Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01307:Cyp2c37'

73483

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.104) question?

Stock #

IGL01307

Quality Score

Status

Chromosome

Chromosomal Location

39992424-40012243 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39992579 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 47 (V47A)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably benign
Transcript: ENSMUST00000049178
AA Change: V47A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: V47A

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,297,159	M2302K	possibly damaging	Het
Actl9	A	G	17: 33,434,178	E404G	probably damaging	Het
Adamts12	A	T	15: 11,237,546	I314L	possibly damaging	Het
Card6	C	A	15: 5,100,002	M637I	possibly damaging	Het
Ccdc122	G	A	14: 77,092,076		probably benign	Het
Cdh10	A	G	15: 18,899,800	D71G	probably benign	Het
Cdk15	A	T	1: 59,287,796	Y214F	probably benign	Het
Cdon	A	G	9: 35,457,564	K365E	probably benign	Het
Ddc	T	A	11: 11,839,462	D271V	probably damaging	Het
Dnah6	G	A	6: 73,065,725	A3290V	probably damaging	Het
Dtl	A	T	1: 191,570,699	S20T	possibly damaging	Het
Egf	A	C	3: 129,739,993	I66S	probably damaging	Het
Eif4a3	T	C	11: 119,293,561	K268E	probably damaging	Het
Fam205a1	G	T	4: 42,850,963	L398I	probably benign	Het
Fbxl16	A	T	17: 25,819,364		probably benign	Het
Fez2	C	T	17: 78,381,600		probably benign	Het
Fras1	C	A	5: 96,781,692	T3985K	probably benign	Het
Gbp4	T	C	5: 105,137,021	M1V	probably null	Het
Gpnmb	A	G	6: 49,045,365	D143G	probably benign	Het
Grm5	A	T	7: 88,075,012	T837S	probably damaging	Het
Hmcn1	T	C	1: 150,745,001	T1153A	possibly damaging	Het
Hp	C	T	8: 109,575,783	V178I	probably benign	Het
Macf1	A	T	4: 123,383,129	V4061E	probably damaging	Het
Msto1	C	A	3: 88,913,686	R34L	probably benign	Het
Mtf2	C	T	5: 108,106,890	T519M	probably damaging	Het
Myo3a	T	A	2: 22,558,289	N25K	probably damaging	Het
Ncapd2	A	G	6: 125,168,619	V1355A	possibly damaging	Het
Nhlrc2	C	A	19: 56,551,799	Y73*	probably null	Het
Nwd2	A	T	5: 63,808,283	S1737C	possibly damaging	Het
Olfr59	T	A	11: 74,289,428	C261S	possibly damaging	Het
Osmr	A	G	15: 6,844,427	V163A	probably damaging	Het
Palm3	T	C	8: 84,029,445	S529P	possibly damaging	Het
Pcnt	A	G	10: 76,411,588	Y1037H	probably damaging	Het
Pkhd1l1	T	C	15: 44,530,029	I1920T	possibly damaging	Het
Plekha7	A	G	7: 116,145,244		probably benign	Het
Psd	C	T	19: 46,314,658	G762R	probably damaging	Het
Psmb8	A	G	17: 34,199,236	T51A	probably benign	Het
Rbm12	A	C	2: 156,095,382		probably benign	Het
Rictor	T	A	15: 6,774,604		probably null	Het
Slc24a5	G	A	2: 125,080,880	G158S	probably damaging	Het
Stag1	A	G	9: 100,951,788		probably benign	Het
Tln2	A	G	9: 67,395,467	M74T	probably benign	Het
Trim24	C	A	6: 37,965,635	D957E	possibly damaging	Het
Trpa1	A	T	1: 14,896,547	M531K	probably benign	Het
Ttn	A	G	2: 76,906,293	Y4376H	possibly damaging	Het
Twsg1	T	C	17: 65,948,651		probably benign	Het
Usp34	T	A	11: 23,417,676	V1671E	probably damaging	Het
Vwa5b2	A	G	16: 20,604,270	D1006G	probably benign	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cyp2c37	APN	19	40001997	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39995833	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39994498	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39993865	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39994102	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39994506	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39995794	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39993825	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39994098	missense	probably benign	0.21
R1637:Cyp2c37	UTSW	19	40001982	nonsense	probably null
R1688:Cyp2c37	UTSW	19	39994443	splice site	probably null
R2258:Cyp2c37	UTSW	19	39995859	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	40000545	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40011832	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40011762	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	40001887	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39994152	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40011732	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39994581	missense	probably benign
R6631:Cyp2c37	UTSW	19	40009843	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39995546	splice site	probably null
R7937:Cyp2c37	UTSW	19	39993758	missense	probably damaging	1.00
R9640:Cyp2c37	UTSW	19	40011736	missense	probably benign	0.01
R9779:Cyp2c37	UTSW	19	40009879	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	40000499	missense	possibly damaging	0.85

Posted On

2013-10-07