Incidental Mutation 'R9803:Vmn2r110'
| ID |
735338 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r110
|
| Ensembl Gene |
ENSMUSG00000091259 |
| Gene Name |
vomeronasal 2, receptor 110 |
| Synonyms |
EG224582 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.156)
|
| Stock # |
R9803 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20794091-20816521 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 20803730 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 282
(T282S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169559]
|
| AlphaFold |
E9PWD5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169559
AA Change: T282S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: T282S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
3.1e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
5.2e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
831 |
4.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.4%
- 20x: 98.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700069L16Rik |
A |
G |
5: 113,841,964 (GRCm39) |
S52P |
unknown |
Het |
| Ank2 |
A |
G |
3: 126,752,726 (GRCm39) |
M330T |
possibly damaging |
Het |
| Ankar |
C |
T |
1: 72,698,340 (GRCm39) |
V905I |
possibly damaging |
Het |
| Anln |
G |
T |
9: 22,283,518 (GRCm39) |
D438E |
probably damaging |
Het |
| C1ql3 |
T |
C |
2: 13,009,200 (GRCm39) |
N215S |
probably damaging |
Het |
| Ccdc110 |
A |
G |
8: 46,395,626 (GRCm39) |
S506G |
probably benign |
Het |
| Ccdc87 |
A |
G |
19: 4,891,175 (GRCm39) |
T556A |
probably benign |
Het |
| Cma1 |
A |
T |
14: 56,179,186 (GRCm39) |
N236K |
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,262,986 (GRCm39) |
F724S |
|
Het |
| Cts8 |
T |
C |
13: 61,401,136 (GRCm39) |
K130R |
possibly damaging |
Het |
| Daam1 |
A |
T |
12: 71,990,922 (GRCm39) |
T179S |
unknown |
Het |
| Fancd2os |
T |
C |
6: 113,574,938 (GRCm39) |
T23A |
possibly damaging |
Het |
| Gbgt1 |
T |
A |
2: 28,394,866 (GRCm39) |
I168N |
probably damaging |
Het |
| Gckr |
G |
A |
5: 31,457,368 (GRCm39) |
G127D |
probably damaging |
Het |
| Gm11444 |
G |
A |
11: 85,737,699 (GRCm39) |
Q164* |
probably null |
Het |
| Gm28042 |
T |
A |
2: 119,868,984 (GRCm39) |
V526E |
possibly damaging |
Het |
| Gm8947 |
T |
C |
1: 151,068,722 (GRCm39) |
V185A |
possibly damaging |
Het |
| Hoxd13 |
C |
A |
2: 74,499,247 (GRCm39) |
H198Q |
possibly damaging |
Het |
| Hps6 |
T |
A |
19: 45,993,947 (GRCm39) |
L628* |
probably null |
Het |
| Igha |
G |
A |
12: 113,222,759 (GRCm39) |
H221Y |
|
Het |
| Ighm |
A |
G |
12: 113,382,635 (GRCm39) |
S453P |
|
Het |
| Inpp5f |
A |
C |
7: 128,278,515 (GRCm39) |
D435A |
possibly damaging |
Het |
| Lfng |
A |
G |
5: 140,593,528 (GRCm39) |
T120A |
probably damaging |
Het |
| Lrrc4 |
C |
T |
6: 28,662,199 (GRCm39) |
A172T |
probably benign |
Het |
| Lrrc56 |
A |
G |
7: 140,787,520 (GRCm39) |
T386A |
probably benign |
Het |
| Mapkbp1 |
A |
T |
2: 119,841,256 (GRCm39) |
H81L |
probably benign |
Het |
| Mfsd14b |
C |
A |
13: 65,221,414 (GRCm39) |
V293L |
probably benign |
Het |
| Mrto4 |
T |
A |
4: 139,076,381 (GRCm39) |
N70I |
probably damaging |
Het |
| Mxra8 |
C |
T |
4: 155,924,282 (GRCm39) |
|
probably benign |
Het |
| Myo1h |
A |
G |
5: 114,483,997 (GRCm39) |
E548G |
|
Het |
| Ncan |
C |
T |
8: 70,560,751 (GRCm39) |
D739N |
probably benign |
Het |
| Or2t45 |
T |
C |
11: 58,669,595 (GRCm39) |
V214A |
probably benign |
Het |
| Oxgr1 |
T |
C |
14: 120,259,563 (GRCm39) |
T215A |
possibly damaging |
Het |
| Pcdhgb7 |
T |
A |
18: 37,885,088 (GRCm39) |
V86E |
probably damaging |
Het |
| Pclo |
G |
A |
5: 14,762,629 (GRCm39) |
V416M |
|
Het |
| Phf3 |
G |
T |
1: 30,869,872 (GRCm39) |
T392K |
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,637,073 (GRCm39) |
V379E |
probably damaging |
Het |
| Ppfia3 |
T |
C |
7: 44,990,539 (GRCm39) |
Y1080C |
probably benign |
Het |
| Ptprs |
C |
A |
17: 56,729,217 (GRCm39) |
G1254C |
probably damaging |
Het |
| Qsox1 |
A |
T |
1: 155,658,416 (GRCm39) |
D384E |
probably benign |
Het |
| Rergl |
A |
G |
6: 139,477,761 (GRCm39) |
F23L |
probably damaging |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Sidt2 |
A |
G |
9: 45,854,912 (GRCm39) |
Y588H |
probably damaging |
Het |
| Tas2r139 |
T |
A |
6: 42,118,066 (GRCm39) |
I66K |
probably damaging |
Het |
| Tbc1d30 |
T |
A |
10: 121,107,980 (GRCm39) |
D474V |
probably damaging |
Het |
| Tenm4 |
G |
A |
7: 96,202,685 (GRCm39) |
G100D |
probably damaging |
Het |
| Tmem258 |
G |
A |
19: 10,184,637 (GRCm39) |
V75I |
probably benign |
Het |
| Tmem91 |
G |
T |
7: 25,369,988 (GRCm39) |
H95N |
probably damaging |
Het |
| Trps1 |
T |
C |
15: 50,710,090 (GRCm39) |
K87E |
possibly damaging |
Het |
| Tspan11 |
T |
A |
6: 127,920,680 (GRCm39) |
M209K |
probably benign |
Het |
| Tspan17 |
C |
A |
13: 54,941,092 (GRCm39) |
Q124K |
probably benign |
Het |
| Uts2b |
G |
A |
16: 27,179,692 (GRCm39) |
R105* |
probably null |
Het |
| Xdh |
T |
A |
17: 74,229,455 (GRCm39) |
M333L |
probably benign |
Het |
| Zbtb3 |
A |
G |
19: 8,781,833 (GRCm39) |
E482G |
probably damaging |
Het |
|
| Other mutations in Vmn2r110 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01774:Vmn2r110
|
APN |
17 |
20,803,889 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01824:Vmn2r110
|
APN |
17 |
20,794,929 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01879:Vmn2r110
|
APN |
17 |
20,794,122 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02168:Vmn2r110
|
APN |
17 |
20,804,062 (GRCm39) |
splice site |
probably benign |
|
|
IGL02178:Vmn2r110
|
APN |
17 |
20,804,706 (GRCm39) |
splice site |
probably null |
|
|
IGL02322:Vmn2r110
|
APN |
17 |
20,794,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r110
|
APN |
17 |
20,816,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02415:Vmn2r110
|
APN |
17 |
20,804,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02491:Vmn2r110
|
APN |
17 |
20,816,400 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02876:Vmn2r110
|
APN |
17 |
20,794,558 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03141:Vmn2r110
|
APN |
17 |
20,803,976 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03270:Vmn2r110
|
APN |
17 |
20,803,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03286:Vmn2r110
|
APN |
17 |
20,804,468 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03379:Vmn2r110
|
APN |
17 |
20,803,906 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4243001:Vmn2r110
|
UTSW |
17 |
20,802,379 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0040:Vmn2r110
|
UTSW |
17 |
20,816,346 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0195:Vmn2r110
|
UTSW |
17 |
20,794,317 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0716:Vmn2r110
|
UTSW |
17 |
20,794,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1199:Vmn2r110
|
UTSW |
17 |
20,803,525 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1767:Vmn2r110
|
UTSW |
17 |
20,800,840 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2212:Vmn2r110
|
UTSW |
17 |
20,794,209 (GRCm39) |
splice site |
probably null |
|
|
R3056:Vmn2r110
|
UTSW |
17 |
20,803,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4093:Vmn2r110
|
UTSW |
17 |
20,803,642 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4418:Vmn2r110
|
UTSW |
17 |
20,803,951 (GRCm39) |
nonsense |
probably null |
|
|
R4598:Vmn2r110
|
UTSW |
17 |
20,804,029 (GRCm39) |
nonsense |
probably null |
|
|
R4754:Vmn2r110
|
UTSW |
17 |
20,816,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5283:Vmn2r110
|
UTSW |
17 |
20,800,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5421:Vmn2r110
|
UTSW |
17 |
20,803,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5672:Vmn2r110
|
UTSW |
17 |
20,816,494 (GRCm39) |
missense |
probably benign |
|
|
R5865:Vmn2r110
|
UTSW |
17 |
20,804,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6642:Vmn2r110
|
UTSW |
17 |
20,803,779 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6799:Vmn2r110
|
UTSW |
17 |
20,803,798 (GRCm39) |
missense |
probably benign |
|
|
R7167:Vmn2r110
|
UTSW |
17 |
20,794,441 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7291:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7320:Vmn2r110
|
UTSW |
17 |
20,816,316 (GRCm39) |
missense |
probably benign |
|
|
R7519:Vmn2r110
|
UTSW |
17 |
20,804,524 (GRCm39) |
missense |
probably benign |
|
|
R8089:Vmn2r110
|
UTSW |
17 |
20,803,807 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8234:Vmn2r110
|
UTSW |
17 |
20,804,691 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8272:Vmn2r110
|
UTSW |
17 |
20,816,490 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8307:Vmn2r110
|
UTSW |
17 |
20,803,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r110
|
UTSW |
17 |
20,804,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8516:Vmn2r110
|
UTSW |
17 |
20,794,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r110
|
UTSW |
17 |
20,804,618 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8691:Vmn2r110
|
UTSW |
17 |
20,803,404 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8859:Vmn2r110
|
UTSW |
17 |
20,794,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8935:Vmn2r110
|
UTSW |
17 |
20,803,957 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8986:Vmn2r110
|
UTSW |
17 |
20,803,823 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9012:Vmn2r110
|
UTSW |
17 |
20,803,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9101:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
|
|
|
R9744:Vmn2r110
|
UTSW |
17 |
20,794,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1088:Vmn2r110
|
UTSW |
17 |
20,803,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGGAAGGTAAATGTCTTCAGGG -3'
(R):5'- TCCCAGATGACCACAAAGGG -3'
Sequencing Primer
(F):5'- AAATGTCTTCAGGGTATTTGTAAGG -3'
(R):5'- AGGAGTCTGCATAGCTTT -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation