Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01312:Tas2r134'

73708

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r134

Ensembl Gene

Gene Name

taste receptor, type 2, member 134

Synonyms

T2R134, Tas2r34

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01312

Quality Score

Status

Chromosome

Chromosomal Location

51627511-51628408 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 51628235 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 242 (L242H)

Ref Sequence

ENSEMBL: ENSMUSP00000064657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070028]

Predicted Effect

probably damaging
Transcript: ENSMUST00000070028
AA Change: L242H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: L242H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	291	1.4e-75	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406P16Rik	A	T	7: 34,256,508	D385E	probably benign	Het
Ankle2	G	T	5: 110,234,352	V65L	probably benign	Het
C3	G	A	17: 57,225,993		probably benign	Het
Colgalt1	G	A	8: 71,622,776	R442H	probably damaging	Het
Epb41l2	A	G	10: 25,441,587	M1V	probably null	Het
Etaa1	A	G	11: 17,945,909	L736S	probably damaging	Het
Fam35a	T	C	14: 34,268,193	D252G	possibly damaging	Het
Foxm1	T	C	6: 128,373,374	F546S	probably damaging	Het
Fscn3	T	C	6: 28,434,470	I348T	probably damaging	Het
Gcm2	T	C	13: 41,103,131	T381A	probably damaging	Het
Nup153	T	C	13: 46,686,824	T1103A	probably benign	Het
Olfr1129	A	G	2: 87,575,174	Q30R	probably damaging	Het
Pde7b	A	G	10: 20,436,194		probably null	Het
St7	T	A	6: 17,922,014	I361N	probably damaging	Het
Stard5	C	T	7: 83,633,189	P70L	probably damaging	Het
Stxbp4	A	G	11: 90,621,649		probably benign	Het
Tnrc6b	G	A	15: 80,923,578	R1577H	probably damaging	Het
Trappc11	C	A	8: 47,505,677	A716S	possibly damaging	Het
Wdr35	C	T	12: 9,008,655	T604M	probably damaging	Het
Zbtb24	T	G	10: 41,451,889	I257S	possibly damaging	Het

Other mutations in Tas2r134

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Tas2r134	APN	2	51628088	missense	possibly damaging	0.90
IGL00563:Tas2r134	APN	2	51628088	missense	possibly damaging	0.90
IGL01121:Tas2r134	APN	2	51627989	missense	probably damaging	1.00
IGL01122:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01128:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01132:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01419:Tas2r134	APN	2	51627747	nonsense	probably null
IGL01774:Tas2r134	APN	2	51628148	missense	probably benign	0.07
IGL02735:Tas2r134	APN	2	51627827	missense	probably damaging	1.00
R0799:Tas2r134	UTSW	2	51628373	missense	probably benign	0.00
R1205:Tas2r134	UTSW	2	51627986	missense	probably benign	0.00
R2267:Tas2r134	UTSW	2	51628237	missense	probably benign	0.01
R3736:Tas2r134	UTSW	2	51627774	missense	probably damaging	1.00
R5254:Tas2r134	UTSW	2	51627547	missense	probably benign	0.39
R5752:Tas2r134	UTSW	2	51627868	missense	probably damaging	1.00
R6162:Tas2r134	UTSW	2	51627559	missense	probably damaging	1.00
R6940:Tas2r134	UTSW	2	51628136	missense	probably benign	0.00
R6954:Tas2r134	UTSW	2	51627770	missense	probably benign	0.00
R6996:Tas2r134	UTSW	2	51627589	missense	probably benign	0.00
R7206:Tas2r134	UTSW	2	51628108	missense	probably benign	0.02
R7303:Tas2r134	UTSW	2	51628133	missense	probably benign	0.01
R7348:Tas2r134	UTSW	2	51628402	missense	possibly damaging	0.92
R7479:Tas2r134	UTSW	2	51627529	missense	not run
R7575:Tas2r134	UTSW	2	51628154	missense	probably damaging	1.00
R7686:Tas2r134	UTSW	2	51628243	missense	possibly damaging	0.54

Posted On

2013-10-07