Incidental Mutation 'IGL01322:Trim15'
ID74088
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim15
Ensembl Gene ENSMUSG00000050747
Gene Nametripartite motif-containing 15
Synonyms1810012B10Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.140) question?
Stock #IGL01322
Quality Score
Status
Chromosome17
Chromosomal Location36860691-36867210 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 36865083 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Tryptophan at position 191 (R191W)
Ref Sequence ENSEMBL: ENSMUSP00000133953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025329] [ENSMUST00000060524] [ENSMUST00000174195]
Predicted Effect probably damaging
Transcript: ENSMUST00000025329
AA Change: R191W

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000025329
Gene: ENSMUSG00000050747
AA Change: R191W

DomainStartEndE-ValueType
RING 15 53 2e-4 SMART
BBOX 73 114 2.41e-12 SMART
coiled coil region 145 229 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000060524
SMART Domains Protein: ENSMUSP00000057928
Gene: ENSMUSG00000073400

DomainStartEndE-ValueType
RING 16 60 1.2e-7 SMART
BBOX 94 135 5.38e-10 SMART
coiled coil region 152 175 N/A INTRINSIC
low complexity region 187 207 N/A INTRINSIC
PRY 309 361 1.04e-25 SMART
SPRY 362 485 1.51e-23 SMART
Predicted Effect unknown
Transcript: ENSMUST00000173639
AA Change: R72W
SMART Domains Protein: ENSMUSP00000133638
Gene: ENSMUSG00000050747
AA Change: R72W

DomainStartEndE-ValueType
SCOP:d1dkza_ 15 105 1e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000174195
AA Change: R191W

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000133953
Gene: ENSMUSG00000050747
AA Change: R191W

DomainStartEndE-ValueType
RING 15 53 2e-4 SMART
BBOX 73 114 2.41e-12 SMART
coiled coil region 145 229 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,439,199 L368Q probably damaging Het
Abca2 T A 2: 25,446,782 probably null Het
Ano7 T A 1: 93,395,508 V497D probably benign Het
B4gat1 T C 19: 5,040,009 Y345H probably damaging Het
Bckdha T A 7: 25,658,707 R12W possibly damaging Het
Bcl7c T A 7: 127,707,436 N93Y probably damaging Het
Cc2d2a C A 5: 43,689,003 T368K probably benign Het
Chek1 G A 9: 36,718,421 Q210* probably null Het
Chrdl2 A G 7: 100,017,041 Y56C probably damaging Het
Cspg4 T A 9: 56,898,588 F2228I probably damaging Het
Dnah7a T C 1: 53,434,046 M3474V probably benign Het
Dph7 T C 2: 24,965,617 S143P possibly damaging Het
Ehbp1 T A 11: 22,089,636 K821N probably damaging Het
Eomes T C 9: 118,484,830 S648P probably benign Het
Fam20a A G 11: 109,682,912 V215A probably damaging Het
Fer1l4 T A 2: 156,020,339 probably null Het
Frem2 A G 3: 53,541,038 V2319A probably benign Het
Gtf3c4 T C 2: 28,833,572 D575G probably benign Het
Ifit1bl2 A G 19: 34,619,004 V404A probably benign Het
Kcnf1 T C 12: 17,175,348 M291V probably benign Het
Klra1 T A 6: 130,364,261 I250F probably benign Het
Klra4 T A 6: 130,062,022 T136S probably benign Het
Mcrs1 A T 15: 99,243,385 I399N probably damaging Het
Neo1 T C 9: 58,907,085 E866G possibly damaging Het
Notch3 T C 17: 32,144,471 D1206G probably damaging Het
Olfr1427 A C 19: 12,099,405 V78G probably benign Het
Olfr1443 A C 19: 12,680,749 I214L probably benign Het
Olfr290 T A 7: 84,916,382 V201E probably damaging Het
Olfr299 T A 7: 86,466,272 I287N probably damaging Het
Olfr479 A G 7: 108,054,981 probably benign Het
Olfr800 A G 10: 129,660,126 T107A probably benign Het
Pnkd A G 1: 74,351,557 N336D probably damaging Het
Prag1 T C 8: 36,103,934 V557A probably benign Het
Ptgfr A C 3: 151,835,686 S62A probably benign Het
Smc2 A G 4: 52,450,842 Y220C probably damaging Het
Sufu G A 19: 46,450,943 E246K probably damaging Het
Sult2a1 T A 7: 13,832,679 R124* probably null Het
Sult4a1 T A 15: 84,086,616 Y196F possibly damaging Het
Ttn A G 2: 76,942,975 V2361A possibly damaging Het
Usp16 T C 16: 87,466,276 V122A possibly damaging Het
Vmn1r122 T A 7: 21,134,111 K6N probably benign Het
Vmn1r34 G A 6: 66,636,915 Q280* probably null Het
Vmn2r45 T A 7: 8,481,333 H491L possibly damaging Het
Wdpcp T C 11: 21,711,949 L407P probably damaging Het
Zfp157 T C 5: 138,447,578 I65T probably benign Het
Other mutations in Trim15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Trim15 APN 17 36867064 missense probably benign 0.00
IGL03024:Trim15 APN 17 36866893 missense probably damaging 1.00
R0310:Trim15 UTSW 17 36866986 missense probably damaging 1.00
R0490:Trim15 UTSW 17 36866355 missense probably benign
R0992:Trim15 UTSW 17 36865011 missense probably damaging 0.98
R1775:Trim15 UTSW 17 36865169 missense probably benign 0.15
R1957:Trim15 UTSW 17 36862323 unclassified probably benign
R3625:Trim15 UTSW 17 36866876 missense possibly damaging 0.74
R4520:Trim15 UTSW 17 36866350 missense probably benign 0.01
R4845:Trim15 UTSW 17 36866983 missense probably benign 0.00
R5644:Trim15 UTSW 17 36866821 missense probably damaging 0.99
R5838:Trim15 UTSW 17 36862840 missense probably damaging 1.00
R5930:Trim15 UTSW 17 36862360 critical splice acceptor site probably null
R6758:Trim15 UTSW 17 36862341 missense probably benign 0.16
R7094:Trim15 UTSW 17 36862896 missense probably benign
R7849:Trim15 UTSW 17 36866872 missense probably benign 0.31
Posted On2013-10-07