Incidental Mutation 'IGL01319:Klrb1-ps1'
ID73969
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klrb1-ps1
Ensembl Gene ENSMUSG00000079295
Gene Namekiller cell lectin-like receptor subfamily B member 1, pseudogene 1
SynonymsNkrp1e
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01319
Quality Score
Status
Chromosome6
Chromosomal Location129116518-129129446 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 129116585 bp
ZygosityHeterozygous
Amino Acid Change Proline to Leucine at position 23 (P23L)
Gene Model predicted gene model for transcript(s):
Predicted Effect possibly damaging
Transcript: ENSMUST00000071391
AA Change: P23L

PolyPhen 2 Score 0.913 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071342
Gene: ENSMUSG00000079295
AA Change: P23L

DomainStartEndE-ValueType
transmembrane domain 43 65 N/A INTRINSIC
CLECT 94 170 1.28e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184388
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203057
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd18 T A 3: 40,933,642 V307E probably benign Het
Bub1b T C 2: 118,614,994 I265T possibly damaging Het
Cntnap3 G A 13: 64,787,837 T404I probably damaging Het
Disc1 T C 8: 125,087,891 S165P probably damaging Het
Dock1 T C 7: 134,789,278 F756L probably benign Het
Dock2 A G 11: 34,698,790 V480A possibly damaging Het
Drc3 A G 11: 60,364,962 D125G probably null Het
Emid1 C T 11: 5,143,859 C96Y probably damaging Het
F13b A G 1: 139,506,793 N99S probably damaging Het
Fam20a A G 11: 109,678,458 probably benign Het
Fancd2 C A 6: 113,584,899 T1243K probably damaging Het
Fbxw14 T C 9: 109,278,791 K172E probably damaging Het
Gm13941 T C 2: 111,094,805 probably null Het
Gtpbp4 A T 13: 8,985,260 N354K probably benign Het
Igkv2-116 T C 6: 68,152,404 L50P probably benign Het
Kng2 T A 16: 23,028,834 I26F probably damaging Het
Krt81 G A 15: 101,463,388 H104Y probably benign Het
Lrpprc T C 17: 84,705,412 probably benign Het
Man2a2 C T 7: 80,361,132 V704M possibly damaging Het
Mbip A G 12: 56,330,242 V303A probably benign Het
Mipep A T 14: 60,843,271 M571L probably benign Het
Ncan A T 8: 70,097,562 V1188D probably damaging Het
Pcdhb4 T C 18: 37,308,513 V292A probably benign Het
Pkd1 T C 17: 24,587,919 probably benign Het
Ppp2r2c T A 5: 36,947,121 S282T possibly damaging Het
Rad54l2 C T 9: 106,719,046 G231D probably benign Het
Rnf20 T G 4: 49,649,326 D443E probably damaging Het
Rptor A G 11: 119,891,170 M1108V probably benign Het
Serpine2 A G 1: 79,810,694 V182A probably damaging Het
Sesn2 C T 4: 132,499,967 probably benign Het
Shank1 C A 7: 44,353,123 A1422E possibly damaging Het
Slc13a4 C T 6: 35,307,353 probably null Het
Snrnp200 T C 2: 127,230,127 probably benign Het
Src G A 2: 157,469,503 G461R probably damaging Het
Tbxas1 A G 6: 39,017,973 I178V probably benign Het
Tmem2 C T 19: 21,844,757 P1172L possibly damaging Het
Triml1 A G 8: 43,141,397 probably benign Het
Tsen2 A T 6: 115,576,984 Q441L probably damaging Het
Ttc23l A G 15: 10,509,406 probably benign Het
Ttc37 A G 13: 76,129,379 H491R probably benign Het
Ttn T C 2: 76,881,304 probably benign Het
Vsig10l C T 7: 43,465,254 S293L probably damaging Het
Zcchc13 C A X: 103,631,000 Q110K possibly damaging Het
Other mutations in Klrb1-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02067:Klrb1-ps1 APN 6 129129388 missense probably damaging 1.00
IGL02218:Klrb1-ps1 APN 6 129129306 splice site noncoding transcript
IGL02316:Klrb1-ps1 APN 6 129116569 exon noncoding transcript
R0035:Klrb1-ps1 UTSW 6 129129343 missense possibly damaging 0.80
R2972:Klrb1-ps1 UTSW 6 129119756 splice site noncoding transcript
R2993:Klrb1-ps1 UTSW 6 129121029 missense probably benign 0.19
R5076:Klrb1-ps1 UTSW 6 129119788 exon noncoding transcript
Posted On2013-10-07