Incidental Mutation 'R9796:Il23a'
ID 734952
Institutional Source Beutler Lab
Gene Symbol Il23a
Ensembl Gene ENSMUSG00000025383
Gene Name interleukin 23, alpha subunit p19
Synonyms IL-23p19, p19, IL-23
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9796 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 128132009-128133953 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 128132829 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 143 (R143G)
Ref Sequence ENSEMBL: ENSMUSP00000026449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026449] [ENSMUST00000085708] [ENSMUST00000105238]
AlphaFold Q9EQ14
Predicted Effect probably benign
Transcript: ENSMUST00000026449
AA Change: R143G

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000026449
Gene: ENSMUSG00000025383
AA Change: R143G

DomainStartEndE-ValueType
Pfam:IL23 28 185 2.4e-98 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000085708
SMART Domains Protein: ENSMUSP00000082855
Gene: ENSMUSG00000040033

DomainStartEndE-ValueType
STAT_int 2 124 4.49e-54 SMART
Pfam:STAT_alpha 138 314 5e-52 PFAM
Pfam:STAT_bind 316 564 1.2e-96 PFAM
SH2 576 652 4.71e-6 SMART
internal_repeat_1 750 778 6.35e-10 PROSPERO
internal_repeat_1 822 850 6.35e-10 PROSPERO
Pfam:STAT2_C 853 907 1.1e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105238
SMART Domains Protein: ENSMUSP00000100872
Gene: ENSMUSG00000040033

DomainStartEndE-ValueType
STAT_int 2 124 4.49e-54 SMART
Pfam:STAT_alpha 141 314 2.6e-49 PFAM
Pfam:STAT_bind 316 564 1.5e-67 PFAM
SH2 577 653 4.71e-6 SMART
internal_repeat_1 751 779 6.69e-10 PROSPERO
internal_repeat_1 823 851 6.69e-10 PROSPERO
Pfam:STAT2_C 854 908 1.7e-27 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik C T 10: 29,101,349 (GRCm39) T574I possibly damaging Het
Aadac T G 3: 59,945,882 (GRCm39) V184G probably damaging Het
Adam6b G A 12: 113,454,272 (GRCm39) C363Y probably damaging Het
Adamts8 T A 9: 30,862,569 (GRCm39) I258N probably damaging Het
Adarb2 C T 13: 8,619,852 (GRCm39) L113F probably damaging Het
Aff4 A G 11: 53,302,824 (GRCm39) N1099S probably damaging Het
Alg10b G T 15: 90,108,728 (GRCm39) A30S possibly damaging Het
Als2 T A 1: 59,209,601 (GRCm39) E1460D probably benign Het
Ascc3 C T 10: 50,608,801 (GRCm39) R1515* probably null Het
Asxl2 C T 12: 3,546,508 (GRCm39) P431S probably benign Het
AU018091 A T 7: 3,213,785 (GRCm39) V153D probably damaging Het
Cd177 A G 7: 24,459,169 (GRCm39) V80A probably benign Het
Cdc16 G T 8: 13,807,693 (GRCm39) probably benign Het
Cdk14 A G 5: 5,316,012 (GRCm39) S4P probably benign Het
Ctu2 A T 8: 123,202,989 (GRCm39) Y8F probably benign Het
Dnhd1 T C 7: 105,342,537 (GRCm39) F1294L probably damaging Het
Epha7 A G 4: 28,817,457 (GRCm39) D37G probably damaging Het
Fan1 T A 7: 64,022,278 (GRCm39) N325I probably benign Het
Fbn1 T A 2: 125,158,941 (GRCm39) M2275L probably benign Het
Fbxo38 T C 18: 62,674,055 (GRCm39) K9E possibly damaging Het
Gm3696 T C 14: 18,435,140 (GRCm39) N48S possibly damaging Het
Greb1l A G 18: 10,538,233 (GRCm39) E1082G possibly damaging Het
Gtdc1 A T 2: 44,715,386 (GRCm39) N52K probably benign Het
Hrh2 C T 13: 54,375,241 (GRCm39) T359I probably benign Het
Ifi44l A G 3: 151,468,419 (GRCm39) V37A Het
Igfn1 C A 1: 135,897,611 (GRCm39) W985L probably benign Het
Il22b A G 10: 118,130,081 (GRCm39) S108P probably benign Het
Kcnv1 T C 15: 44,977,987 (GRCm39) D17G unknown Het
Klk1 T C 7: 43,877,965 (GRCm39) W74R possibly damaging Het
Lmntd2 A T 7: 140,793,597 (GRCm39) N96K possibly damaging Het
Lrch4 A G 5: 137,635,269 (GRCm39) H253R probably damaging Het
Lrrc8d A T 5: 105,959,917 (GRCm39) D109V probably benign Het
Magi3 T C 3: 103,928,291 (GRCm39) T1004A probably benign Het
Mapk10 A G 5: 103,135,101 (GRCm39) V287A possibly damaging Het
Mtss2 G A 8: 111,456,753 (GRCm39) probably null Het
Mybpc1 T C 10: 88,406,497 (GRCm39) I116V possibly damaging Het
Mylk4 T A 13: 32,900,643 (GRCm39) M296L probably damaging Het
Nav3 A G 10: 109,527,969 (GRCm39) F2238S probably damaging Het
Or11g26 G T 14: 50,753,229 (GRCm39) L189F probably damaging Het
Pax6 T C 2: 105,522,541 (GRCm39) F243L probably damaging Het
Pcdhb22 G A 18: 37,652,404 (GRCm39) E34K possibly damaging Het
Pdzrn4 T A 15: 92,578,353 (GRCm39) F359I possibly damaging Het
Prkn A T 17: 11,456,554 (GRCm39) D126V possibly damaging Het
Rnf168 C T 16: 32,117,872 (GRCm39) R478C probably damaging Het
Sh3gl2 G A 4: 85,295,765 (GRCm39) V156I possibly damaging Het
Taf2 A T 15: 54,910,832 (GRCm39) M614K probably damaging Het
Tbc1d31 G A 15: 57,833,179 (GRCm39) V973M probably damaging Het
Tmem131l T G 3: 83,829,402 (GRCm39) K1085T probably damaging Het
Tpst1 A G 5: 130,163,300 (GRCm39) T366A probably benign Het
Unc50 A G 1: 37,471,679 (GRCm39) T110A probably benign Het
Vmn2r60 A G 7: 41,785,172 (GRCm39) H128R probably benign Het
Vps13a A T 19: 16,631,828 (GRCm39) N2602K probably benign Het
Vps13d A G 4: 144,854,505 (GRCm39) probably null Het
Vps50 A G 6: 3,562,300 (GRCm39) E465G probably damaging Het
Other mutations in Il23a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7363:Il23a UTSW 10 128,133,020 (GRCm39) missense probably damaging 1.00
R9159:Il23a UTSW 10 128,133,427 (GRCm39) nonsense probably null
R9322:Il23a UTSW 10 128,132,990 (GRCm39) missense probably benign
R9477:Il23a UTSW 10 128,133,922 (GRCm39) start gained probably benign
R9775:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
R9777:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
R9798:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- ATGGTAGCCATGGGAACCTG -3'
(R):5'- CTGACATCTTCAAAGGGGAGCC -3'

Sequencing Primer
(F):5'- AACCTGGGCATCCTTAAGCTG -3'
(R):5'- TTCAAAGGGGAGCCTGCTCTAC -3'
Posted On 2022-11-14