdk17 UTSW 10 93,064,559 (GRCm39) missense probably damaging 1.00
R6164:Cdk17 UTSW 10 93,071,331 (GRCm39) missense probably benign 0.26
R6209:Cdk17 UTSW 10 93,044,093 (GRCm39) missense probably benign 0.05
R6384:Cdk17 UTSW 10 93,047,827 (GRCm39) missense probably damaging 0.99
R6627:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R6698:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R7164:Cdk17 UTSW 10 93,068,343 (GRCm39) missense probably benign 0.07
R8096:Cdk17 UTSW 10 93,052,229 (GRCm39) missense probably damaging 0.98
R8118:Cdk17 UTSW 10 93,052,252 (GRCm39) missense possibly damaging 0.46
R8459:Cdk17 UTSW 10 93,068,289 (GRCm39) missense probably damaging 0.99
R8670:Cdk17 UTSW 10 93,061,958 (GRCm39) nonsense probably null
R8722:Cdk17 UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
R8829:Cdk17 UTSW 10 93,042,920 (GRCm39) unclassified probably benign
R9077:Cdk17 UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
R9488:Cdk17 UTSW 10 93,044,066 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGAGGTTTACTCTGCTCTGTATAC -3'
(R):5'- TGACTGATCCCTTTCTGTTGAGTAC -3'

Sequencing Primer
(F):5'- TTTGAGCAGAGACTCACCATGTAGC -3'
(R):5'- ATCCCTTTCTGTTGAGTACTTTGG -3'
Posted On 2022-11-14