Mutagenetix > Incidental Mutation

Incidental Mutation 'R9800:Or10ag57'

735139

Institutional Source

Beutler Lab

Gene Symbol

Or10ag57

Ensembl Gene

ENSMUSG00000047594

Gene Name

olfactory receptor family 10 subfamily AG member 57

Synonyms

GA_x6K02T2Q125-48880078-48881058, Olfr1122, MOR264-1

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R9800 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

87218051-87219031 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 87218508 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 153 (C153F)

Ref Sequence

ENSEMBL: ENSMUSP00000149403 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056435] [ENSMUST00000215371]

AlphaFold

Q8VGT9

Predicted Effect

probably damaging
Transcript: ENSMUST00000056435
AA Change: C153F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052190
Gene: ENSMUSG00000047594
AA Change: C153F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	43	319	6.3e-51	PFAM
Pfam:7tm_1	53	302	5.8e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215371
AA Change: C153F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.5%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	A	7: 120,119,283 (GRCm39)	I1009N	possibly damaging	Het
Abtb3	C	A	10: 85,224,079 (GRCm39)	A296E	unknown	Het
Adcy8	T	A	15: 64,571,095 (GRCm39)	N1213Y	probably benign	Het
Ahctf1	T	C	1: 179,581,433 (GRCm39)	S1590G	possibly damaging	Het
Ahcyl1	A	T	3: 107,577,588 (GRCm39)	N277K	probably damaging	Het
Ank2	A	T	3: 126,740,149 (GRCm39)	S1912T	unknown	Het
Ank3	T	A	10: 69,733,957 (GRCm39)	N740K	unknown	Het
Atp13a3	A	C	16: 30,159,051 (GRCm39)	I800S	probably benign	Het
AU041133	T	A	10: 81,986,679 (GRCm39)	C111S	probably damaging	Het
Azi2	T	A	9: 117,884,924 (GRCm39)	I211N	probably benign	Het
Camk2b	T	C	11: 5,922,408 (GRCm39)	N480S	probably damaging	Het
Card6	A	G	15: 5,128,702 (GRCm39)	V898A	probably benign	Het
Copb2	T	A	9: 98,461,081 (GRCm39)	M381K	probably damaging	Het
Cplx3	T	C	9: 57,523,060 (GRCm39)	D133G	probably damaging	Het
Crisp1	A	T	17: 40,616,071 (GRCm39)	M102K	probably damaging	Het
Dcxr	A	T	11: 120,618,084 (GRCm39)		probably benign	Het
Dennd5a	C	A	7: 109,500,374 (GRCm39)	R917L	probably benign	Het
Egflam	T	A	15: 7,279,525 (GRCm39)	T494S	probably benign	Het
Fkbpl	T	A	17: 34,864,691 (GRCm39)	M153K	probably benign	Het
Helz2	A	T	2: 180,882,616 (GRCm39)	I59N	probably damaging	Het
Ldlrap1	T	C	4: 134,477,303 (GRCm39)	T194A	probably benign	Het
Lrrc27	T	C	7: 138,807,913 (GRCm39)	M340T	probably benign	Het
Lum	T	A	10: 97,404,157 (GRCm39)	S17R	probably benign	Het
Malrd1	A	G	2: 15,847,405 (GRCm39)	K1182E	unknown	Het
Map3k2	A	T	18: 32,333,069 (GRCm39)	D81V	possibly damaging	Het
Muc5b	A	T	7: 141,415,480 (GRCm39)	T2809S	possibly damaging	Het
Nle1	C	A	11: 82,793,876 (GRCm39)	V387L	probably benign	Het
Nr1h4	T	C	10: 89,290,618 (GRCm39)	D474G	probably benign	Het
Nup205	T	C	6: 35,163,468 (GRCm39)	I144T	possibly damaging	Het
Or1e17	C	A	11: 73,831,986 (GRCm39)	L305I	probably benign	Het
Or2a56	A	T	6: 42,933,091 (GRCm39)	I220F	probably damaging	Het
Or4f15	G	A	2: 111,814,194 (GRCm39)	S75L	possibly damaging	Het
Or4n4	G	A	14: 50,519,701 (GRCm39)	T3I	probably benign	Het
Or51f1	T	C	7: 102,506,093 (GRCm39)	Y132C	probably benign	Het
Pkn3	C	T	2: 29,973,290 (GRCm39)	R371*	probably null	Het
Plin2	A	T	4: 86,586,742 (GRCm39)	S30T	possibly damaging	Het
Ppfibp1	T	C	6: 146,917,769 (GRCm39)	V475A	probably benign	Het
Ppp2ca	T	C	11: 52,008,910 (GRCm39)	Y137H	probably damaging	Het
Rasgrf2	T	A	13: 92,267,860 (GRCm39)	Q48L	probably damaging	Het
Rnf168	G	C	16: 32,117,386 (GRCm39)	V316L	probably benign	Het
Shank1	G	A	7: 43,962,342 (GRCm39)	S71N	unknown	Het
Spata31d1d	T	C	13: 59,874,637 (GRCm39)	H966R	possibly damaging	Het
Speg	C	A	1: 75,399,358 (GRCm39)	D2268E	probably benign	Het
Srp54c	A	G	12: 55,296,811 (GRCm39)	I170V	probably benign	Het
Syde2	A	G	3: 145,704,364 (GRCm39)	R439G	probably benign	Het
Tcof1	T	C	18: 60,949,558 (GRCm39)	K1155R	unknown	Het
Tmem184c	T	C	8: 78,323,087 (GRCm39)	I592V	probably benign	Het
Trav6-7-dv9	A	G	14: 53,947,669 (GRCm39)	Y57C	probably damaging	Het
Trpc1	T	A	9: 95,625,303 (GRCm39)	I108F	probably damaging	Het
Virma	A	T	4: 11,546,007 (GRCm39)	H1615L	probably damaging	Het
Vmn2r10	A	T	5: 109,150,404 (GRCm39)	D213E	probably damaging	Het
Vmn2r116	T	A	17: 23,620,399 (GRCm39)	V711E	probably damaging	Het
Vps16	T	C	2: 130,282,405 (GRCm39)	F413L	probably benign	Het
Vwa1	G	A	4: 155,857,336 (GRCm39)	P154L	probably damaging	Het
Wasf1	T	C	10: 40,812,693 (GRCm39)	I494T	unknown	Het
Wdr36	A	G	18: 32,985,700 (GRCm39)	D539G	possibly damaging	Het
Zfp81	A	T	17: 33,554,411 (GRCm39)	C134*	probably null	Het

Other mutations in Or10ag57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01783:Or10ag57	APN	2	87,218,182 (GRCm39)	missense	probably benign	0.39
IGL01783:Or10ag57	APN	2	87,218,187 (GRCm39)	missense	possibly damaging	0.91
IGL02396:Or10ag57	APN	2	87,218,049 (GRCm39)	utr 5 prime	probably benign
IGL03338:Or10ag57	APN	2	87,218,470 (GRCm39)	missense	probably benign	0.05
IGL03373:Or10ag57	APN	2	87,218,577 (GRCm39)	missense	probably damaging	1.00
R0594:Or10ag57	UTSW	2	87,218,298 (GRCm39)	missense	probably damaging	1.00
R1245:Or10ag57	UTSW	2	87,218,553 (GRCm39)	missense	probably benign	0.00
R1376:Or10ag57	UTSW	2	87,218,162 (GRCm39)	missense	probably benign	0.00
R1376:Or10ag57	UTSW	2	87,218,162 (GRCm39)	missense	probably benign	0.00
R1471:Or10ag57	UTSW	2	87,218,862 (GRCm39)	missense	probably damaging	1.00
R1681:Or10ag57	UTSW	2	87,218,964 (GRCm39)	missense	possibly damaging	0.95
R1995:Or10ag57	UTSW	2	87,218,175 (GRCm39)	missense	probably damaging	0.97
R2246:Or10ag57	UTSW	2	87,218,195 (GRCm39)	missense	probably benign	0.00
R2341:Or10ag57	UTSW	2	87,218,084 (GRCm39)	missense	probably benign
R4008:Or10ag57	UTSW	2	87,218,924 (GRCm39)	missense	possibly damaging	0.67
R4009:Or10ag57	UTSW	2	87,218,924 (GRCm39)	missense	possibly damaging	0.67
R4011:Or10ag57	UTSW	2	87,218,924 (GRCm39)	missense	possibly damaging	0.67
R4119:Or10ag57	UTSW	2	87,218,187 (GRCm39)	missense	possibly damaging	0.91
R4547:Or10ag57	UTSW	2	87,218,504 (GRCm39)	missense	probably benign	0.07
R4665:Or10ag57	UTSW	2	87,218,220 (GRCm39)	missense	probably damaging	1.00
R4666:Or10ag57	UTSW	2	87,218,220 (GRCm39)	missense	probably damaging	1.00
R4801:Or10ag57	UTSW	2	87,218,553 (GRCm39)	missense	probably benign	0.00
R4802:Or10ag57	UTSW	2	87,218,553 (GRCm39)	missense	probably benign	0.00
R5049:Or10ag57	UTSW	2	87,219,002 (GRCm39)	missense	probably benign	0.00
R5070:Or10ag57	UTSW	2	87,218,507 (GRCm39)	missense	probably damaging	1.00
R7594:Or10ag57	UTSW	2	87,218,613 (GRCm39)	missense	probably damaging	1.00
R7684:Or10ag57	UTSW	2	87,218,372 (GRCm39)	missense	probably damaging	0.99
R8064:Or10ag57	UTSW	2	87,218,853 (GRCm39)	missense	probably benign	0.00
R8218:Or10ag57	UTSW	2	87,218,922 (GRCm39)	missense	probably damaging	0.99
R8282:Or10ag57	UTSW	2	87,218,852 (GRCm39)	missense	probably benign	0.01
R8335:Or10ag57	UTSW	2	87,218,204 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TCCCAAGGATGCTCATGGAC -3'
(R):5'- GAAATGGGACCATGATAAACACTAC -3'

Sequencing Primer
(F):5'- CAAGGATGCTCATGGACCTTTGTAC -3'
(R):5'- CACTACTGAAGCAATATAGATGGC -3'

Posted On

2022-11-14