Incidental Mutation 'IGL01307:Nwd2'
ID 73489
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nwd2
Ensembl Gene ENSMUSG00000090061
Gene Name NACHT and WD repeat domain containing 2
Synonyms 3110047P20Rik, B830017A01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # IGL01307
Quality Score
Status
Chromosome 5
Chromosomal Location 63806446-63967889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63965626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 1737 (S1737C)
Ref Sequence ENSEMBL: ENSMUSP00000124712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081747] [ENSMUST00000159584] [ENSMUST00000196575]
AlphaFold Q6P5U7
Predicted Effect probably benign
Transcript: ENSMUST00000081747
SMART Domains Protein: ENSMUSP00000080443
Gene: ENSMUSG00000060512

DomainStartEndE-ValueType
Pfam:DUF4699 9 313 2.5e-123 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000159584
AA Change: S1737C

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124712
Gene: ENSMUSG00000090061
AA Change: S1737C

DomainStartEndE-ValueType
Pfam:DUF4062 42 145 1.5e-8 PFAM
Blast:AAA 408 691 3e-29 BLAST
WD40 939 995 1.06e2 SMART
WD40 998 1037 8.96e-2 SMART
Blast:WD40 1091 1126 9e-19 BLAST
Blast:WD40 1129 1170 1e-17 BLAST
Blast:WD40 1220 1260 3e-16 BLAST
WD40 1263 1302 3.4e-2 SMART
WD40 1347 1385 2.65e1 SMART
WD40 1386 1425 1.58e2 SMART
Blast:WD40 1466 1507 3e-19 BLAST
Blast:WD40 1606 1644 4e-18 BLAST
Blast:KR 1686 1730 2e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000162757
Predicted Effect probably benign
Transcript: ENSMUST00000196575
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,247,159 (GRCm39) M2302K possibly damaging Het
Actl9 A G 17: 33,653,152 (GRCm39) E404G probably damaging Het
Adamts12 A T 15: 11,237,632 (GRCm39) I314L possibly damaging Het
Card6 C A 15: 5,129,484 (GRCm39) M637I possibly damaging Het
Ccdc122 G A 14: 77,329,516 (GRCm39) probably benign Het
Cdh10 A G 15: 18,899,886 (GRCm39) D71G probably benign Het
Cdk15 A T 1: 59,326,955 (GRCm39) Y214F probably benign Het
Cdon A G 9: 35,368,860 (GRCm39) K365E probably benign Het
Cyp2c37 T C 19: 39,981,023 (GRCm39) V47A probably benign Het
Ddc T A 11: 11,789,462 (GRCm39) D271V probably damaging Het
Dnah6 G A 6: 73,042,708 (GRCm39) A3290V probably damaging Het
Dtl A T 1: 191,302,811 (GRCm39) S20T possibly damaging Het
Egf A C 3: 129,533,642 (GRCm39) I66S probably damaging Het
Eif4a3 T C 11: 119,184,387 (GRCm39) K268E probably damaging Het
Fbxl16 A T 17: 26,038,338 (GRCm39) probably benign Het
Fez2 C T 17: 78,689,029 (GRCm39) probably benign Het
Fras1 C A 5: 96,929,551 (GRCm39) T3985K probably benign Het
Gbp4 T C 5: 105,284,887 (GRCm39) M1V probably null Het
Gpnmb A G 6: 49,022,299 (GRCm39) D143G probably benign Het
Grm5 A T 7: 87,724,220 (GRCm39) T837S probably damaging Het
Hmcn1 T C 1: 150,620,752 (GRCm39) T1153A possibly damaging Het
Hp C T 8: 110,302,415 (GRCm39) V178I probably benign Het
Macf1 A T 4: 123,276,922 (GRCm39) V4061E probably damaging Het
Msto1 C A 3: 88,820,993 (GRCm39) R34L probably benign Het
Mtf2 C T 5: 108,254,756 (GRCm39) T519M probably damaging Het
Myo3a T A 2: 22,448,301 (GRCm39) N25K probably damaging Het
Ncapd2 A G 6: 125,145,582 (GRCm39) V1355A possibly damaging Het
Nhlrc2 C A 19: 56,540,231 (GRCm39) Y73* probably null Het
Or1p1 T A 11: 74,180,254 (GRCm39) C261S possibly damaging Het
Osmr A G 15: 6,873,908 (GRCm39) V163A probably damaging Het
Palm3 T C 8: 84,756,074 (GRCm39) S529P possibly damaging Het
Pcnt A G 10: 76,247,422 (GRCm39) Y1037H probably damaging Het
Pkhd1l1 T C 15: 44,393,425 (GRCm39) I1920T possibly damaging Het
Plekha7 A G 7: 115,744,479 (GRCm39) probably benign Het
Psd C T 19: 46,303,097 (GRCm39) G762R probably damaging Het
Psmb8 A G 17: 34,418,210 (GRCm39) T51A probably benign Het
Rbm12 A C 2: 155,937,302 (GRCm39) probably benign Het
Rictor T A 15: 6,804,085 (GRCm39) probably null Het
Slc24a5 G A 2: 124,922,800 (GRCm39) G158S probably damaging Het
Spata31f1a G T 4: 42,850,963 (GRCm39) L398I probably benign Het
Stag1 A G 9: 100,833,841 (GRCm39) probably benign Het
Tln2 A G 9: 67,302,749 (GRCm39) M74T probably benign Het
Trim24 C A 6: 37,942,570 (GRCm39) D957E possibly damaging Het
Trpa1 A T 1: 14,966,771 (GRCm39) M531K probably benign Het
Ttn A G 2: 76,736,637 (GRCm39) Y4376H possibly damaging Het
Twsg1 T C 17: 66,255,646 (GRCm39) probably benign Het
Usp34 T A 11: 23,367,676 (GRCm39) V1671E probably damaging Het
Vwa5b2 A G 16: 20,423,020 (GRCm39) D1006G probably benign Het
Other mutations in Nwd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Nwd2 APN 5 63,962,818 (GRCm39) missense probably benign
IGL01111:Nwd2 APN 5 63,964,643 (GRCm39) missense probably damaging 1.00
IGL01152:Nwd2 APN 5 63,963,872 (GRCm39) missense possibly damaging 0.74
IGL01449:Nwd2 APN 5 63,962,937 (GRCm39) missense probably damaging 1.00
IGL01624:Nwd2 APN 5 63,964,153 (GRCm39) missense probably damaging 1.00
IGL01997:Nwd2 APN 5 63,961,938 (GRCm39) missense probably damaging 0.99
IGL02007:Nwd2 APN 5 63,962,042 (GRCm39) missense possibly damaging 0.87
IGL02143:Nwd2 APN 5 63,948,996 (GRCm39) splice site probably null
IGL02184:Nwd2 APN 5 63,963,020 (GRCm39) missense probably damaging 1.00
IGL02379:Nwd2 APN 5 63,962,644 (GRCm39) missense probably damaging 1.00
IGL02489:Nwd2 APN 5 63,962,570 (GRCm39) missense probably damaging 1.00
IGL02580:Nwd2 APN 5 63,965,512 (GRCm39) missense probably damaging 0.99
IGL02682:Nwd2 APN 5 63,962,021 (GRCm39) missense probably damaging 1.00
IGL02682:Nwd2 APN 5 63,962,020 (GRCm39) missense probably benign 0.03
IGL02891:Nwd2 APN 5 63,882,570 (GRCm39) missense possibly damaging 0.91
IGL03135:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
IGL03149:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
R0113:Nwd2 UTSW 5 63,965,241 (GRCm39) missense probably damaging 1.00
R0172:Nwd2 UTSW 5 63,963,712 (GRCm39) missense probably benign 0.44
R0196:Nwd2 UTSW 5 63,963,694 (GRCm39) missense probably benign 0.37
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0309:Nwd2 UTSW 5 63,964,561 (GRCm39) missense probably damaging 1.00
R0311:Nwd2 UTSW 5 63,962,341 (GRCm39) missense probably damaging 0.99
R0335:Nwd2 UTSW 5 63,962,116 (GRCm39) missense probably benign 0.00
R0384:Nwd2 UTSW 5 63,963,025 (GRCm39) missense probably benign 0.11
R0496:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0497:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0498:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0505:Nwd2 UTSW 5 63,962,454 (GRCm39) missense probably damaging 1.00
R0655:Nwd2 UTSW 5 63,948,928 (GRCm39) missense possibly damaging 0.73
R0762:Nwd2 UTSW 5 63,957,757 (GRCm39) missense probably benign 0.33
R0835:Nwd2 UTSW 5 63,957,473 (GRCm39) missense probably damaging 0.99
R0926:Nwd2 UTSW 5 63,965,234 (GRCm39) missense probably damaging 0.99
R0948:Nwd2 UTSW 5 63,964,655 (GRCm39) missense probably damaging 1.00
R1015:Nwd2 UTSW 5 63,964,154 (GRCm39) missense probably damaging 1.00
R1086:Nwd2 UTSW 5 63,963,917 (GRCm39) missense probably damaging 1.00
R1186:Nwd2 UTSW 5 63,807,367 (GRCm39) utr 5 prime probably benign
R1305:Nwd2 UTSW 5 63,902,540 (GRCm39) missense probably damaging 0.97
R1542:Nwd2 UTSW 5 63,964,318 (GRCm39) missense probably damaging 1.00
R1548:Nwd2 UTSW 5 63,957,525 (GRCm39) missense probably benign 0.00
R1553:Nwd2 UTSW 5 63,957,848 (GRCm39) missense probably benign 0.00
R1636:Nwd2 UTSW 5 63,964,900 (GRCm39) missense probably damaging 1.00
R1658:Nwd2 UTSW 5 63,964,589 (GRCm39) missense probably damaging 1.00
R1763:Nwd2 UTSW 5 63,965,614 (GRCm39) missense probably benign
R1800:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R1813:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1861:Nwd2 UTSW 5 63,962,197 (GRCm39) missense probably damaging 0.96
R1889:Nwd2 UTSW 5 63,965,009 (GRCm39) missense possibly damaging 0.49
R1896:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1919:Nwd2 UTSW 5 63,963,523 (GRCm39) missense probably damaging 1.00
R1922:Nwd2 UTSW 5 63,951,585 (GRCm39) missense probably benign
R2258:Nwd2 UTSW 5 63,962,499 (GRCm39) missense probably benign 0.00
R2292:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R2504:Nwd2 UTSW 5 63,961,717 (GRCm39) missense probably benign 0.02
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2958:Nwd2 UTSW 5 63,963,325 (GRCm39) missense probably benign 0.01
R3034:Nwd2 UTSW 5 63,957,446 (GRCm39) missense probably damaging 1.00
R3422:Nwd2 UTSW 5 63,882,536 (GRCm39) missense possibly damaging 0.46
R3423:Nwd2 UTSW 5 63,957,504 (GRCm39) missense probably damaging 1.00
R3439:Nwd2 UTSW 5 63,961,895 (GRCm39) missense probably benign 0.00
R4193:Nwd2 UTSW 5 63,964,808 (GRCm39) missense probably damaging 1.00
R4254:Nwd2 UTSW 5 63,963,889 (GRCm39) missense possibly damaging 0.74
R4384:Nwd2 UTSW 5 63,963,914 (GRCm39) missense probably damaging 1.00
R4707:Nwd2 UTSW 5 63,951,665 (GRCm39) missense probably damaging 1.00
R4713:Nwd2 UTSW 5 63,961,803 (GRCm39) missense probably benign 0.00
R4735:Nwd2 UTSW 5 63,965,594 (GRCm39) missense probably benign 0.34
R4744:Nwd2 UTSW 5 63,964,310 (GRCm39) missense probably damaging 1.00
R4795:Nwd2 UTSW 5 63,962,776 (GRCm39) missense probably benign 0.21
R4835:Nwd2 UTSW 5 63,965,189 (GRCm39) missense probably benign 0.00
R4839:Nwd2 UTSW 5 63,962,893 (GRCm39) missense possibly damaging 0.92
R4896:Nwd2 UTSW 5 63,962,151 (GRCm39) missense probably damaging 1.00
R5017:Nwd2 UTSW 5 63,807,484 (GRCm39) utr 5 prime probably benign
R5170:Nwd2 UTSW 5 63,963,380 (GRCm39) missense probably damaging 0.99
R5312:Nwd2 UTSW 5 63,963,415 (GRCm39) nonsense probably null
R5330:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5331:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5419:Nwd2 UTSW 5 63,965,051 (GRCm39) missense probably benign 0.11
R5434:Nwd2 UTSW 5 63,964,991 (GRCm39) missense probably benign 0.00
R5445:Nwd2 UTSW 5 63,962,681 (GRCm39) missense probably damaging 1.00
R5761:Nwd2 UTSW 5 63,882,573 (GRCm39) missense probably damaging 1.00
R5788:Nwd2 UTSW 5 63,965,114 (GRCm39) missense probably benign 0.00
R5907:Nwd2 UTSW 5 63,963,326 (GRCm39) missense probably damaging 0.99
R5959:Nwd2 UTSW 5 63,965,413 (GRCm39) missense probably benign 0.32
R6002:Nwd2 UTSW 5 63,962,143 (GRCm39) missense probably benign
R6027:Nwd2 UTSW 5 63,965,563 (GRCm39) missense possibly damaging 0.65
R6082:Nwd2 UTSW 5 63,962,374 (GRCm39) missense possibly damaging 0.96
R6163:Nwd2 UTSW 5 63,963,131 (GRCm39) missense probably benign 0.00
R6172:Nwd2 UTSW 5 63,964,249 (GRCm39) missense probably damaging 0.98
R6334:Nwd2 UTSW 5 63,957,596 (GRCm39) missense possibly damaging 0.95
R6447:Nwd2 UTSW 5 63,964,898 (GRCm39) missense probably benign 0.41
R6649:Nwd2 UTSW 5 63,882,527 (GRCm39) missense possibly damaging 0.89
R6855:Nwd2 UTSW 5 63,961,794 (GRCm39) missense probably benign 0.00
R7034:Nwd2 UTSW 5 63,962,258 (GRCm39) missense probably damaging 1.00
R7168:Nwd2 UTSW 5 63,964,837 (GRCm39) missense probably benign 0.04
R7326:Nwd2 UTSW 5 63,957,752 (GRCm39) missense probably damaging 1.00
R7561:Nwd2 UTSW 5 63,964,434 (GRCm39) nonsense probably null
R7576:Nwd2 UTSW 5 63,964,736 (GRCm39) missense probably benign 0.00
R7580:Nwd2 UTSW 5 63,965,624 (GRCm39) missense probably benign 0.05
R7723:Nwd2 UTSW 5 63,965,347 (GRCm39) missense possibly damaging 0.69
R7769:Nwd2 UTSW 5 63,961,847 (GRCm39) missense probably damaging 0.99
R8293:Nwd2 UTSW 5 63,962,663 (GRCm39) missense probably benign 0.05
R8517:Nwd2 UTSW 5 63,948,925 (GRCm39) missense probably damaging 1.00
R8782:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
R8792:Nwd2 UTSW 5 63,963,047 (GRCm39) missense probably damaging 0.97
R8888:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8895:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8901:Nwd2 UTSW 5 63,963,685 (GRCm39) missense probably damaging 1.00
R8913:Nwd2 UTSW 5 63,963,440 (GRCm39) missense possibly damaging 0.80
R8920:Nwd2 UTSW 5 63,948,863 (GRCm39) missense probably damaging 1.00
R9052:Nwd2 UTSW 5 63,961,773 (GRCm39) missense probably damaging 1.00
R9362:Nwd2 UTSW 5 63,961,747 (GRCm39) missense probably benign 0.23
R9368:Nwd2 UTSW 5 63,962,306 (GRCm39) missense probably damaging 0.99
R9377:Nwd2 UTSW 5 63,957,740 (GRCm39) missense probably damaging 1.00
R9430:Nwd2 UTSW 5 63,964,665 (GRCm39) missense probably damaging 1.00
R9655:Nwd2 UTSW 5 63,964,568 (GRCm39) nonsense probably null
R9661:Nwd2 UTSW 5 63,957,780 (GRCm39) missense probably damaging 0.97
R9736:Nwd2 UTSW 5 63,951,600 (GRCm39) missense probably damaging 1.00
R9793:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
R9795:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
RF020:Nwd2 UTSW 5 63,963,066 (GRCm39) nonsense probably null
X0023:Nwd2 UTSW 5 63,964,306 (GRCm39) missense probably damaging 0.99
Z1176:Nwd2 UTSW 5 63,963,500 (GRCm39) missense probably damaging 1.00
Z1176:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
Z1177:Nwd2 UTSW 5 63,964,669 (GRCm39) nonsense probably null
Z1177:Nwd2 UTSW 5 63,962,327 (GRCm39) missense possibly damaging 0.60
Posted On 2013-10-07