Incidental Mutation 'R9798:Il23a'
ID 735063
Institutional Source Beutler Lab
Gene Symbol Il23a
Ensembl Gene ENSMUSG00000025383
Gene Name interleukin 23, alpha subunit p19
Synonyms IL-23p19, p19, IL-23
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9798 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 128132009-128133953 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 128132829 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 143 (R143G)
Ref Sequence ENSEMBL: ENSMUSP00000026449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026449] [ENSMUST00000085708] [ENSMUST00000105238]
AlphaFold Q9EQ14
Predicted Effect probably benign
Transcript: ENSMUST00000026449
AA Change: R143G

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000026449
Gene: ENSMUSG00000025383
AA Change: R143G

DomainStartEndE-ValueType
Pfam:IL23 28 185 2.4e-98 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000085708
SMART Domains Protein: ENSMUSP00000082855
Gene: ENSMUSG00000040033

DomainStartEndE-ValueType
STAT_int 2 124 4.49e-54 SMART
Pfam:STAT_alpha 138 314 5e-52 PFAM
Pfam:STAT_bind 316 564 1.2e-96 PFAM
SH2 576 652 4.71e-6 SMART
internal_repeat_1 750 778 6.35e-10 PROSPERO
internal_repeat_1 822 850 6.35e-10 PROSPERO
Pfam:STAT2_C 853 907 1.1e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105238
SMART Domains Protein: ENSMUSP00000100872
Gene: ENSMUSG00000040033

DomainStartEndE-ValueType
STAT_int 2 124 4.49e-54 SMART
Pfam:STAT_alpha 141 314 2.6e-49 PFAM
Pfam:STAT_bind 316 564 1.5e-67 PFAM
SH2 577 653 4.71e-6 SMART
internal_repeat_1 751 779 6.69e-10 PROSPERO
internal_repeat_1 823 851 6.69e-10 PROSPERO
Pfam:STAT2_C 854 908 1.7e-27 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik A T 13: 61,000,934 (GRCm39) S201T possibly damaging Het
Adamtsl1 A G 4: 86,074,927 (GRCm39) D98G probably damaging Het
Ahnak A G 19: 8,990,983 (GRCm39) D4089G probably damaging Het
Alpk3 T A 7: 80,742,400 (GRCm39) M739K probably benign Het
Asns T C 6: 7,689,395 (GRCm39) N36D possibly damaging Het
Bbs7 A T 3: 36,652,439 (GRCm39) M338K probably benign Het
Bbx T C 16: 50,045,121 (GRCm39) D480G probably damaging Het
Cc2d2b G A 19: 40,783,080 (GRCm39) V626I unknown Het
Celsr3 A T 9: 108,705,794 (GRCm39) D759V probably damaging Het
Entpd1 G A 19: 40,715,789 (GRCm39) V319M possibly damaging Het
Espnl G T 1: 91,251,286 (GRCm39) G127V probably damaging Het
Fgfr1 C T 8: 26,053,523 (GRCm39) T266I unknown Het
Fktn C T 4: 53,747,128 (GRCm39) H344Y probably damaging Het
Fryl T C 5: 73,192,402 (GRCm39) M2678V probably benign Het
Fsip2 T A 2: 82,810,225 (GRCm39) Y2181* probably null Het
Gm21698 A T 5: 26,189,184 (GRCm39) D256E probably damaging Het
Hipk1 C T 3: 103,651,431 (GRCm39) V1156I possibly damaging Het
Igsf10 T A 3: 59,239,126 (GRCm39) I352F probably damaging Het
Igsf5 C A 16: 96,174,075 (GRCm39) T35K probably damaging Het
Kctd11 T G 11: 69,770,732 (GRCm39) H102P probably damaging Het
Msln T C 17: 25,972,771 (GRCm39) T37A probably benign Het
Or7g29 T A 9: 19,286,577 (GRCm39) Y200F probably benign Het
Or8u10 T C 2: 85,915,606 (GRCm39) N172D probably damaging Het
Phtf1 T C 3: 103,904,869 (GRCm39) S506P probably benign Het
Pias3 T C 3: 96,606,881 (GRCm39) I57T probably damaging Het
Psmc2 A G 5: 22,000,806 (GRCm39) I94V probably benign Het
Ripor1 T C 8: 106,342,798 (GRCm39) Y224H possibly damaging Het
Rrh C T 3: 129,605,421 (GRCm39) V229M probably damaging Het
Scaf4 G A 16: 90,045,533 (GRCm39) R526C unknown Het
Slc1a6 G A 10: 78,629,167 (GRCm39) probably null Het
Slc4a7 A G 14: 14,782,056 (GRCm38) D937G probably damaging Het
Slco1b2 C A 6: 141,601,079 (GRCm39) T134K probably damaging Het
Sptbn4 T C 7: 27,056,717 (GRCm39) *2562W probably null Het
Ston1 T C 17: 88,944,472 (GRCm39) V626A probably damaging Het
Synpo A T 18: 60,736,832 (GRCm39) D371E possibly damaging Het
Tex15 T A 8: 34,062,721 (GRCm39) V717D probably damaging Het
Tmod3 A C 9: 75,436,805 (GRCm39) N43K probably damaging Het
Tmod3 G T 9: 75,436,801 (GRCm39) L45I possibly damaging Het
Tmod3 G C 9: 75,436,803 (GRCm39) A44G probably damaging Het
Top2b T C 14: 16,389,845 (GRCm38) F228L probably damaging Het
Trappc14 A G 5: 138,259,940 (GRCm39) M372T possibly damaging Het
Ush2a A G 1: 188,644,002 (GRCm39) T4455A possibly damaging Het
Vmn1r178 C A 7: 23,593,733 (GRCm39) Y260* probably null Het
Vps13c T A 9: 67,826,646 (GRCm39) I1429N probably damaging Het
Wdr31 A G 4: 62,381,651 (GRCm39) V60A probably benign Het
Other mutations in Il23a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7363:Il23a UTSW 10 128,133,020 (GRCm39) missense probably damaging 1.00
R9159:Il23a UTSW 10 128,133,427 (GRCm39) nonsense probably null
R9322:Il23a UTSW 10 128,132,990 (GRCm39) missense probably benign
R9477:Il23a UTSW 10 128,133,922 (GRCm39) start gained probably benign
R9775:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
R9777:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
R9796:Il23a UTSW 10 128,132,829 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- ATGGTAGCCATGGGAACCTG -3'
(R):5'- TGACATCTTCAAAGGGGAGCC -3'

Sequencing Primer
(F):5'- AACCTGGGCATCCTTAAGCTG -3'
(R):5'- TTCAAAGGGGAGCCTGCTCTAC -3'
Posted On 2022-11-14