Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01314:Mug2'

73774

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mug2

Ensembl Gene

ENSMUSG00000030131

Gene Name

murinoglobulin 2

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01314

Quality Score

Status

Chromosome

Chromosomal Location

122006761-122085965 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 122081279 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 1267 (F1267L)

Ref Sequence

ENSEMBL: ENSMUSP00000080469 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081777]

AlphaFold

P28666

Predicted Effect

possibly damaging
Transcript: ENSMUST00000081777
AA Change: F1267L

PolyPhen 2 Score 0.621 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000080469
Gene: ENSMUSG00000030131
AA Change: F1267L

Domain	Start	End	E-Value	Type
Pfam:A2M_N	128	221	3.5e-21	PFAM
A2M_N_2	449	599	1.05e-42	SMART
low complexity region	711	728	N/A	INTRINSIC
A2M	740	830	7.16e-36	SMART
Pfam:Thiol-ester_cl	963	992	1e-18	PFAM
low complexity region	994	1005	N/A	INTRINSIC
Pfam:A2M_comp	1012	1097	5.8e-34	PFAM
Pfam:A2M_comp	1093	1243	3e-47	PFAM
A2M_recep	1353	1440	1.85e-38	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts12	C	T	15: 11,071,853 (GRCm38)	A161V	probably benign	Het
Bptf	A	T	11: 107,054,853 (GRCm38)	V2520E	probably damaging	Het
C87436	T	C	6: 86,457,855 (GRCm38)	F395S	probably damaging	Het
Capn1	T	C	19: 5,989,984 (GRCm38)		probably benign	Het
Ceacam5	T	A	7: 17,747,256 (GRCm38)	Y309*	probably null	Het
Clasp2	A	G	9: 113,906,127 (GRCm38)	D1011G	possibly damaging	Het
Csmd3	A	G	15: 47,849,755 (GRCm38)	Y1608H	probably damaging	Het
Dcaf1	T	C	9: 106,834,191 (GRCm38)	I77T	probably benign	Het
Dcdc2a	T	C	13: 25,102,604 (GRCm38)	L170P	probably damaging	Het
Ddx28	A	G	8: 106,010,580 (GRCm38)	F282S	probably damaging	Het
Egf	A	G	3: 129,686,260 (GRCm38)	I497T	probably benign	Het
Emsy	A	G	7: 98,593,455 (GRCm38)	V1159A	probably benign	Het
Hk3	C	A	13: 55,007,063 (GRCm38)		probably benign	Het
Htt	A	G	5: 34,878,856 (GRCm38)	D2049G	probably benign	Het
Inpp5d	C	A	1: 87,683,750 (GRCm38)	S45*	probably null	Het
Irf8	A	G	8: 120,753,380 (GRCm38)	Y119C	probably damaging	Het
Klk1b4	T	C	7: 44,211,176 (GRCm38)		probably null	Het
Macf1	A	G	4: 123,486,720 (GRCm38)	S1273P	probably damaging	Het
Man2c1	A	T	9: 57,141,819 (GRCm38)	H867L	probably benign	Het
Mgat4e	T	C	1: 134,541,449 (GRCm38)	T286A	probably damaging	Het
Necab1	T	A	4: 15,005,079 (GRCm38)	E128D	probably damaging	Het
Or10ak9	G	A	4: 118,869,131 (GRCm38)	V117I	probably benign	Het
Pds5a	A	G	5: 65,615,294 (GRCm38)	V1322A	probably benign	Het
Poc1b	C	T	10: 99,129,641 (GRCm38)	T144I	probably damaging	Het
Prcc	T	A	3: 87,870,080 (GRCm38)	N196Y	probably damaging	Het
Psma5	G	A	3: 108,279,795 (GRCm38)	V237M	possibly damaging	Het
Rap1gds1	A	G	3: 139,050,561 (GRCm38)	L11P	probably damaging	Het
Rapgef3	A	G	15: 97,748,223 (GRCm38)	F132S	probably damaging	Het
Rgs13	T	G	1: 144,171,441 (GRCm38)	D14A	probably benign	Het
Rlig1	A	C	10: 100,573,611 (GRCm38)	D313E	probably damaging	Het
Stxbp4	A	G	11: 90,621,649 (GRCm38)		probably benign	Het
Tcerg1	C	A	18: 42,573,309 (GRCm38)	A1017D	probably damaging	Het
Tent5c	T	C	3: 100,473,174 (GRCm38)	K89E	probably benign	Het
Tmem79	T	C	3: 88,332,576 (GRCm38)	I276V	possibly damaging	Het
Tmem94	C	A	11: 115,790,009 (GRCm38)	H113N	probably damaging	Het
Vil1	G	A	1: 74,428,238 (GRCm38)	D715N	probably damaging	Het
Vmn2r96	A	G	17: 18,582,964 (GRCm38)	T187A	probably benign	Het
Zfhx4	T	A	3: 5,413,094 (GRCm38)	S3590T	probably damaging	Het

Other mutations in Mug2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00708:Mug2	APN	6	122,047,487 (GRCm38)	missense	possibly damaging	0.83
IGL00957:Mug2	APN	6	122,040,654 (GRCm38)	missense	probably damaging	0.99
IGL01338:Mug2	APN	6	122,049,628 (GRCm38)	splice site	probably benign
IGL01477:Mug2	APN	6	122,081,684 (GRCm38)	splice site	probably benign
IGL01926:Mug2	APN	6	122,036,104 (GRCm38)	splice site	probably benign
IGL02019:Mug2	APN	6	122,047,435 (GRCm38)	missense	probably benign	0.02
IGL02305:Mug2	APN	6	122,036,056 (GRCm38)	missense	probably benign
IGL02310:Mug2	APN	6	122,059,123 (GRCm38)	splice site	probably benign
IGL02484:Mug2	APN	6	122,072,753 (GRCm38)	missense	probably damaging	1.00
IGL02516:Mug2	APN	6	122,070,843 (GRCm38)	missense	probably damaging	1.00
IGL02531:Mug2	APN	6	122,072,771 (GRCm38)	missense	probably damaging	1.00
IGL02666:Mug2	APN	6	122,081,326 (GRCm38)	missense	probably damaging	1.00
IGL02936:Mug2	APN	6	122,081,387 (GRCm38)	critical splice donor site	probably null
R0114:Mug2	UTSW	6	122,040,648 (GRCm38)	missense	probably damaging	1.00
R0119:Mug2	UTSW	6	122,036,063 (GRCm38)	missense	probably benign	0.00
R0123:Mug2	UTSW	6	122,074,714 (GRCm38)	missense	possibly damaging	0.89
R0144:Mug2	UTSW	6	122,071,011 (GRCm38)	splice site	probably benign
R0225:Mug2	UTSW	6	122,074,714 (GRCm38)	missense	possibly damaging	0.89
R0514:Mug2	UTSW	6	122,081,599 (GRCm38)	missense	probably damaging	1.00
R0763:Mug2	UTSW	6	122,075,294 (GRCm38)	missense	probably benign
R0959:Mug2	UTSW	6	122,085,495 (GRCm38)	missense	probably benign	0.33
R1104:Mug2	UTSW	6	122,059,055 (GRCm38)	missense	probably benign
R1239:Mug2	UTSW	6	122,081,678 (GRCm38)	splice site	probably benign
R1318:Mug2	UTSW	6	122,077,402 (GRCm38)	missense	probably damaging	1.00
R1460:Mug2	UTSW	6	122,040,533 (GRCm38)	splice site	probably benign
R1706:Mug2	UTSW	6	122,036,232 (GRCm38)	splice site	probably benign
R1761:Mug2	UTSW	6	122,074,705 (GRCm38)	missense	probably benign	0.20
R1901:Mug2	UTSW	6	122,071,842 (GRCm38)	missense	probably benign	0.02
R1913:Mug2	UTSW	6	122,070,870 (GRCm38)	missense	probably damaging	1.00
R1943:Mug2	UTSW	6	122,079,639 (GRCm38)	missense	probably benign
R2054:Mug2	UTSW	6	122,077,492 (GRCm38)	missense	probably damaging	1.00
R2060:Mug2	UTSW	6	122,079,612 (GRCm38)	missense	probably benign
R2420:Mug2	UTSW	6	122,083,460 (GRCm38)	missense	probably damaging	1.00
R2432:Mug2	UTSW	6	122,084,376 (GRCm38)	missense	possibly damaging	0.93
R2916:Mug2	UTSW	6	122,074,724 (GRCm38)	splice site	probably null
R2918:Mug2	UTSW	6	122,074,724 (GRCm38)	splice site	probably null
R3423:Mug2	UTSW	6	122,047,506 (GRCm38)	splice site	probably benign
R3834:Mug2	UTSW	6	122,049,787 (GRCm38)	critical splice donor site	probably null
R3902:Mug2	UTSW	6	122,075,567 (GRCm38)	missense	probably damaging	1.00
R3941:Mug2	UTSW	6	122,063,563 (GRCm38)	missense	probably benign
R4227:Mug2	UTSW	6	122,040,732 (GRCm38)	missense	probably benign	0.10
R4284:Mug2	UTSW	6	122,063,673 (GRCm38)	missense	probably benign	0.00
R4287:Mug2	UTSW	6	122,063,673 (GRCm38)	missense	probably benign	0.00
R4377:Mug2	UTSW	6	122,071,007 (GRCm38)	critical splice donor site	probably null
R4419:Mug2	UTSW	6	122,079,630 (GRCm38)	missense	probably damaging	1.00
R4498:Mug2	UTSW	6	122,082,752 (GRCm38)	missense	probably damaging	0.99
R4566:Mug2	UTSW	6	122,079,638 (GRCm38)	missense	probably benign	0.00
R4690:Mug2	UTSW	6	122,036,296 (GRCm38)	missense	probably benign
R4732:Mug2	UTSW	6	122,071,872 (GRCm38)	missense	probably damaging	0.99
R4733:Mug2	UTSW	6	122,071,872 (GRCm38)	missense	probably damaging	0.99
R4741:Mug2	UTSW	6	122,079,613 (GRCm38)	missense	probably benign
R4888:Mug2	UTSW	6	122,081,195 (GRCm38)	missense	probably damaging	1.00
R5199:Mug2	UTSW	6	122,040,660 (GRCm38)	missense	probably benign
R5347:Mug2	UTSW	6	122,081,592 (GRCm38)	missense	probably damaging	1.00
R5457:Mug2	UTSW	6	122,049,729 (GRCm38)	nonsense	probably null
R5495:Mug2	UTSW	6	122,079,650 (GRCm38)	missense	probably damaging	0.96
R5509:Mug2	UTSW	6	122,084,381 (GRCm38)	missense	possibly damaging	0.84
R6006:Mug2	UTSW	6	122,083,500 (GRCm38)	missense	probably null	0.98
R6180:Mug2	UTSW	6	122,079,606 (GRCm38)	missense	probably benign	0.01
R6184:Mug2	UTSW	6	122,037,046 (GRCm38)	missense	probably benign
R6199:Mug2	UTSW	6	122,047,439 (GRCm38)	missense	probably benign	0.05
R6262:Mug2	UTSW	6	122,075,255 (GRCm38)	missense	probably damaging	1.00
R6416:Mug2	UTSW	6	122,082,754 (GRCm38)	missense	probably damaging	1.00
R6548:Mug2	UTSW	6	122,047,442 (GRCm38)	missense	probably damaging	1.00
R6703:Mug2	UTSW	6	122,078,694 (GRCm38)	missense	probably benign	0.25
R7106:Mug2	UTSW	6	122,082,721 (GRCm38)	missense	probably damaging	1.00
R7131:Mug2	UTSW	6	122,075,247 (GRCm38)	missense	probably damaging	1.00
R7372:Mug2	UTSW	6	122,083,466 (GRCm38)	missense	possibly damaging	0.88
R7379:Mug2	UTSW	6	122,047,487 (GRCm38)	missense	possibly damaging	0.83
R7419:Mug2	UTSW	6	122,040,570 (GRCm38)	missense	possibly damaging	0.86
R7423:Mug2	UTSW	6	122,079,726 (GRCm38)	missense	probably benign	0.00
R7581:Mug2	UTSW	6	122,063,711 (GRCm38)	missense	probably damaging	1.00
R7582:Mug2	UTSW	6	122,079,644 (GRCm38)	missense	probably damaging	0.99
R7672:Mug2	UTSW	6	122,040,719 (GRCm38)	missense	probably benign	0.37
R7713:Mug2	UTSW	6	122,078,795 (GRCm38)	missense	possibly damaging	0.83
R7759:Mug2	UTSW	6	122,081,358 (GRCm38)	missense	probably damaging	1.00
R7834:Mug2	UTSW	6	122,036,282 (GRCm38)	missense	probably benign
R7850:Mug2	UTSW	6	122,075,211 (GRCm38)	missense	probably damaging	1.00
R8029:Mug2	UTSW	6	122,081,545 (GRCm38)	critical splice acceptor site	probably null
R8127:Mug2	UTSW	6	122,075,608 (GRCm38)	missense	probably benign	0.01
R8335:Mug2	UTSW	6	122,040,584 (GRCm38)	missense	probably benign
R8348:Mug2	UTSW	6	122,072,233 (GRCm38)	nonsense	probably null
R8557:Mug2	UTSW	6	122,063,701 (GRCm38)	missense	probably damaging	0.99
R8798:Mug2	UTSW	6	122,081,610 (GRCm38)	missense	probably damaging	1.00
R8823:Mug2	UTSW	6	122,063,689 (GRCm38)	missense	possibly damaging	0.89
R9029:Mug2	UTSW	6	122,084,369 (GRCm38)	missense	probably damaging	1.00
R9153:Mug2	UTSW	6	122,040,668 (GRCm38)	missense	possibly damaging	0.71
R9185:Mug2	UTSW	6	122,077,483 (GRCm38)	missense	probably benign	0.06
R9186:Mug2	UTSW	6	122,075,289 (GRCm38)	missense	probably damaging	0.99
R9418:Mug2	UTSW	6	122,040,741 (GRCm38)	missense	probably benign	0.00
R9464:Mug2	UTSW	6	122,051,731 (GRCm38)	missense	probably benign	0.01
R9622:Mug2	UTSW	6	122,051,792 (GRCm38)	missense	probably benign	0.29
Z1177:Mug2	UTSW	6	122,037,121 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-10-07