Incidental Mutation 'IGL01323:Triml1'
ID 74149
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Triml1
Ensembl Gene ENSMUSG00000031651
Gene Name tripartite motif family-like 1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # IGL01323
Quality Score
Chromosome 8
Chromosomal Location 43129807-43141486 bp(-) (GRCm38)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to C at 43138563 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000050267 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059692]
AlphaFold Q8BVP1
Predicted Effect probably null
Transcript: ENSMUST00000059692
SMART Domains Protein: ENSMUSP00000050267
Gene: ENSMUSG00000031651

RING 22 62 1.14e-8 SMART
coiled coil region 196 235 N/A INTRINSIC
PRY 291 343 4.64e-23 SMART
Pfam:SPRY 346 462 6.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211446
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211541
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef2 A G 2: 166,871,495 (GRCm38) D1272G probably damaging Het
Ascl2 A G 7: 142,968,388 (GRCm38) S108P probably benign Het
B3gat1 T C 9: 26,755,910 (GRCm38) V146A possibly damaging Het
Barhl1 C T 2: 28,915,546 (GRCm38) S45N probably benign Het
Birc6 C T 17: 74,622,925 (GRCm38) A2370V probably damaging Het
C1qtnf7 A G 5: 43,609,260 (GRCm38) D67G possibly damaging Het
Cand2 A G 6: 115,785,125 (GRCm38) T171A probably benign Het
Ccdc77 T C 6: 120,334,796 (GRCm38) Q247R probably benign Het
Cenpp A T 13: 49,647,642 (GRCm38) V100D probably damaging Het
Cep135 A G 5: 76,591,765 (GRCm38) T3A probably benign Het
Eef2k T C 7: 120,884,815 (GRCm38) probably benign Het
Fga T C 3: 83,030,211 (GRCm38) S132P probably damaging Het
Gpr6 T A 10: 41,071,559 (GRCm38) N9I possibly damaging Het
Gvin2 A G 7: 105,896,802 (GRCm38) S2348P possibly damaging Het
Hacd3 A G 9: 64,998,305 (GRCm38) F184L probably damaging Het
Heatr1 T C 13: 12,398,938 (GRCm38) I132T possibly damaging Het
Igfbp7 A G 5: 77,352,037 (GRCm38) probably benign Het
Ighv8-6 T C 12: 115,165,857 (GRCm38) D93G possibly damaging Het
Izumo3 A G 4: 92,146,390 (GRCm38) probably benign Het
Jade2 T C 11: 51,825,338 (GRCm38) T347A possibly damaging Het
Kif18a A G 2: 109,298,442 (GRCm38) T419A probably benign Het
Krt34 A G 11: 100,038,780 (GRCm38) S267P possibly damaging Het
Krt4 T G 15: 101,920,281 (GRCm38) K383Q probably damaging Het
Lgals7 G T 7: 28,865,564 (GRCm38) E42D probably benign Het
Morc2b A G 17: 33,137,319 (GRCm38) V493A possibly damaging Het
Mtif2 T A 11: 29,541,447 (GRCm38) S557R probably damaging Het
Nup43 T A 10: 7,669,556 (GRCm38) F83I probably benign Het
Oosp2 A G 19: 11,647,461 (GRCm38) L155S probably damaging Het
Or1o1 G T 17: 37,406,140 (GRCm38) M197I probably benign Het
Plxnd1 T A 6: 115,966,799 (GRCm38) T1180S possibly damaging Het
Prpf39 T A 12: 65,042,724 (GRCm38) F79I possibly damaging Het
Prph G A 15: 99,058,636 (GRCm38) S465N possibly damaging Het
Purg A T 8: 33,386,603 (GRCm38) I90L probably damaging Het
Pxdn C A 12: 29,987,137 (GRCm38) Q305K probably benign Het
R3hdm1 G A 1: 128,216,543 (GRCm38) S816N probably benign Het
Src G A 2: 157,469,503 (GRCm38) G461R probably damaging Het
Tmem201 G A 4: 149,719,588 (GRCm38) probably benign Het
Tnfrsf22 G A 7: 143,643,374 (GRCm38) P76L probably damaging Het
Upp1 A G 11: 9,136,100 (GRCm38) *312W probably null Het
Wdfy3 G T 5: 101,895,064 (GRCm38) S1940R probably damaging Het
Xpc T C 6: 91,492,353 (GRCm38) Y804C probably damaging Het
Xrn2 C T 2: 147,034,847 (GRCm38) probably benign Het
Zfp106 A T 2: 120,524,464 (GRCm38) D1275E possibly damaging Het
Other mutations in Triml1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00768:Triml1 APN 8 43,140,961 (GRCm38) splice site probably benign
IGL00920:Triml1 APN 8 43,138,682 (GRCm38) missense probably damaging 1.00
IGL01319:Triml1 APN 8 43,141,397 (GRCm38) utr 5 prime probably benign
IGL01998:Triml1 APN 8 43,141,313 (GRCm38) missense probably damaging 1.00
IGL02394:Triml1 APN 8 43,138,592 (GRCm38) missense possibly damaging 0.57
R0359:Triml1 UTSW 8 43,130,505 (GRCm38) missense probably damaging 1.00
R0400:Triml1 UTSW 8 43,141,040 (GRCm38) missense probably benign 0.03
R1799:Triml1 UTSW 8 43,130,475 (GRCm38) missense probably damaging 1.00
R2008:Triml1 UTSW 8 43,130,605 (GRCm38) missense probably damaging 0.97
R2363:Triml1 UTSW 8 43,141,371 (GRCm38) missense probably damaging 0.99
R2405:Triml1 UTSW 8 43,130,283 (GRCm38) missense probably damaging 1.00
R5333:Triml1 UTSW 8 43,130,290 (GRCm38) missense possibly damaging 0.82
R6093:Triml1 UTSW 8 43,140,718 (GRCm38) missense probably benign 0.04
R6244:Triml1 UTSW 8 43,138,756 (GRCm38) nonsense probably null
R6808:Triml1 UTSW 8 43,141,221 (GRCm38) missense probably damaging 0.99
R6860:Triml1 UTSW 8 43,130,566 (GRCm38) missense probably damaging 1.00
R7231:Triml1 UTSW 8 43,136,371 (GRCm38) missense probably benign
R7826:Triml1 UTSW 8 43,138,766 (GRCm38) missense possibly damaging 0.95
R8054:Triml1 UTSW 8 43,130,383 (GRCm38) missense probably damaging 0.99
R8100:Triml1 UTSW 8 43,138,680 (GRCm38) missense probably benign
R8234:Triml1 UTSW 8 43,141,248 (GRCm38) missense probably benign 0.25
R9135:Triml1 UTSW 8 43,130,587 (GRCm38) missense probably damaging 1.00
Z1088:Triml1 UTSW 8 43,130,398 (GRCm38) missense probably damaging 1.00
Z1177:Triml1 UTSW 8 43,140,705 (GRCm38) missense possibly damaging 0.73
Posted On 2013-10-07