Incidental Mutation 'R9658:Olfr630'
ID 735542
Institutional Source Beutler Lab
Gene Symbol Olfr630
Ensembl Gene ENSMUSG00000050281
Gene Name olfactory receptor 630
Synonyms MOR17-1, GA_x6K02T2PBJ9-6483085-6482126
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R9658 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 103753480-103757333 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 103754821 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 255 (V255M)
Ref Sequence ENSEMBL: ENSMUSP00000102493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106880]
AlphaFold Q9EQQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000106880
AA Change: V255M

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000102493
Gene: ENSMUSG00000050281
AA Change: V255M

Pfam:7TM_GPCR_Srsx 37 305 3.7e-8 PFAM
Pfam:7tm_1 43 294 8.4e-25 PFAM
Pfam:7tm_4 144 287 9e-29 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.4%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503L19Rik C T 18: 70,467,330 (GRCm38) probably null Het
Abca12 T C 1: 71,286,475 (GRCm38) I1521M probably damaging Het
Abcc3 A G 11: 94,372,877 (GRCm38) S268P possibly damaging Het
Adamts20 G C 15: 94,351,745 (GRCm38) P464A probably damaging Het
Apoa1 C A 9: 46,229,982 (GRCm38) D125E probably benign Het
Atp6v0a1 C A 11: 101,018,588 (GRCm38) Q48K probably benign Het
Bptf T C 11: 107,111,344 (GRCm38) N314S probably damaging Het
Cdh7 T C 1: 110,061,055 (GRCm38) V229A probably damaging Het
Cfap46 G A 7: 139,666,313 (GRCm38) T378M Het
Clca3b T A 3: 144,837,814 (GRCm38) D418V probably damaging Het
Dennd4c T A 4: 86,836,388 (GRCm38) L1545* probably null Het
Dnajc13 A G 9: 104,238,529 (GRCm38) V27A probably benign Het
Eif2ak2 A T 17: 78,876,203 (GRCm38) D72E probably benign Het
Eif2ak4 T C 2: 118,439,030 (GRCm38) I862T probably damaging Het
Eif4g1 T C 16: 20,684,113 (GRCm38) I1022T probably benign Het
Enpp3 A T 10: 24,773,904 (GRCm38) *875R probably null Het
F11 T C 8: 45,245,634 (GRCm38) Y491C probably damaging Het
Fam155a T C 8: 9,770,114 (GRCm38) D302G probably benign Het
Fam98c A C 7: 29,152,781 (GRCm38) W118G probably damaging Het
Fbxo43 A T 15: 36,152,136 (GRCm38) L509Q probably damaging Het
Fbxw5 A G 2: 25,503,858 (GRCm38) H366R probably damaging Het
Flt1 G T 5: 147,588,567 (GRCm38) N920K probably damaging Het
Git1 T A 11: 77,499,755 (GRCm38) F106I probably damaging Het
Glipr1l2 A G 10: 112,106,963 (GRCm38) E241G probably damaging Het
Gm11639 A G 11: 104,720,294 (GRCm38) K321E probably benign Het
Gm2381 A C 7: 42,820,305 (GRCm38) C132G probably damaging Het
Gm49383 A G 12: 69,192,854 (GRCm38) I237T Het
Gm7324 T A 14: 43,714,825 (GRCm38) D308E probably benign Het
Gpr17 A G 18: 31,947,368 (GRCm38) L214P probably damaging Het
Gtf3c1 A T 7: 125,707,562 (GRCm38) L39Q probably damaging Het
H2-Q6 C T 17: 35,425,209 (GRCm38) R56C probably damaging Het
Hcar2 T C 5: 123,864,469 (GRCm38) T324A possibly damaging Het
Ksr2 T C 5: 117,747,360 (GRCm38) S750P probably damaging Het
Lipi C A 16: 75,560,801 (GRCm38) R292L probably benign Het
Map4k3 C A 17: 80,653,877 (GRCm38) M133I probably benign Het
Marf1 A T 16: 14,140,223 (GRCm38) L805Q probably damaging Het
Mccc2 T A 13: 99,954,246 (GRCm38) R460W probably damaging Het
Mgam A G 6: 40,744,377 (GRCm38) D312G possibly damaging Het
Nadk2 A T 15: 9,103,361 (GRCm38) K360* probably null Het
Nars2 A G 7: 97,039,971 (GRCm38) I367V probably benign Het
Nppb T C 4: 147,986,494 (GRCm38) S109P possibly damaging Het
Odf2 G A 2: 29,889,801 (GRCm38) R15Q probably benign Het
Olfr1312 C A 2: 112,042,478 (GRCm38) A185S probably damaging Het
Olfr209 A T 16: 59,361,743 (GRCm38) H158Q probably damaging Het
Osbpl1a A T 18: 12,756,212 (GRCm38) I949N probably benign Het
Pan3 T C 5: 147,543,071 (GRCm38) F55L probably benign Het
Patj A G 4: 98,465,140 (GRCm38) D640G probably null Het
Pdxk T C 10: 78,451,569 (GRCm38) K53E probably benign Het
Pja2 A G 17: 64,292,873 (GRCm38) S539P probably damaging Het
Plscr1 T A 9: 92,266,482 (GRCm38) C158* probably null Het
Prdm14 T C 1: 13,118,921 (GRCm38) T400A probably benign Het
Rag1 C T 2: 101,642,884 (GRCm38) V638M possibly damaging Het
Ros1 A G 10: 52,090,973 (GRCm38) S1734P probably damaging Het
S100a9 T C 3: 90,692,774 (GRCm38) H105R unknown Het
Shisa9 A T 16: 12,244,656 (GRCm38) Q247L possibly damaging Het
Slc14a1 C A 18: 78,109,592 (GRCm38) A367S probably damaging Het
Slc27a4 G A 2: 29,811,289 (GRCm38) R364Q probably damaging Het
Spag17 C T 3: 100,027,616 (GRCm38) P713S possibly damaging Het
Tbc1d4 T A 14: 101,608,420 (GRCm38) H14L probably damaging Het
Tmem144 T A 3: 79,822,684 (GRCm38) Y253F probably damaging Het
Tmem204 C T 17: 25,080,348 (GRCm38) G66R possibly damaging Het
Tnfrsf1b A T 4: 145,215,854 (GRCm38) V453E probably damaging Het
Tns1 G T 1: 73,942,024 (GRCm38) N1060K probably benign Het
Tns1 G C 1: 73,942,023 (GRCm38) Q1061E probably benign Het
Trav5-1 A G 14: 52,622,971 (GRCm38) K78E probably benign Het
Ttn C T 2: 76,885,013 (GRCm38) E7912K unknown Het
Usp17lc G A 7: 103,418,182 (GRCm38) G228D possibly damaging Het
Uvssa T C 5: 33,410,989 (GRCm38) C574R probably damaging Het
Veph1 G A 3: 66,264,013 (GRCm38) Q3* probably null Het
Vps13b T A 15: 35,623,628 (GRCm38) D1230E probably benign Het
Xkr9 T A 1: 13,701,094 (GRCm38) I278N probably damaging Het
Zbed4 C A 15: 88,780,539 (GRCm38) A270E probably benign Het
Zfp366 A T 13: 99,228,927 (GRCm38) T199S probably benign Het
Other mutations in Olfr630
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Olfr630 APN 7 103,755,006 (GRCm38) missense probably damaging 1.00
IGL01111:Olfr630 APN 7 103,755,373 (GRCm38) missense probably benign 0.07
IGL02456:Olfr630 APN 7 103,755,493 (GRCm38) missense possibly damaging 0.94
IGL03173:Olfr630 APN 7 103,754,976 (GRCm38) missense probably benign 0.00
R1104:Olfr630 UTSW 7 103,754,976 (GRCm38) missense probably benign 0.00
R1507:Olfr630 UTSW 7 103,755,021 (GRCm38) missense probably benign 0.00
R1695:Olfr630 UTSW 7 103,754,924 (GRCm38) nonsense probably null
R1966:Olfr630 UTSW 7 103,755,168 (GRCm38) missense probably damaging 1.00
R1971:Olfr630 UTSW 7 103,755,320 (GRCm38) nonsense probably null
R2696:Olfr630 UTSW 7 103,755,528 (GRCm38) missense probably damaging 0.96
R4943:Olfr630 UTSW 7 103,755,296 (GRCm38) missense probably benign 0.12
R5622:Olfr630 UTSW 7 103,755,169 (GRCm38) missense probably damaging 0.99
R6365:Olfr630 UTSW 7 103,755,195 (GRCm38) missense probably benign 0.00
R7592:Olfr630 UTSW 7 103,755,072 (GRCm38) missense probably damaging 1.00
R8146:Olfr630 UTSW 7 103,755,303 (GRCm38) missense probably damaging 1.00
R8283:Olfr630 UTSW 7 103,754,812 (GRCm38) missense possibly damaging 0.51
R8867:Olfr630 UTSW 7 103,754,686 (GRCm38) nonsense probably null
R8875:Olfr630 UTSW 7 103,755,255 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2022-11-14