Incidental Mutation 'IGL01323:Izumo3'
ID74148
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Izumo3
Ensembl Gene ENSMUSG00000028533
Gene NameIZUMO family member 3
Synonyms1700011H22Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01323
Quality Score
Status
Chromosome4
Chromosomal Location92144329-92147234 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 92146390 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121187 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107108] [ENSMUST00000143542]
Predicted Effect probably benign
Transcript: ENSMUST00000107108
SMART Domains Protein: ENSMUSP00000102725
Gene: ENSMUSG00000028533

DomainStartEndE-ValueType
low complexity region 7 17 N/A INTRINSIC
Pfam:IZUMO 22 165 6.7e-44 PFAM
transmembrane domain 179 201 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143542
SMART Domains Protein: ENSMUSP00000121187
Gene: ENSMUSG00000028533

DomainStartEndE-ValueType
Pfam:IZUMO 3 95 4.2e-27 PFAM
transmembrane domain 109 131 N/A INTRINSIC
low complexity region 144 157 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,871,495 D1272G probably damaging Het
Ascl2 A G 7: 142,968,388 S108P probably benign Het
B3gat1 T C 9: 26,755,910 V146A possibly damaging Het
Barhl1 C T 2: 28,915,546 S45N probably benign Het
Birc6 C T 17: 74,622,925 A2370V probably damaging Het
C1qtnf7 A G 5: 43,609,260 D67G possibly damaging Het
Cand2 A G 6: 115,785,125 T171A probably benign Het
Ccdc77 T C 6: 120,334,796 Q247R probably benign Het
Cenpp A T 13: 49,647,642 V100D probably damaging Het
Cep135 A G 5: 76,591,765 T3A probably benign Het
Eef2k T C 7: 120,884,815 probably benign Het
Fga T C 3: 83,030,211 S132P probably damaging Het
Gm4070 A G 7: 105,896,802 S2348P possibly damaging Het
Gpr6 T A 10: 41,071,559 N9I possibly damaging Het
Hacd3 A G 9: 64,998,305 F184L probably damaging Het
Heatr1 T C 13: 12,398,938 I132T possibly damaging Het
Igfbp7 A G 5: 77,352,037 probably benign Het
Ighv8-6 T C 12: 115,165,857 D93G possibly damaging Het
Jade2 T C 11: 51,825,338 T347A possibly damaging Het
Kif18a A G 2: 109,298,442 T419A probably benign Het
Krt34 A G 11: 100,038,780 S267P possibly damaging Het
Krt4 T G 15: 101,920,281 K383Q probably damaging Het
Lgals7 G T 7: 28,865,564 E42D probably benign Het
Morc2b A G 17: 33,137,319 V493A possibly damaging Het
Mtif2 T A 11: 29,541,447 S557R probably damaging Het
Nup43 T A 10: 7,669,556 F83I probably benign Het
Olfr107 G T 17: 37,406,140 M197I probably benign Het
Oosp2 A G 19: 11,647,461 L155S probably damaging Het
Plxnd1 T A 6: 115,966,799 T1180S possibly damaging Het
Prpf39 T A 12: 65,042,724 F79I possibly damaging Het
Prph G A 15: 99,058,636 S465N possibly damaging Het
Purg A T 8: 33,386,603 I90L probably damaging Het
Pxdn C A 12: 29,987,137 Q305K probably benign Het
R3hdm1 G A 1: 128,216,543 S816N probably benign Het
Src G A 2: 157,469,503 G461R probably damaging Het
Tmem201 G A 4: 149,719,588 probably benign Het
Tnfrsf22 G A 7: 143,643,374 P76L probably damaging Het
Triml1 T C 8: 43,138,563 probably null Het
Upp1 A G 11: 9,136,100 *312W probably null Het
Wdfy3 G T 5: 101,895,064 S1940R probably damaging Het
Xpc T C 6: 91,492,353 Y804C probably damaging Het
Xrn2 C T 2: 147,034,847 probably benign Het
Zfp106 A T 2: 120,524,464 D1275E possibly damaging Het
Other mutations in Izumo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Izumo3 APN 4 92146980 intron probably benign
IGL01586:Izumo3 APN 4 92146295 critical splice donor site probably null
IGL02794:Izumo3 APN 4 92146963 missense probably benign
IGL03146:Izumo3 APN 4 92145039 missense probably damaging 0.97
IGL03180:Izumo3 APN 4 92146287 splice site probably benign
R0053:Izumo3 UTSW 4 92145030 missense probably damaging 0.99
R0137:Izumo3 UTSW 4 92147200 splice site probably benign
R1222:Izumo3 UTSW 4 92145047 missense probably damaging 1.00
R1558:Izumo3 UTSW 4 92146903 missense probably damaging 1.00
R1605:Izumo3 UTSW 4 92144740 missense probably damaging 0.99
R4413:Izumo3 UTSW 4 92146899 missense probably damaging 1.00
R4834:Izumo3 UTSW 4 92146971 missense possibly damaging 0.95
R5362:Izumo3 UTSW 4 92146800 missense possibly damaging 0.87
R7348:Izumo3 UTSW 4 92147218 missense possibly damaging 0.71
R7783:Izumo3 UTSW 4 92145023 missense probably damaging 0.98
R8104:Izumo3 UTSW 4 92146908 nonsense probably null
Z1088:Izumo3 UTSW 4 92146933 missense probably damaging 0.98
Posted On2013-10-07