Incidental Mutation 'IGL01322:Zfp157'
ID 74095
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp157
Ensembl Gene ENSMUSG00000036898
Gene Name zinc finger protein 157
Synonyms 2610020C11Rik, Roma, A630094N24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL01322
Quality Score
Status
Chromosome 5
Chromosomal Location 138439730-138458956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 138445840 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 65 (I65T)
Ref Sequence ENSEMBL: ENSMUSP00000083018 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085856] [ENSMUST00000100524] [ENSMUST00000110912]
AlphaFold Q6PCM4
Predicted Effect probably benign
Transcript: ENSMUST00000085856
AA Change: I65T

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000083018
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
ZnF_C2H2 183 205 3.69e-4 SMART
ZnF_C2H2 211 233 3.16e-3 SMART
ZnF_C2H2 239 261 3.63e-3 SMART
ZnF_C2H2 267 289 2.24e-3 SMART
ZnF_C2H2 295 317 1.47e-3 SMART
ZnF_C2H2 323 345 1.95e-3 SMART
ZnF_C2H2 351 373 1.28e-3 SMART
ZnF_C2H2 379 401 2.4e-3 SMART
ZnF_C2H2 407 429 9.73e-4 SMART
ZnF_C2H2 435 457 4.4e-2 SMART
ZnF_C2H2 463 485 1.01e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100524
AA Change: I65T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000098093
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110912
AA Change: I65T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000106537
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134706
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137711
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151095
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display accelerated ductal elongation during puberty and accelerated alveologenesis during pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,038,422 (GRCm39) L368Q probably damaging Het
Abca2 T A 2: 25,336,794 (GRCm39) probably null Het
Ano7 T A 1: 93,323,230 (GRCm39) V497D probably benign Het
B4gat1 T C 19: 5,090,037 (GRCm39) Y345H probably damaging Het
Bckdha T A 7: 25,358,132 (GRCm39) R12W possibly damaging Het
Bcl7c T A 7: 127,306,608 (GRCm39) N93Y probably damaging Het
Cc2d2a C A 5: 43,846,345 (GRCm39) T368K probably benign Het
Chek1 G A 9: 36,629,717 (GRCm39) Q210* probably null Het
Chrdl2 A G 7: 99,666,248 (GRCm39) Y56C probably damaging Het
Cspg4 T A 9: 56,805,872 (GRCm39) F2228I probably damaging Het
Dnah7a T C 1: 53,473,205 (GRCm39) M3474V probably benign Het
Dph7 T C 2: 24,855,629 (GRCm39) S143P possibly damaging Het
Ehbp1 T A 11: 22,039,636 (GRCm39) K821N probably damaging Het
Eomes T C 9: 118,313,898 (GRCm39) S648P probably benign Het
Fam20a A G 11: 109,573,738 (GRCm39) V215A probably damaging Het
Fer1l4 T A 2: 155,862,259 (GRCm39) probably null Het
Frem2 A G 3: 53,448,459 (GRCm39) V2319A probably benign Het
Gtf3c4 T C 2: 28,723,584 (GRCm39) D575G probably benign Het
Ifit1bl2 A G 19: 34,596,404 (GRCm39) V404A probably benign Het
Kcnf1 T C 12: 17,225,349 (GRCm39) M291V probably benign Het
Klra1 T A 6: 130,341,224 (GRCm39) I250F probably benign Het
Klra4 T A 6: 130,038,985 (GRCm39) T136S probably benign Het
Mcrs1 A T 15: 99,141,266 (GRCm39) I399N probably damaging Het
Neo1 T C 9: 58,814,368 (GRCm39) E866G possibly damaging Het
Notch3 T C 17: 32,363,445 (GRCm39) D1206G probably damaging Het
Or10ab4 A G 7: 107,654,188 (GRCm39) probably benign Het
Or14c43 T A 7: 86,115,480 (GRCm39) I287N probably damaging Het
Or4z4 A C 19: 12,076,769 (GRCm39) V78G probably benign Het
Or5ae1 T A 7: 84,565,590 (GRCm39) V201E probably damaging Het
Or5b95 A C 19: 12,658,113 (GRCm39) I214L probably benign Het
Or6c210 A G 10: 129,495,995 (GRCm39) T107A probably benign Het
Pnkd A G 1: 74,390,716 (GRCm39) N336D probably damaging Het
Prag1 T C 8: 36,571,088 (GRCm39) V557A probably benign Het
Ptgfr A C 3: 151,541,323 (GRCm39) S62A probably benign Het
Smc2 A G 4: 52,450,842 (GRCm39) Y220C probably damaging Het
Sufu G A 19: 46,439,382 (GRCm39) E246K probably damaging Het
Sult2a1 T A 7: 13,566,604 (GRCm39) R124* probably null Het
Sult4a1 T A 15: 83,970,817 (GRCm39) Y196F possibly damaging Het
Trim15 G A 17: 37,175,975 (GRCm39) R191W probably damaging Het
Ttn A G 2: 76,773,319 (GRCm39) V2361A possibly damaging Het
Usp16 T C 16: 87,263,164 (GRCm39) V122A possibly damaging Het
Vmn1r122 T A 7: 20,868,036 (GRCm39) K6N probably benign Het
Vmn1r34 G A 6: 66,613,899 (GRCm39) Q280* probably null Het
Vmn2r45 T A 7: 8,484,332 (GRCm39) H491L possibly damaging Het
Wdpcp T C 11: 21,661,949 (GRCm39) L407P probably damaging Het
Other mutations in Zfp157
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Zfp157 APN 5 138,445,859 (GRCm39) nonsense probably null
R1476:Zfp157 UTSW 5 138,453,357 (GRCm39) critical splice donor site probably null
R1883:Zfp157 UTSW 5 138,443,102 (GRCm39) missense probably damaging 1.00
R1884:Zfp157 UTSW 5 138,443,102 (GRCm39) missense probably damaging 1.00
R3401:Zfp157 UTSW 5 138,455,273 (GRCm39) missense probably benign 0.35
R4237:Zfp157 UTSW 5 138,445,803 (GRCm39) missense probably damaging 1.00
R4239:Zfp157 UTSW 5 138,445,803 (GRCm39) missense probably damaging 1.00
R4573:Zfp157 UTSW 5 138,455,191 (GRCm39) missense probably damaging 0.97
R4785:Zfp157 UTSW 5 138,443,051 (GRCm39) missense probably damaging 1.00
R4914:Zfp157 UTSW 5 138,454,557 (GRCm39) missense possibly damaging 0.85
R5476:Zfp157 UTSW 5 138,455,443 (GRCm39) missense possibly damaging 0.92
R6128:Zfp157 UTSW 5 138,453,281 (GRCm39) missense possibly damaging 0.95
R6473:Zfp157 UTSW 5 138,454,188 (GRCm39) missense probably damaging 0.99
R6572:Zfp157 UTSW 5 138,455,313 (GRCm39) missense possibly damaging 0.92
R6990:Zfp157 UTSW 5 138,454,772 (GRCm39) nonsense probably null
R7638:Zfp157 UTSW 5 138,454,172 (GRCm39) missense probably benign 0.04
R7966:Zfp157 UTSW 5 138,445,833 (GRCm39) missense probably benign 0.14
R7994:Zfp157 UTSW 5 138,453,450 (GRCm39) splice site probably null
R8057:Zfp157 UTSW 5 138,454,336 (GRCm39) missense probably damaging 1.00
R8397:Zfp157 UTSW 5 138,454,518 (GRCm39) missense probably damaging 1.00
Z1088:Zfp157 UTSW 5 138,455,461 (GRCm39) missense probably damaging 0.98
Posted On 2013-10-07