Incidental Mutation 'R9730:Try4'
ID 736010
Institutional Source Beutler Lab
Gene Symbol Try4
Ensembl Gene ENSMUSG00000054106
Gene Name trypsin 4
Synonyms 0910001B19Rik, Td
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9730 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 41279206-41282467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41281996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 194 (D194V)
Ref Sequence ENSEMBL: ENSMUSP00000031913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031913]
AlphaFold Q9R0T7
Predicted Effect probably damaging
Transcript: ENSMUST00000031913
AA Change: D194V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031913
Gene: ENSMUSG00000054106
AA Change: D194V

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Tryp_SPc 23 239 9.72e-105 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 G A 17: 45,829,534 (GRCm39) R807Q probably benign Het
Alms1 G A 6: 85,606,420 (GRCm39) R2221Q probably benign Het
Alox12 C T 11: 70,140,920 (GRCm39) A372T probably benign Het
Ank2 T C 3: 127,019,493 (GRCm39) M2V Het
Cdon A G 9: 35,398,263 (GRCm39) I993M probably benign Het
Chil5 T C 3: 105,926,470 (GRCm39) T120A possibly damaging Het
Clca4b T C 3: 144,632,979 (GRCm39) H157R probably damaging Het
Clip2 C T 5: 134,533,616 (GRCm39) R487Q probably benign Het
Cyp39a1 A G 17: 43,991,029 (GRCm39) N113D probably benign Het
Dact3 A G 7: 16,609,540 (GRCm39) E64G possibly damaging Het
Dennd3 A G 15: 73,426,959 (GRCm39) K779E probably damaging Het
Etnppl C T 3: 130,415,958 (GRCm39) A115V probably damaging Het
Exoc6 C T 19: 37,588,032 (GRCm39) T555I probably benign Het
Fbxw11 A G 11: 32,688,395 (GRCm39) T419A probably damaging Het
Hcn4 G T 9: 58,731,493 (GRCm39) M233I unknown Het
Hgfac T C 5: 35,204,282 (GRCm39) V515A probably damaging Het
Hikeshi T C 7: 89,569,371 (GRCm39) Y150C probably benign Het
Igf1r A G 7: 67,839,423 (GRCm39) Y645C probably damaging Het
Iqgap1 A G 7: 80,401,124 (GRCm39) I521T possibly damaging Het
Ldhal6b A G 17: 5,468,094 (GRCm39) V280A possibly damaging Het
Map1s C T 8: 71,369,178 (GRCm39) A909V possibly damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Or5b106 T A 19: 13,123,747 (GRCm39) Y92F possibly damaging Het
Plaa G A 4: 94,466,660 (GRCm39) P484S probably benign Het
Ppp1r3a G T 6: 14,721,923 (GRCm39) A301D probably benign Het
Prdm2 A G 4: 142,858,659 (GRCm39) S1544P possibly damaging Het
Scara3 A G 14: 66,168,261 (GRCm39) V452A probably damaging Het
Slc12a9 T A 5: 137,325,732 (GRCm39) D293V probably benign Het
Slc14a1 C A 18: 78,152,807 (GRCm39) A367S probably damaging Het
Smg1 T C 7: 117,783,004 (GRCm39) N1101S unknown Het
Spocd1 A G 4: 129,850,305 (GRCm39) probably benign Het
Synj1 A T 16: 90,757,552 (GRCm39) D865E probably damaging Het
Trim21 T C 7: 102,213,247 (GRCm39) D17G probably benign Het
Zfp30 A G 7: 29,492,139 (GRCm39) E212G probably damaging Het
Zfp445 A C 9: 122,681,490 (GRCm39) I817R probably damaging Het
Zfp534 A T 4: 147,759,378 (GRCm39) H430Q probably damaging Het
Other mutations in Try4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Try4 APN 6 41,281,960 (GRCm39) missense probably damaging 1.00
IGL02216:Try4 APN 6 41,281,965 (GRCm39) missense probably benign
R0537:Try4 UTSW 6 41,281,296 (GRCm39) missense probably benign
R0731:Try4 UTSW 6 41,281,301 (GRCm39) missense probably benign 0.01
R1113:Try4 UTSW 6 41,282,308 (GRCm39) missense possibly damaging 0.90
R1833:Try4 UTSW 6 41,280,365 (GRCm39) missense probably damaging 0.98
R2246:Try4 UTSW 6 41,282,406 (GRCm39) missense possibly damaging 0.80
R4131:Try4 UTSW 6 41,282,335 (GRCm39) nonsense probably null
R4414:Try4 UTSW 6 41,281,905 (GRCm39) missense possibly damaging 0.84
R5457:Try4 UTSW 6 41,280,355 (GRCm39) missense probably damaging 1.00
R5707:Try4 UTSW 6 41,281,977 (GRCm39) missense possibly damaging 0.65
R6023:Try4 UTSW 6 41,280,355 (GRCm39) missense probably damaging 1.00
R7131:Try4 UTSW 6 41,281,337 (GRCm39) missense probably benign 0.03
R7783:Try4 UTSW 6 41,279,229 (GRCm39) missense possibly damaging 0.96
R8051:Try4 UTSW 6 41,281,996 (GRCm39) missense probably damaging 0.99
R9320:Try4 UTSW 6 41,282,008 (GRCm39) critical splice donor site probably null
RF007:Try4 UTSW 6 41,282,297 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGATGCTCCATGGTCTGTAGAC -3'
(R):5'- AAGATGCCATTCTAGCCATGC -3'

Sequencing Primer
(F):5'- ATGGTCTGTAGACTTTCTCCACTGG -3'
(R):5'- ATGCCATTCTAGCCATGCTTTGC -3'
Posted On 2022-11-14