Incidental Mutation 'IGL01322:Zfp157'
ID74095
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp157
Ensembl Gene ENSMUSG00000036898
Gene Namezinc finger protein 157
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL01322
Quality Score
Status
Chromosome5
Chromosomal Location138441468-138460694 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 138447578 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 65 (I65T)
Ref Sequence ENSEMBL: ENSMUSP00000083018 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085856] [ENSMUST00000100524] [ENSMUST00000110912]
Predicted Effect probably benign
Transcript: ENSMUST00000085856
AA Change: I65T

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000083018
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
ZnF_C2H2 183 205 3.69e-4 SMART
ZnF_C2H2 211 233 3.16e-3 SMART
ZnF_C2H2 239 261 3.63e-3 SMART
ZnF_C2H2 267 289 2.24e-3 SMART
ZnF_C2H2 295 317 1.47e-3 SMART
ZnF_C2H2 323 345 1.95e-3 SMART
ZnF_C2H2 351 373 1.28e-3 SMART
ZnF_C2H2 379 401 2.4e-3 SMART
ZnF_C2H2 407 429 9.73e-4 SMART
ZnF_C2H2 435 457 4.4e-2 SMART
ZnF_C2H2 463 485 1.01e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100524
AA Change: I65T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000098093
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110912
AA Change: I65T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000106537
Gene: ENSMUSG00000036898
AA Change: I65T

DomainStartEndE-ValueType
KRAB 4 64 3.64e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134706
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137711
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151095
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display accelerated ductal elongation during puberty and accelerated alveologenesis during pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,439,199 L368Q probably damaging Het
Abca2 T A 2: 25,446,782 probably null Het
Ano7 T A 1: 93,395,508 V497D probably benign Het
B4gat1 T C 19: 5,040,009 Y345H probably damaging Het
Bckdha T A 7: 25,658,707 R12W possibly damaging Het
Bcl7c T A 7: 127,707,436 N93Y probably damaging Het
Cc2d2a C A 5: 43,689,003 T368K probably benign Het
Chek1 G A 9: 36,718,421 Q210* probably null Het
Chrdl2 A G 7: 100,017,041 Y56C probably damaging Het
Cspg4 T A 9: 56,898,588 F2228I probably damaging Het
Dnah7a T C 1: 53,434,046 M3474V probably benign Het
Dph7 T C 2: 24,965,617 S143P possibly damaging Het
Ehbp1 T A 11: 22,089,636 K821N probably damaging Het
Eomes T C 9: 118,484,830 S648P probably benign Het
Fam20a A G 11: 109,682,912 V215A probably damaging Het
Fer1l4 T A 2: 156,020,339 probably null Het
Frem2 A G 3: 53,541,038 V2319A probably benign Het
Gtf3c4 T C 2: 28,833,572 D575G probably benign Het
Ifit1bl2 A G 19: 34,619,004 V404A probably benign Het
Kcnf1 T C 12: 17,175,348 M291V probably benign Het
Klra1 T A 6: 130,364,261 I250F probably benign Het
Klra4 T A 6: 130,062,022 T136S probably benign Het
Mcrs1 A T 15: 99,243,385 I399N probably damaging Het
Neo1 T C 9: 58,907,085 E866G possibly damaging Het
Notch3 T C 17: 32,144,471 D1206G probably damaging Het
Olfr1427 A C 19: 12,099,405 V78G probably benign Het
Olfr1443 A C 19: 12,680,749 I214L probably benign Het
Olfr290 T A 7: 84,916,382 V201E probably damaging Het
Olfr299 T A 7: 86,466,272 I287N probably damaging Het
Olfr479 A G 7: 108,054,981 probably benign Het
Olfr800 A G 10: 129,660,126 T107A probably benign Het
Pnkd A G 1: 74,351,557 N336D probably damaging Het
Prag1 T C 8: 36,103,934 V557A probably benign Het
Ptgfr A C 3: 151,835,686 S62A probably benign Het
Smc2 A G 4: 52,450,842 Y220C probably damaging Het
Sufu G A 19: 46,450,943 E246K probably damaging Het
Sult2a1 T A 7: 13,832,679 R124* probably null Het
Sult4a1 T A 15: 84,086,616 Y196F possibly damaging Het
Trim15 G A 17: 36,865,083 R191W probably damaging Het
Ttn A G 2: 76,942,975 V2361A possibly damaging Het
Usp16 T C 16: 87,466,276 V122A possibly damaging Het
Vmn1r122 T A 7: 21,134,111 K6N probably benign Het
Vmn1r34 G A 6: 66,636,915 Q280* probably null Het
Vmn2r45 T A 7: 8,481,333 H491L possibly damaging Het
Wdpcp T C 11: 21,711,949 L407P probably damaging Het
Other mutations in Zfp157
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Zfp157 APN 5 138447597 nonsense probably null
R1476:Zfp157 UTSW 5 138455095 critical splice donor site probably null
R1883:Zfp157 UTSW 5 138444840 missense probably damaging 1.00
R1884:Zfp157 UTSW 5 138444840 missense probably damaging 1.00
R3401:Zfp157 UTSW 5 138457011 missense probably benign 0.35
R4237:Zfp157 UTSW 5 138447541 missense probably damaging 1.00
R4239:Zfp157 UTSW 5 138447541 missense probably damaging 1.00
R4573:Zfp157 UTSW 5 138456929 missense probably damaging 0.97
R4785:Zfp157 UTSW 5 138444789 missense probably damaging 1.00
R4914:Zfp157 UTSW 5 138456295 missense possibly damaging 0.85
R5476:Zfp157 UTSW 5 138457181 missense possibly damaging 0.92
R6128:Zfp157 UTSW 5 138455019 missense possibly damaging 0.95
R6473:Zfp157 UTSW 5 138455926 missense probably damaging 0.99
R6572:Zfp157 UTSW 5 138457051 missense possibly damaging 0.92
R6990:Zfp157 UTSW 5 138456510 nonsense probably null
R7638:Zfp157 UTSW 5 138455910 missense probably benign 0.04
R7966:Zfp157 UTSW 5 138447571 missense probably benign 0.14
R7994:Zfp157 UTSW 5 138455188 splice site probably null
R8057:Zfp157 UTSW 5 138456074 missense probably damaging 1.00
R8397:Zfp157 UTSW 5 138456256 missense probably damaging 1.00
Z1088:Zfp157 UTSW 5 138457199 missense probably damaging 0.98
Posted On2013-10-07