Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01308:Trmo'

73532

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trmo

Ensembl Gene

ENSMUSG00000028331

Gene Name

tRNA methyltransferase O

Synonyms

5830415F09Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01308

Quality Score

Status

Chromosome

Chromosomal Location

46376505-46389437 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

C to T at 46377053 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000119785 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030015] [ENSMUST00000086563] [ENSMUST00000151903]

AlphaFold

Q562D6

Predicted Effect

probably benign
Transcript: ENSMUST00000030015

SMART Domains

Protein: ENSMUSP00000030015
Gene: ENSMUSG00000028331

Domain	Start	End	E-Value	Type
Pfam:UPF0066	42	165	2.3e-45	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000086563
AA Change: G484S

SMART Domains

Protein: ENSMUSP00000083752
Gene: ENSMUSG00000028331
AA Change: G484S

Domain	Start	End	E-Value	Type
Pfam:UPF0066	44	164	1.2e-46	PFAM
low complexity region	431	442	N/A	INTRINSIC
low complexity region	443	456	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000151903

SMART Domains

Protein: ENSMUSP00000119785
Gene: ENSMUSG00000028331

Domain	Start	End	E-Value	Type
Pfam:UPF0066	49	172	4.1e-45	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	A	G	7: 78,748,997 (GRCm39)	D1256G	probably damaging	Het
Acot7	A	T	4: 152,345,353 (GRCm39)	M308L	probably benign	Het
Adarb2	A	G	13: 8,253,329 (GRCm39)	R25G	possibly damaging	Het
Ano1	C	A	7: 144,149,235 (GRCm39)	Q875H	probably damaging	Het
Ano6	G	A	15: 95,811,542 (GRCm39)		probably null	Het
Defa40	C	T	8: 21,740,434 (GRCm39)	T80I	probably damaging	Het
Efcab3	A	T	11: 104,611,523 (GRCm39)	D455V	probably benign	Het
Ehbp1	G	A	11: 22,088,022 (GRCm39)	P354L	probably damaging	Het
Eml5	T	C	12: 98,768,572 (GRCm39)	H1454R	probably damaging	Het
Esyt1	T	A	10: 128,355,660 (GRCm39)	N421Y	possibly damaging	Het
Gen1	T	C	12: 11,306,871 (GRCm39)	T100A	probably damaging	Het
Jak3	A	T	8: 72,137,810 (GRCm39)	D780V	probably damaging	Het
Klrb1a	A	G	6: 128,595,008 (GRCm39)		probably benign	Het
Lrp8	A	G	4: 107,721,273 (GRCm39)	I826M	probably benign	Het
Mcmbp	G	A	7: 128,316,209 (GRCm39)	Q214*	probably null	Het
Mtmr7	A	T	8: 41,050,388 (GRCm39)	Y136N	probably damaging	Het
Ndor1	A	G	2: 25,140,151 (GRCm39)	Y88H	probably benign	Het
Nkx2-4	A	G	2: 146,926,260 (GRCm39)	Y201H	possibly damaging	Het
Or3a1d	A	G	11: 74,237,486 (GRCm39)	L308P	probably damaging	Het
Or52n4b	T	A	7: 108,143,933 (GRCm39)	L65*	probably null	Het
Or6c5	A	T	10: 129,074,476 (GRCm39)	T153S	probably benign	Het
Pigg	T	C	5: 108,484,343 (GRCm39)	L663P	probably damaging	Het
Pik3cd	A	G	4: 149,741,917 (GRCm39)	V343A	probably damaging	Het
Plekha4	A	G	7: 45,187,659 (GRCm39)	S244G	probably damaging	Het
Prkce	T	A	17: 86,932,890 (GRCm39)	D623E	probably damaging	Het
Rasgrf2	A	G	13: 92,159,425 (GRCm39)		probably benign	Het
Rexo5	T	C	7: 119,433,499 (GRCm39)	W419R	probably damaging	Het
Rnaseh2b	A	G	14: 62,602,706 (GRCm39)		probably null	Het
Rras	A	G	7: 44,670,709 (GRCm39)	Y193C	possibly damaging	Het
Sall4	T	C	2: 168,592,164 (GRCm39)	I997V	probably damaging	Het
Sec31b	A	G	19: 44,512,122 (GRCm39)	F591L	probably benign	Het
Skic2	A	G	17: 35,059,610 (GRCm39)	L232P	probably benign	Het
Slc13a3	A	T	2: 165,248,700 (GRCm39)	I526N	probably damaging	Het
Slc6a11	C	T	6: 114,111,626 (GRCm39)	T103M	probably damaging	Het
Snrnp25	A	G	11: 32,158,745 (GRCm39)		probably benign	Het
Tex264	T	C	9: 106,539,607 (GRCm39)	K201E	possibly damaging	Het
Tgfb1	G	T	7: 25,387,442 (GRCm39)	R50L	probably damaging	Het
Tle4	A	G	19: 14,445,625 (GRCm39)	V207A	probably benign	Het
Tmed1	A	T	9: 21,421,338 (GRCm39)	C45*	probably null	Het
Tmem260	A	G	14: 48,749,415 (GRCm39)	N638S	probably damaging	Het
Traf3ip3	T	C	1: 192,867,199 (GRCm39)	E274G	probably damaging	Het
Trak1	T	C	9: 121,272,802 (GRCm39)		probably null	Het
Trim3	A	T	7: 105,266,676 (GRCm39)	V502E	probably damaging	Het
Xab2	C	T	8: 3,666,332 (GRCm39)	R192Q	probably benign	Het

Other mutations in Trmo

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00593:Trmo	APN	4	46,382,490 (GRCm39)	missense	probably benign
IGL01296:Trmo	APN	4	46,387,589 (GRCm39)	missense	probably damaging	1.00
IGL01544:Trmo	APN	4	46,386,169 (GRCm39)	missense	probably damaging	1.00
IGL01545:Trmo	APN	4	46,386,169 (GRCm39)	missense	probably damaging	1.00
IGL01722:Trmo	APN	4	46,386,092 (GRCm39)	critical splice donor site	probably null
IGL02085:Trmo	APN	4	46,380,217 (GRCm39)	missense	probably damaging	1.00
IGL02927:Trmo	APN	4	46,387,602 (GRCm39)	missense	probably damaging	1.00
R0645:Trmo	UTSW	4	46,377,083 (GRCm39)	utr 3 prime	probably benign
R0745:Trmo	UTSW	4	46,382,104 (GRCm39)	missense	probably damaging	1.00
R1365:Trmo	UTSW	4	46,380,278 (GRCm39)	missense	probably damaging	1.00
R1835:Trmo	UTSW	4	46,380,158 (GRCm39)	missense	probably damaging	1.00
R3928:Trmo	UTSW	4	46,382,647 (GRCm39)	missense	probably damaging	1.00
R3929:Trmo	UTSW	4	46,382,647 (GRCm39)	missense	probably damaging	1.00
R4497:Trmo	UTSW	4	46,382,140 (GRCm39)	missense	probably damaging	1.00
R4938:Trmo	UTSW	4	46,382,388 (GRCm39)	missense	probably benign	0.00
R4980:Trmo	UTSW	4	46,389,364 (GRCm39)	nonsense	probably null
R5209:Trmo	UTSW	4	46,387,740 (GRCm39)	missense	probably damaging	0.99
R5639:Trmo	UTSW	4	46,382,073 (GRCm39)	missense	probably benign	0.00
R5855:Trmo	UTSW	4	46,382,568 (GRCm39)	missense	probably benign	0.43
R6151:Trmo	UTSW	4	46,389,390 (GRCm39)	missense	probably damaging	1.00
R7351:Trmo	UTSW	4	46,387,716 (GRCm39)	missense	possibly damaging	0.78
R8684:Trmo	UTSW	4	46,386,253 (GRCm39)	critical splice acceptor site	probably null
R8684:Trmo	UTSW	4	46,386,251 (GRCm39)	nonsense	probably null
R8823:Trmo	UTSW	4	46,382,604 (GRCm39)	missense	probably damaging	1.00
R8856:Trmo	UTSW	4	46,387,625 (GRCm39)	missense	probably benign	0.01
R9039:Trmo	UTSW	4	46,382,322 (GRCm39)	missense	probably benign	0.00
R9331:Trmo	UTSW	4	46,387,642 (GRCm39)	missense	possibly damaging	0.50

Posted On

2013-10-07