Mutagenetix > Incidental Mutation

Incidental Mutation 'R9796:Or11g26'

734960

Institutional Source

Beutler Lab

Gene Symbol

Or11g26

Ensembl Gene

ENSMUSG00000068431

Gene Name

olfactory receptor family 11 subfamily G member 26

Synonyms

Olfr742, MOR106-6, GA_x6K02T2PMLR-6224293-6225228

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R9796 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50752578-50753697 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 50753229 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 189 (L189F)

Ref Sequence

ENSEMBL: ENSMUSP00000150814 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089836] [ENSMUST00000213935] [ENSMUST00000217437]

AlphaFold

A2RTP5

Predicted Effect

probably damaging
Transcript: ENSMUST00000089836
AA Change: L189F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000087273
Gene: ENSMUSG00000068431
AA Change: L189F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.9e-55	PFAM
Pfam:7tm_1	45	294	1.5e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213935
AA Change: L189F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000217437
AA Change: L189F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	C	T	10: 29,101,349 (GRCm39)	T574I	possibly damaging	Het
Aadac	T	G	3: 59,945,882 (GRCm39)	V184G	probably damaging	Het
Adam6b	G	A	12: 113,454,272 (GRCm39)	C363Y	probably damaging	Het
Adamts8	T	A	9: 30,862,569 (GRCm39)	I258N	probably damaging	Het
Adarb2	C	T	13: 8,619,852 (GRCm39)	L113F	probably damaging	Het
Aff4	A	G	11: 53,302,824 (GRCm39)	N1099S	probably damaging	Het
Alg10b	G	T	15: 90,108,728 (GRCm39)	A30S	possibly damaging	Het
Als2	T	A	1: 59,209,601 (GRCm39)	E1460D	probably benign	Het
Ascc3	C	T	10: 50,608,801 (GRCm39)	R1515*	probably null	Het
Asxl2	C	T	12: 3,546,508 (GRCm39)	P431S	probably benign	Het
AU018091	A	T	7: 3,213,785 (GRCm39)	V153D	probably damaging	Het
Cd177	A	G	7: 24,459,169 (GRCm39)	V80A	probably benign	Het
Cdc16	G	T	8: 13,807,693 (GRCm39)		probably benign	Het
Cdk14	A	G	5: 5,316,012 (GRCm39)	S4P	probably benign	Het
Ctu2	A	T	8: 123,202,989 (GRCm39)	Y8F	probably benign	Het
Dnhd1	T	C	7: 105,342,537 (GRCm39)	F1294L	probably damaging	Het
Epha7	A	G	4: 28,817,457 (GRCm39)	D37G	probably damaging	Het
Fan1	T	A	7: 64,022,278 (GRCm39)	N325I	probably benign	Het
Fbn1	T	A	2: 125,158,941 (GRCm39)	M2275L	probably benign	Het
Fbxo38	T	C	18: 62,674,055 (GRCm39)	K9E	possibly damaging	Het
Gm3696	T	C	14: 18,435,140 (GRCm39)	N48S	possibly damaging	Het
Greb1l	A	G	18: 10,538,233 (GRCm39)	E1082G	possibly damaging	Het
Gtdc1	A	T	2: 44,715,386 (GRCm39)	N52K	probably benign	Het
Hrh2	C	T	13: 54,375,241 (GRCm39)	T359I	probably benign	Het
Ifi44l	A	G	3: 151,468,419 (GRCm39)	V37A		Het
Igfn1	C	A	1: 135,897,611 (GRCm39)	W985L	probably benign	Het
Il22b	A	G	10: 118,130,081 (GRCm39)	S108P	probably benign	Het
Il23a	G	C	10: 128,132,829 (GRCm39)	R143G	probably benign	Het
Kcnv1	T	C	15: 44,977,987 (GRCm39)	D17G	unknown	Het
Klk1	T	C	7: 43,877,965 (GRCm39)	W74R	possibly damaging	Het
Lmntd2	A	T	7: 140,793,597 (GRCm39)	N96K	possibly damaging	Het
Lrch4	A	G	5: 137,635,269 (GRCm39)	H253R	probably damaging	Het
Lrrc8d	A	T	5: 105,959,917 (GRCm39)	D109V	probably benign	Het
Magi3	T	C	3: 103,928,291 (GRCm39)	T1004A	probably benign	Het
Mapk10	A	G	5: 103,135,101 (GRCm39)	V287A	possibly damaging	Het
Mtss2	G	A	8: 111,456,753 (GRCm39)		probably null	Het
Mybpc1	T	C	10: 88,406,497 (GRCm39)	I116V	possibly damaging	Het
Mylk4	T	A	13: 32,900,643 (GRCm39)	M296L	probably damaging	Het
Nav3	A	G	10: 109,527,969 (GRCm39)	F2238S	probably damaging	Het
Pax6	T	C	2: 105,522,541 (GRCm39)	F243L	probably damaging	Het
Pcdhb22	G	A	18: 37,652,404 (GRCm39)	E34K	possibly damaging	Het
Pdzrn4	T	A	15: 92,578,353 (GRCm39)	F359I	possibly damaging	Het
Prkn	A	T	17: 11,456,554 (GRCm39)	D126V	possibly damaging	Het
Rnf168	C	T	16: 32,117,872 (GRCm39)	R478C	probably damaging	Het
Sh3gl2	G	A	4: 85,295,765 (GRCm39)	V156I	possibly damaging	Het
Taf2	A	T	15: 54,910,832 (GRCm39)	M614K	probably damaging	Het
Tbc1d31	G	A	15: 57,833,179 (GRCm39)	V973M	probably damaging	Het
Tmem131l	T	G	3: 83,829,402 (GRCm39)	K1085T	probably damaging	Het
Tpst1	A	G	5: 130,163,300 (GRCm39)	T366A	probably benign	Het
Unc50	A	G	1: 37,471,679 (GRCm39)	T110A	probably benign	Het
Vmn2r60	A	G	7: 41,785,172 (GRCm39)	H128R	probably benign	Het
Vps13a	A	T	19: 16,631,828 (GRCm39)	N2602K	probably benign	Het
Vps13d	A	G	4: 144,854,505 (GRCm39)		probably null	Het
Vps50	A	G	6: 3,562,300 (GRCm39)	E465G	probably damaging	Het

Other mutations in Or11g26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02385:Or11g26	APN	14	50,752,900 (GRCm39)	missense	probably damaging	0.97
R0046:Or11g26	UTSW	14	50,753,596 (GRCm39)	makesense	probably null
R0369:Or11g26	UTSW	14	50,753,282 (GRCm39)	missense	probably benign	0.00
R0612:Or11g26	UTSW	14	50,752,939 (GRCm39)	missense	probably benign
R1588:Or11g26	UTSW	14	50,753,584 (GRCm39)	missense	probably benign
R1726:Or11g26	UTSW	14	50,753,636 (GRCm39)	splice site	probably null
R1998:Or11g26	UTSW	14	50,752,813 (GRCm39)	missense	probably benign	0.00
R2875:Or11g26	UTSW	14	50,753,269 (GRCm39)	missense	probably benign	0.06
R4009:Or11g26	UTSW	14	50,753,419 (GRCm39)	missense	possibly damaging	0.77
R5119:Or11g26	UTSW	14	50,752,966 (GRCm39)	missense	probably benign	0.00
R5232:Or11g26	UTSW	14	50,753,495 (GRCm39)	missense	probably damaging	0.99
R5627:Or11g26	UTSW	14	50,753,257 (GRCm39)	missense	probably benign
R5930:Or11g26	UTSW	14	50,753,249 (GRCm39)	missense	probably benign
R6597:Or11g26	UTSW	14	50,753,008 (GRCm39)	missense	probably benign	0.11
R7441:Or11g26	UTSW	14	50,752,853 (GRCm39)	missense	probably damaging	1.00
R7596:Or11g26	UTSW	14	50,753,002 (GRCm39)	missense	probably benign	0.14
R8051:Or11g26	UTSW	14	50,753,100 (GRCm39)	missense	probably benign	0.00
R8294:Or11g26	UTSW	14	50,753,083 (GRCm39)	missense	possibly damaging	0.81
R8329:Or11g26	UTSW	14	50,753,015 (GRCm39)	missense	probably damaging	0.99
R8380:Or11g26	UTSW	14	50,753,297 (GRCm39)	missense	probably benign	0.00
R9517:Or11g26	UTSW	14	50,752,770 (GRCm39)	missense	probably benign
R9647:Or11g26	UTSW	14	50,753,552 (GRCm39)	missense	probably damaging	1.00
R9694:Or11g26	UTSW	14	50,752,669 (GRCm39)	missense	probably benign
Z1088:Or11g26	UTSW	14	50,752,984 (GRCm39)	missense	possibly damaging	0.90
Z1176:Or11g26	UTSW	14	50,753,522 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAGTCATGGCATTTGATCG -3'
(R):5'- AAACTACTGTGAGATGAGACCCG -3'

Sequencing Primer
(F):5'- GCAGTCATGGCATTTGATCGATACC -3'
(R):5'- TGTGAGATGAGACCCGCAAGTG -3'

Posted On

2022-11-14