Incidental Mutation 'IGL01321:Lrrc59'
ID74036
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc59
Ensembl Gene ENSMUSG00000020869
Gene Nameleucine rich repeat containing 59
SynonymsC78668
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.249) question?
Stock #IGL01321
Quality Score
Status
Chromosome11
Chromosomal Location94629767-94645216 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 94638600 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 167 (R167*)
Ref Sequence ENSEMBL: ENSMUSP00000021239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021239]
Predicted Effect probably null
Transcript: ENSMUST00000021239
AA Change: R167*
SMART Domains Protein: ENSMUSP00000021239
Gene: ENSMUSG00000020869
AA Change: R167*

DomainStartEndE-ValueType
LRR 38 60 6.22e0 SMART
LRR 61 83 1.33e-1 SMART
LRR 84 106 3.75e0 SMART
LRR 107 131 1.09e2 SMART
coiled coil region 148 216 N/A INTRINSIC
transmembrane domain 244 266 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138782
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009B22Rik A T 11: 51,685,843 V76D probably damaging Het
Acnat2 A G 4: 49,380,269 S370P probably damaging Het
Adamts5 T C 16: 85,899,475 R265G probably benign Het
Cd2ap T C 17: 42,845,389 S86G possibly damaging Het
Cers3 A C 7: 66,786,003 probably benign Het
Dnaaf2 G T 12: 69,196,602 P562T probably damaging Het
Dnajc21 A C 15: 10,447,102 V520G probably benign Het
Dpcr1 A T 17: 35,636,866 N490K probably damaging Het
Dync1h1 A G 12: 110,625,607 probably benign Het
Extl3 T C 14: 65,066,762 N733D probably benign Het
Gm5499 T A 17: 87,078,500 noncoding transcript Het
Gstm6 T C 3: 107,941,063 Q180R probably benign Het
Hdlbp G A 1: 93,423,802 R460W probably damaging Het
Ift81 T C 5: 122,610,968 D40G probably damaging Het
Igsf3 T A 3: 101,427,022 probably benign Het
Kcnb2 A G 1: 15,312,923 T158A probably benign Het
Macf1 A G 4: 123,440,774 C4397R probably damaging Het
Morc1 T C 16: 48,582,462 S583P probably benign Het
Nipsnap2 T A 5: 129,757,141 *282R probably null Het
Olfr1160 A T 2: 88,006,245 C178S probably damaging Het
Olfr703 T C 7: 106,844,749 L46P probably damaging Het
Parp14 T A 16: 35,856,559 Q1013L probably benign Het
Pdzd8 A C 19: 59,301,529 S480A probably benign Het
Piezo1 A T 8: 122,487,600 S1609R probably damaging Het
Pkp4 G A 2: 59,350,627 probably null Het
Plpp2 A T 10: 79,527,493 V106D probably damaging Het
Rimbp2 T C 5: 128,786,752 Y724C probably benign Het
Rpgrip1l A T 8: 91,260,873 L852* probably null Het
Samd9l T A 6: 3,376,259 D334V probably benign Het
Sipa1l2 G A 8: 125,491,518 T360M probably damaging Het
Slc30a2 A T 4: 134,343,300 D5V probably damaging Het
Spata31 T C 13: 64,921,754 I572T probably benign Het
Tma16 G A 8: 66,476,860 L161F probably benign Het
Trim69 A T 2: 122,173,284 E238V possibly damaging Het
Zfhx4 A G 3: 5,242,328 T205A probably benign Het
Other mutations in Lrrc59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01525:Lrrc59 APN 11 94634696 missense probably damaging 0.99
IGL01929:Lrrc59 APN 11 94643516 missense possibly damaging 0.69
IGL01958:Lrrc59 APN 11 94638528 splice site probably null
IGL02635:Lrrc59 APN 11 94643456 missense probably damaging 1.00
R0277:Lrrc59 UTSW 11 94643422 missense probably damaging 1.00
R0323:Lrrc59 UTSW 11 94643422 missense probably damaging 1.00
R1794:Lrrc59 UTSW 11 94638595 missense probably benign
R4833:Lrrc59 UTSW 11 94634672 missense probably benign 0.00
R6242:Lrrc59 UTSW 11 94634983 missense possibly damaging 0.65
R6817:Lrrc59 UTSW 11 94630065 missense probably damaging 1.00
R7709:Lrrc59 UTSW 11 94634985 missense probably damaging 1.00
R7724:Lrrc59 UTSW 11 94643344 missense probably damaging 0.99
R8066:Lrrc59 UTSW 11 94634600 missense possibly damaging 0.88
Z1176:Lrrc59 UTSW 11 94643321 missense probably benign 0.19
Posted On2013-10-07