Mutagenetix > Incidental Mutation

Incidental Mutation 'R9798:Vmn1r178'

735050

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r178

Ensembl Gene

ENSMUSG00000062598

Gene Name

vomeronasal 1 receptor 178

Synonyms

V1rd13, LOC232959

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R9798 (G1)

Quality Score

195.009

Status

Not validated

Chromosome

Chromosomal Location

23592954-23593868 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 23593733 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 260 (Y260*)

Ref Sequence

ENSEMBL: ENSMUSP00000077666 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078593] [ENSMUST00000226450] [ENSMUST00000226489] [ENSMUST00000226640] [ENSMUST00000227993]

AlphaFold

Q8R2B6

Predicted Effect

probably null
Transcript: ENSMUST00000078593
AA Change: Y260*

SMART Domains

Protein: ENSMUSP00000077666
Gene: ENSMUSG00000062598
AA Change: Y260*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	7.9e-11	PFAM
Pfam:7tm_1	15	283	2.5e-7	PFAM
Pfam:V1R	41	296	7.8e-19	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226450
AA Change: Y260*

Predicted Effect

probably null
Transcript: ENSMUST00000226489
AA Change: Y187*

Predicted Effect

probably null
Transcript: ENSMUST00000226640
AA Change: Y187*

Predicted Effect

probably null
Transcript: ENSMUST00000227993
AA Change: Y260*

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930486L24Rik	A	T	13: 61,000,934 (GRCm39)	S201T	possibly damaging	Het
Adamtsl1	A	G	4: 86,074,927 (GRCm39)	D98G	probably damaging	Het
Ahnak	A	G	19: 8,990,983 (GRCm39)	D4089G	probably damaging	Het
Alpk3	T	A	7: 80,742,400 (GRCm39)	M739K	probably benign	Het
Asns	T	C	6: 7,689,395 (GRCm39)	N36D	possibly damaging	Het
Bbs7	A	T	3: 36,652,439 (GRCm39)	M338K	probably benign	Het
Bbx	T	C	16: 50,045,121 (GRCm39)	D480G	probably damaging	Het
Cc2d2b	G	A	19: 40,783,080 (GRCm39)	V626I	unknown	Het
Celsr3	A	T	9: 108,705,794 (GRCm39)	D759V	probably damaging	Het
Entpd1	G	A	19: 40,715,789 (GRCm39)	V319M	possibly damaging	Het
Espnl	G	T	1: 91,251,286 (GRCm39)	G127V	probably damaging	Het
Fgfr1	C	T	8: 26,053,523 (GRCm39)	T266I	unknown	Het
Fktn	C	T	4: 53,747,128 (GRCm39)	H344Y	probably damaging	Het
Fryl	T	C	5: 73,192,402 (GRCm39)	M2678V	probably benign	Het
Fsip2	T	A	2: 82,810,225 (GRCm39)	Y2181*	probably null	Het
Gm21698	A	T	5: 26,189,184 (GRCm39)	D256E	probably damaging	Het
Hipk1	C	T	3: 103,651,431 (GRCm39)	V1156I	possibly damaging	Het
Igsf10	T	A	3: 59,239,126 (GRCm39)	I352F	probably damaging	Het
Igsf5	C	A	16: 96,174,075 (GRCm39)	T35K	probably damaging	Het
Il23a	G	C	10: 128,132,829 (GRCm39)	R143G	probably benign	Het
Kctd11	T	G	11: 69,770,732 (GRCm39)	H102P	probably damaging	Het
Msln	T	C	17: 25,972,771 (GRCm39)	T37A	probably benign	Het
Or7g29	T	A	9: 19,286,577 (GRCm39)	Y200F	probably benign	Het
Or8u10	T	C	2: 85,915,606 (GRCm39)	N172D	probably damaging	Het
Phtf1	T	C	3: 103,904,869 (GRCm39)	S506P	probably benign	Het
Pias3	T	C	3: 96,606,881 (GRCm39)	I57T	probably damaging	Het
Psmc2	A	G	5: 22,000,806 (GRCm39)	I94V	probably benign	Het
Ripor1	T	C	8: 106,342,798 (GRCm39)	Y224H	possibly damaging	Het
Rrh	C	T	3: 129,605,421 (GRCm39)	V229M	probably damaging	Het
Scaf4	G	A	16: 90,045,533 (GRCm39)	R526C	unknown	Het
Slc1a6	G	A	10: 78,629,167 (GRCm39)		probably null	Het
Slc4a7	A	G	14: 14,782,056 (GRCm38)	D937G	probably damaging	Het
Slco1b2	C	A	6: 141,601,079 (GRCm39)	T134K	probably damaging	Het
Sptbn4	T	C	7: 27,056,717 (GRCm39)	*2562W	probably null	Het
Ston1	T	C	17: 88,944,472 (GRCm39)	V626A	probably damaging	Het
Synpo	A	T	18: 60,736,832 (GRCm39)	D371E	possibly damaging	Het
Tex15	T	A	8: 34,062,721 (GRCm39)	V717D	probably damaging	Het
Tmod3	A	C	9: 75,436,805 (GRCm39)	N43K	probably damaging	Het
Tmod3	G	T	9: 75,436,801 (GRCm39)	L45I	possibly damaging	Het
Tmod3	G	C	9: 75,436,803 (GRCm39)	A44G	probably damaging	Het
Top2b	T	C	14: 16,389,845 (GRCm38)	F228L	probably damaging	Het
Trappc14	A	G	5: 138,259,940 (GRCm39)	M372T	possibly damaging	Het
Ush2a	A	G	1: 188,644,002 (GRCm39)	T4455A	possibly damaging	Het
Vps13c	T	A	9: 67,826,646 (GRCm39)	I1429N	probably damaging	Het
Wdr31	A	G	4: 62,381,651 (GRCm39)	V60A	probably benign	Het

Other mutations in Vmn1r178

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01697:Vmn1r178	APN	7	23,593,114 (GRCm39)	missense	probably damaging	0.99
IGL01781:Vmn1r178	APN	7	23,593,434 (GRCm39)	missense	probably damaging	1.00
IGL01934:Vmn1r178	APN	7	23,593,362 (GRCm39)	missense	probably damaging	1.00
IGL02571:Vmn1r178	APN	7	23,593,660 (GRCm39)	missense	probably damaging	0.99
IGL02727:Vmn1r178	APN	7	23,593,871 (GRCm39)	splice site	probably null
IGL03112:Vmn1r178	APN	7	23,593,086 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn1r178	UTSW	7	23,593,609 (GRCm39)	missense	possibly damaging	0.93
R0830:Vmn1r178	UTSW	7	23,593,452 (GRCm39)	missense	possibly damaging	0.91
R1186:Vmn1r178	UTSW	7	23,593,317 (GRCm39)	nonsense	probably null
R1340:Vmn1r178	UTSW	7	23,593,281 (GRCm39)	missense	probably benign	0.34
R1640:Vmn1r178	UTSW	7	23,593,548 (GRCm39)	missense	possibly damaging	0.70
R1696:Vmn1r178	UTSW	7	23,593,625 (GRCm39)	missense	probably damaging	0.99
R1746:Vmn1r178	UTSW	7	23,593,329 (GRCm39)	missense	probably benign	0.00
R3084:Vmn1r178	UTSW	7	23,593,331 (GRCm39)	missense	possibly damaging	0.94
R4368:Vmn1r178	UTSW	7	23,593,447 (GRCm39)	missense	probably damaging	1.00
R5199:Vmn1r178	UTSW	7	23,593,814 (GRCm39)	missense	probably benign	0.11
R6380:Vmn1r178	UTSW	7	23,592,984 (GRCm39)	missense	possibly damaging	0.62
R7000:Vmn1r178	UTSW	7	23,593,762 (GRCm39)	missense	probably benign	0.21
R7142:Vmn1r178	UTSW	7	23,593,035 (GRCm39)	missense	probably damaging	1.00
R7268:Vmn1r178	UTSW	7	23,593,378 (GRCm39)	missense	probably benign	0.05
R8829:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R8832:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R9068:Vmn1r178	UTSW	7	23,593,404 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GACCAGTGTCTCCATGGTACTTC -3'
(R):5'- GCCTTGTTGATGCAAAAGATGTTG -3'

Sequencing Primer
(F):5'- ATGGTACTTCTCCTCCATAGACATCG -3'
(R):5'- GTTGATGCAAAAGATGTTGAACACAC -3'

Posted On

2022-11-14