Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01314:Vmn2r96'

73770

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r96

Ensembl Gene

ENSMUSG00000091679

Gene Name

vomeronasal 2, receptor 96

Synonyms

EG433070

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL01314

Quality Score

Status

Chromosome

Chromosomal Location

18573151-18616003 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18582964 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 187 (T187A)

Ref Sequence

ENSEMBL: ENSMUSP00000131564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]

AlphaFold

E9PZU5

Predicted Effect

probably benign
Transcript: ENSMUST00000165692
AA Change: T187A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: T187A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	257	8.6e-20	PFAM
Pfam:NCD3G	317	370	3.7e-22	PFAM
Pfam:7tm_3	402	638	3.9e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000177244
AA Change: T379A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: T379A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	245	4.2e-19	PFAM
Pfam:NCD3G	317	370	6.9e-21	PFAM
Pfam:7tm_3	400	639	3.4e-75	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231261

Predicted Effect

probably benign
Transcript: ENSMUST00000231286
AA Change: T379A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430F08Rik	A	C	10: 100,573,611	D313E	probably damaging	Het
Adamts12	C	T	15: 11,071,853	A161V	probably benign	Het
Bptf	A	T	11: 107,054,853	V2520E	probably damaging	Het
C87436	T	C	6: 86,457,855	F395S	probably damaging	Het
Capn1	T	C	19: 5,989,984		probably benign	Het
Ceacam5	T	A	7: 17,747,256	Y309*	probably null	Het
Clasp2	A	G	9: 113,906,127	D1011G	possibly damaging	Het
Csmd3	A	G	15: 47,849,755	Y1608H	probably damaging	Het
Dcaf1	T	C	9: 106,834,191	I77T	probably benign	Het
Dcdc2a	T	C	13: 25,102,604	L170P	probably damaging	Het
Ddx28	A	G	8: 106,010,580	F282S	probably damaging	Het
Egf	A	G	3: 129,686,260	I497T	probably benign	Het
Emsy	A	G	7: 98,593,455	V1159A	probably benign	Het
Fam46c	T	C	3: 100,473,174	K89E	probably benign	Het
Hk3	C	A	13: 55,007,063		probably benign	Het
Htt	A	G	5: 34,878,856	D2049G	probably benign	Het
Inpp5d	C	A	1: 87,683,750	S45*	probably null	Het
Irf8	A	G	8: 120,753,380	Y119C	probably damaging	Het
Klk1b4	T	C	7: 44,211,176		probably null	Het
Macf1	A	G	4: 123,486,720	S1273P	probably damaging	Het
Man2c1	A	T	9: 57,141,819	H867L	probably benign	Het
Mgat4e	T	C	1: 134,541,449	T286A	probably damaging	Het
Mug2	T	C	6: 122,081,279	F1267L	possibly damaging	Het
Necab1	T	A	4: 15,005,079	E128D	probably damaging	Het
Olfr1331	G	A	4: 118,869,131	V117I	probably benign	Het
Pds5a	A	G	5: 65,615,294	V1322A	probably benign	Het
Poc1b	C	T	10: 99,129,641	T144I	probably damaging	Het
Prcc	T	A	3: 87,870,080	N196Y	probably damaging	Het
Psma5	G	A	3: 108,279,795	V237M	possibly damaging	Het
Rap1gds1	A	G	3: 139,050,561	L11P	probably damaging	Het
Rapgef3	A	G	15: 97,748,223	F132S	probably damaging	Het
Rgs13	T	G	1: 144,171,441	D14A	probably benign	Het
Stxbp4	A	G	11: 90,621,649		probably benign	Het
Tcerg1	C	A	18: 42,573,309	A1017D	probably damaging	Het
Tmem79	T	C	3: 88,332,576	I276V	possibly damaging	Het
Tmem94	C	A	11: 115,790,009	H113N	probably damaging	Het
Vil1	G	A	1: 74,428,238	D715N	probably damaging	Het
Zfhx4	T	A	3: 5,413,094	S3590T	probably damaging	Het

Other mutations in Vmn2r96

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Vmn2r96	APN	17	18583815	missense	probably benign	0.00
IGL00563:Vmn2r96	APN	17	18583815	missense	probably benign	0.00
IGL00769:Vmn2r96	APN	17	18583819	missense	probably benign	0.00
IGL01983:Vmn2r96	APN	17	18597265	missense	probably damaging	0.99
IGL02314:Vmn2r96	APN	17	18583959	missense	probably benign	0.01
IGL02600:Vmn2r96	APN	17	18597567	missense	probably benign
IGL02672:Vmn2r96	APN	17	18598114	missense	probably benign	0.02
IGL02750:Vmn2r96	APN	17	18582589	missense	probably benign	0.01
IGL03068:Vmn2r96	APN	17	18582875	missense	probably benign	0.00
IGL03411:Vmn2r96	APN	17	18586372	missense	possibly damaging	0.88
R0316:Vmn2r96	UTSW	17	18582565	missense	probably damaging	1.00
R0502:Vmn2r96	UTSW	17	18584000	missense	probably benign
R0580:Vmn2r96	UTSW	17	18582638	missense	probably damaging	1.00
R0652:Vmn2r96	UTSW	17	18597568	missense	probably benign	0.05
R0789:Vmn2r96	UTSW	17	18582476	missense	possibly damaging	0.81
R1462:Vmn2r96	UTSW	17	18597398	missense	possibly damaging	0.94
R1462:Vmn2r96	UTSW	17	18597398	missense	possibly damaging	0.94
R1660:Vmn2r96	UTSW	17	18597726	missense	probably benign	0.00
R1755:Vmn2r96	UTSW	17	18582653	missense	possibly damaging	0.50
R1843:Vmn2r96	UTSW	17	18597921	missense	probably benign	0.14
R1943:Vmn2r96	UTSW	17	18586402	missense	probably benign	0.09
R1993:Vmn2r96	UTSW	17	18583876	missense	probably damaging	1.00
R2018:Vmn2r96	UTSW	17	18584001	missense	probably benign
R2405:Vmn2r96	UTSW	17	18597840	missense	probably damaging	0.96
R3977:Vmn2r96	UTSW	17	18597679	missense	probably damaging	1.00
R3979:Vmn2r96	UTSW	17	18597679	missense	probably damaging	1.00
R4059:Vmn2r96	UTSW	17	18598077	missense	probably benign	0.20
R4693:Vmn2r96	UTSW	17	18583008	missense	probably benign	0.03
R4709:Vmn2r96	UTSW	17	18582826	missense	probably benign	0.36
R4776:Vmn2r96	UTSW	17	18597508	missense	probably damaging	1.00
R4882:Vmn2r96	UTSW	17	18597604	missense	probably damaging	1.00
R4920:Vmn2r96	UTSW	17	18582656	missense	probably benign	0.07
R5143:Vmn2r96	UTSW	17	18583858	missense	possibly damaging	0.65
R5301:Vmn2r96	UTSW	17	18597688	missense	probably damaging	0.98
R5507:Vmn2r96	UTSW	17	18597829	missense	probably damaging	1.00
R6151:Vmn2r96	UTSW	17	18583959	missense	probably benign	0.01
R6181:Vmn2r96	UTSW	17	18583864	missense	probably benign
R6339:Vmn2r96	UTSW	17	18583862	missense	possibly damaging	0.84
R6404:Vmn2r96	UTSW	17	18597531	missense	probably damaging	1.00
R6452:Vmn2r96	UTSW	17	18583855	missense	probably benign	0.07
R6749:Vmn2r96	UTSW	17	18598090	missense	probably damaging	0.99
R6813:Vmn2r96	UTSW	17	18581854	missense	probably benign	0.04
R6851:Vmn2r96	UTSW	17	18582538	missense	possibly damaging	0.95
R6944:Vmn2r96	UTSW	17	18597629	missense	probably benign	0.16
R6949:Vmn2r96	UTSW	17	18597838	missense	probably damaging	1.00
R6962:Vmn2r96	UTSW	17	18598021	missense	probably damaging	0.99
R6990:Vmn2r96	UTSW	17	18583820	missense	probably benign
R7149:Vmn2r96	UTSW	17	18597727	missense	possibly damaging	0.89
R7346:Vmn2r96	UTSW	17	18582767	missense	probably benign	0.15
R7385:Vmn2r96	UTSW	17	18583040	missense	probably damaging	1.00
R7442:Vmn2r96	UTSW	17	18573400	missense	probably benign	0.02
R7509:Vmn2r96	UTSW	17	18582733	missense	probably benign	0.02
R7652:Vmn2r96	UTSW	17	18573570	missense	probably benign
R7659:Vmn2r96	UTSW	17	18573487	missense	probably benign	0.00
R7753:Vmn2r96	UTSW	17	18586401	missense	possibly damaging	0.46
R7855:Vmn2r96	UTSW	17	18597868	missense	possibly damaging	0.59
R8166:Vmn2r96	UTSW	17	18582482	missense	probably damaging	1.00
R8260:Vmn2r96	UTSW	17	18583981	missense	probably benign	0.04
R8323:Vmn2r96	UTSW	17	18582761	missense	probably damaging	0.99
R8787:Vmn2r96	UTSW	17	18597988	missense	probably damaging	1.00
R8837:Vmn2r96	UTSW	17	18582626	missense	probably benign
R8933:Vmn2r96	UTSW	17	18583979	missense	probably benign	0.11
R9306:Vmn2r96	UTSW	17	18582964	missense	probably benign	0.00
R9481:Vmn2r96	UTSW	17	18573359	start gained	probably benign
R9626:Vmn2r96	UTSW	17	18573496	missense	probably benign	0.14
R9629:Vmn2r96	UTSW	17	18582995	missense	probably benign	0.15
Z1088:Vmn2r96	UTSW	17	18597366	missense	possibly damaging	0.86
Z1177:Vmn2r96	UTSW	17	18598114	missense	probably benign	0.02

Posted On

2013-10-07