Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01322:Sult2a1'

74072

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sult2a1

Ensembl Gene

ENSMUSG00000078798

Gene Name

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1

Synonyms

Std, Sth1, mSTa1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL01322

Quality Score

Status

Chromosome

Chromosomal Location

13796246-13837409 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 13832679 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 124 (R124*)

Ref Sequence

ENSEMBL: ENSMUSP00000104162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108522]

Predicted Effect

probably null
Transcript: ENSMUST00000108522
AA Change: R124*

SMART Domains

Protein: ENSMUSP00000104162
Gene: ENSMUSG00000078798
AA Change: R124*

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	34	278	4.6e-83	PFAM
Pfam:Sulfotransfer_3	35	205	5.8e-11	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	A	7: 120,439,199	L368Q	probably damaging	Het
Abca2	T	A	2: 25,446,782		probably null	Het
Ano7	T	A	1: 93,395,508	V497D	probably benign	Het
B4gat1	T	C	19: 5,040,009	Y345H	probably damaging	Het
Bckdha	T	A	7: 25,658,707	R12W	possibly damaging	Het
Bcl7c	T	A	7: 127,707,436	N93Y	probably damaging	Het
Cc2d2a	C	A	5: 43,689,003	T368K	probably benign	Het
Chek1	G	A	9: 36,718,421	Q210*	probably null	Het
Chrdl2	A	G	7: 100,017,041	Y56C	probably damaging	Het
Cspg4	T	A	9: 56,898,588	F2228I	probably damaging	Het
Dnah7a	T	C	1: 53,434,046	M3474V	probably benign	Het
Dph7	T	C	2: 24,965,617	S143P	possibly damaging	Het
Ehbp1	T	A	11: 22,089,636	K821N	probably damaging	Het
Eomes	T	C	9: 118,484,830	S648P	probably benign	Het
Fam20a	A	G	11: 109,682,912	V215A	probably damaging	Het
Fer1l4	T	A	2: 156,020,339		probably null	Het
Frem2	A	G	3: 53,541,038	V2319A	probably benign	Het
Gtf3c4	T	C	2: 28,833,572	D575G	probably benign	Het
Ifit1bl2	A	G	19: 34,619,004	V404A	probably benign	Het
Kcnf1	T	C	12: 17,175,348	M291V	probably benign	Het
Klra1	T	A	6: 130,364,261	I250F	probably benign	Het
Klra4	T	A	6: 130,062,022	T136S	probably benign	Het
Mcrs1	A	T	15: 99,243,385	I399N	probably damaging	Het
Neo1	T	C	9: 58,907,085	E866G	possibly damaging	Het
Notch3	T	C	17: 32,144,471	D1206G	probably damaging	Het
Olfr1427	A	C	19: 12,099,405	V78G	probably benign	Het
Olfr1443	A	C	19: 12,680,749	I214L	probably benign	Het
Olfr290	T	A	7: 84,916,382	V201E	probably damaging	Het
Olfr299	T	A	7: 86,466,272	I287N	probably damaging	Het
Olfr479	A	G	7: 108,054,981		probably benign	Het
Olfr800	A	G	10: 129,660,126	T107A	probably benign	Het
Pnkd	A	G	1: 74,351,557	N336D	probably damaging	Het
Prag1	T	C	8: 36,103,934	V557A	probably benign	Het
Ptgfr	A	C	3: 151,835,686	S62A	probably benign	Het
Smc2	A	G	4: 52,450,842	Y220C	probably damaging	Het
Sufu	G	A	19: 46,450,943	E246K	probably damaging	Het
Sult4a1	T	A	15: 84,086,616	Y196F	possibly damaging	Het
Trim15	G	A	17: 36,865,083	R191W	probably damaging	Het
Ttn	A	G	2: 76,942,975	V2361A	possibly damaging	Het
Usp16	T	C	16: 87,466,276	V122A	possibly damaging	Het
Vmn1r122	T	A	7: 21,134,111	K6N	probably benign	Het
Vmn1r34	G	A	6: 66,636,915	Q280*	probably null	Het
Vmn2r45	T	A	7: 8,481,333	H491L	possibly damaging	Het
Wdpcp	T	C	11: 21,711,949	L407P	probably damaging	Het
Zfp157	T	C	5: 138,447,578	I65T	probably benign	Het

Other mutations in Sult2a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00896:Sult2a1	APN	7	13832640	missense	probably benign	0.02
IGL00990:Sult2a1	APN	7	13804036	missense	probably benign
IGL02558:Sult2a1	APN	7	13832595	missense	probably benign	0.03
IGL03033:Sult2a1	APN	7	13832710	splice site	probably benign
IGL03199:Sult2a1	APN	7	13832660	missense	probably damaging	1.00
R1633:Sult2a1	UTSW	7	13801426	missense	probably benign	0.01
R1903:Sult2a1	UTSW	7	13835975	missense	possibly damaging	0.94
R2295:Sult2a1	UTSW	7	13835959	critical splice donor site	probably null
R4207:Sult2a1	UTSW	7	13801547	missense	probably benign	0.00
R5444:Sult2a1	UTSW	7	13836019	missense	possibly damaging	0.80
R6233:Sult2a1	UTSW	7	13832675	missense	probably damaging	1.00
R6317:Sult2a1	UTSW	7	13836020	missense	probably benign	0.00
R6853:Sult2a1	UTSW	7	13801487	missense	possibly damaging	0.50
R7098:Sult2a1	UTSW	7	13816053	splice site	probably null
Z1088:Sult2a1	UTSW	7	13801414	missense	probably benign
Z1088:Sult2a1	UTSW	7	13801435	missense	probably benign	0.00
Z1088:Sult2a1	UTSW	7	13804036	missense	probably benign
Z1176:Sult2a1	UTSW	7	13801414	missense	probably benign
Z1176:Sult2a1	UTSW	7	13801435	missense	probably benign	0.00
Z1176:Sult2a1	UTSW	7	13804036	missense	probably benign
Z1176:Sult2a1	UTSW	7	13835967	missense	probably damaging	1.00
Z1177:Sult2a1	UTSW	7	13796363	frame shift	probably null
Z1177:Sult2a1	UTSW	7	13801414	missense	probably benign
Z1177:Sult2a1	UTSW	7	13801435	missense	probably benign	0.00
Z1177:Sult2a1	UTSW	7	13804036	missense	probably benign

Posted On

2013-10-07