Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00531:Zfp281'

7366

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp281

Ensembl Gene

ENSMUSG00000041483

Gene Name

zinc finger protein 281

Synonyms

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00531

Quality Score

Status

Chromosome

Chromosomal Location

136552639-136557791 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 136555648 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 875 (D875E)

Ref Sequence

ENSEMBL: ENSMUSP00000107677 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047734] [ENSMUST00000112046]

AlphaFold

Q99LI5

Predicted Effect

probably damaging
Transcript: ENSMUST00000047734
AA Change: D875E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000039003
Gene: ENSMUSG00000041483
AA Change: D875E

Domain	Start	End	E-Value	Type
low complexity region	4	36	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
low complexity region	161	171	N/A	INTRINSIC
low complexity region	180	191	N/A	INTRINSIC
low complexity region	230	241	N/A	INTRINSIC
ZnF_C2H2	258	280	3.34e-2	SMART
ZnF_C2H2	286	308	6.78e-3	SMART
ZnF_C2H2	314	336	1.43e-1	SMART
ZnF_C2H2	342	362	2.97e1	SMART
low complexity region	397	407	N/A	INTRINSIC
low complexity region	488	501	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112046
AA Change: D875E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000107677
Gene: ENSMUSG00000041483
AA Change: D875E

Domain	Start	End	E-Value	Type
low complexity region	4	36	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
low complexity region	161	171	N/A	INTRINSIC
low complexity region	180	191	N/A	INTRINSIC
low complexity region	230	241	N/A	INTRINSIC
ZnF_C2H2	258	280	3.34e-2	SMART
ZnF_C2H2	286	308	6.78e-3	SMART
ZnF_C2H2	314	336	1.43e-1	SMART
ZnF_C2H2	342	362	2.97e1	SMART
low complexity region	397	407	N/A	INTRINSIC
low complexity region	488	501	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180797

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 12 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Dnah17	A	G	11: 117,933,999 (GRCm39)	I3525T	probably damaging	Het
Ednrb	T	C	14: 104,057,455 (GRCm39)	Y369C	probably damaging	Het
Folh1	T	A	7: 86,368,977 (GRCm39)	I717L	possibly damaging	Het
Golga2	T	A	2: 32,195,226 (GRCm39)	D706E	probably benign	Het
Miip	C	A	4: 147,950,322 (GRCm39)	W91C	probably damaging	Het
Nav3	T	C	10: 109,539,171 (GRCm39)	S2077G	probably null	Het
Nsrp1	G	A	11: 76,937,021 (GRCm39)	R392*	probably null	Het
Ryr3	T	C	2: 112,493,357 (GRCm39)		probably benign	Het
Son	A	G	16: 91,461,210 (GRCm39)	K177R	probably damaging	Het
Stau1	A	G	2: 166,806,542 (GRCm39)	S13P	probably benign	Het
Tnc	G	A	4: 63,889,390 (GRCm39)		probably benign	Het
Vezf1	G	A	11: 87,964,320 (GRCm39)	M157I	probably benign	Het

Other mutations in Zfp281

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01408:Zfp281	APN	1	136,553,853 (GRCm39)	missense	probably damaging	1.00
IGL02037:Zfp281	APN	1	136,555,185 (GRCm39)	missense	possibly damaging	0.64
IGL03233:Zfp281	APN	1	136,554,567 (GRCm39)	missense	possibly damaging	0.82
PIT4486001:Zfp281	UTSW	1	136,554,741 (GRCm39)	missense	possibly damaging	0.48
R1514:Zfp281	UTSW	1	136,554,435 (GRCm39)	missense	probably benign	0.00
R1784:Zfp281	UTSW	1	136,553,091 (GRCm39)	small insertion	probably benign
R1785:Zfp281	UTSW	1	136,553,091 (GRCm39)	small insertion	probably benign
R2049:Zfp281	UTSW	1	136,553,091 (GRCm39)	small insertion	probably benign
R2142:Zfp281	UTSW	1	136,553,091 (GRCm39)	small insertion	probably benign
R4086:Zfp281	UTSW	1	136,553,859 (GRCm39)	missense	probably damaging	1.00
R4087:Zfp281	UTSW	1	136,553,859 (GRCm39)	missense	probably damaging	1.00
R4088:Zfp281	UTSW	1	136,553,859 (GRCm39)	missense	probably damaging	1.00
R4090:Zfp281	UTSW	1	136,553,859 (GRCm39)	missense	probably damaging	1.00
R4819:Zfp281	UTSW	1	136,553,448 (GRCm39)	missense	probably benign
R5380:Zfp281	UTSW	1	136,553,676 (GRCm39)	missense	possibly damaging	0.93
R6033:Zfp281	UTSW	1	136,554,464 (GRCm39)	missense	probably benign	0.14
R6033:Zfp281	UTSW	1	136,554,464 (GRCm39)	missense	probably benign	0.14
R6056:Zfp281	UTSW	1	136,553,178 (GRCm39)	missense	possibly damaging	0.93
R6213:Zfp281	UTSW	1	136,553,250 (GRCm39)	missense	probably benign	0.01
R7402:Zfp281	UTSW	1	136,553,190 (GRCm39)	missense	probably damaging	0.99
R7503:Zfp281	UTSW	1	136,554,678 (GRCm39)	missense	possibly damaging	0.67
R7969:Zfp281	UTSW	1	136,553,772 (GRCm39)	missense	probably benign	0.06
R8343:Zfp281	UTSW	1	136,555,620 (GRCm39)	missense	probably damaging	1.00
R8722:Zfp281	UTSW	1	136,553,334 (GRCm39)	missense	probably benign	0.00
R9199:Zfp281	UTSW	1	136,553,643 (GRCm39)	missense	probably benign
R9461:Zfp281	UTSW	1	136,554,500 (GRCm39)	missense	probably benign	0.28
R9487:Zfp281	UTSW	1	136,555,143 (GRCm39)	missense	probably damaging	0.96
R9532:Zfp281	UTSW	1	136,554,894 (GRCm39)	missense	probably benign
R9541:Zfp281	UTSW	1	136,555,303 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-04-20