Mutagenetix > Incidental Mutation

Incidental Mutation 'R9797:Zfp955a'

735029

Institutional Source

Beutler Lab

Gene Symbol

Zfp955a

Ensembl Gene

ENSMUSG00000094441

Gene Name

zinc finger protein 955A

Synonyms

AI842447

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R9797 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

33458692-33474119 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 33461888 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 81 (H81Q)

Ref Sequence

ENSEMBL: ENSMUSP00000008830 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000008830]

AlphaFold

Q80XR7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000008830
AA Change: H81Q

PolyPhen 2 Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000008830
Gene: ENSMUSG00000094441
AA Change: H81Q

Domain	Start	End	E-Value	Type
KRAB	10	71	7.08e-15	SMART
ZnF_C2H2	230	252	7.29e0	SMART
ZnF_C2H2	258	280	5.72e-1	SMART
ZnF_C2H2	290	312	6.57e-1	SMART
ZnF_C2HC	291	307	9.75e0	SMART
ZnF_C2H2	318	340	7.67e-2	SMART
ZnF_C2H2	346	368	3.16e-3	SMART
ZnF_C2H2	374	396	1.18e-2	SMART
ZnF_C2H2	402	424	2.99e-4	SMART
ZnF_C2H2	430	452	2.09e-3	SMART
ZnF_C2H2	458	480	6.57e-1	SMART
ZnF_C2HC	459	475	4.03e1	SMART
ZnF_C2H2	486	508	1.28e-3	SMART
ZnF_C2H2	514	536	2.36e-2	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.5%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr3b	A	G	5: 26,054,895 (GRCm39)	Y403C	probably benign	Het
Afdn	A	G	17: 14,066,562 (GRCm39)	I600V	probably benign	Het
Akr1b8	G	A	6: 34,333,278 (GRCm39)	E52K	possibly damaging	Het
Alas1	A	G	9: 106,113,842 (GRCm39)	S468P	probably damaging	Het
Atp13a5	T	C	16: 29,133,491 (GRCm39)	T432A	probably benign	Het
B3glct	A	T	5: 149,650,304 (GRCm39)	T136S	probably benign	Het
Bahcc1	A	T	11: 120,159,147 (GRCm39)	R125*	probably null	Het
Brat1	A	G	5: 140,704,273 (GRCm39)	E842G	probably damaging	Het
Cacna1b	A	G	2: 24,508,287 (GRCm39)	L1830S	probably damaging	Het
Cd109	A	G	9: 78,579,217 (GRCm39)	N620D	probably benign	Het
Cdhr1	T	A	14: 36,803,462 (GRCm39)	D538V	probably damaging	Het
Cfap74	G	A	4: 155,514,402 (GRCm39)	C546Y		Het
Colq	T	A	14: 31,250,777 (GRCm39)	R343*	probably null	Het
Dmxl2	T	C	9: 54,358,187 (GRCm39)	K330R	probably benign	Het
Dnah5	A	G	15: 28,233,316 (GRCm39)	K225R	probably benign	Het
Dnase1l3	C	T	14: 7,984,127 (GRCm38)	S95N	probably damaging	Het
Fyco1	C	A	9: 123,626,761 (GRCm39)	A1317S	probably benign	Het
Gm9195	G	A	14: 72,687,705 (GRCm39)	P1944L	probably damaging	Het
Gse1	T	G	8: 121,215,864 (GRCm39)	L4R	probably damaging	Het
Gstm1	T	C	3: 107,925,080 (GRCm39)	I4M	probably benign	Het
Ighv2-3	A	T	12: 113,574,945 (GRCm39)	I70K	possibly damaging	Het
Krt71	C	T	15: 101,645,069 (GRCm39)	R414H	probably damaging	Het
Mcmbp	T	C	7: 128,317,696 (GRCm39)	E183G	possibly damaging	Het
Med13l	T	C	5: 118,880,144 (GRCm39)	S1079P	probably damaging	Het
Megf11	A	G	9: 64,545,591 (GRCm39)	I125V	possibly damaging	Het
Mtmr4	T	A	11: 87,494,962 (GRCm39)	V418E	probably damaging	Het
Mttp	T	C	3: 137,814,725 (GRCm39)	T517A	probably damaging	Het
Mx1	A	G	16: 97,252,893 (GRCm39)	V409A	probably benign	Het
Olfml1	C	A	7: 107,167,069 (GRCm39)	H33N	probably benign	Het
Or13p8	A	C	4: 118,584,079 (GRCm39)	I212L	probably benign	Het
Or4k15b	A	T	14: 50,272,224 (GRCm39)	V212D	probably benign	Het
Or5w19	A	T	2: 87,698,478 (GRCm39)	I48F	possibly damaging	Het
Or6k2	T	C	1: 173,986,417 (GRCm39)	I26T	probably benign	Het
Or6n1	T	A	1: 173,917,356 (GRCm39)	I250N	possibly damaging	Het
Parp12	C	A	6: 39,067,185 (GRCm39)	V536F	probably damaging	Het
Phf11a	T	C	14: 59,514,862 (GRCm39)	E273G	possibly damaging	Het
Pramel27	A	G	4: 143,579,818 (GRCm39)	T468A	possibly damaging	Het
Psd3	A	G	8: 68,210,778 (GRCm39)	Y743H	probably damaging	Het
Rnf213	T	A	11: 119,333,365 (GRCm39)	I2859N		Het
Sec23a	A	T	12: 59,052,060 (GRCm39)	C88*	probably null	Het
Sepsecs	A	G	5: 52,826,239 (GRCm39)		probably null	Het
Slc35e3	G	A	10: 117,572,016 (GRCm39)	T293I	probably benign	Het
Slc49a3	G	T	5: 108,593,403 (GRCm39)	T145N	probably benign	Het
Smu1	A	G	4: 40,739,538 (GRCm39)	I424T	possibly damaging	Het
Spata16	T	A	3: 26,968,925 (GRCm39)	I435N	probably damaging	Het
Tasp1	A	G	2: 139,838,015 (GRCm39)	S156P	probably benign	Het
Tmem237	A	C	1: 59,144,735 (GRCm39)	S398A	probably damaging	Het
Ttc39c	T	A	18: 12,828,542 (GRCm39)	L234Q	probably damaging	Het
Ubxn11	C	A	4: 133,851,426 (GRCm39)	T22K	probably benign	Het
Uts2r	C	A	11: 121,051,518 (GRCm39)	S127R	probably damaging	Het
Vmn1r236	A	G	17: 21,506,969 (GRCm39)	D29G	probably benign	Het
Vmn2r87	A	G	10: 130,308,138 (GRCm39)	I700T	probably damaging	Het
Vmn2r87	T	A	10: 130,312,064 (GRCm39)	T517S	probably benign	Het
Vps13b	T	A	15: 35,675,022 (GRCm39)	V1714E	probably damaging	Het
Wrn	T	A	8: 33,758,950 (GRCm39)	I1003L	probably benign	Het
Ylpm1	A	G	12: 85,077,109 (GRCm39)	D1278G	possibly damaging	Het
Zfp1006	T	A	8: 129,946,534 (GRCm39)	H97L	probably benign	Het
Zfyve26	T	C	12: 79,293,006 (GRCm39)	T2048A	probably damaging	Het

Other mutations in Zfp955a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01115:Zfp955a	APN	17	33,461,554 (GRCm39)	nonsense	probably null
IGL01859:Zfp955a	APN	17	33,462,693 (GRCm39)	missense	probably benign	0.45
IGL02612:Zfp955a	APN	17	33,463,039 (GRCm39)	missense	probably damaging	0.99
IGL02894:Zfp955a	APN	17	33,461,426 (GRCm39)	nonsense	probably null
IGL02933:Zfp955a	APN	17	33,462,683 (GRCm39)	splice site	probably null
R0145:Zfp955a	UTSW	17	33,461,430 (GRCm39)	missense	probably damaging	0.98
R0577:Zfp955a	UTSW	17	33,461,068 (GRCm39)	missense	probably damaging	0.99
R0963:Zfp955a	UTSW	17	33,462,726 (GRCm39)	missense	probably benign	0.00
R1588:Zfp955a	UTSW	17	33,460,791 (GRCm39)	missense	probably benign	0.00
R1614:Zfp955a	UTSW	17	33,461,306 (GRCm39)	missense	possibly damaging	0.72
R1704:Zfp955a	UTSW	17	33,460,699 (GRCm39)	nonsense	probably null
R1994:Zfp955a	UTSW	17	33,460,620 (GRCm39)	missense	probably damaging	0.99
R2043:Zfp955a	UTSW	17	33,461,527 (GRCm39)	missense	possibly damaging	0.94
R2091:Zfp955a	UTSW	17	33,461,731 (GRCm39)	nonsense	probably null
R2091:Zfp955a	UTSW	17	33,461,731 (GRCm39)	nonsense	probably null
R4077:Zfp955a	UTSW	17	33,460,675 (GRCm39)	missense	probably benign	0.15
R4078:Zfp955a	UTSW	17	33,460,675 (GRCm39)	missense	probably benign	0.15
R4689:Zfp955a	UTSW	17	33,461,040 (GRCm39)	missense	probably damaging	1.00
R4735:Zfp955a	UTSW	17	33,460,696 (GRCm39)	missense	probably benign	0.09
R4870:Zfp955a	UTSW	17	33,460,699 (GRCm39)	nonsense	probably null
R4904:Zfp955a	UTSW	17	33,461,162 (GRCm39)	nonsense	probably null
R5180:Zfp955a	UTSW	17	33,461,592 (GRCm39)	missense	probably benign	0.15
R6006:Zfp955a	UTSW	17	33,460,660 (GRCm39)	missense	probably damaging	1.00
R7132:Zfp955a	UTSW	17	33,460,589 (GRCm39)	nonsense	probably null
R7403:Zfp955a	UTSW	17	33,462,720 (GRCm39)	missense	probably benign	0.01
R7457:Zfp955a	UTSW	17	33,463,025 (GRCm39)	nonsense	probably null
R7547:Zfp955a	UTSW	17	33,461,797 (GRCm39)	missense	probably benign	0.05
R8263:Zfp955a	UTSW	17	33,463,087 (GRCm39)	missense	probably damaging	1.00
R8265:Zfp955a	UTSW	17	33,463,087 (GRCm39)	missense	probably damaging	1.00
R8330:Zfp955a	UTSW	17	33,463,087 (GRCm39)	missense	probably damaging	1.00
R8947:Zfp955a	UTSW	17	33,460,955 (GRCm39)	missense	probably damaging	1.00
R9052:Zfp955a	UTSW	17	33,461,279 (GRCm39)	missense	possibly damaging	0.53
R9352:Zfp955a	UTSW	17	33,461,335 (GRCm39)	missense	probably benign	0.01
R9557:Zfp955a	UTSW	17	33,461,107 (GRCm39)	nonsense	probably null
R9683:Zfp955a	UTSW	17	33,461,587 (GRCm39)	missense	probably benign	0.01
R9784:Zfp955a	UTSW	17	33,461,149 (GRCm39)	missense	probably damaging	1.00
X0062:Zfp955a	UTSW	17	33,460,976 (GRCm39)	missense	probably benign	0.37

Predicted Primers

PCR Primer
(F):5'- AGAATAGGTGACGTCTTTCCAAC -3'
(R):5'- GGAACAGGCCTAGTTTGTGC -3'

Sequencing Primer
(F):5'- CACGAGTTCCTGACATCTGTATGG -3'
(R):5'- AGGCCTAGTTTGTGCTCACTTTC -3'

Posted On

2022-11-14