Incidental Mutation 'R9800:Ppp2ca'
ID 735172
Institutional Source Beutler Lab
Gene Symbol Ppp2ca
Ensembl Gene ENSMUSG00000020349
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms PP2A
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9800 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 51989651-52013576 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52008910 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 137 (Y137H)
Ref Sequence ENSEMBL: ENSMUSP00000020608 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020608]
AlphaFold P63330
Predicted Effect probably damaging
Transcript: ENSMUST00000020608
AA Change: Y137H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000020608
Gene: ENSMUSG00000020349
AA Change: Y137H

DomainStartEndE-ValueType
PP2Ac 23 293 3.46e-155 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null embryos die before gastrulation and exhibit widespread degeneration. Mesoderm is not formed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,119,283 (GRCm39) I1009N possibly damaging Het
Abtb3 C A 10: 85,224,079 (GRCm39) A296E unknown Het
Adcy8 T A 15: 64,571,095 (GRCm39) N1213Y probably benign Het
Ahctf1 T C 1: 179,581,433 (GRCm39) S1590G possibly damaging Het
Ahcyl1 A T 3: 107,577,588 (GRCm39) N277K probably damaging Het
Ank2 A T 3: 126,740,149 (GRCm39) S1912T unknown Het
Ank3 T A 10: 69,733,957 (GRCm39) N740K unknown Het
Atp13a3 A C 16: 30,159,051 (GRCm39) I800S probably benign Het
AU041133 T A 10: 81,986,679 (GRCm39) C111S probably damaging Het
Azi2 T A 9: 117,884,924 (GRCm39) I211N probably benign Het
Camk2b T C 11: 5,922,408 (GRCm39) N480S probably damaging Het
Card6 A G 15: 5,128,702 (GRCm39) V898A probably benign Het
Copb2 T A 9: 98,461,081 (GRCm39) M381K probably damaging Het
Cplx3 T C 9: 57,523,060 (GRCm39) D133G probably damaging Het
Crisp1 A T 17: 40,616,071 (GRCm39) M102K probably damaging Het
Dcxr A T 11: 120,618,084 (GRCm39) probably benign Het
Dennd5a C A 7: 109,500,374 (GRCm39) R917L probably benign Het
Egflam T A 15: 7,279,525 (GRCm39) T494S probably benign Het
Fkbpl T A 17: 34,864,691 (GRCm39) M153K probably benign Het
Helz2 A T 2: 180,882,616 (GRCm39) I59N probably damaging Het
Ldlrap1 T C 4: 134,477,303 (GRCm39) T194A probably benign Het
Lrrc27 T C 7: 138,807,913 (GRCm39) M340T probably benign Het
Lum T A 10: 97,404,157 (GRCm39) S17R probably benign Het
Malrd1 A G 2: 15,847,405 (GRCm39) K1182E unknown Het
Map3k2 A T 18: 32,333,069 (GRCm39) D81V possibly damaging Het
Muc5b A T 7: 141,415,480 (GRCm39) T2809S possibly damaging Het
Nle1 C A 11: 82,793,876 (GRCm39) V387L probably benign Het
Nr1h4 T C 10: 89,290,618 (GRCm39) D474G probably benign Het
Nup205 T C 6: 35,163,468 (GRCm39) I144T possibly damaging Het
Or10ag57 G T 2: 87,218,508 (GRCm39) C153F probably damaging Het
Or1e17 C A 11: 73,831,986 (GRCm39) L305I probably benign Het
Or2a56 A T 6: 42,933,091 (GRCm39) I220F probably damaging Het
Or4f15 G A 2: 111,814,194 (GRCm39) S75L possibly damaging Het
Or4n4 G A 14: 50,519,701 (GRCm39) T3I probably benign Het
Or51f1 T C 7: 102,506,093 (GRCm39) Y132C probably benign Het
Pkn3 C T 2: 29,973,290 (GRCm39) R371* probably null Het
Plin2 A T 4: 86,586,742 (GRCm39) S30T possibly damaging Het
Ppfibp1 T C 6: 146,917,769 (GRCm39) V475A probably benign Het
Rasgrf2 T A 13: 92,267,860 (GRCm39) Q48L probably damaging Het
Rnf168 G C 16: 32,117,386 (GRCm39) V316L probably benign Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Spata31d1d T C 13: 59,874,637 (GRCm39) H966R possibly damaging Het
Speg C A 1: 75,399,358 (GRCm39) D2268E probably benign Het
Srp54c A G 12: 55,296,811 (GRCm39) I170V probably benign Het
Syde2 A G 3: 145,704,364 (GRCm39) R439G probably benign Het
Tcof1 T C 18: 60,949,558 (GRCm39) K1155R unknown Het
Tmem184c T C 8: 78,323,087 (GRCm39) I592V probably benign Het
Trav6-7-dv9 A G 14: 53,947,669 (GRCm39) Y57C probably damaging Het
Trpc1 T A 9: 95,625,303 (GRCm39) I108F probably damaging Het
Virma A T 4: 11,546,007 (GRCm39) H1615L probably damaging Het
Vmn2r10 A T 5: 109,150,404 (GRCm39) D213E probably damaging Het
Vmn2r116 T A 17: 23,620,399 (GRCm39) V711E probably damaging Het
Vps16 T C 2: 130,282,405 (GRCm39) F413L probably benign Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Wasf1 T C 10: 40,812,693 (GRCm39) I494T unknown Het
Wdr36 A G 18: 32,985,700 (GRCm39) D539G possibly damaging Het
Zfp81 A T 17: 33,554,411 (GRCm39) C134* probably null Het
Other mutations in Ppp2ca
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Ppp2ca APN 11 52,012,776 (GRCm39) missense probably benign 0.02
IGL01767:Ppp2ca APN 11 52,008,882 (GRCm39) nonsense probably null
IGL01982:Ppp2ca APN 11 51,989,891 (GRCm39) missense probably benign
IGL03260:Ppp2ca APN 11 52,003,975 (GRCm39) missense probably damaging 0.96
R0539:Ppp2ca UTSW 11 52,008,989 (GRCm39) critical splice donor site probably null
R0788:Ppp2ca UTSW 11 52,003,969 (GRCm39) missense possibly damaging 0.92
R0855:Ppp2ca UTSW 11 52,012,752 (GRCm39) missense probably benign 0.01
R1539:Ppp2ca UTSW 11 52,011,800 (GRCm39) missense probably damaging 0.99
R1591:Ppp2ca UTSW 11 51,989,916 (GRCm39) missense possibly damaging 0.93
R1766:Ppp2ca UTSW 11 52,012,773 (GRCm39) missense probably benign
R2267:Ppp2ca UTSW 11 52,008,913 (GRCm39) missense probably damaging 1.00
R2268:Ppp2ca UTSW 11 52,008,913 (GRCm39) missense probably damaging 1.00
R3933:Ppp2ca UTSW 11 52,010,089 (GRCm39) missense probably damaging 1.00
R4199:Ppp2ca UTSW 11 51,989,928 (GRCm39) missense probably benign
R4992:Ppp2ca UTSW 11 52,004,033 (GRCm39) missense possibly damaging 0.52
R5261:Ppp2ca UTSW 11 51,989,937 (GRCm39) missense probably benign
R5684:Ppp2ca UTSW 11 52,004,154 (GRCm39) missense probably damaging 1.00
R5729:Ppp2ca UTSW 11 52,008,856 (GRCm39) missense probably damaging 1.00
R5766:Ppp2ca UTSW 11 52,004,014 (GRCm39) missense probably damaging 1.00
R7186:Ppp2ca UTSW 11 52,010,080 (GRCm39) missense possibly damaging 0.95
R8073:Ppp2ca UTSW 11 52,010,124 (GRCm39) missense possibly damaging 0.53
R9014:Ppp2ca UTSW 11 52,009,510 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTAGAGATGTGCACTCTCAGC -3'
(R):5'- TGTATCCCCAAATGGAAAATCACTG -3'

Sequencing Primer
(F):5'- TCAGTTGGAACTCTGGATTTACC -3'
(R):5'- TGGAAAATCACTGCCTGCTAAAC -3'
Posted On 2022-11-14