Incidental Mutation 'IGL01323:Tnfrsf22'
ID 74111
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnfrsf22
Ensembl Gene ENSMUSG00000010751
Gene Name tumor necrosis factor receptor superfamily, member 22
Synonyms C130035G06Rik, mDcTrailr2, Tnfrh2, 2810028K06Rik, SOBa
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL01323
Quality Score
Status
Chromosome 7
Chromosomal Location 143188543-143203398 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 143197111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 76 (P76L)
Ref Sequence ENSEMBL: ENSMUSP00000119297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075588] [ENSMUST00000084396] [ENSMUST00000146692]
AlphaFold Q9ER62
Predicted Effect probably damaging
Transcript: ENSMUST00000075588
AA Change: P76L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000075018
Gene: ENSMUSG00000010751
AA Change: P76L

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
transmembrane domain 177 196 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000084396
AA Change: P76L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000081432
Gene: ENSMUSG00000010751
AA Change: P76L

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000146692
AA Change: P76L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000119297
Gene: ENSMUSG00000010751
AA Change: P76L

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207189
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,713,415 (GRCm39) D1272G probably damaging Het
Ascl2 A G 7: 142,522,125 (GRCm39) S108P probably benign Het
B3gat1 T C 9: 26,667,206 (GRCm39) V146A possibly damaging Het
Barhl1 C T 2: 28,805,558 (GRCm39) S45N probably benign Het
Birc6 C T 17: 74,929,920 (GRCm39) A2370V probably damaging Het
C1qtnf7 A G 5: 43,766,602 (GRCm39) D67G possibly damaging Het
Cand2 A G 6: 115,762,086 (GRCm39) T171A probably benign Het
Ccdc77 T C 6: 120,311,757 (GRCm39) Q247R probably benign Het
Cenpp A T 13: 49,801,118 (GRCm39) V100D probably damaging Het
Cep135 A G 5: 76,739,612 (GRCm39) T3A probably benign Het
Eef2k T C 7: 120,484,038 (GRCm39) probably benign Het
Fga T C 3: 82,937,518 (GRCm39) S132P probably damaging Het
Gpr6 T A 10: 40,947,555 (GRCm39) N9I possibly damaging Het
Gvin2 A G 7: 105,546,009 (GRCm39) S2348P possibly damaging Het
Hacd3 A G 9: 64,905,587 (GRCm39) F184L probably damaging Het
Heatr1 T C 13: 12,413,819 (GRCm39) I132T possibly damaging Het
Igfbp7 A G 5: 77,499,884 (GRCm39) probably benign Het
Ighv8-6 T C 12: 115,129,477 (GRCm39) D93G possibly damaging Het
Izumo3 A G 4: 92,034,627 (GRCm39) probably benign Het
Jade2 T C 11: 51,716,165 (GRCm39) T347A possibly damaging Het
Kif18a A G 2: 109,128,787 (GRCm39) T419A probably benign Het
Krt34 A G 11: 99,929,606 (GRCm39) S267P possibly damaging Het
Krt4 T G 15: 101,828,716 (GRCm39) K383Q probably damaging Het
Lgals7 G T 7: 28,564,989 (GRCm39) E42D probably benign Het
Morc2b A G 17: 33,356,293 (GRCm39) V493A possibly damaging Het
Mtif2 T A 11: 29,491,447 (GRCm39) S557R probably damaging Het
Nup43 T A 10: 7,545,320 (GRCm39) F83I probably benign Het
Oosp2 A G 19: 11,624,825 (GRCm39) L155S probably damaging Het
Or1o1 G T 17: 37,717,031 (GRCm39) M197I probably benign Het
Plxnd1 T A 6: 115,943,760 (GRCm39) T1180S possibly damaging Het
Prpf39 T A 12: 65,089,498 (GRCm39) F79I possibly damaging Het
Prph G A 15: 98,956,517 (GRCm39) S465N possibly damaging Het
Purg A T 8: 33,876,631 (GRCm39) I90L probably damaging Het
Pxdn C A 12: 30,037,136 (GRCm39) Q305K probably benign Het
R3hdm1 G A 1: 128,144,280 (GRCm39) S816N probably benign Het
Src G A 2: 157,311,423 (GRCm39) G461R probably damaging Het
Tmem201 G A 4: 149,804,045 (GRCm39) probably benign Het
Triml1 T C 8: 43,591,600 (GRCm39) probably null Het
Upp1 A G 11: 9,086,100 (GRCm39) *312W probably null Het
Wdfy3 G T 5: 102,042,930 (GRCm39) S1940R probably damaging Het
Xpc T C 6: 91,469,335 (GRCm39) Y804C probably damaging Het
Xrn2 C T 2: 146,876,767 (GRCm39) probably benign Het
Zfp106 A T 2: 120,354,945 (GRCm39) D1275E possibly damaging Het
Other mutations in Tnfrsf22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01959:Tnfrsf22 APN 7 143,197,012 (GRCm39) critical splice donor site probably null
IGL02395:Tnfrsf22 APN 7 143,197,053 (GRCm39) missense probably damaging 1.00
IGL02608:Tnfrsf22 APN 7 143,198,533 (GRCm39) nonsense probably null
IGL03054:Tnfrsf22 UTSW 7 143,194,532 (GRCm39) missense probably damaging 1.00
R1987:Tnfrsf22 UTSW 7 143,192,126 (GRCm39) unclassified probably benign
R2228:Tnfrsf22 UTSW 7 143,198,513 (GRCm39) splice site probably null
R2229:Tnfrsf22 UTSW 7 143,198,513 (GRCm39) splice site probably null
R4562:Tnfrsf22 UTSW 7 143,203,313 (GRCm39) missense unknown
R4829:Tnfrsf22 UTSW 7 143,197,067 (GRCm39) missense possibly damaging 0.91
R6486:Tnfrsf22 UTSW 7 143,194,493 (GRCm39) missense possibly damaging 0.93
R6903:Tnfrsf22 UTSW 7 143,193,641 (GRCm39) unclassified probably benign
R7146:Tnfrsf22 UTSW 7 143,194,556 (GRCm39) missense probably damaging 1.00
R7406:Tnfrsf22 UTSW 7 143,194,564 (GRCm39) missense probably damaging 1.00
R8108:Tnfrsf22 UTSW 7 143,192,110 (GRCm39) missense unknown
R8969:Tnfrsf22 UTSW 7 143,192,173 (GRCm39) missense unknown
R9613:Tnfrsf22 UTSW 7 143,198,583 (GRCm39) missense probably benign 0.00
Posted On 2013-10-07