Incidental Mutation 'IGL01323:Cand2'
ID 74124
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cand2
Ensembl Gene ENSMUSG00000030319
Gene Name cullin associated and neddylation dissociated 2 (putative)
Synonyms Tp120b, 2210404G23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01323
Quality Score
Status
Chromosome 6
Chromosomal Location 115751518-115782516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115762086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 171 (T171A)
Ref Sequence ENSEMBL: ENSMUSP00000075377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075995]
AlphaFold Q6ZQ73
Predicted Effect probably benign
Transcript: ENSMUST00000075995
AA Change: T171A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075377
Gene: ENSMUSG00000030319
AA Change: T171A

DomainStartEndE-ValueType
low complexity region 325 347 N/A INTRINSIC
low complexity region 536 548 N/A INTRINSIC
low complexity region 553 562 N/A INTRINSIC
low complexity region 665 686 N/A INTRINSIC
low complexity region 736 748 N/A INTRINSIC
Pfam:HEAT 861 890 4.4e-5 PFAM
Pfam:TIP120 1044 1209 6e-64 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,713,415 (GRCm39) D1272G probably damaging Het
Ascl2 A G 7: 142,522,125 (GRCm39) S108P probably benign Het
B3gat1 T C 9: 26,667,206 (GRCm39) V146A possibly damaging Het
Barhl1 C T 2: 28,805,558 (GRCm39) S45N probably benign Het
Birc6 C T 17: 74,929,920 (GRCm39) A2370V probably damaging Het
C1qtnf7 A G 5: 43,766,602 (GRCm39) D67G possibly damaging Het
Ccdc77 T C 6: 120,311,757 (GRCm39) Q247R probably benign Het
Cenpp A T 13: 49,801,118 (GRCm39) V100D probably damaging Het
Cep135 A G 5: 76,739,612 (GRCm39) T3A probably benign Het
Eef2k T C 7: 120,484,038 (GRCm39) probably benign Het
Fga T C 3: 82,937,518 (GRCm39) S132P probably damaging Het
Gpr6 T A 10: 40,947,555 (GRCm39) N9I possibly damaging Het
Gvin2 A G 7: 105,546,009 (GRCm39) S2348P possibly damaging Het
Hacd3 A G 9: 64,905,587 (GRCm39) F184L probably damaging Het
Heatr1 T C 13: 12,413,819 (GRCm39) I132T possibly damaging Het
Igfbp7 A G 5: 77,499,884 (GRCm39) probably benign Het
Ighv8-6 T C 12: 115,129,477 (GRCm39) D93G possibly damaging Het
Izumo3 A G 4: 92,034,627 (GRCm39) probably benign Het
Jade2 T C 11: 51,716,165 (GRCm39) T347A possibly damaging Het
Kif18a A G 2: 109,128,787 (GRCm39) T419A probably benign Het
Krt34 A G 11: 99,929,606 (GRCm39) S267P possibly damaging Het
Krt4 T G 15: 101,828,716 (GRCm39) K383Q probably damaging Het
Lgals7 G T 7: 28,564,989 (GRCm39) E42D probably benign Het
Morc2b A G 17: 33,356,293 (GRCm39) V493A possibly damaging Het
Mtif2 T A 11: 29,491,447 (GRCm39) S557R probably damaging Het
Nup43 T A 10: 7,545,320 (GRCm39) F83I probably benign Het
Oosp2 A G 19: 11,624,825 (GRCm39) L155S probably damaging Het
Or1o1 G T 17: 37,717,031 (GRCm39) M197I probably benign Het
Plxnd1 T A 6: 115,943,760 (GRCm39) T1180S possibly damaging Het
Prpf39 T A 12: 65,089,498 (GRCm39) F79I possibly damaging Het
Prph G A 15: 98,956,517 (GRCm39) S465N possibly damaging Het
Purg A T 8: 33,876,631 (GRCm39) I90L probably damaging Het
Pxdn C A 12: 30,037,136 (GRCm39) Q305K probably benign Het
R3hdm1 G A 1: 128,144,280 (GRCm39) S816N probably benign Het
Src G A 2: 157,311,423 (GRCm39) G461R probably damaging Het
Tmem201 G A 4: 149,804,045 (GRCm39) probably benign Het
Tnfrsf22 G A 7: 143,197,111 (GRCm39) P76L probably damaging Het
Triml1 T C 8: 43,591,600 (GRCm39) probably null Het
Upp1 A G 11: 9,086,100 (GRCm39) *312W probably null Het
Wdfy3 G T 5: 102,042,930 (GRCm39) S1940R probably damaging Het
Xpc T C 6: 91,469,335 (GRCm39) Y804C probably damaging Het
Xrn2 C T 2: 146,876,767 (GRCm39) probably benign Het
Zfp106 A T 2: 120,354,945 (GRCm39) D1275E possibly damaging Het
Other mutations in Cand2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:Cand2 APN 6 115,759,755 (GRCm39) missense probably benign 0.43
IGL01777:Cand2 APN 6 115,769,818 (GRCm39) missense probably damaging 0.99
IGL02008:Cand2 APN 6 115,780,599 (GRCm39) missense probably damaging 1.00
IGL02185:Cand2 APN 6 115,766,471 (GRCm39) missense probably benign 0.01
IGL02219:Cand2 APN 6 115,780,773 (GRCm39) missense probably damaging 1.00
IGL02240:Cand2 APN 6 115,780,623 (GRCm39) missense probably damaging 1.00
IGL02329:Cand2 APN 6 115,766,568 (GRCm39) missense probably damaging 1.00
IGL02396:Cand2 APN 6 115,768,149 (GRCm39) splice site probably benign
IGL02893:Cand2 APN 6 115,768,921 (GRCm39) missense probably damaging 1.00
IGL03161:Cand2 APN 6 115,769,698 (GRCm39) missense probably benign 0.45
IGL03170:Cand2 APN 6 115,774,861 (GRCm39) missense probably damaging 1.00
IGL03257:Cand2 APN 6 115,776,944 (GRCm39) missense possibly damaging 0.80
succor UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R0196:Cand2 UTSW 6 115,766,463 (GRCm39) missense probably damaging 1.00
R0390:Cand2 UTSW 6 115,751,614 (GRCm39) missense possibly damaging 0.90
R0534:Cand2 UTSW 6 115,764,197 (GRCm39) missense probably damaging 0.96
R0630:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0631:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0662:Cand2 UTSW 6 115,764,171 (GRCm39) missense probably benign 0.00
R0671:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0708:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0849:Cand2 UTSW 6 115,769,352 (GRCm39) missense probably damaging 1.00
R1992:Cand2 UTSW 6 115,762,093 (GRCm39) missense possibly damaging 0.88
R3428:Cand2 UTSW 6 115,766,668 (GRCm39) missense probably benign
R3773:Cand2 UTSW 6 115,762,178 (GRCm39) missense probably damaging 0.96
R4329:Cand2 UTSW 6 115,776,949 (GRCm39) missense possibly damaging 0.64
R4489:Cand2 UTSW 6 115,766,427 (GRCm39) missense probably damaging 1.00
R4553:Cand2 UTSW 6 115,769,172 (GRCm39) missense probably damaging 1.00
R4577:Cand2 UTSW 6 115,768,220 (GRCm39) missense probably damaging 1.00
R4634:Cand2 UTSW 6 115,774,948 (GRCm39) missense probably damaging 1.00
R4850:Cand2 UTSW 6 115,778,909 (GRCm39) missense probably benign 0.14
R5155:Cand2 UTSW 6 115,769,219 (GRCm39) missense probably benign 0.42
R5190:Cand2 UTSW 6 115,766,474 (GRCm39) missense probably damaging 1.00
R5378:Cand2 UTSW 6 115,778,912 (GRCm39) missense probably benign 0.00
R5407:Cand2 UTSW 6 115,762,161 (GRCm39) missense possibly damaging 0.76
R5698:Cand2 UTSW 6 115,768,704 (GRCm39) missense probably damaging 1.00
R5701:Cand2 UTSW 6 115,774,893 (GRCm39) missense probably damaging 0.99
R6172:Cand2 UTSW 6 115,768,271 (GRCm39) missense probably benign 0.00
R6763:Cand2 UTSW 6 115,776,930 (GRCm39) missense probably benign 0.00
R6920:Cand2 UTSW 6 115,768,250 (GRCm39) missense possibly damaging 0.93
R7229:Cand2 UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R7520:Cand2 UTSW 6 115,762,212 (GRCm39) nonsense probably null
R8183:Cand2 UTSW 6 115,768,879 (GRCm39) missense probably benign 0.14
R8698:Cand2 UTSW 6 115,763,852 (GRCm39) missense probably damaging 1.00
R8755:Cand2 UTSW 6 115,769,941 (GRCm39) missense probably damaging 1.00
R8795:Cand2 UTSW 6 115,763,889 (GRCm39) missense probably benign 0.01
R8900:Cand2 UTSW 6 115,757,894 (GRCm39) missense probably benign 0.00
R9072:Cand2 UTSW 6 115,769,490 (GRCm39) missense probably damaging 0.99
R9242:Cand2 UTSW 6 115,768,923 (GRCm39) missense probably benign 0.27
R9262:Cand2 UTSW 6 115,759,730 (GRCm39) missense probably benign 0.27
R9547:Cand2 UTSW 6 115,759,757 (GRCm39) missense probably benign 0.00
R9676:Cand2 UTSW 6 115,769,122 (GRCm39) missense probably benign 0.26
Posted On 2013-10-07