Mutagenetix > Incidental Mutation

Incidental Mutation 'R9678:Parm1'

735764

Institutional Source

Beutler Lab

Gene Symbol

Parm1

Ensembl Gene

ENSMUSG00000034981

Gene Name

prostate androgen-regulated mucin-like protein 1

Synonyms

2210012L08Rik, 9130213B05Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R9678 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

91665559-91771870 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 91742144 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 171 (T171A)

Ref Sequence

ENSEMBL: ENSMUSP00000042844 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040576]

AlphaFold

Q923D3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000040576
AA Change: T171A

PolyPhen 2 Score 0.707 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000042844
Gene: ENSMUSG00000034981
AA Change: T171A

Domain	Start	End	E-Value	Type
Pfam:PARM	15	296	5.3e-120	PFAM

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre1	A	G	17: 57,750,997 (GRCm39)	N557S	probably damaging	Het
Atr	C	T	9: 95,792,610 (GRCm39)	A1644V	possibly damaging	Het
C4b	A	G	17: 34,960,763 (GRCm39)		probably null	Het
Cdca2	A	T	14: 67,937,778 (GRCm39)	C292S	unknown	Het
Cdkn1c	T	C	7: 143,014,383 (GRCm39)	D21G	probably benign	Het
Clec12a	C	A	6: 129,330,628 (GRCm39)	T70K	probably benign	Het
Crnkl1	A	T	2: 145,761,875 (GRCm39)	S561T	probably benign	Het
Dock4	TGTGCCGGTGCCGGTGCCGGTGCCGGTGCC	TGTGCCGGTGCCGGTGCCGGTGCCGGTGCCGGTGCC	12: 40,894,379 (GRCm39)		probably benign	Het
Dock4	CGGTGC	CGGTGCGGGTGC	12: 40,894,396 (GRCm39)		probably benign	Het
Dock4	TGCCGG	TGCCGGCGCCGG	12: 40,894,387 (GRCm39)		probably benign	Het
Ehbp1	T	C	11: 22,101,108 (GRCm39)	D274G	possibly damaging	Het
Fsd2	T	C	7: 81,209,449 (GRCm39)	Y131C	probably damaging	Het
Gm10153	C	A	7: 141,743,723 (GRCm39)	C115F	unknown	Het
Gm10376	A	T	14: 42,873,024 (GRCm39)	M1K	probably null	Het
Gm10837	A	T	14: 122,728,438 (GRCm39)	K105*	probably null	Het
H3f3a	A	G	1: 180,637,680 (GRCm39)		probably null	Het
Igkv10-96	T	A	6: 68,609,224 (GRCm39)	M24L	probably benign	Het
Inpp4a	T	C	1: 37,405,952 (GRCm39)	S157P	probably damaging	Het
Meaf6	A	G	4: 124,996,689 (GRCm39)	N133S	possibly damaging	Het
Nphp3	T	C	9: 103,900,686 (GRCm39)	V648A	possibly damaging	Het
Or1i2	C	T	10: 78,447,717 (GRCm39)	G253R	probably damaging	Het
Or5k17	A	G	16: 58,746,640 (GRCm39)	M98T	probably benign	Het
Pik3r1	G	T	13: 101,839,289 (GRCm39)	R188S	probably damaging	Het
Rbsn	T	C	6: 92,188,619 (GRCm39)	H32R	probably damaging	Het
Sdk2	G	T	11: 113,685,789 (GRCm39)	Y1910*	probably null	Het
Slfn8	T	C	11: 82,907,723 (GRCm39)	I273M	probably damaging	Het
Sult1a1	C	T	7: 126,273,536 (GRCm39)	V132I	probably benign	Het
Tagln3	T	A	16: 45,544,605 (GRCm39)	Y22F	probably damaging	Het
Tenm4	A	G	7: 96,386,619 (GRCm39)	E575G	possibly damaging	Het
Trim24	T	C	6: 37,942,449 (GRCm39)	V987A	probably damaging	Het
Trpm7	C	A	2: 126,686,290 (GRCm39)	V313F	probably damaging	Het
Trub1	A	T	19: 57,446,549 (GRCm39)	N93I	probably benign	Het
Ugdh	A	G	5: 65,581,470 (GRCm39)	V60A	possibly damaging	Het
Ugt2b5	A	C	5: 87,273,186 (GRCm39)	D493E	probably damaging	Het
Utrn	G	T	10: 12,615,159 (GRCm39)	D337E	probably benign	Het
Vmn2r14	A	G	5: 109,364,041 (GRCm39)	L625P	probably damaging	Het
Vmn2r89	A	G	14: 51,693,511 (GRCm39)	D287G	probably benign	Het
Xirp2	A	T	2: 67,339,788 (GRCm39)	E676D	possibly damaging	Het
Zbbx	A	G	3: 75,046,841 (GRCm39)	L26P	probably damaging	Het

Other mutations in Parm1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01363:Parm1	APN	5	91,760,877 (GRCm39)	missense	probably damaging	0.98
R0243:Parm1	UTSW	5	91,742,153 (GRCm39)	missense	possibly damaging	0.94
R0601:Parm1	UTSW	5	91,742,123 (GRCm39)	missense	probably benign	0.10
R1538:Parm1	UTSW	5	91,742,306 (GRCm39)	missense	possibly damaging	0.71
R2159:Parm1	UTSW	5	91,760,923 (GRCm39)	missense	probably damaging	0.98
R2256:Parm1	UTSW	5	91,741,980 (GRCm39)	missense	possibly damaging	0.93
R2853:Parm1	UTSW	5	91,742,124 (GRCm39)	missense	probably benign	0.01
R2859:Parm1	UTSW	5	91,742,165 (GRCm39)	missense	possibly damaging	0.71
R2938:Parm1	UTSW	5	91,742,328 (GRCm39)	missense	possibly damaging	0.52
R4095:Parm1	UTSW	5	91,742,039 (GRCm39)	missense	probably benign
R4222:Parm1	UTSW	5	91,741,726 (GRCm39)	missense	probably benign	0.00
R4883:Parm1	UTSW	5	91,741,775 (GRCm39)	missense	possibly damaging	0.71
R6599:Parm1	UTSW	5	91,741,718 (GRCm39)	missense	possibly damaging	0.86
R6723:Parm1	UTSW	5	91,770,856 (GRCm39)	missense	probably damaging	0.97
R6799:Parm1	UTSW	5	91,742,070 (GRCm39)	missense	possibly damaging	0.93
R6885:Parm1	UTSW	5	91,742,069 (GRCm39)	missense	possibly damaging	0.71
R7714:Parm1	UTSW	5	91,741,791 (GRCm39)	missense	possibly damaging	0.93
R7783:Parm1	UTSW	5	91,741,724 (GRCm39)	missense	probably benign
R8004:Parm1	UTSW	5	91,742,132 (GRCm39)	missense	probably benign	0.00
R9623:Parm1	UTSW	5	91,760,923 (GRCm39)	missense	probably damaging	0.98
Z1177:Parm1	UTSW	5	91,742,088 (GRCm39)	missense	probably benign	0.41

Predicted Primers

PCR Primer
(F):5'- GGATGTCAACAGCACAGACTC -3'
(R):5'- GGTCTCAGACTCACAGATCAC -3'

Sequencing Primer
(F):5'- GTTCCCCTCAACAAGCAGTGATG -3'
(R):5'- ACAGATCACTTTGCCAGGTTCAG -3'

Posted On

2022-11-14