Incidental Mutation 'IGL01322:Vmn2r45'
ID 74067
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r45
Ensembl Gene ENSMUSG00000090662
Gene Name vomeronasal 2, receptor 45
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL01322
Quality Score
Status
Chromosome 7
Chromosomal Location 8474468-8491958 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 8484332 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 491 (H491L)
Ref Sequence ENSEMBL: ENSMUSP00000129466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164845]
AlphaFold L7N2B5
Predicted Effect possibly damaging
Transcript: ENSMUST00000164845
AA Change: H491L

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: H491L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 469 4.5e-26 PFAM
Pfam:NCD3G 512 565 6.4e-21 PFAM
Pfam:7tm_3 598 833 2.1e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,038,422 (GRCm39) L368Q probably damaging Het
Abca2 T A 2: 25,336,794 (GRCm39) probably null Het
Ano7 T A 1: 93,323,230 (GRCm39) V497D probably benign Het
B4gat1 T C 19: 5,090,037 (GRCm39) Y345H probably damaging Het
Bckdha T A 7: 25,358,132 (GRCm39) R12W possibly damaging Het
Bcl7c T A 7: 127,306,608 (GRCm39) N93Y probably damaging Het
Cc2d2a C A 5: 43,846,345 (GRCm39) T368K probably benign Het
Chek1 G A 9: 36,629,717 (GRCm39) Q210* probably null Het
Chrdl2 A G 7: 99,666,248 (GRCm39) Y56C probably damaging Het
Cspg4 T A 9: 56,805,872 (GRCm39) F2228I probably damaging Het
Dnah7a T C 1: 53,473,205 (GRCm39) M3474V probably benign Het
Dph7 T C 2: 24,855,629 (GRCm39) S143P possibly damaging Het
Ehbp1 T A 11: 22,039,636 (GRCm39) K821N probably damaging Het
Eomes T C 9: 118,313,898 (GRCm39) S648P probably benign Het
Fam20a A G 11: 109,573,738 (GRCm39) V215A probably damaging Het
Fer1l4 T A 2: 155,862,259 (GRCm39) probably null Het
Frem2 A G 3: 53,448,459 (GRCm39) V2319A probably benign Het
Gtf3c4 T C 2: 28,723,584 (GRCm39) D575G probably benign Het
Ifit1bl2 A G 19: 34,596,404 (GRCm39) V404A probably benign Het
Kcnf1 T C 12: 17,225,349 (GRCm39) M291V probably benign Het
Klra1 T A 6: 130,341,224 (GRCm39) I250F probably benign Het
Klra4 T A 6: 130,038,985 (GRCm39) T136S probably benign Het
Mcrs1 A T 15: 99,141,266 (GRCm39) I399N probably damaging Het
Neo1 T C 9: 58,814,368 (GRCm39) E866G possibly damaging Het
Notch3 T C 17: 32,363,445 (GRCm39) D1206G probably damaging Het
Or10ab4 A G 7: 107,654,188 (GRCm39) probably benign Het
Or14c43 T A 7: 86,115,480 (GRCm39) I287N probably damaging Het
Or4z4 A C 19: 12,076,769 (GRCm39) V78G probably benign Het
Or5ae1 T A 7: 84,565,590 (GRCm39) V201E probably damaging Het
Or5b95 A C 19: 12,658,113 (GRCm39) I214L probably benign Het
Or6c210 A G 10: 129,495,995 (GRCm39) T107A probably benign Het
Pnkd A G 1: 74,390,716 (GRCm39) N336D probably damaging Het
Prag1 T C 8: 36,571,088 (GRCm39) V557A probably benign Het
Ptgfr A C 3: 151,541,323 (GRCm39) S62A probably benign Het
Smc2 A G 4: 52,450,842 (GRCm39) Y220C probably damaging Het
Sufu G A 19: 46,439,382 (GRCm39) E246K probably damaging Het
Sult2a1 T A 7: 13,566,604 (GRCm39) R124* probably null Het
Sult4a1 T A 15: 83,970,817 (GRCm39) Y196F possibly damaging Het
Trim15 G A 17: 37,175,975 (GRCm39) R191W probably damaging Het
Ttn A G 2: 76,773,319 (GRCm39) V2361A possibly damaging Het
Usp16 T C 16: 87,263,164 (GRCm39) V122A possibly damaging Het
Vmn1r122 T A 7: 20,868,036 (GRCm39) K6N probably benign Het
Vmn1r34 G A 6: 66,613,899 (GRCm39) Q280* probably null Het
Wdpcp T C 11: 21,661,949 (GRCm39) L407P probably damaging Het
Zfp157 T C 5: 138,445,840 (GRCm39) I65T probably benign Het
Other mutations in Vmn2r45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn2r45 APN 7 8,488,622 (GRCm39) missense probably benign 0.00
IGL01402:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01404:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01529:Vmn2r45 APN 7 8,486,493 (GRCm39) missense probably benign
IGL01596:Vmn2r45 APN 7 8,486,272 (GRCm39) missense probably damaging 0.98
IGL01646:Vmn2r45 APN 7 8,486,337 (GRCm39) missense probably benign 0.18
IGL01819:Vmn2r45 APN 7 8,488,556 (GRCm39) missense probably benign 0.00
IGL02096:Vmn2r45 APN 7 8,484,443 (GRCm39) missense probably damaging 0.99
IGL02130:Vmn2r45 APN 7 8,486,556 (GRCm39) missense possibly damaging 0.46
IGL02409:Vmn2r45 APN 7 8,488,727 (GRCm39) missense probably benign 0.03
IGL02517:Vmn2r45 APN 7 8,486,185 (GRCm39) nonsense probably null
IGL02633:Vmn2r45 APN 7 8,488,728 (GRCm39) missense probably benign 0.01
IGL02940:Vmn2r45 APN 7 8,475,369 (GRCm39) missense probably damaging 0.99
IGL03281:Vmn2r45 APN 7 8,486,603 (GRCm39) missense probably damaging 1.00
IGL03358:Vmn2r45 APN 7 8,474,715 (GRCm39) missense probably damaging 1.00
BB004:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
BB014:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R0382:Vmn2r45 UTSW 7 8,486,098 (GRCm39) missense probably benign 0.06
R0532:Vmn2r45 UTSW 7 8,474,820 (GRCm39) missense probably damaging 0.99
R0932:Vmn2r45 UTSW 7 8,478,380 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r45 UTSW 7 8,488,542 (GRCm39) missense probably benign 0.00
R1580:Vmn2r45 UTSW 7 8,474,746 (GRCm39) missense possibly damaging 0.95
R1817:Vmn2r45 UTSW 7 8,475,372 (GRCm39) missense probably damaging 1.00
R1996:Vmn2r45 UTSW 7 8,475,024 (GRCm39) missense probably damaging 1.00
R2050:Vmn2r45 UTSW 7 8,475,021 (GRCm39) missense probably damaging 1.00
R2284:Vmn2r45 UTSW 7 8,488,765 (GRCm39) missense probably benign 0.02
R4019:Vmn2r45 UTSW 7 8,474,580 (GRCm39) nonsense probably null
R4227:Vmn2r45 UTSW 7 8,486,277 (GRCm39) missense probably damaging 0.98
R4381:Vmn2r45 UTSW 7 8,474,912 (GRCm39) nonsense probably null
R4618:Vmn2r45 UTSW 7 8,486,436 (GRCm39) missense probably benign 0.00
R4624:Vmn2r45 UTSW 7 8,484,341 (GRCm39) missense probably damaging 1.00
R4704:Vmn2r45 UTSW 7 8,486,535 (GRCm39) nonsense probably null
R4735:Vmn2r45 UTSW 7 8,486,472 (GRCm39) missense probably damaging 1.00
R4868:Vmn2r45 UTSW 7 8,484,480 (GRCm39) missense probably benign 0.06
R4983:Vmn2r45 UTSW 7 8,486,116 (GRCm39) missense probably damaging 0.99
R5246:Vmn2r45 UTSW 7 8,486,251 (GRCm39) missense probably benign 0.00
R5430:Vmn2r45 UTSW 7 8,486,333 (GRCm39) nonsense probably null
R5504:Vmn2r45 UTSW 7 8,486,176 (GRCm39) missense probably benign 0.03
R5511:Vmn2r45 UTSW 7 8,474,832 (GRCm39) missense probably benign 0.19
R5745:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R5814:Vmn2r45 UTSW 7 8,474,475 (GRCm39) missense probably benign 0.00
R6223:Vmn2r45 UTSW 7 8,486,301 (GRCm39) missense probably benign
R6267:Vmn2r45 UTSW 7 8,475,207 (GRCm39) missense probably benign 0.26
R6623:Vmn2r45 UTSW 7 8,474,500 (GRCm39) missense probably benign 0.09
R6999:Vmn2r45 UTSW 7 8,486,219 (GRCm39) missense probably benign
R7242:Vmn2r45 UTSW 7 8,488,612 (GRCm39) nonsense probably null
R7491:Vmn2r45 UTSW 7 8,484,342 (GRCm39) missense probably benign 0.27
R7620:Vmn2r45 UTSW 7 8,486,222 (GRCm39) nonsense probably null
R7719:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7720:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7853:Vmn2r45 UTSW 7 8,485,987 (GRCm39) missense possibly damaging 0.90
R7873:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R7882:Vmn2r45 UTSW 7 8,486,409 (GRCm39) missense possibly damaging 0.82
R7927:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R8684:Vmn2r45 UTSW 7 8,486,511 (GRCm39) missense probably damaging 0.99
R8780:Vmn2r45 UTSW 7 8,484,371 (GRCm39) missense possibly damaging 0.94
R8811:Vmn2r45 UTSW 7 8,474,881 (GRCm39) missense probably damaging 1.00
R8893:Vmn2r45 UTSW 7 8,488,619 (GRCm39) missense probably damaging 1.00
R9043:Vmn2r45 UTSW 7 8,474,904 (GRCm39) missense possibly damaging 0.92
R9208:Vmn2r45 UTSW 7 8,486,298 (GRCm39) missense probably damaging 1.00
R9327:Vmn2r45 UTSW 7 8,474,532 (GRCm39) missense probably damaging 1.00
R9586:Vmn2r45 UTSW 7 8,486,050 (GRCm39) missense probably benign 0.01
R9599:Vmn2r45 UTSW 7 8,478,457 (GRCm39) critical splice acceptor site probably null
U24488:Vmn2r45 UTSW 7 8,475,361 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r45 UTSW 7 8,474,484 (GRCm39) missense probably benign 0.16
Posted On 2013-10-07