Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01314:Mug2'

73774

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mug2

Ensembl Gene

ENSMUSG00000030131

Gene Name

murinoglobulin 2

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL01314

Quality Score

Status

Chromosome

Chromosomal Location

122006761-122085965 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 122081279 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 1267 (F1267L)

Ref Sequence

ENSEMBL: ENSMUSP00000080469 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081777]

AlphaFold

P28666

Predicted Effect

possibly damaging
Transcript: ENSMUST00000081777
AA Change: F1267L

PolyPhen 2 Score 0.621 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000080469
Gene: ENSMUSG00000030131
AA Change: F1267L

Domain	Start	End	E-Value	Type
Pfam:A2M_N	128	221	3.5e-21	PFAM
A2M_N_2	449	599	1.05e-42	SMART
low complexity region	711	728	N/A	INTRINSIC
A2M	740	830	7.16e-36	SMART
Pfam:Thiol-ester_cl	963	992	1e-18	PFAM
low complexity region	994	1005	N/A	INTRINSIC
Pfam:A2M_comp	1012	1097	5.8e-34	PFAM
Pfam:A2M_comp	1093	1243	3e-47	PFAM
A2M_recep	1353	1440	1.85e-38	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430F08Rik	A	C	10: 100,573,611	D313E	probably damaging	Het
Adamts12	C	T	15: 11,071,853	A161V	probably benign	Het
Bptf	A	T	11: 107,054,853	V2520E	probably damaging	Het
C87436	T	C	6: 86,457,855	F395S	probably damaging	Het
Capn1	T	C	19: 5,989,984		probably benign	Het
Ceacam5	T	A	7: 17,747,256	Y309*	probably null	Het
Clasp2	A	G	9: 113,906,127	D1011G	possibly damaging	Het
Csmd3	A	G	15: 47,849,755	Y1608H	probably damaging	Het
Dcaf1	T	C	9: 106,834,191	I77T	probably benign	Het
Dcdc2a	T	C	13: 25,102,604	L170P	probably damaging	Het
Ddx28	A	G	8: 106,010,580	F282S	probably damaging	Het
Egf	A	G	3: 129,686,260	I497T	probably benign	Het
Emsy	A	G	7: 98,593,455	V1159A	probably benign	Het
Fam46c	T	C	3: 100,473,174	K89E	probably benign	Het
Hk3	C	A	13: 55,007,063		probably benign	Het
Htt	A	G	5: 34,878,856	D2049G	probably benign	Het
Inpp5d	C	A	1: 87,683,750	S45*	probably null	Het
Irf8	A	G	8: 120,753,380	Y119C	probably damaging	Het
Klk1b4	T	C	7: 44,211,176		probably null	Het
Macf1	A	G	4: 123,486,720	S1273P	probably damaging	Het
Man2c1	A	T	9: 57,141,819	H867L	probably benign	Het
Mgat4e	T	C	1: 134,541,449	T286A	probably damaging	Het
Necab1	T	A	4: 15,005,079	E128D	probably damaging	Het
Olfr1331	G	A	4: 118,869,131	V117I	probably benign	Het
Pds5a	A	G	5: 65,615,294	V1322A	probably benign	Het
Poc1b	C	T	10: 99,129,641	T144I	probably damaging	Het
Prcc	T	A	3: 87,870,080	N196Y	probably damaging	Het
Psma5	G	A	3: 108,279,795	V237M	possibly damaging	Het
Rap1gds1	A	G	3: 139,050,561	L11P	probably damaging	Het
Rapgef3	A	G	15: 97,748,223	F132S	probably damaging	Het
Rgs13	T	G	1: 144,171,441	D14A	probably benign	Het
Stxbp4	A	G	11: 90,621,649		probably benign	Het
Tcerg1	C	A	18: 42,573,309	A1017D	probably damaging	Het
Tmem79	T	C	3: 88,332,576	I276V	possibly damaging	Het
Tmem94	C	A	11: 115,790,009	H113N	probably damaging	Het
Vil1	G	A	1: 74,428,238	D715N	probably damaging	Het
Vmn2r96	A	G	17: 18,582,964	T187A	probably benign	Het
Zfhx4	T	A	3: 5,413,094	S3590T	probably damaging	Het

Other mutations in Mug2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00708:Mug2	APN	6	122047487	missense	possibly damaging	0.83
IGL00957:Mug2	APN	6	122040654	missense	probably damaging	0.99
IGL01338:Mug2	APN	6	122049628	splice site	probably benign
IGL01477:Mug2	APN	6	122081684	splice site	probably benign
IGL01926:Mug2	APN	6	122036104	splice site	probably benign
IGL02019:Mug2	APN	6	122047435	missense	probably benign	0.02
IGL02305:Mug2	APN	6	122036056	missense	probably benign
IGL02310:Mug2	APN	6	122059123	splice site	probably benign
IGL02484:Mug2	APN	6	122072753	missense	probably damaging	1.00
IGL02516:Mug2	APN	6	122070843	missense	probably damaging	1.00
IGL02531:Mug2	APN	6	122072771	missense	probably damaging	1.00
IGL02666:Mug2	APN	6	122081326	missense	probably damaging	1.00
IGL02936:Mug2	APN	6	122081387	critical splice donor site	probably null
R0114:Mug2	UTSW	6	122040648	missense	probably damaging	1.00
R0119:Mug2	UTSW	6	122036063	missense	probably benign	0.00
R0123:Mug2	UTSW	6	122074714	missense	possibly damaging	0.89
R0144:Mug2	UTSW	6	122071011	splice site	probably benign
R0225:Mug2	UTSW	6	122074714	missense	possibly damaging	0.89
R0514:Mug2	UTSW	6	122081599	missense	probably damaging	1.00
R0763:Mug2	UTSW	6	122075294	missense	probably benign
R0959:Mug2	UTSW	6	122085495	missense	probably benign	0.33
R1104:Mug2	UTSW	6	122059055	missense	probably benign
R1239:Mug2	UTSW	6	122081678	splice site	probably benign
R1318:Mug2	UTSW	6	122077402	missense	probably damaging	1.00
R1460:Mug2	UTSW	6	122040533	splice site	probably benign
R1706:Mug2	UTSW	6	122036232	splice site	probably benign
R1761:Mug2	UTSW	6	122074705	missense	probably benign	0.20
R1901:Mug2	UTSW	6	122071842	missense	probably benign	0.02
R1913:Mug2	UTSW	6	122070870	missense	probably damaging	1.00
R1943:Mug2	UTSW	6	122079639	missense	probably benign
R2054:Mug2	UTSW	6	122077492	missense	probably damaging	1.00
R2060:Mug2	UTSW	6	122079612	missense	probably benign
R2420:Mug2	UTSW	6	122083460	missense	probably damaging	1.00
R2432:Mug2	UTSW	6	122084376	missense	possibly damaging	0.93
R2916:Mug2	UTSW	6	122074724	splice site	probably null
R2918:Mug2	UTSW	6	122074724	splice site	probably null
R3423:Mug2	UTSW	6	122047506	splice site	probably benign
R3834:Mug2	UTSW	6	122049787	critical splice donor site	probably null
R3902:Mug2	UTSW	6	122075567	missense	probably damaging	1.00
R3941:Mug2	UTSW	6	122063563	missense	probably benign
R4227:Mug2	UTSW	6	122040732	missense	probably benign	0.10
R4284:Mug2	UTSW	6	122063673	missense	probably benign	0.00
R4287:Mug2	UTSW	6	122063673	missense	probably benign	0.00
R4377:Mug2	UTSW	6	122071007	critical splice donor site	probably null
R4419:Mug2	UTSW	6	122079630	missense	probably damaging	1.00
R4498:Mug2	UTSW	6	122082752	missense	probably damaging	0.99
R4566:Mug2	UTSW	6	122079638	missense	probably benign	0.00
R4690:Mug2	UTSW	6	122036296	missense	probably benign
R4732:Mug2	UTSW	6	122071872	missense	probably damaging	0.99
R4733:Mug2	UTSW	6	122071872	missense	probably damaging	0.99
R4741:Mug2	UTSW	6	122079613	missense	probably benign
R4888:Mug2	UTSW	6	122081195	missense	probably damaging	1.00
R5199:Mug2	UTSW	6	122040660	missense	probably benign
R5347:Mug2	UTSW	6	122081592	missense	probably damaging	1.00
R5457:Mug2	UTSW	6	122049729	nonsense	probably null
R5495:Mug2	UTSW	6	122079650	missense	probably damaging	0.96
R5509:Mug2	UTSW	6	122084381	missense	possibly damaging	0.84
R6006:Mug2	UTSW	6	122083500	missense	probably null	0.98
R6180:Mug2	UTSW	6	122079606	missense	probably benign	0.01
R6184:Mug2	UTSW	6	122037046	missense	probably benign
R6199:Mug2	UTSW	6	122047439	missense	probably benign	0.05
R6262:Mug2	UTSW	6	122075255	missense	probably damaging	1.00
R6416:Mug2	UTSW	6	122082754	missense	probably damaging	1.00
R6548:Mug2	UTSW	6	122047442	missense	probably damaging	1.00
R6703:Mug2	UTSW	6	122078694	missense	probably benign	0.25
R7106:Mug2	UTSW	6	122082721	missense	probably damaging	1.00
R7131:Mug2	UTSW	6	122075247	missense	probably damaging	1.00
R7372:Mug2	UTSW	6	122083466	missense	possibly damaging	0.88
R7379:Mug2	UTSW	6	122047487	missense	possibly damaging	0.83
R7419:Mug2	UTSW	6	122040570	missense	possibly damaging	0.86
R7423:Mug2	UTSW	6	122079726	missense	probably benign	0.00
R7581:Mug2	UTSW	6	122063711	missense	probably damaging	1.00
R7582:Mug2	UTSW	6	122079644	missense	probably damaging	0.99
R7672:Mug2	UTSW	6	122040719	missense	probably benign	0.37
R7713:Mug2	UTSW	6	122078795	missense	possibly damaging	0.83
R7759:Mug2	UTSW	6	122081358	missense	probably damaging	1.00
R7834:Mug2	UTSW	6	122036282	missense	probably benign
R7850:Mug2	UTSW	6	122075211	missense	probably damaging	1.00
R8029:Mug2	UTSW	6	122081545	critical splice acceptor site	probably null
R8127:Mug2	UTSW	6	122075608	missense	probably benign	0.01
R8335:Mug2	UTSW	6	122040584	missense	probably benign
R8348:Mug2	UTSW	6	122072233	nonsense	probably null
R8557:Mug2	UTSW	6	122063701	missense	probably damaging	0.99
R8798:Mug2	UTSW	6	122081610	missense	probably damaging	1.00
R8823:Mug2	UTSW	6	122063689	missense	possibly damaging	0.89
R9029:Mug2	UTSW	6	122084369	missense	probably damaging	1.00
R9153:Mug2	UTSW	6	122040668	missense	possibly damaging	0.71
R9185:Mug2	UTSW	6	122077483	missense	probably benign	0.06
R9186:Mug2	UTSW	6	122075289	missense	probably damaging	0.99
R9418:Mug2	UTSW	6	122040741	missense	probably benign	0.00
R9464:Mug2	UTSW	6	122051731	missense	probably benign	0.01
R9622:Mug2	UTSW	6	122051792	missense	probably benign	0.29
Z1177:Mug2	UTSW	6	122037121	missense	probably damaging	1.00

Posted On

2013-10-07