Mutagenetix > Incidental Mutation

Incidental Mutation 'R9678:Vmn2r14'

735765

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r14

Ensembl Gene

ENSMUSG00000091059

Gene Name

vomeronasal 2, receptor 14

Synonyms

EG231591

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.420) question?

Stock #

R9678 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

109215502-109224622 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 109216175 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 625 (L625P)

Ref Sequence

ENSEMBL: ENSMUSP00000128015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170341]

AlphaFold

E9Q759

Predicted Effect

probably damaging
Transcript: ENSMUST00000170341
AA Change: L625P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: L625P

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.3e-31	PFAM
Pfam:NCD3G	507	561	1.1e-17	PFAM
Pfam:7tm_3	594	829	1.2e-55	PFAM

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.3%
20x: 98.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre1	A	G	17: 57,443,997	N557S	probably damaging	Het
Atr	C	T	9: 95,910,557	A1644V	possibly damaging	Het
C4b	A	G	17: 34,741,789		probably null	Het
Cdca2	A	T	14: 67,700,329	C292S	unknown	Het
Cdkn1c	T	C	7: 143,460,646	D21G	probably benign	Het
Clec12a	C	A	6: 129,353,665	T70K	probably benign	Het
Crnkl1	A	T	2: 145,919,955	S561T	probably benign	Het
Dock4	TGTGCCGGTGCCGGTGCCGGTGCCGGTGCC	TGTGCCGGTGCCGGTGCCGGTGCCGGTGCCGGTGCC	12: 40,844,380		probably benign	Het
Dock4	TGCCGG	TGCCGGCGCCGG	12: 40,844,388		probably benign	Het
Dock4	CGGTGC	CGGTGCGGGTGC	12: 40,844,397		probably benign	Het
Ehbp1	T	C	11: 22,151,108	D274G	possibly damaging	Het
Fsd2	T	C	7: 81,559,701	Y131C	probably damaging	Het
Gm10153	C	A	7: 142,189,986	C115F	unknown	Het
Gm10376	A	T	14: 43,015,567	M1K	probably null	Het
Gm10837	A	T	14: 122,491,026	K105*	probably null	Het
H3f3a	A	G	1: 180,810,115		probably null	Het
Igkv10-96	T	A	6: 68,632,240	M24L	probably benign	Het
Inpp4a	T	C	1: 37,366,871	S157P	probably damaging	Het
Meaf6	A	G	4: 125,102,896	N133S	possibly damaging	Het
Nphp3	T	C	9: 104,023,487	V648A	possibly damaging	Het
Olfr1357	C	T	10: 78,611,883	G253R	probably damaging	Het
Olfr181	A	G	16: 58,926,277	M98T	probably benign	Het
Parm1	A	G	5: 91,594,285	T171A	possibly damaging	Het
Pik3r1	G	T	13: 101,702,781	R188S	probably damaging	Het
Rbsn	T	C	6: 92,211,638	H32R	probably damaging	Het
Sdk2	G	T	11: 113,794,963	Y1910*	probably null	Het
Slfn8	T	C	11: 83,016,897	I273M	probably damaging	Het
Sult1a1	C	T	7: 126,674,364	V132I	probably benign	Het
Tagln3	T	A	16: 45,724,242	Y22F	probably damaging	Het
Tenm4	A	G	7: 96,737,412	E575G	possibly damaging	Het
Trim24	T	C	6: 37,965,514	V987A	probably damaging	Het
Trpm7	C	A	2: 126,844,370	V313F	probably damaging	Het
Trub1	A	T	19: 57,458,117	N93I	probably benign	Het
Ugdh	A	G	5: 65,424,127	V60A	possibly damaging	Het
Ugt2b5	A	C	5: 87,125,327	D493E	probably damaging	Het
Utrn	G	T	10: 12,739,415	D337E	probably benign	Het
Vmn2r89	A	G	14: 51,456,054	D287G	probably benign	Het
Xirp2	A	T	2: 67,509,444	E676D	possibly damaging	Het
Zbbx	A	G	3: 75,139,534	L26P	probably damaging	Het

Other mutations in Vmn2r14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn2r14	APN	5	109216314	nonsense	probably null
IGL01504:Vmn2r14	APN	5	109221419	missense	probably benign	0.01
IGL01828:Vmn2r14	APN	5	109224577	missense	possibly damaging	0.71
IGL02093:Vmn2r14	APN	5	109220409	missense	possibly damaging	0.94
IGL02103:Vmn2r14	APN	5	109224483	missense	probably damaging	0.96
IGL02123:Vmn2r14	APN	5	109220067	missense	probably damaging	1.00
IGL02145:Vmn2r14	APN	5	109220588	nonsense	probably null
IGL02676:Vmn2r14	APN	5	109220016	missense	probably benign	0.03
IGL02720:Vmn2r14	APN	5	109221439	missense	probably damaging	1.00
IGL02877:Vmn2r14	APN	5	109220188	missense	probably damaging	0.99
IGL02974:Vmn2r14	APN	5	109221426	missense	possibly damaging	0.55
IGL03151:Vmn2r14	APN	5	109216394	missense	probably damaging	1.00
IGL03297:Vmn2r14	APN	5	109216107	missense	probably damaging	1.00
IGL03386:Vmn2r14	APN	5	109220484	missense	possibly damaging	0.90
IGL03394:Vmn2r14	APN	5	109219836	missense	probably null	0.83
ANU74:Vmn2r14	UTSW	5	109219044	missense	probably benign	0.00
R0316:Vmn2r14	UTSW	5	109218896	missense	probably benign	0.07
R0755:Vmn2r14	UTSW	5	109216360	missense	possibly damaging	0.81
R1219:Vmn2r14	UTSW	5	109224574	missense	probably benign	0.17
R1321:Vmn2r14	UTSW	5	109216251	missense	probably benign	0.08
R1465:Vmn2r14	UTSW	5	109220329	missense	possibly damaging	0.47
R1465:Vmn2r14	UTSW	5	109220329	missense	possibly damaging	0.47
R1509:Vmn2r14	UTSW	5	109215996	missense	probably benign	0.00
R1551:Vmn2r14	UTSW	5	109221417	missense	probably damaging	1.00
R1628:Vmn2r14	UTSW	5	109219972	missense	probably benign	0.00
R1668:Vmn2r14	UTSW	5	109219047	nonsense	probably null
R2013:Vmn2r14	UTSW	5	109221243	missense	probably benign	0.00
R2201:Vmn2r14	UTSW	5	109218832	splice site	probably null
R2417:Vmn2r14	UTSW	5	109224463	missense	probably benign	0.00
R3029:Vmn2r14	UTSW	5	109215910	missense	probably damaging	1.00
R3120:Vmn2r14	UTSW	5	109224565	missense	probably null	0.00
R3729:Vmn2r14	UTSW	5	109216229	missense	probably damaging	1.00
R3762:Vmn2r14	UTSW	5	109220167	missense	probably benign	0.02
R3943:Vmn2r14	UTSW	5	109216064	missense	probably damaging	1.00
R3944:Vmn2r14	UTSW	5	109216064	missense	probably damaging	1.00
R4222:Vmn2r14	UTSW	5	109216283	missense	probably benign	0.00
R4224:Vmn2r14	UTSW	5	109216283	missense	probably benign	0.00
R4239:Vmn2r14	UTSW	5	109216411	critical splice acceptor site	probably null
R4240:Vmn2r14	UTSW	5	109216411	critical splice acceptor site	probably null
R4782:Vmn2r14	UTSW	5	109221504	missense	probably benign	0.01
R4832:Vmn2r14	UTSW	5	109216110	missense	probably damaging	1.00
R4884:Vmn2r14	UTSW	5	109221518	splice site	probably null
R4896:Vmn2r14	UTSW	5	109220380	missense	probably benign	0.19
R5004:Vmn2r14	UTSW	5	109220380	missense	probably benign	0.19
R5117:Vmn2r14	UTSW	5	109216095	missense	probably benign	0.16
R5285:Vmn2r14	UTSW	5	109217576	missense	probably damaging	0.98
R5413:Vmn2r14	UTSW	5	109221288	missense	probably benign	0.29
R5569:Vmn2r14	UTSW	5	109220395	missense	probably benign	0.44
R5701:Vmn2r14	UTSW	5	109219950	missense	probably damaging	1.00
R5726:Vmn2r14	UTSW	5	109217620	missense	possibly damaging	0.95
R5763:Vmn2r14	UTSW	5	109215858	missense	possibly damaging	0.49
R5872:Vmn2r14	UTSW	5	109221356	missense	probably benign
R5985:Vmn2r14	UTSW	5	109220216	missense	possibly damaging	0.89
R6268:Vmn2r14	UTSW	5	109221417	missense	possibly damaging	0.87
R6273:Vmn2r14	UTSW	5	109221267	missense	probably benign	0.44
R6409:Vmn2r14	UTSW	5	109216230	missense	probably benign	0.09
R6944:Vmn2r14	UTSW	5	109216059	missense	probably benign	0.22
R6944:Vmn2r14	UTSW	5	109216274	missense	probably benign	0.06
R7608:Vmn2r14	UTSW	5	109221410	missense	probably benign	0.03
R7740:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R7768:Vmn2r14	UTSW	5	109220220	missense	probably benign	0.01
R7804:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R7872:Vmn2r14	UTSW	5	109221353	missense	probably benign	0.02
R7993:Vmn2r14	UTSW	5	109215996	missense	probably benign	0.00
R8006:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R8007:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R8187:Vmn2r14	UTSW	5	109220554	missense	probably benign	0.03
R8369:Vmn2r14	UTSW	5	109221476	missense	probably damaging	1.00
R8463:Vmn2r14	UTSW	5	109221474	missense	probably benign	0.30
R8968:Vmn2r14	UTSW	5	109217667	missense	probably benign	0.01
R9008:Vmn2r14	UTSW	5	109220027	missense	probably benign	0.00
R9030:Vmn2r14	UTSW	5	109220188	missense	probably damaging	0.99
R9039:Vmn2r14	UTSW	5	109220036	nonsense	probably null
R9150:Vmn2r14	UTSW	5	109219917	missense	probably damaging	1.00
R9164:Vmn2r14	UTSW	5	109216221	missense	probably damaging	1.00
R9216:Vmn2r14	UTSW	5	109221246	missense	probably benign	0.01
R9225:Vmn2r14	UTSW	5	109221422	missense	probably damaging	1.00
R9245:Vmn2r14	UTSW	5	109220310	missense	possibly damaging	0.89
R9342:Vmn2r14	UTSW	5	109220562	missense	probably damaging	1.00
R9472:Vmn2r14	UTSW	5	109220096	missense	probably benign	0.00
R9774:Vmn2r14	UTSW	5	109221260	missense	probably benign	0.07
Z1177:Vmn2r14	UTSW	5	109219875	missense	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- AAGTTAGGTGCCCCTGATGC -3'
(R):5'- GGTGTCCAGATGATAAGTATGCC -3'

Sequencing Primer
(F):5'- CATCTTTCCCCCTGGAGAAGTGAG -3'
(R):5'- CCAGATGATAAGTATGCCAACTTAG -3'

Posted On

2022-11-14