Incidental Mutation 'R9797:Vmn2r87'
| ID |
735006 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R9797 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130308138 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 700
(I700T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164227
AA Change: I700T
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: I700T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.5%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actr3b |
A |
G |
5: 26,054,895 (GRCm39) |
Y403C |
probably benign |
Het |
| Afdn |
A |
G |
17: 14,066,562 (GRCm39) |
I600V |
probably benign |
Het |
| Akr1b8 |
G |
A |
6: 34,333,278 (GRCm39) |
E52K |
possibly damaging |
Het |
| Alas1 |
A |
G |
9: 106,113,842 (GRCm39) |
S468P |
probably damaging |
Het |
| Atp13a5 |
T |
C |
16: 29,133,491 (GRCm39) |
T432A |
probably benign |
Het |
| B3glct |
A |
T |
5: 149,650,304 (GRCm39) |
T136S |
probably benign |
Het |
| Bahcc1 |
A |
T |
11: 120,159,147 (GRCm39) |
R125* |
probably null |
Het |
| Brat1 |
A |
G |
5: 140,704,273 (GRCm39) |
E842G |
probably damaging |
Het |
| Cacna1b |
A |
G |
2: 24,508,287 (GRCm39) |
L1830S |
probably damaging |
Het |
| Cd109 |
A |
G |
9: 78,579,217 (GRCm39) |
N620D |
probably benign |
Het |
| Cdhr1 |
T |
A |
14: 36,803,462 (GRCm39) |
D538V |
probably damaging |
Het |
| Cfap74 |
G |
A |
4: 155,514,402 (GRCm39) |
C546Y |
|
Het |
| Colq |
T |
A |
14: 31,250,777 (GRCm39) |
R343* |
probably null |
Het |
| Dmxl2 |
T |
C |
9: 54,358,187 (GRCm39) |
K330R |
probably benign |
Het |
| Dnah5 |
A |
G |
15: 28,233,316 (GRCm39) |
K225R |
probably benign |
Het |
| Dnase1l3 |
C |
T |
14: 7,984,127 (GRCm38) |
S95N |
probably damaging |
Het |
| Fyco1 |
C |
A |
9: 123,626,761 (GRCm39) |
A1317S |
probably benign |
Het |
| Gm9195 |
G |
A |
14: 72,687,705 (GRCm39) |
P1944L |
probably damaging |
Het |
| Gse1 |
T |
G |
8: 121,215,864 (GRCm39) |
L4R |
probably damaging |
Het |
| Gstm1 |
T |
C |
3: 107,925,080 (GRCm39) |
I4M |
probably benign |
Het |
| Ighv2-3 |
A |
T |
12: 113,574,945 (GRCm39) |
I70K |
possibly damaging |
Het |
| Krt71 |
C |
T |
15: 101,645,069 (GRCm39) |
R414H |
probably damaging |
Het |
| Mcmbp |
T |
C |
7: 128,317,696 (GRCm39) |
E183G |
possibly damaging |
Het |
| Med13l |
T |
C |
5: 118,880,144 (GRCm39) |
S1079P |
probably damaging |
Het |
| Megf11 |
A |
G |
9: 64,545,591 (GRCm39) |
I125V |
possibly damaging |
Het |
| Mtmr4 |
T |
A |
11: 87,494,962 (GRCm39) |
V418E |
probably damaging |
Het |
| Mttp |
T |
C |
3: 137,814,725 (GRCm39) |
T517A |
probably damaging |
Het |
| Mx1 |
A |
G |
16: 97,252,893 (GRCm39) |
V409A |
probably benign |
Het |
| Olfml1 |
C |
A |
7: 107,167,069 (GRCm39) |
H33N |
probably benign |
Het |
| Or13p8 |
A |
C |
4: 118,584,079 (GRCm39) |
I212L |
probably benign |
Het |
| Or4k15b |
A |
T |
14: 50,272,224 (GRCm39) |
V212D |
probably benign |
Het |
| Or5w19 |
A |
T |
2: 87,698,478 (GRCm39) |
I48F |
possibly damaging |
Het |
| Or6k2 |
T |
C |
1: 173,986,417 (GRCm39) |
I26T |
probably benign |
Het |
| Or6n1 |
T |
A |
1: 173,917,356 (GRCm39) |
I250N |
possibly damaging |
Het |
| Parp12 |
C |
A |
6: 39,067,185 (GRCm39) |
V536F |
probably damaging |
Het |
| Phf11a |
T |
C |
14: 59,514,862 (GRCm39) |
E273G |
possibly damaging |
Het |
| Pramel27 |
A |
G |
4: 143,579,818 (GRCm39) |
T468A |
possibly damaging |
Het |
| Psd3 |
A |
G |
8: 68,210,778 (GRCm39) |
Y743H |
probably damaging |
Het |
| Rnf213 |
T |
A |
11: 119,333,365 (GRCm39) |
I2859N |
|
Het |
| Sec23a |
A |
T |
12: 59,052,060 (GRCm39) |
C88* |
probably null |
Het |
| Sepsecs |
A |
G |
5: 52,826,239 (GRCm39) |
|
probably null |
Het |
| Slc35e3 |
G |
A |
10: 117,572,016 (GRCm39) |
T293I |
probably benign |
Het |
| Slc49a3 |
G |
T |
5: 108,593,403 (GRCm39) |
T145N |
probably benign |
Het |
| Smu1 |
A |
G |
4: 40,739,538 (GRCm39) |
I424T |
possibly damaging |
Het |
| Spata16 |
T |
A |
3: 26,968,925 (GRCm39) |
I435N |
probably damaging |
Het |
| Tasp1 |
A |
G |
2: 139,838,015 (GRCm39) |
S156P |
probably benign |
Het |
| Tmem237 |
A |
C |
1: 59,144,735 (GRCm39) |
S398A |
probably damaging |
Het |
| Ttc39c |
T |
A |
18: 12,828,542 (GRCm39) |
L234Q |
probably damaging |
Het |
| Ubxn11 |
C |
A |
4: 133,851,426 (GRCm39) |
T22K |
probably benign |
Het |
| Uts2r |
C |
A |
11: 121,051,518 (GRCm39) |
S127R |
probably damaging |
Het |
| Vmn1r236 |
A |
G |
17: 21,506,969 (GRCm39) |
D29G |
probably benign |
Het |
| Vps13b |
T |
A |
15: 35,675,022 (GRCm39) |
V1714E |
probably damaging |
Het |
| Wrn |
T |
A |
8: 33,758,950 (GRCm39) |
I1003L |
probably benign |
Het |
| Ylpm1 |
A |
G |
12: 85,077,109 (GRCm39) |
D1278G |
possibly damaging |
Het |
| Zfp1006 |
T |
A |
8: 129,946,534 (GRCm39) |
H97L |
probably benign |
Het |
| Zfp955a |
A |
C |
17: 33,461,888 (GRCm39) |
H81Q |
possibly damaging |
Het |
| Zfyve26 |
T |
C |
12: 79,293,006 (GRCm39) |
T2048A |
probably damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4590:Vmn2r87
|
UTSW |
10 |
130,315,014 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCAGCATGCTGAAAGTTAGG -3'
(R):5'- TTGAACATCCCAACCAGGTC -3'
Sequencing Primer
(F):5'- GCTTCATTGAATCTGTCAGGAAG -3'
(R):5'- AGGTCACCTGCATCCTGC -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation