Incidental Mutation 'R9799:Ccl25'
ID 735102
Institutional Source Beutler Lab
Gene Symbol Ccl25
Ensembl Gene ENSMUSG00000023235
Gene Name C-C motif chemokine ligand 25
Synonyms Scya25, CKb15, TECK
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R9799 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 4375210-4410020 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 4377799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 20 (F20L)
Ref Sequence ENSEMBL: ENSMUSP00000117515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069762] [ENSMUST00000098949] [ENSMUST00000098950] [ENSMUST00000127460] [ENSMUST00000136191] [ENSMUST00000155797]
AlphaFold O35903
Predicted Effect unknown
Transcript: ENSMUST00000069762
AA Change: F20L
Predicted Effect unknown
Transcript: ENSMUST00000098949
AA Change: F20L
Predicted Effect probably benign
Transcript: ENSMUST00000098950
SMART Domains Protein: ENSMUSP00000096549
Gene: ENSMUSG00000040028

DomainStartEndE-ValueType
RRM 21 94 1.3e-22 SMART
RRM 107 182 1.91e-20 SMART
RRM 245 318 6.15e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127460
AA Change: F20L

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000120719
Gene: ENSMUSG00000023235
AA Change: F20L

DomainStartEndE-ValueType
transmembrane domain 87 109 N/A INTRINSIC
SCY 111 172 1.34e-5 SMART
Predicted Effect unknown
Transcript: ENSMUST00000136191
AA Change: F20L
SMART Domains Protein: ENSMUSP00000117515
Gene: ENSMUSG00000023235
AA Change: F20L

DomainStartEndE-ValueType
Pfam:IL8 23 66 2.3e-8 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000155797
AA Change: F20L
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,132,998 (GRCm39) Y1309C probably benign Het
Adcy2 T C 13: 68,768,961 (GRCm39) T1056A probably benign Het
Adcy2 T A 13: 68,805,489 (GRCm39) R826S probably damaging Het
Agxt T C 1: 93,063,070 (GRCm39) W19R probably benign Het
Akr1b8 G A 6: 34,333,278 (GRCm39) E52K possibly damaging Het
Arhgef10 T C 8: 14,990,268 (GRCm39) Y248H probably damaging Het
Arhgef38 T C 3: 132,855,391 (GRCm39) D232G unknown Het
Arid4b T C 13: 14,358,967 (GRCm39) S668P probably benign Het
Ccdc136 T A 6: 29,417,505 (GRCm39) S775R probably damaging Het
Cimap1a A T 7: 140,430,706 (GRCm39) E254D probably benign Het
Cr2 T A 1: 194,842,988 (GRCm39) H218L probably benign Het
Csnka2ip T C 16: 64,298,672 (GRCm39) K564R unknown Het
Cyp2r1 A G 7: 114,151,207 (GRCm39) F371L probably benign Het
Ddx50 A T 10: 62,469,812 (GRCm39) F392I probably damaging Het
Dnah7a T C 1: 53,557,968 (GRCm39) T2149A probably benign Het
Emx2 A G 19: 59,448,036 (GRCm39) Y130C possibly damaging Het
Erbin T C 13: 103,971,384 (GRCm39) D744G probably benign Het
Gcm2 T C 13: 41,258,924 (GRCm39) N140S probably damaging Het
Gnai2 C T 9: 107,512,380 (GRCm39) A13T probably benign Het
Gpr150 T C 13: 76,204,636 (GRCm39) Y103C possibly damaging Het
Gstp2 A G 19: 4,091,901 (GRCm39) probably null Het
Kdr A G 5: 76,117,752 (GRCm39) I667T possibly damaging Het
Lpin1 A G 12: 16,612,400 (GRCm39) I534T Het
Lrrtm3 T A 10: 63,925,749 (GRCm39) probably benign Het
Meiob C T 17: 25,042,574 (GRCm39) T134I probably benign Het
Msh2 G T 17: 88,024,933 (GRCm39) A604S probably damaging Het
Mterf3 T C 13: 67,062,780 (GRCm39) T319A possibly damaging Het
Myo3a C T 2: 22,490,181 (GRCm39) T1514I probably damaging Het
Ndfip2 T C 14: 105,496,400 (GRCm39) M98T possibly damaging Het
Nfatc2ip A G 7: 125,989,739 (GRCm39) V215A probably damaging Het
Or52e19 A T 7: 102,959,065 (GRCm39) T46S probably damaging Het
Or8k41 A T 2: 86,313,732 (GRCm39) M118K probably damaging Het
Pabpc6 C T 17: 9,888,114 (GRCm39) E146K probably damaging Het
Pde3b A G 7: 114,122,613 (GRCm39) Y727C probably damaging Het
Pemt A G 11: 59,937,174 (GRCm39) F30L possibly damaging Het
Plch1 A G 3: 63,605,591 (GRCm39) S1438P possibly damaging Het
Pnma2 T A 14: 67,154,009 (GRCm39) H144Q probably benign Het
Ppp1r14b A G 19: 6,952,825 (GRCm39) N70S possibly damaging Het
Psmd1 T A 1: 86,054,236 (GRCm39) M725K possibly damaging Het
Rab3gap1 A G 1: 127,858,489 (GRCm39) K533E probably benign Het
Rb1cc1 C A 1: 6,315,126 (GRCm39) H426Q probably damaging Het
Rimbp3 A G 16: 17,027,641 (GRCm39) E355G possibly damaging Het
Rxfp1 A G 3: 79,578,182 (GRCm39) F170L probably damaging Het
Sema3f G T 9: 107,562,562 (GRCm39) A473E probably damaging Het
Serpinb3a T G 1: 106,974,892 (GRCm39) I214L probably benign Het
Siglec1 G T 2: 130,915,941 (GRCm39) P1307Q probably damaging Het
Srd5a2 A C 17: 74,331,535 (GRCm39) I154S possibly damaging Het
Sugp1 A G 8: 70,523,068 (GRCm39) E537G probably damaging Het
Tbc1d30 T C 10: 121,142,074 (GRCm39) E91G possibly damaging Het
Tiparp A T 3: 65,454,973 (GRCm39) N373Y probably benign Het
Tmem217 A C 17: 29,745,232 (GRCm39) I166S probably damaging Het
Top1 T A 2: 160,563,406 (GRCm39) Y746N probably damaging Het
Tubb2a C T 13: 34,260,607 (GRCm39) D31N probably benign Het
Utrn T G 10: 12,585,736 (GRCm39) I1014L probably benign Het
Vtn T C 11: 78,392,625 (GRCm39) I401T probably benign Het
Wwc2 G T 8: 48,321,595 (GRCm39) H506Q unknown Het
Xab2 G T 8: 3,668,182 (GRCm39) T132N probably benign Het
Other mutations in Ccl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02070:Ccl25 APN 8 4,398,700 (GRCm39) intron probably benign
IGL02188:Ccl25 APN 8 4,398,552 (GRCm39) intron probably benign
IGL03338:Ccl25 APN 8 4,399,898 (GRCm39) intron probably benign
R0584:Ccl25 UTSW 8 4,404,085 (GRCm39) splice site probably benign
R0613:Ccl25 UTSW 8 4,399,850 (GRCm39) missense probably benign 0.42
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1413:Ccl25 UTSW 8 4,403,892 (GRCm39) makesense probably null
R3844:Ccl25 UTSW 8 4,404,183 (GRCm39) missense possibly damaging 0.86
R4279:Ccl25 UTSW 8 4,399,829 (GRCm39) missense probably damaging 1.00
R4921:Ccl25 UTSW 8 4,403,913 (GRCm39) missense possibly damaging 0.92
R7021:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7033:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7630:Ccl25 UTSW 8 4,403,955 (GRCm39) missense probably damaging 1.00
R8317:Ccl25 UTSW 8 4,404,138 (GRCm39) missense probably benign 0.00
R8550:Ccl25 UTSW 8 4,377,890 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- ACTTTCATATCCACACATTGGCAC -3'
(R):5'- TTTAGAGCCCACCTTCCTGG -3'

Sequencing Primer
(F):5'- ACATTGGCACACACACTGTTTG -3'
(R):5'- GGCTTACCCTCTGAACTACAATC -3'
Posted On 2022-11-14