Incidental Mutation 'IGL01318:Olfr77'
ID73941
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr77
Ensembl Gene ENSMUSG00000051118
Gene Nameolfactory receptor 77
SynonymsMOR143-1, 18A, GA_x6K02T2PVTD-13660026-13660964
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL01318
Quality Score
Status
Chromosome9
Chromosomal Location19916865-19929124 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 19920758 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 183 (E183G)
Ref Sequence ENSEMBL: ENSMUSP00000149055 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057596] [ENSMUST00000217347]
Predicted Effect probably benign
Transcript: ENSMUST00000057596
AA Change: E183G

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: E183G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-53 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217347
AA Change: E183G

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930550L24Rik T A X: 58,919,469 I196N probably damaging Het
Alg10b T C 15: 90,228,389 probably benign Het
Ambn T C 5: 88,460,695 probably benign Het
Asap2 A G 12: 21,247,295 D585G probably null Het
Chaf1a G T 17: 56,059,336 probably benign Het
Ddhd1 A G 14: 45,616,551 S443P probably damaging Het
Dlk2 A G 17: 46,302,464 E215G probably damaging Het
Efhd2 T C 4: 141,859,865 N202S probably benign Het
Fam208b A C 13: 3,575,067 S946A possibly damaging Het
Gkap1 A T 13: 58,237,039 I308K probably damaging Het
Gm14025 C A 2: 129,038,702 V435L probably benign Het
Gm9848 T A 13: 113,108,240 noncoding transcript Het
Hmcn1 G A 1: 150,719,240 T1826I probably damaging Het
Htr5a T C 5: 27,842,744 V99A probably benign Het
Inha T G 1: 75,509,928 F289C probably damaging Het
Kcna3 T C 3: 107,037,978 V519A probably benign Het
Kcnma1 A T 14: 23,314,322 probably benign Het
Kctd1 A G 18: 15,062,690 V292A possibly damaging Het
Map2k4 A G 11: 65,756,263 probably benign Het
Mfap2 G T 4: 141,015,545 A175S possibly damaging Het
Milr1 G A 11: 106,765,245 A114T possibly damaging Het
Mogs G T 6: 83,118,577 V792F probably damaging Het
Nt5dc3 T A 10: 86,825,225 M418K possibly damaging Het
Olfr1098 A T 2: 86,922,949 N194K probably benign Het
Olfr1448 A G 19: 12,920,126 L61P probably damaging Het
Osbpl10 G A 9: 115,232,122 W756* probably null Het
Pgam5 A G 5: 110,265,525 Y235H probably damaging Het
Pgm5 G T 19: 24,816,478 A274E probably damaging Het
Prex1 C A 2: 166,569,340 probably benign Het
Prps1l1 A T 12: 34,985,378 N164I probably benign Het
Ralbp1 C A 17: 65,864,282 R232L probably damaging Het
Rnaseh2a C T 8: 84,965,123 probably benign Het
Stard9 A T 2: 120,698,719 H1819L possibly damaging Het
Stom T A 2: 35,336,877 I15F probably benign Het
Tph1 T G 7: 46,665,238 T22P probably damaging Het
Uqcrfs1 A G 13: 30,540,921 I212T probably benign Het
Ush2a T C 1: 188,814,353 I3442T probably benign Het
Vmn2r113 A G 17: 22,958,335 I698V probably benign Het
Vmn2r75 T C 7: 86,165,566 I240V probably benign Het
Wdr17 T C 8: 54,672,550 T432A probably damaging Het
Other mutations in Olfr77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Olfr77 APN 9 19920949 missense possibly damaging 0.87
IGL01547:Olfr77 APN 9 19920901 missense probably benign 0.00
IGL01635:Olfr77 APN 9 19920484 missense probably damaging 1.00
IGL02112:Olfr77 APN 9 19920525 missense possibly damaging 0.48
IGL02858:Olfr77 APN 9 19920451 missense probably damaging 0.99
IGL02904:Olfr77 APN 9 19921097 missense probably damaging 1.00
IGL02956:Olfr77 APN 9 19921052 missense possibly damaging 0.87
IGL03066:Olfr77 APN 9 19920371 missense probably benign 0.12
R0662:Olfr77 UTSW 9 19920500 missense probably damaging 1.00
R1222:Olfr77 UTSW 9 19921048 missense possibly damaging 0.87
R1572:Olfr77 UTSW 9 19920912 missense probably benign 0.35
R1761:Olfr77 UTSW 9 19921149 makesense probably null
R2409:Olfr77 UTSW 9 19920776 missense probably benign 0.31
R2409:Olfr77 UTSW 9 19920781 missense probably damaging 1.00
R3621:Olfr77 UTSW 9 19920913 missense probably damaging 0.99
R3849:Olfr77 UTSW 9 19920809 missense probably damaging 1.00
R3850:Olfr77 UTSW 9 19920809 missense probably damaging 1.00
R4277:Olfr77 UTSW 9 19920389 missense possibly damaging 0.91
R4768:Olfr77 UTSW 9 19920545 missense possibly damaging 0.56
R4979:Olfr77 UTSW 9 19920359 missense probably benign 0.03
R5276:Olfr77 UTSW 9 19920621 missense possibly damaging 0.87
R5503:Olfr77 UTSW 9 19920379 missense probably benign 0.36
R5760:Olfr77 UTSW 9 19920754 missense probably benign 0.00
R5778:Olfr77 UTSW 9 19921041 missense probably benign 0.20
R5930:Olfr77 UTSW 9 19920910 missense probably damaging 0.99
R6012:Olfr77 UTSW 9 19920941 missense probably damaging 0.99
R7269:Olfr77 UTSW 9 19920335 missense possibly damaging 0.95
Z1088:Olfr77 UTSW 9 19920712 missense probably damaging 1.00
Posted On2013-10-07