Incidental Mutation 'R9763:Or10a3n'
ID 735810
Institutional Source Beutler Lab
Gene Symbol Or10a3n
Ensembl Gene ENSMUSG00000066239
Gene Name olfactory receptor family 10 subfamily A member 3N
Synonyms GA_x6K02T2PBJ9-11224559-11223615, MOR268-6, Olfr519
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R9763 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 108492668-108493612 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 108493210 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 140 (I140L)
Ref Sequence ENSEMBL: ENSMUSP00000081804 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084752] [ENSMUST00000202706]
AlphaFold K7N645
Predicted Effect probably benign
Transcript: ENSMUST00000084752
AA Change: I140L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000081804
Gene: ENSMUSG00000066239
AA Change: I140L

DomainStartEndE-ValueType
Pfam:7tm_4 36 313 1.3e-59 PFAM
Pfam:7TM_GPCR_Srsx 40 310 3.3e-6 PFAM
Pfam:7tm_1 46 305 3.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000202706
AA Change: I135L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000144271
Gene: ENSMUSG00000066239
AA Change: I135L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-59 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.1e-5 PFAM
Pfam:7tm_1 41 300 1.2e-24 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,302,717 (GRCm39) D2167E possibly damaging Het
Acadsb T A 7: 131,045,327 (GRCm39) Y420N probably benign Het
Adcy1 T A 11: 7,014,126 (GRCm39) L176Q probably damaging Het
Amdhd1 T A 10: 93,367,398 (GRCm39) K252M possibly damaging Het
Aspa C A 11: 73,213,094 (GRCm39) E83* probably null Het
Atat1 A G 17: 36,220,899 (GRCm39) L10P probably damaging Het
Ccdc141 T A 2: 76,869,919 (GRCm39) N862I probably damaging Het
Cdkal1 A T 13: 29,809,692 (GRCm39) C217* probably null Het
Cttnbp2 C T 6: 18,435,240 (GRCm39) S206N probably benign Het
Dner A T 1: 84,361,656 (GRCm39) I651N possibly damaging Het
Efcab3 G A 11: 104,890,485 (GRCm39) G4189E possibly damaging Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Ercc6l2 T C 13: 63,982,438 (GRCm39) V91A probably damaging Het
Gask1a A G 9: 121,805,421 (GRCm39) D404G probably damaging Het
Gm13941 A G 2: 110,931,518 (GRCm39) L38S unknown Het
Golph3l G A 3: 95,517,085 (GRCm39) E198K possibly damaging Het
Hecw2 A C 1: 53,963,074 (GRCm39) D812E probably damaging Het
Ikzf2 T A 1: 69,587,835 (GRCm39) E212V possibly damaging Het
Il6st C T 13: 112,627,051 (GRCm39) S281F probably damaging Het
Kmt2d CTGTTG CTG 15: 98,743,057 (GRCm39) probably benign Het
Krt71 T G 15: 101,646,757 (GRCm39) K317T probably damaging Het
Lgi4 T C 7: 30,760,020 (GRCm39) F72S probably damaging Het
Map3k1 C T 13: 111,912,499 (GRCm39) R174H probably damaging Het
Marveld3 T A 8: 110,688,375 (GRCm39) H122L probably benign Het
Mrgprb2 A G 7: 48,202,174 (GRCm39) S184P probably benign Het
Mylk G T 16: 34,699,482 (GRCm39) G282* probably null Het
Myo16 T A 8: 10,450,528 (GRCm39) M510K unknown Het
Naip5 C G 13: 100,367,269 (GRCm39) A276P probably damaging Het
Or10a3 T A 7: 108,480,874 (GRCm39) probably benign Het
Or3a1d T C 11: 74,238,041 (GRCm39) Y3C probably damaging Het
Or4e5 T G 14: 52,728,307 (GRCm39) Y38S probably damaging Het
Or8j3 A T 2: 86,028,181 (GRCm39) M305K probably benign Het
Or9g20 T G 2: 85,630,060 (GRCm39) N185H possibly damaging Het
Pdzrn4 T C 15: 92,668,376 (GRCm39) Y843H probably damaging Het
Prkca A G 11: 107,903,867 (GRCm39) V242A possibly damaging Het
Rbbp8 A T 18: 11,865,261 (GRCm39) M717L probably benign Het
Rnf150 T C 8: 83,732,968 (GRCm39) S272P probably benign Het
Rtraf A G 14: 19,866,314 (GRCm39) V134A probably damaging Het
Rubcnl T A 14: 75,287,108 (GRCm39) L592* probably null Het
Slc23a1 A G 18: 35,755,364 (GRCm39) S484P probably damaging Het
Slmap A G 14: 26,204,118 (GRCm39) Y68H probably damaging Het
Speer4b C A 5: 27,705,206 (GRCm39) V56L probably damaging Het
Sycp2l T A 13: 41,306,232 (GRCm39) S84T Het
Syne1 T C 10: 5,007,858 (GRCm39) D122G probably benign Het
Timd2 G T 11: 46,573,540 (GRCm39) P155T probably benign Het
Topbp1 G A 9: 103,223,923 (GRCm39) R1401Q probably benign Het
Trim36 C A 18: 46,309,125 (GRCm39) D312Y probably benign Het
Vps13c A G 9: 67,818,860 (GRCm39) T1094A probably benign Het
Vwa8 T A 14: 79,186,988 (GRCm39) Y465N probably damaging Het
Zfpm1 T C 8: 123,062,531 (GRCm39) L530P probably damaging Het
Zmynd10 A T 9: 107,425,965 (GRCm39) T100S probably benign Het
Other mutations in Or10a3n
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01634:Or10a3n APN 7 108,493,292 (GRCm39) missense probably benign 0.22
IGL02043:Or10a3n APN 7 108,493,046 (GRCm39) nonsense probably null
PIT4382001:Or10a3n UTSW 7 108,493,309 (GRCm39) missense probably damaging 1.00
R1183:Or10a3n UTSW 7 108,492,948 (GRCm39) missense probably damaging 1.00
R1596:Or10a3n UTSW 7 108,493,086 (GRCm39) missense probably damaging 1.00
R1647:Or10a3n UTSW 7 108,492,972 (GRCm39) missense probably damaging 1.00
R1648:Or10a3n UTSW 7 108,492,972 (GRCm39) missense probably damaging 1.00
R3952:Or10a3n UTSW 7 108,493,189 (GRCm39) missense probably benign 0.00
R4611:Or10a3n UTSW 7 108,493,324 (GRCm39) missense probably damaging 1.00
R4723:Or10a3n UTSW 7 108,493,028 (GRCm39) missense probably benign 0.09
R5838:Or10a3n UTSW 7 108,493,292 (GRCm39) missense probably benign 0.22
R6483:Or10a3n UTSW 7 108,493,318 (GRCm39) missense possibly damaging 0.76
R6516:Or10a3n UTSW 7 108,492,972 (GRCm39) missense probably damaging 1.00
R7353:Or10a3n UTSW 7 108,493,429 (GRCm39) missense probably damaging 1.00
R7748:Or10a3n UTSW 7 108,493,285 (GRCm39) missense probably benign 0.22
R7975:Or10a3n UTSW 7 108,493,019 (GRCm39) nonsense probably null
R8823:Or10a3n UTSW 7 108,493,155 (GRCm39) missense probably benign 0.00
R8913:Or10a3n UTSW 7 108,492,736 (GRCm39) missense probably damaging 0.99
R8914:Or10a3n UTSW 7 108,492,736 (GRCm39) missense probably damaging 0.99
R9066:Or10a3n UTSW 7 108,493,253 (GRCm39) nonsense probably null
R9093:Or10a3n UTSW 7 108,493,609 (GRCm39) missense probably benign 0.05
Z1088:Or10a3n UTSW 7 108,492,980 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AATGGTGCTTGTGAAGGCATAG -3'
(R):5'- CTGTTTCAGCACAGTCATCAC -3'

Sequencing Primer
(F):5'- CTTCAAACAGGAAGGTGTCTGCAC -3'
(R):5'- GTTTCAGCACAGTCATCACACCTG -3'
Posted On 2022-11-14