Incidental Mutation 'IGL01307:Gbp4'
ID 73473
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gbp4
Ensembl Gene ENSMUSG00000079363
Gene Name guanylate binding protein 4
Synonyms Mpa2, Mpa-2, Mag-2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01307
Quality Score
Status
Chromosome 5
Chromosomal Location 105263633-105287452 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to C at 105284887 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 1 (M1V)
Ref Sequence ENSEMBL: ENSMUSP00000142528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031235] [ENSMUST00000100961] [ENSMUST00000100962] [ENSMUST00000196204] [ENSMUST00000196677] [ENSMUST00000197799] [ENSMUST00000199629]
AlphaFold A4UUI3
Predicted Effect probably benign
Transcript: ENSMUST00000031235
SMART Domains Protein: ENSMUSP00000031235
Gene: ENSMUSG00000034438

DomainStartEndE-ValueType
Pfam:GBP 16 213 5.4e-91 PFAM
Pfam:GBP_C 206 493 1e-115 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000100961
SMART Domains Protein: ENSMUSP00000098521
Gene: ENSMUSG00000029298

DomainStartEndE-ValueType
Pfam:GBP 16 279 3.8e-124 PFAM
Pfam:GBP_C 281 575 4.5e-115 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000100962
AA Change: M1V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000098522
Gene: ENSMUSG00000079363
AA Change: M1V

DomainStartEndE-ValueType
Pfam:GBP 16 287 4.2e-91 PFAM
Pfam:GBP_C 289 583 4.4e-117 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000196204
AA Change: M1V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000142528
Gene: ENSMUSG00000079363
AA Change: M1V

DomainStartEndE-ValueType
Pfam:GBP 16 76 1e-19 PFAM
low complexity region 82 103 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196677
SMART Domains Protein: ENSMUSP00000142795
Gene: ENSMUSG00000079363

DomainStartEndE-ValueType
Pfam:GBP 1 149 3e-56 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000197799
AA Change: M1V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000142493
Gene: ENSMUSG00000079363
AA Change: M1V

DomainStartEndE-ValueType
Pfam:GBP 16 184 3.3e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198278
Predicted Effect probably benign
Transcript: ENSMUST00000199629
SMART Domains Protein: ENSMUSP00000143689
Gene: ENSMUSG00000079363

DomainStartEndE-ValueType
Pfam:GBP 1 127 1.5e-43 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,247,159 (GRCm39) M2302K possibly damaging Het
Actl9 A G 17: 33,653,152 (GRCm39) E404G probably damaging Het
Adamts12 A T 15: 11,237,632 (GRCm39) I314L possibly damaging Het
Card6 C A 15: 5,129,484 (GRCm39) M637I possibly damaging Het
Ccdc122 G A 14: 77,329,516 (GRCm39) probably benign Het
Cdh10 A G 15: 18,899,886 (GRCm39) D71G probably benign Het
Cdk15 A T 1: 59,326,955 (GRCm39) Y214F probably benign Het
Cdon A G 9: 35,368,860 (GRCm39) K365E probably benign Het
Cyp2c37 T C 19: 39,981,023 (GRCm39) V47A probably benign Het
Ddc T A 11: 11,789,462 (GRCm39) D271V probably damaging Het
Dnah6 G A 6: 73,042,708 (GRCm39) A3290V probably damaging Het
Dtl A T 1: 191,302,811 (GRCm39) S20T possibly damaging Het
Egf A C 3: 129,533,642 (GRCm39) I66S probably damaging Het
Eif4a3 T C 11: 119,184,387 (GRCm39) K268E probably damaging Het
Fbxl16 A T 17: 26,038,338 (GRCm39) probably benign Het
Fez2 C T 17: 78,689,029 (GRCm39) probably benign Het
Fras1 C A 5: 96,929,551 (GRCm39) T3985K probably benign Het
Gpnmb A G 6: 49,022,299 (GRCm39) D143G probably benign Het
Grm5 A T 7: 87,724,220 (GRCm39) T837S probably damaging Het
Hmcn1 T C 1: 150,620,752 (GRCm39) T1153A possibly damaging Het
Hp C T 8: 110,302,415 (GRCm39) V178I probably benign Het
Macf1 A T 4: 123,276,922 (GRCm39) V4061E probably damaging Het
Msto1 C A 3: 88,820,993 (GRCm39) R34L probably benign Het
Mtf2 C T 5: 108,254,756 (GRCm39) T519M probably damaging Het
Myo3a T A 2: 22,448,301 (GRCm39) N25K probably damaging Het
Ncapd2 A G 6: 125,145,582 (GRCm39) V1355A possibly damaging Het
Nhlrc2 C A 19: 56,540,231 (GRCm39) Y73* probably null Het
Nwd2 A T 5: 63,965,626 (GRCm39) S1737C possibly damaging Het
Or1p1 T A 11: 74,180,254 (GRCm39) C261S possibly damaging Het
Osmr A G 15: 6,873,908 (GRCm39) V163A probably damaging Het
Palm3 T C 8: 84,756,074 (GRCm39) S529P possibly damaging Het
Pcnt A G 10: 76,247,422 (GRCm39) Y1037H probably damaging Het
Pkhd1l1 T C 15: 44,393,425 (GRCm39) I1920T possibly damaging Het
Plekha7 A G 7: 115,744,479 (GRCm39) probably benign Het
Psd C T 19: 46,303,097 (GRCm39) G762R probably damaging Het
Psmb8 A G 17: 34,418,210 (GRCm39) T51A probably benign Het
Rbm12 A C 2: 155,937,302 (GRCm39) probably benign Het
Rictor T A 15: 6,804,085 (GRCm39) probably null Het
Slc24a5 G A 2: 124,922,800 (GRCm39) G158S probably damaging Het
Spata31f1a G T 4: 42,850,963 (GRCm39) L398I probably benign Het
Stag1 A G 9: 100,833,841 (GRCm39) probably benign Het
Tln2 A G 9: 67,302,749 (GRCm39) M74T probably benign Het
Trim24 C A 6: 37,942,570 (GRCm39) D957E possibly damaging Het
Trpa1 A T 1: 14,966,771 (GRCm39) M531K probably benign Het
Ttn A G 2: 76,736,637 (GRCm39) Y4376H possibly damaging Het
Twsg1 T C 17: 66,255,646 (GRCm39) probably benign Het
Usp34 T A 11: 23,367,676 (GRCm39) V1671E probably damaging Het
Vwa5b2 A G 16: 20,423,020 (GRCm39) D1006G probably benign Het
Other mutations in Gbp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01834:Gbp4 APN 5 105,273,468 (GRCm39) missense probably damaging 1.00
IGL02100:Gbp4 APN 5 105,269,941 (GRCm39) unclassified probably benign
IGL02119:Gbp4 APN 5 105,268,908 (GRCm39) missense probably benign 0.14
IGL02364:Gbp4 APN 5 105,284,740 (GRCm39) missense probably damaging 1.00
IGL03026:Gbp4 APN 5 105,267,866 (GRCm39) missense possibly damaging 0.88
PIT4651001:Gbp4 UTSW 5 105,266,289 (GRCm39) missense probably benign 0.08
R0147:Gbp4 UTSW 5 105,267,362 (GRCm39) missense probably benign 0.17
R0148:Gbp4 UTSW 5 105,267,362 (GRCm39) missense probably benign 0.17
R0413:Gbp4 UTSW 5 105,268,972 (GRCm39) missense possibly damaging 0.85
R0415:Gbp4 UTSW 5 105,268,972 (GRCm39) missense possibly damaging 0.85
R0478:Gbp4 UTSW 5 105,267,299 (GRCm39) missense probably benign 0.01
R0546:Gbp4 UTSW 5 105,268,836 (GRCm39) missense probably damaging 1.00
R0638:Gbp4 UTSW 5 105,269,706 (GRCm39) missense probably damaging 0.98
R1528:Gbp4 UTSW 5 105,269,658 (GRCm39) splice site probably null
R1541:Gbp4 UTSW 5 105,266,275 (GRCm39) missense probably benign
R2099:Gbp4 UTSW 5 105,268,947 (GRCm39) missense probably damaging 1.00
R2112:Gbp4 UTSW 5 105,283,042 (GRCm39) missense possibly damaging 0.95
R2994:Gbp4 UTSW 5 105,284,886 (GRCm39) start codon destroyed probably null 0.86
R4021:Gbp4 UTSW 5 105,268,789 (GRCm39) missense probably damaging 0.96
R4258:Gbp4 UTSW 5 105,284,841 (GRCm39) missense probably damaging 1.00
R4489:Gbp4 UTSW 5 105,269,773 (GRCm39) missense probably damaging 1.00
R5164:Gbp4 UTSW 5 105,284,743 (GRCm39) nonsense probably null
R5195:Gbp4 UTSW 5 105,267,398 (GRCm39) missense probably benign 0.00
R5406:Gbp4 UTSW 5 105,267,387 (GRCm39) missense possibly damaging 0.76
R5550:Gbp4 UTSW 5 105,269,911 (GRCm39) missense probably damaging 1.00
R5701:Gbp4 UTSW 5 105,266,265 (GRCm39) missense possibly damaging 0.60
R5814:Gbp4 UTSW 5 105,267,785 (GRCm39) missense probably benign 0.27
R6128:Gbp4 UTSW 5 105,283,030 (GRCm39) missense possibly damaging 0.93
R6307:Gbp4 UTSW 5 105,270,975 (GRCm39) nonsense probably null
R6513:Gbp4 UTSW 5 105,270,986 (GRCm39) missense possibly damaging 0.69
R6870:Gbp4 UTSW 5 105,273,444 (GRCm39) missense probably damaging 1.00
R6938:Gbp4 UTSW 5 105,282,943 (GRCm39) missense probably damaging 0.99
R7063:Gbp4 UTSW 5 105,266,314 (GRCm39) missense probably damaging 0.96
R7124:Gbp4 UTSW 5 105,267,825 (GRCm39) missense possibly damaging 0.45
R7457:Gbp4 UTSW 5 105,267,419 (GRCm39) missense probably damaging 0.98
R7615:Gbp4 UTSW 5 105,270,848 (GRCm39) missense possibly damaging 0.95
R7877:Gbp4 UTSW 5 105,266,161 (GRCm39) missense probably benign 0.34
R7905:Gbp4 UTSW 5 105,268,953 (GRCm39) missense probably damaging 1.00
R8274:Gbp4 UTSW 5 105,267,338 (GRCm39) missense probably benign 0.01
R8377:Gbp4 UTSW 5 105,266,328 (GRCm39) missense probably benign 0.02
R8414:Gbp4 UTSW 5 105,284,703 (GRCm39) missense probably benign 0.05
R8423:Gbp4 UTSW 5 105,267,800 (GRCm39) missense probably damaging 1.00
R8979:Gbp4 UTSW 5 105,267,248 (GRCm39) missense probably benign 0.00
R9485:Gbp4 UTSW 5 105,269,796 (GRCm39) missense probably damaging 1.00
R9579:Gbp4 UTSW 5 105,270,947 (GRCm39) missense probably damaging 1.00
R9598:Gbp4 UTSW 5 105,284,740 (GRCm39) missense probably damaging 1.00
S24628:Gbp4 UTSW 5 105,268,972 (GRCm39) missense possibly damaging 0.85
X0067:Gbp4 UTSW 5 105,273,491 (GRCm39) missense probably damaging 0.98
Z1088:Gbp4 UTSW 5 105,268,863 (GRCm39) missense probably damaging 1.00
Z1177:Gbp4 UTSW 5 105,273,001 (GRCm39) missense probably null 0.89
Z1177:Gbp4 UTSW 5 105,267,315 (GRCm39) nonsense probably null
Posted On 2013-10-07