Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01309:Lrrc41'

73583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc41

Ensembl Gene

ENSMUSG00000028703

Gene Name

leucine rich repeat containing 41

Synonyms

MUF1, D630045E04Rik, D730026A16Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.401) question?

Stock #

IGL01309

Quality Score

Status

Chromosome

Chromosomal Location

115932466-115954240 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 115953663 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 783 (L783P)

Ref Sequence

ENSEMBL: ENSMUSP00000030471 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030471] [ENSMUST00000102704] [ENSMUST00000102705]

AlphaFold

Q8K1C9

Predicted Effect

probably damaging
Transcript: ENSMUST00000030471
AA Change: L783P

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703
AA Change: L783P

Domain	Start	End	E-Value	Type
low complexity region	30	45	N/A	INTRINSIC
low complexity region	280	291	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
low complexity region	352	382	N/A	INTRINSIC
low complexity region	417	429	N/A	INTRINSIC
SCOP:d1yrga_	449	742	4e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000102704

SMART Domains

Protein: ENSMUSP00000099765
Gene: ENSMUSG00000028702

Domain	Start	End	E-Value	Type
DEXDc	149	357	1.66e-41	SMART
Blast:DEXDc	391	427	5e-13	BLAST
low complexity region	441	456	N/A	INTRINSIC
HELICc	527	611	1.39e-20	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000102705

SMART Domains

Protein: ENSMUSP00000099766
Gene: ENSMUSG00000028702

Domain	Start	End	E-Value	Type
Pfam:Rad54_N	10	138	7.8e-9	PFAM
DEXDc	149	357	1.66e-41	SMART
Blast:DEXDc	391	427	5e-13	BLAST
low complexity region	441	456	N/A	INTRINSIC
HELICc	527	611	1.39e-20	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134983

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139147

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610318N02Rik	A	G	16: 16,931,410 (GRCm39)	V275A	possibly damaging	Het
Adamts2	A	G	11: 50,694,528 (GRCm39)	D1105G	probably benign	Het
Adgrb3	T	A	1: 25,151,352 (GRCm39)	M195L	possibly damaging	Het
Adrm1	A	G	2: 179,817,756 (GRCm39)		probably benign	Het
Atg13	T	A	2: 91,509,176 (GRCm39)	I457F	possibly damaging	Het
BC034090	T	C	1: 155,102,130 (GRCm39)	N45D	probably damaging	Het
C3	C	T	17: 57,516,652 (GRCm39)		probably benign	Het
Cacna1a	G	A	8: 85,249,657 (GRCm39)	G221D	probably damaging	Het
Calr	A	G	8: 85,573,335 (GRCm39)		probably null	Het
Chd3	C	T	11: 69,248,557 (GRCm39)	V825I	probably damaging	Het
Chdh	T	G	14: 29,757,761 (GRCm39)		probably benign	Het
Ckap5	T	C	2: 91,400,529 (GRCm39)	V627A	probably damaging	Het
Commd3	A	G	2: 18,677,289 (GRCm39)	E5G	probably benign	Het
Ddi1	T	C	9: 6,265,773 (GRCm39)	R199G	probably damaging	Het
Dennd4c	A	G	4: 86,723,724 (GRCm39)		probably benign	Het
Dok7	G	A	5: 35,236,912 (GRCm39)	G293D	possibly damaging	Het
Epm2aip1	T	C	9: 111,102,596 (GRCm39)	V523A	probably benign	Het
Fam171b	C	T	2: 83,709,791 (GRCm39)	Q488*	probably null	Het
Gabbr1	G	A	17: 37,359,499 (GRCm39)		probably null	Het
Gm5965	T	G	16: 88,575,219 (GRCm39)	S131A	possibly damaging	Het
Gpcpd1	T	C	2: 132,392,244 (GRCm39)	D235G	probably damaging	Het
Grip1	A	T	10: 119,767,207 (GRCm39)	K111*	probably null	Het
Itih4	G	T	14: 30,613,706 (GRCm39)	D308Y	probably damaging	Het
Kcnj6	A	G	16: 94,633,314 (GRCm39)	Y266H	probably damaging	Het
Map4k5	T	C	12: 69,888,737 (GRCm39)	D298G	probably benign	Het
Mapkbp1	T	C	2: 119,849,423 (GRCm39)	F712L	probably damaging	Het
Mcoln2	T	C	3: 145,869,282 (GRCm39)		probably benign	Het
Megf11	T	A	9: 64,588,698 (GRCm39)	S532R	probably benign	Het
Mkx	T	C	18: 6,937,192 (GRCm39)	D284G	probably benign	Het
Mmp16	A	G	4: 18,116,185 (GRCm39)	I596M	probably damaging	Het
Msto1	C	A	3: 88,820,993 (GRCm39)	R34L	probably benign	Het
Mtmr9	A	G	14: 63,764,254 (GRCm39)	L491P	probably damaging	Het
Or4a66	T	G	2: 88,531,310 (GRCm39)	Y121S	probably damaging	Het
Or8b52	T	A	9: 38,576,289 (GRCm39)	I284L	probably benign	Het
Or9s13	T	C	1: 92,548,057 (GRCm39)	M143T	probably damaging	Het
Otor	T	C	2: 142,920,532 (GRCm39)	V38A	possibly damaging	Het
Pcdhb12	G	T	18: 37,569,207 (GRCm39)	D118Y	probably damaging	Het
Prelp	T	C	1: 133,842,545 (GRCm39)	H200R	probably benign	Het
Prmt5	T	C	14: 54,747,334 (GRCm39)	Y481C	probably damaging	Het
Psg23	T	G	7: 18,348,465 (GRCm39)	D114A	probably damaging	Het
Ptger4	A	T	15: 5,272,239 (GRCm39)	Y127N	probably damaging	Het
Rabgap1l	C	A	1: 160,528,368 (GRCm39)	V385L	probably benign	Het
Rergl	T	A	6: 139,470,256 (GRCm39)	K191*	probably null	Het
Sart3	A	G	5: 113,897,311 (GRCm39)	F252S	probably damaging	Het
Sbno1	A	T	5: 124,519,769 (GRCm39)	S1169T	probably benign	Het
Serpinb8	C	T	1: 107,532,448 (GRCm39)	T180M	probably damaging	Het
Sipa1l1	G	A	12: 82,434,470 (GRCm39)	E747K	probably benign	Het
Sptb	T	A	12: 76,634,237 (GRCm39)	D2158V	probably benign	Het
Sycp2	T	G	2: 177,999,904 (GRCm39)	D1024A	probably benign	Het
Tbr1	T	G	2: 61,636,411 (GRCm39)	N262K	possibly damaging	Het
Tnrc6a	A	T	7: 122,770,717 (GRCm39)	I836F	probably benign	Het
Ttn	T	C	2: 76,769,091 (GRCm39)	E2823G	probably damaging	Het
Uqcrc1	T	A	9: 108,778,026 (GRCm39)	L441Q	possibly damaging	Het
Vmn1r180	T	C	7: 23,652,424 (GRCm39)	F196L	probably damaging	Het
Vmn2r111	T	C	17: 22,787,997 (GRCm39)	I451M	possibly damaging	Het
Zcchc7	A	T	4: 44,926,060 (GRCm39)	H353L	probably damaging	Het

Other mutations in Lrrc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01358:Lrrc41	APN	4	115,932,784 (GRCm39)	missense	probably benign	0.16
IGL01734:Lrrc41	APN	4	115,950,331 (GRCm39)	critical splice donor site	probably null
IGL01986:Lrrc41	APN	4	115,946,519 (GRCm39)	missense	probably benign	0.27
IGL02159:Lrrc41	APN	4	115,945,683 (GRCm39)	missense	probably benign	0.03
IGL02892:Lrrc41	APN	4	115,946,032 (GRCm39)	missense	possibly damaging	0.68
IGL03135:Lrrc41	APN	4	115,945,728 (GRCm39)	missense	probably benign
R1478:Lrrc41	UTSW	4	115,952,405 (GRCm39)	nonsense	probably null
R1765:Lrrc41	UTSW	4	115,946,248 (GRCm39)	missense	possibly damaging	0.94
R2233:Lrrc41	UTSW	4	115,953,582 (GRCm39)	missense	possibly damaging	0.66
R4080:Lrrc41	UTSW	4	115,937,743 (GRCm39)	splice site	probably null
R4677:Lrrc41	UTSW	4	115,952,332 (GRCm39)	missense	probably benign
R4833:Lrrc41	UTSW	4	115,950,374 (GRCm39)	unclassified	probably benign
R4877:Lrrc41	UTSW	4	115,936,602 (GRCm39)	missense	probably damaging	0.99
R4926:Lrrc41	UTSW	4	115,946,521 (GRCm39)	missense	possibly damaging	0.46
R6459:Lrrc41	UTSW	4	115,945,977 (GRCm39)	missense	possibly damaging	0.95
R6817:Lrrc41	UTSW	4	115,946,502 (GRCm39)	missense	possibly damaging	0.66
R6834:Lrrc41	UTSW	4	115,953,726 (GRCm39)	missense	possibly damaging	0.46
R7479:Lrrc41	UTSW	4	115,946,238 (GRCm39)	missense	probably damaging	0.96
R7512:Lrrc41	UTSW	4	115,950,191 (GRCm39)	missense	possibly damaging	0.66
R7593:Lrrc41	UTSW	4	115,950,141 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrrc41	UTSW	4	115,952,085 (GRCm39)	missense	possibly damaging	0.79
R8810:Lrrc41	UTSW	4	115,932,488 (GRCm39)	unclassified	probably benign
R9134:Lrrc41	UTSW	4	115,945,782 (GRCm39)	missense	possibly damaging	0.89
R9495:Lrrc41	UTSW	4	115,932,806 (GRCm39)	critical splice donor site	probably null

Posted On

2013-10-07