Incidental Mutation 'IGL01329:Iqcf4'
ID74427
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iqcf4
Ensembl Gene ENSMUSG00000041009
Gene NameIQ motif containing F4
Synonyms1700042N06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL01329
Quality Score
Status
Chromosome9
Chromosomal Location106568319-106570996 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 106570633 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 26 (K26E)
Ref Sequence ENSEMBL: ENSMUSP00000082192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085111]
Predicted Effect probably benign
Transcript: ENSMUST00000085111
AA Change: K26E

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000082192
Gene: ENSMUSG00000041009
AA Change: K26E

DomainStartEndE-ValueType
coiled coil region 14 41 N/A INTRINSIC
IQ 66 88 2.72e-3 SMART
IQ 89 111 2.32e2 SMART
IQ 122 144 9.33e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700028P14Rik A G 19: 23,652,736 probably benign Het
Abcb4 T C 5: 8,894,166 probably null Het
Ankib1 A T 5: 3,734,194 probably benign Het
Birc3 T C 9: 7,860,732 Y195C probably damaging Het
Cand2 T C 6: 115,782,794 I142T probably benign Het
Cd163l1 T A 7: 140,224,639 probably null Het
Cdh15 T C 8: 122,865,323 probably benign Het
Ceacam5 G A 7: 17,745,609 G217D probably damaging Het
Cfap54 T A 10: 93,081,523 H25L unknown Het
Col22a1 A G 15: 71,907,040 V266A probably benign Het
D3Ertd751e A G 3: 41,748,697 D69G probably benign Het
Dnah3 T C 7: 120,022,941 I1518V probably damaging Het
Entpd8 A G 2: 25,084,346 K381R probably benign Het
Fli1 T A 9: 32,424,101 K345I probably damaging Het
G6pd2 T C 5: 61,809,938 V352A probably damaging Het
Gbp11 C T 5: 105,327,616 probably null Het
Gm11992 A G 11: 9,068,383 *292W probably null Het
Ifnar2 T A 16: 91,391,711 probably benign Het
Impg1 T C 9: 80,322,829 K661R probably benign Het
Inf2 G T 12: 112,611,856 E651* probably null Het
Ints1 A G 5: 139,767,503 probably benign Het
Map4k3 A G 17: 80,644,184 V289A probably benign Het
Mis18bp1 T C 12: 65,158,441 K319R possibly damaging Het
Nubpl T C 12: 52,305,855 V291A probably damaging Het
Olfr1085 T C 2: 86,658,207 N84D probably benign Het
Olfr1305 A G 2: 111,872,950 F302L probably benign Het
Olfr726 C T 14: 50,083,997 R228H probably benign Het
Olfr983 A G 9: 40,092,028 S313P possibly damaging Het
Otof A G 5: 30,441,379 S29P probably benign Het
Pcca A G 14: 122,690,133 D436G possibly damaging Het
Rasef T A 4: 73,727,645 T496S probably damaging Het
Saa2 A G 7: 46,753,472 D49G probably benign Het
Scn2a A G 2: 65,717,508 I1015V probably benign Het
Sim2 T C 16: 94,106,260 Y154H possibly damaging Het
Spag17 A G 3: 100,095,549 H1863R probably benign Het
Supt16 C T 14: 52,177,032 E438K probably benign Het
Svil A G 18: 5,064,501 E1111G probably benign Het
Trabd2b T C 4: 114,409,125 V112A probably damaging Het
Vmn1r205 T C 13: 22,592,103 I276M probably benign Het
Vps13d A T 4: 145,156,206 I939N possibly damaging Het
Zc3h11a T C 1: 133,625,862 M515V probably benign Het
Zfp457 T C 13: 67,294,266 T82A possibly damaging Het
Other mutations in Iqcf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0781:Iqcf4 UTSW 9 106568661 missense probably benign 0.06
R1764:Iqcf4 UTSW 9 106568694 missense probably benign 0.12
R4525:Iqcf4 UTSW 9 106570628 missense possibly damaging 0.51
R4703:Iqcf4 UTSW 9 106568320 splice site probably null
R5823:Iqcf4 UTSW 9 106568601 missense probably benign 0.00
R6298:Iqcf4 UTSW 9 106568675 missense probably benign 0.25
R7773:Iqcf4 UTSW 9 106568613 missense probably benign 0.08
R7780:Iqcf4 UTSW 9 106568661 missense possibly damaging 0.93
R7818:Iqcf4 UTSW 9 106570539 nonsense probably null
RF003:Iqcf4 UTSW 9 106570607 small insertion probably benign
RF007:Iqcf4 UTSW 9 106570609 small insertion probably benign
RF016:Iqcf4 UTSW 9 106570609 small insertion probably benign
RF028:Iqcf4 UTSW 9 106570614 small insertion probably benign
RF031:Iqcf4 UTSW 9 106570615 small insertion probably benign
RF036:Iqcf4 UTSW 9 106570611 small insertion probably benign
RF041:Iqcf4 UTSW 9 106570613 nonsense probably null
RF042:Iqcf4 UTSW 9 106570605 small insertion probably benign
RF043:Iqcf4 UTSW 9 106570613 small insertion probably benign
RF045:Iqcf4 UTSW 9 106570610 small insertion probably benign
RF046:Iqcf4 UTSW 9 106570610 small insertion probably benign
RF047:Iqcf4 UTSW 9 106570612 small insertion probably benign
RF063:Iqcf4 UTSW 9 106570617 small insertion probably benign
Posted On2013-10-07