Incidental Mutation 'R9789:Zfp322a'
ID 734554
Institutional Source Beutler Lab
Gene Symbol Zfp322a
Ensembl Gene ENSMUSG00000046351
Gene Name zinc finger protein 322A
Synonyms 9630054P07Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R9789 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 23537273-23553378 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23540558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 395 (K395E)
Ref Sequence ENSEMBL: ENSMUSP00000061524 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050101] [ENSMUST00000125328] [ENSMUST00000145451] [ENSMUST00000152557]
AlphaFold Q8BZ89
Predicted Effect possibly damaging
Transcript: ENSMUST00000050101
AA Change: K395E

PolyPhen 2 Score 0.835 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000061524
Gene: ENSMUSG00000046351
AA Change: K395E

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
ZnF_C2H2 165 187 2.95e-3 SMART
ZnF_C2H2 193 215 1.95e-3 SMART
ZnF_C2H2 221 243 4.79e-3 SMART
ZnF_C2H2 249 271 5.14e-3 SMART
ZnF_C2H2 277 299 8.94e-3 SMART
ZnF_C2H2 303 325 5.68e1 SMART
ZnF_C2H2 361 383 1.89e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125328
SMART Domains Protein: ENSMUSP00000120804
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145451
SMART Domains Protein: ENSMUSP00000119883
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152557
SMART Domains Protein: ENSMUSP00000118754
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,231,357 (GRCm39) S1038R probably benign Het
Aar2 T C 2: 156,392,745 (GRCm39) F45L probably damaging Het
Abcg2 A G 6: 58,641,533 (GRCm39) Y122C probably damaging Het
Arfgef1 A T 1: 10,243,427 (GRCm39) W1041R probably damaging Het
Ash1l A G 3: 88,873,373 (GRCm39) N52S probably benign Het
Asrgl1 T A 19: 9,093,974 (GRCm39) T185S probably damaging Het
Astl T A 2: 127,192,146 (GRCm39) S234T probably damaging Het
Atp5mf T C 5: 145,120,656 (GRCm39) Y87C probably damaging Het
Atxn7l1 A T 12: 33,396,062 (GRCm39) R264W probably damaging Het
Axin2 T C 11: 108,840,180 (GRCm39) Y828H probably damaging Het
Bnipl T C 3: 95,153,140 (GRCm39) D145G possibly damaging Het
C8b A T 4: 104,640,191 (GRCm39) M165L probably benign Het
Cd109 T C 9: 78,541,944 (GRCm39) L87P possibly damaging Het
Cdk17 C T 10: 93,060,891 (GRCm39) P232S probably damaging Het
Cnot1 T C 8: 96,455,772 (GRCm39) E1995G probably damaging Het
Csf2rb2 G A 15: 78,169,196 (GRCm39) A653V probably benign Het
Cutc A G 19: 43,756,699 (GRCm39) N264D probably benign Het
Cxcr4 C T 1: 128,516,884 (GRCm39) W259* probably null Het
Dnah8 T C 17: 30,980,104 (GRCm39) probably null Het
Dsp T C 13: 38,367,937 (GRCm39) I652T probably benign Het
Dstyk A T 1: 132,381,859 (GRCm39) M538L probably benign Het
Eppk1 T A 15: 75,993,219 (GRCm39) I1221F probably benign Het
Ern2 T A 7: 121,769,485 (GRCm39) Y847F probably damaging Het
Exosc7 T A 9: 122,959,990 (GRCm39) V197D probably damaging Het
Gabra1 T C 11: 42,024,352 (GRCm39) Y441C probably damaging Het
Garem1 G A 18: 21,262,985 (GRCm39) P610S possibly damaging Het
Garem2 T A 5: 30,319,330 (GRCm39) V264E probably damaging Het
Gata2 G A 6: 88,177,272 (GRCm39) G101S probably benign Het
Gcnt4 A G 13: 97,083,429 (GRCm39) T242A probably benign Het
Ghitm A C 14: 36,852,719 (GRCm39) Y120* probably null Het
Gimap7 A G 6: 48,700,470 (GRCm39) S19G probably damaging Het
Gm5475 G A 15: 100,324,881 (GRCm39) G103E unknown Het
Gstcd A T 3: 132,790,357 (GRCm39) C137S probably damaging Het
Gtf2b AATCATC AATC 3: 142,477,178 (GRCm39) probably benign Het
Hfm1 T C 5: 107,065,346 (GRCm39) D111G probably benign Het
Ighg2b A G 12: 113,270,304 (GRCm39) I238T Het
Il2ra A C 2: 11,685,161 (GRCm39) M166L probably benign Het
Itga1 A T 13: 115,171,820 (GRCm39) L95* probably null Het
Itpr3 A G 17: 27,308,915 (GRCm39) T373A probably benign Het
Klhl28 A G 12: 64,996,871 (GRCm39) V490A probably damaging Het
Kntc1 A T 5: 123,898,706 (GRCm39) N200I possibly damaging Het
L3mbtl4 A G 17: 68,766,794 (GRCm39) K167R probably benign Het
Lgals1 A T 15: 78,813,930 (GRCm39) T63S probably benign Het
Lnpep C A 17: 17,795,596 (GRCm39) C305F probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Mcmbp A G 7: 128,311,583 (GRCm39) I310T possibly damaging Het
Mical2 G A 7: 111,945,996 (GRCm39) R986H probably damaging Het
Muc5b A T 7: 141,415,330 (GRCm39) S2759C possibly damaging Het
Myh7 A G 14: 55,229,384 (GRCm39) V138A possibly damaging Het
Ncr1 T G 7: 4,344,300 (GRCm39) probably null Het
Ndufa10 A T 1: 92,397,610 (GRCm39) D145E possibly damaging Het
Neo1 T A 9: 58,801,307 (GRCm39) probably null Het
Ninl A T 2: 150,791,701 (GRCm39) S941T probably benign Het
Nrm T A 17: 36,172,411 (GRCm39) probably null Het
Nup214 T C 2: 31,907,227 (GRCm39) V1018A possibly damaging Het
Odf1 A G 15: 38,219,716 (GRCm39) I15V probably benign Het
Or10al2 T A 17: 37,983,059 (GRCm39) N48K probably damaging Het
Or10j7 C T 1: 173,011,458 (GRCm39) R181H probably benign Het
Or1e1c A T 11: 73,265,710 (GRCm39) N48I probably damaging Het
Or4b1d T A 2: 89,969,004 (GRCm39) T160S probably benign Het
Or52e18 A T 7: 104,609,657 (GRCm39) I94N probably damaging Het
Or5m10 C T 2: 85,717,338 (GRCm39) H65Y probably damaging Het
Or5p66 A T 7: 107,885,898 (GRCm39) V145D probably benign Het
Or7g32 C A 9: 19,389,382 (GRCm39) D55Y probably benign Het
Osgin2 A T 4: 15,998,957 (GRCm39) Y222N probably damaging Het
Pcdhga10 T C 18: 37,882,363 (GRCm39) V708A probably benign Het
Pfn3 T C 13: 55,562,900 (GRCm39) D27G possibly damaging Het
Plch2 A G 4: 155,095,322 (GRCm39) probably null Het
Plin2 C A 4: 86,576,914 (GRCm39) Q270H probably damaging Het
Polk A G 13: 96,630,403 (GRCm39) F386S probably damaging Het
Prkar1a G A 11: 109,556,778 (GRCm39) G286E probably damaging Het
Prodh A T 16: 17,898,049 (GRCm39) L276Q probably damaging Het
Ranbp10 T C 8: 106,513,306 (GRCm39) N202S probably damaging Het
Rapgef6 C A 11: 54,540,097 (GRCm39) T724K probably benign Het
Rnf144a T A 12: 26,377,574 (GRCm39) K56N probably benign Het
Rpa1 T A 11: 75,203,938 (GRCm39) K303I probably damaging Het
Slc16a9 A C 10: 70,118,340 (GRCm39) N220H possibly damaging Het
Slc28a3 T C 13: 58,724,664 (GRCm39) I197V probably benign Het
Slc35d1 A T 4: 103,071,946 (GRCm39) F19I Het
Sohlh2 A T 3: 55,099,721 (GRCm39) E164D probably damaging Het
Sord A T 2: 122,093,765 (GRCm39) K295* probably null Het
Spata31d1b A G 13: 59,860,196 (GRCm39) Y23C probably benign Het
Stard9 T A 2: 120,510,417 (GRCm39) Y333N probably damaging Het
Tas2r107 A G 6: 131,636,753 (GRCm39) F99L probably damaging Het
Thap12 C T 7: 98,352,592 (GRCm39) probably benign Het
Tmprss9 A T 10: 80,730,993 (GRCm39) T840S probably benign Het
Trim16 T A 11: 62,720,026 (GRCm39) probably null Het
Ttc16 C T 2: 32,664,805 (GRCm39) probably null Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Unc80 A T 1: 66,651,371 (GRCm39) Y1572F possibly damaging Het
Usp42 G T 5: 143,706,060 (GRCm39) A320D possibly damaging Het
Vmn2r94 T C 17: 18,464,038 (GRCm39) T751A probably damaging Het
Zbtb41 C T 1: 139,368,084 (GRCm39) L591F probably damaging Het
Zdhhc5 T A 2: 84,524,662 (GRCm39) E219D probably damaging Het
Zfp248 A T 6: 118,406,012 (GRCm39) F526I probably damaging Het
Zfp423 G A 8: 88,506,877 (GRCm39) P1156S probably benign Het
Zfp644 T C 5: 106,786,131 (GRCm39) T139A possibly damaging Het
Other mutations in Zfp322a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02579:Zfp322a APN 13 23,541,613 (GRCm39) missense probably damaging 0.97
R1395:Zfp322a UTSW 13 23,540,945 (GRCm39) missense probably benign 0.01
R1975:Zfp322a UTSW 13 23,541,074 (GRCm39) missense probably damaging 1.00
R2100:Zfp322a UTSW 13 23,541,460 (GRCm39) missense possibly damaging 0.85
R2332:Zfp322a UTSW 13 23,541,494 (GRCm39) missense probably damaging 1.00
R2571:Zfp322a UTSW 13 23,540,614 (GRCm39) missense probably damaging 1.00
R4959:Zfp322a UTSW 13 23,541,052 (GRCm39) missense probably damaging 1.00
R5245:Zfp322a UTSW 13 23,541,156 (GRCm39) nonsense probably null
R5310:Zfp322a UTSW 13 23,541,532 (GRCm39) missense possibly damaging 0.90
R5389:Zfp322a UTSW 13 23,541,149 (GRCm39) missense probably damaging 1.00
R5525:Zfp322a UTSW 13 23,541,685 (GRCm39) missense probably benign
R5810:Zfp322a UTSW 13 23,541,579 (GRCm39) nonsense probably null
R7299:Zfp322a UTSW 13 23,541,314 (GRCm39) missense probably benign 0.22
R7299:Zfp322a UTSW 13 23,541,313 (GRCm39) missense probably damaging 0.97
R7301:Zfp322a UTSW 13 23,541,314 (GRCm39) missense probably benign 0.22
R7301:Zfp322a UTSW 13 23,541,313 (GRCm39) missense probably damaging 0.97
R8670:Zfp322a UTSW 13 23,541,274 (GRCm39) missense possibly damaging 0.83
R9108:Zfp322a UTSW 13 23,541,437 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATAAAGGTGTCCTGACAGGGC -3'
(R):5'- GTGACTTCCTCCTAGGTATGGAC -3'

Sequencing Primer
(F):5'- ACAGTTCCTAAGACTGTAGACTCTC -3'
(R):5'- CTTCGTTGCCCAGCAGAAAATGAG -3'
Posted On 2022-11-14