Incidental Mutation 'IGL01323:Lgals7'
ID 74136
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lgals7
Ensembl Gene ENSMUSG00000053522
Gene Name lectin, galactose binding, soluble 7
Synonyms Galectin-7, Pig1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # IGL01323
Quality Score
Status
Chromosome 7
Chromosomal Location 28563278-28565709 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 28564989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 42 (E42D)
Ref Sequence ENSEMBL: ENSMUSP00000123110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081457] [ENSMUST00000138272]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000081457
AA Change: E42D

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000080179
Gene: ENSMUSG00000053522
AA Change: E42D

DomainStartEndE-ValueType
GLECT 4 136 3.91e-48 SMART
Gal-bind_lectin 10 135 1.68e-53 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128001
Predicted Effect probably benign
Transcript: ENSMUST00000138272
AA Change: E42D

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000123110
Gene: ENSMUSG00000053522
AA Change: E42D

DomainStartEndE-ValueType
GLECT 4 86 1.92e-6 SMART
Gal-bind_lectin 10 86 7.37e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207552
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,713,415 (GRCm39) D1272G probably damaging Het
Ascl2 A G 7: 142,522,125 (GRCm39) S108P probably benign Het
B3gat1 T C 9: 26,667,206 (GRCm39) V146A possibly damaging Het
Barhl1 C T 2: 28,805,558 (GRCm39) S45N probably benign Het
Birc6 C T 17: 74,929,920 (GRCm39) A2370V probably damaging Het
C1qtnf7 A G 5: 43,766,602 (GRCm39) D67G possibly damaging Het
Cand2 A G 6: 115,762,086 (GRCm39) T171A probably benign Het
Ccdc77 T C 6: 120,311,757 (GRCm39) Q247R probably benign Het
Cenpp A T 13: 49,801,118 (GRCm39) V100D probably damaging Het
Cep135 A G 5: 76,739,612 (GRCm39) T3A probably benign Het
Eef2k T C 7: 120,484,038 (GRCm39) probably benign Het
Fga T C 3: 82,937,518 (GRCm39) S132P probably damaging Het
Gpr6 T A 10: 40,947,555 (GRCm39) N9I possibly damaging Het
Gvin2 A G 7: 105,546,009 (GRCm39) S2348P possibly damaging Het
Hacd3 A G 9: 64,905,587 (GRCm39) F184L probably damaging Het
Heatr1 T C 13: 12,413,819 (GRCm39) I132T possibly damaging Het
Igfbp7 A G 5: 77,499,884 (GRCm39) probably benign Het
Ighv8-6 T C 12: 115,129,477 (GRCm39) D93G possibly damaging Het
Izumo3 A G 4: 92,034,627 (GRCm39) probably benign Het
Jade2 T C 11: 51,716,165 (GRCm39) T347A possibly damaging Het
Kif18a A G 2: 109,128,787 (GRCm39) T419A probably benign Het
Krt34 A G 11: 99,929,606 (GRCm39) S267P possibly damaging Het
Krt4 T G 15: 101,828,716 (GRCm39) K383Q probably damaging Het
Morc2b A G 17: 33,356,293 (GRCm39) V493A possibly damaging Het
Mtif2 T A 11: 29,491,447 (GRCm39) S557R probably damaging Het
Nup43 T A 10: 7,545,320 (GRCm39) F83I probably benign Het
Oosp2 A G 19: 11,624,825 (GRCm39) L155S probably damaging Het
Or1o1 G T 17: 37,717,031 (GRCm39) M197I probably benign Het
Plxnd1 T A 6: 115,943,760 (GRCm39) T1180S possibly damaging Het
Prpf39 T A 12: 65,089,498 (GRCm39) F79I possibly damaging Het
Prph G A 15: 98,956,517 (GRCm39) S465N possibly damaging Het
Purg A T 8: 33,876,631 (GRCm39) I90L probably damaging Het
Pxdn C A 12: 30,037,136 (GRCm39) Q305K probably benign Het
R3hdm1 G A 1: 128,144,280 (GRCm39) S816N probably benign Het
Src G A 2: 157,311,423 (GRCm39) G461R probably damaging Het
Tmem201 G A 4: 149,804,045 (GRCm39) probably benign Het
Tnfrsf22 G A 7: 143,197,111 (GRCm39) P76L probably damaging Het
Triml1 T C 8: 43,591,600 (GRCm39) probably null Het
Upp1 A G 11: 9,086,100 (GRCm39) *312W probably null Het
Wdfy3 G T 5: 102,042,930 (GRCm39) S1940R probably damaging Het
Xpc T C 6: 91,469,335 (GRCm39) Y804C probably damaging Het
Xrn2 C T 2: 146,876,767 (GRCm39) probably benign Het
Zfp106 A T 2: 120,354,945 (GRCm39) D1275E possibly damaging Het
Other mutations in Lgals7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01673:Lgals7 APN 7 28,565,621 (GRCm39) unclassified probably benign
IGL02054:Lgals7 APN 7 28,565,614 (GRCm39) missense probably damaging 1.00
IGL02331:Lgals7 APN 7 28,565,143 (GRCm39) missense probably benign 0.36
R6833:Lgals7 UTSW 7 28,565,087 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07