Incidental Mutation 'IGL01322:Or6c210'
ID 74073
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c210
Ensembl Gene ENSMUSG00000108114
Gene Name olfactory receptor family 6 subfamily C member 210
Synonyms GA_x6K02T2PULF-11338429-11339364, MOR114-7, Olfr800
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # IGL01322
Quality Score
Status
Chromosome 10
Chromosomal Location 129495677-129496612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129495995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 107 (T107A)
Ref Sequence ENSEMBL: ENSMUSP00000151047 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104903] [ENSMUST00000217094]
AlphaFold Q8VFH7
Predicted Effect probably benign
Transcript: ENSMUST00000104903
AA Change: T107A

PolyPhen 2 Score 0.265 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100499
Gene: ENSMUSG00000108114
AA Change: T107A

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 7.3e-43 PFAM
Pfam:7tm_1 38 287 6.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217094
AA Change: T107A

PolyPhen 2 Score 0.265 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,038,422 (GRCm39) L368Q probably damaging Het
Abca2 T A 2: 25,336,794 (GRCm39) probably null Het
Ano7 T A 1: 93,323,230 (GRCm39) V497D probably benign Het
B4gat1 T C 19: 5,090,037 (GRCm39) Y345H probably damaging Het
Bckdha T A 7: 25,358,132 (GRCm39) R12W possibly damaging Het
Bcl7c T A 7: 127,306,608 (GRCm39) N93Y probably damaging Het
Cc2d2a C A 5: 43,846,345 (GRCm39) T368K probably benign Het
Chek1 G A 9: 36,629,717 (GRCm39) Q210* probably null Het
Chrdl2 A G 7: 99,666,248 (GRCm39) Y56C probably damaging Het
Cspg4 T A 9: 56,805,872 (GRCm39) F2228I probably damaging Het
Dnah7a T C 1: 53,473,205 (GRCm39) M3474V probably benign Het
Dph7 T C 2: 24,855,629 (GRCm39) S143P possibly damaging Het
Ehbp1 T A 11: 22,039,636 (GRCm39) K821N probably damaging Het
Eomes T C 9: 118,313,898 (GRCm39) S648P probably benign Het
Fam20a A G 11: 109,573,738 (GRCm39) V215A probably damaging Het
Fer1l4 T A 2: 155,862,259 (GRCm39) probably null Het
Frem2 A G 3: 53,448,459 (GRCm39) V2319A probably benign Het
Gtf3c4 T C 2: 28,723,584 (GRCm39) D575G probably benign Het
Ifit1bl2 A G 19: 34,596,404 (GRCm39) V404A probably benign Het
Kcnf1 T C 12: 17,225,349 (GRCm39) M291V probably benign Het
Klra1 T A 6: 130,341,224 (GRCm39) I250F probably benign Het
Klra4 T A 6: 130,038,985 (GRCm39) T136S probably benign Het
Mcrs1 A T 15: 99,141,266 (GRCm39) I399N probably damaging Het
Neo1 T C 9: 58,814,368 (GRCm39) E866G possibly damaging Het
Notch3 T C 17: 32,363,445 (GRCm39) D1206G probably damaging Het
Or10ab4 A G 7: 107,654,188 (GRCm39) probably benign Het
Or14c43 T A 7: 86,115,480 (GRCm39) I287N probably damaging Het
Or4z4 A C 19: 12,076,769 (GRCm39) V78G probably benign Het
Or5ae1 T A 7: 84,565,590 (GRCm39) V201E probably damaging Het
Or5b95 A C 19: 12,658,113 (GRCm39) I214L probably benign Het
Pnkd A G 1: 74,390,716 (GRCm39) N336D probably damaging Het
Prag1 T C 8: 36,571,088 (GRCm39) V557A probably benign Het
Ptgfr A C 3: 151,541,323 (GRCm39) S62A probably benign Het
Smc2 A G 4: 52,450,842 (GRCm39) Y220C probably damaging Het
Sufu G A 19: 46,439,382 (GRCm39) E246K probably damaging Het
Sult2a1 T A 7: 13,566,604 (GRCm39) R124* probably null Het
Sult4a1 T A 15: 83,970,817 (GRCm39) Y196F possibly damaging Het
Trim15 G A 17: 37,175,975 (GRCm39) R191W probably damaging Het
Ttn A G 2: 76,773,319 (GRCm39) V2361A possibly damaging Het
Usp16 T C 16: 87,263,164 (GRCm39) V122A possibly damaging Het
Vmn1r122 T A 7: 20,868,036 (GRCm39) K6N probably benign Het
Vmn1r34 G A 6: 66,613,899 (GRCm39) Q280* probably null Het
Vmn2r45 T A 7: 8,484,332 (GRCm39) H491L possibly damaging Het
Wdpcp T C 11: 21,661,949 (GRCm39) L407P probably damaging Het
Zfp157 T C 5: 138,445,840 (GRCm39) I65T probably benign Het
Other mutations in Or6c210
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01915:Or6c210 APN 10 129,496,519 (GRCm39) missense probably benign 0.05
IGL02458:Or6c210 APN 10 129,496,475 (GRCm39) missense probably benign 0.38
IGL02721:Or6c210 APN 10 129,495,824 (GRCm39) missense probably benign
R0032:Or6c210 UTSW 10 129,496,269 (GRCm39) missense probably benign 0.05
R0442:Or6c210 UTSW 10 129,495,693 (GRCm39) missense probably benign 0.00
R1564:Or6c210 UTSW 10 129,495,884 (GRCm39) missense probably benign 0.22
R1580:Or6c210 UTSW 10 129,496,184 (GRCm39) missense probably benign 0.10
R1593:Or6c210 UTSW 10 129,496,094 (GRCm39) nonsense probably null
R1911:Or6c210 UTSW 10 129,495,981 (GRCm39) missense probably benign 0.07
R2001:Or6c210 UTSW 10 129,496,290 (GRCm39) missense probably benign 0.02
R2223:Or6c210 UTSW 10 129,495,678 (GRCm39) start codon destroyed probably null 1.00
R3876:Or6c210 UTSW 10 129,496,143 (GRCm39) missense probably benign 0.39
R3884:Or6c210 UTSW 10 129,496,407 (GRCm39) missense probably damaging 1.00
R4366:Or6c210 UTSW 10 129,496,400 (GRCm39) missense probably benign 0.02
R4689:Or6c210 UTSW 10 129,496,185 (GRCm39) missense probably benign 0.01
R4909:Or6c210 UTSW 10 129,496,589 (GRCm39) missense probably benign 0.01
R5638:Or6c210 UTSW 10 129,495,969 (GRCm39) missense possibly damaging 0.80
R5835:Or6c210 UTSW 10 129,495,803 (GRCm39) missense probably benign 0.39
R5838:Or6c210 UTSW 10 129,495,907 (GRCm39) missense probably benign 0.41
R6150:Or6c210 UTSW 10 129,495,803 (GRCm39) missense probably benign 0.39
R6248:Or6c210 UTSW 10 129,496,532 (GRCm39) missense probably benign 0.39
R8094:Or6c210 UTSW 10 129,495,933 (GRCm39) missense probably damaging 0.99
R9013:Or6c210 UTSW 10 129,495,702 (GRCm39) missense probably damaging 1.00
R9224:Or6c210 UTSW 10 129,496,007 (GRCm39) missense probably damaging 1.00
R9390:Or6c210 UTSW 10 129,495,938 (GRCm39) missense probably benign 0.01
R9726:Or6c210 UTSW 10 129,495,920 (GRCm39) missense possibly damaging 0.67
R9777:Or6c210 UTSW 10 129,495,705 (GRCm39) missense probably benign 0.17
Posted On 2013-10-07