Incidental Mutation 'IGL01321:Gstm6'
ID74041
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gstm6
Ensembl Gene ENSMUSG00000068762
Gene Nameglutathione S-transferase, mu 6
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01321
Quality Score
Status
Chromosome3
Chromosomal Location107938847-107943749 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 107941063 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Arginine at position 180 (Q180R)
Ref Sequence ENSEMBL: ENSMUSP00000102295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106681] [ENSMUST00000106683] [ENSMUST00000106684] [ENSMUST00000106685] [ENSMUST00000155926]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000106680
SMART Domains Protein: ENSMUSP00000102291
Gene: ENSMUSG00000068762

DomainStartEndE-ValueType
Pfam:GST_N 3 77 6.2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106681
AA Change: Q132R

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000102292
Gene: ENSMUSG00000068762
AA Change: Q132R

DomainStartEndE-ValueType
Pfam:GST_N 1 48 9.4e-12 PFAM
Pfam:GST_C_3 7 154 7.6e-11 PFAM
Pfam:GST_C 70 154 3.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106683
AA Change: Q71R

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000102294
Gene: ENSMUSG00000068762
AA Change: Q71R

DomainStartEndE-ValueType
Pfam:GST_C_3 4 95 6.3e-11 PFAM
Pfam:GST_C 6 97 2.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106684
AA Change: Q180R

PolyPhen 2 Score 0.147 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102295
Gene: ENSMUSG00000068762
AA Change: Q180R

DomainStartEndE-ValueType
Pfam:GST_N 3 82 2e-22 PFAM
Pfam:GST_C_3 41 204 4.1e-12 PFAM
Pfam:GST_C 104 205 5.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106685
AA Change: Q166R

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000102296
Gene: ENSMUSG00000068762
AA Change: Q166R

DomainStartEndE-ValueType
Pfam:GST_N 3 82 7.9e-23 PFAM
Pfam:GST_C 104 192 8.4e-20 PFAM
Pfam:GST_C_3 113 190 6.8e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155926
SMART Domains Protein: ENSMUSP00000139500
Gene: ENSMUSG00000068762

DomainStartEndE-ValueType
Pfam:GST_N 1 48 1.9e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009B22Rik A T 11: 51,685,843 V76D probably damaging Het
Acnat2 A G 4: 49,380,269 S370P probably damaging Het
Adamts5 T C 16: 85,899,475 R265G probably benign Het
Cd2ap T C 17: 42,845,389 S86G possibly damaging Het
Cers3 A C 7: 66,786,003 probably benign Het
Dnaaf2 G T 12: 69,196,602 P562T probably damaging Het
Dnajc21 A C 15: 10,447,102 V520G probably benign Het
Dpcr1 A T 17: 35,636,866 N490K probably damaging Het
Dync1h1 A G 12: 110,625,607 probably benign Het
Extl3 T C 14: 65,066,762 N733D probably benign Het
Gm5499 T A 17: 87,078,500 noncoding transcript Het
Hdlbp G A 1: 93,423,802 R460W probably damaging Het
Ift81 T C 5: 122,610,968 D40G probably damaging Het
Igsf3 T A 3: 101,427,022 probably benign Het
Kcnb2 A G 1: 15,312,923 T158A probably benign Het
Lrrc59 C T 11: 94,638,600 R167* probably null Het
Macf1 A G 4: 123,440,774 C4397R probably damaging Het
Morc1 T C 16: 48,582,462 S583P probably benign Het
Nipsnap2 T A 5: 129,757,141 *282R probably null Het
Olfr1160 A T 2: 88,006,245 C178S probably damaging Het
Olfr703 T C 7: 106,844,749 L46P probably damaging Het
Parp14 T A 16: 35,856,559 Q1013L probably benign Het
Pdzd8 A C 19: 59,301,529 S480A probably benign Het
Piezo1 A T 8: 122,487,600 S1609R probably damaging Het
Pkp4 G A 2: 59,350,627 probably null Het
Plpp2 A T 10: 79,527,493 V106D probably damaging Het
Rimbp2 T C 5: 128,786,752 Y724C probably benign Het
Rpgrip1l A T 8: 91,260,873 L852* probably null Het
Samd9l T A 6: 3,376,259 D334V probably benign Het
Sipa1l2 G A 8: 125,491,518 T360M probably damaging Het
Slc30a2 A T 4: 134,343,300 D5V probably damaging Het
Spata31 T C 13: 64,921,754 I572T probably benign Het
Tma16 G A 8: 66,476,860 L161F probably benign Het
Trim69 A T 2: 122,173,284 E238V possibly damaging Het
Zfhx4 A G 3: 5,242,328 T205A probably benign Het
Other mutations in Gstm6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02100:Gstm6 APN 3 107942337 missense probably benign 0.20
IGL02685:Gstm6 APN 3 107941191 missense probably benign 0.25
R1221:Gstm6 UTSW 3 107941102 missense probably damaging 1.00
R2428:Gstm6 UTSW 3 107943606 missense possibly damaging 0.82
R2763:Gstm6 UTSW 3 107941042 missense possibly damaging 0.65
R6178:Gstm6 UTSW 3 107941081 missense probably benign 0.01
R6545:Gstm6 UTSW 3 107942365 missense probably damaging 1.00
R6730:Gstm6 UTSW 3 107942725 nonsense probably null
R8240:Gstm6 UTSW 3 107942137 missense probably damaging 0.99
X0018:Gstm6 UTSW 3 107942747 missense probably damaging 1.00
Posted On2013-10-07