Incidental Mutation 'IGL01330:Fut9'
ID 74462
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fut9
Ensembl Gene ENSMUSG00000055373
Gene Name fucosyltransferase 9
Synonyms mFuc-TIX, mFUT9
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01330
Quality Score
Chromosome 4
Chromosomal Location 25609332-25800244 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25619791 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 341 (V341A)
Ref Sequence ENSEMBL: ENSMUSP00000103834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084770] [ENSMUST00000108199]
AlphaFold O88819
Predicted Effect possibly damaging
Transcript: ENSMUST00000084770
AA Change: V341A

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000081826
Gene: ENSMUSG00000055373
AA Change: V341A

Pfam:Glyco_transf_10 6 358 2.9e-140 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000108199
AA Change: V341A

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000103834
Gene: ENSMUSG00000055373
AA Change: V341A

transmembrane domain 7 29 N/A INTRINSIC
Pfam:Glyco_tran_10_N 61 169 1.4e-43 PFAM
Pfam:Glyco_transf_10 185 357 4.8e-69 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased number of neuronal stem cells with increased self-renewal capacity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf A G 19: 31,920,951 (GRCm38) E245G possibly damaging Het
Acap2 T C 16: 31,154,677 (GRCm38) I43V probably damaging Het
Acot11 T C 4: 106,771,484 (GRCm38) T36A probably benign Het
Bsn A G 9: 108,110,913 (GRCm38) probably benign Het
Capza2 T C 6: 17,654,171 (GRCm38) probably null Het
Cerkl A G 2: 79,368,781 (GRCm38) I155T possibly damaging Het
Dclre1b T C 3: 103,803,126 (GRCm38) T490A probably benign Het
Efcab6 G A 15: 84,044,300 (GRCm38) S31L probably benign Het
Faim T A 9: 98,992,535 (GRCm38) M67K probably damaging Het
Frem2 T G 3: 53,655,241 (GRCm38) Q615P possibly damaging Het
Grhpr T C 4: 44,986,375 (GRCm38) F142L probably benign Het
Kif14 T C 1: 136,476,374 (GRCm38) V532A probably damaging Het
Klk1b9 T A 7: 43,978,443 (GRCm38) L55* probably null Het
Kmt2e C A 5: 23,497,948 (GRCm38) P1042Q possibly damaging Het
Mpped1 T A 15: 83,800,119 (GRCm38) I114N probably damaging Het
Mtap C A 4: 89,171,223 (GRCm38) T148K probably damaging Het
Muc16 G A 9: 18,508,507 (GRCm38) A8347V possibly damaging Het
Nhs A T X: 161,841,453 (GRCm38) S967T probably damaging Het
Npas3 A G 12: 54,048,819 (GRCm38) Y344C probably damaging Het
Olfr1431 T C 19: 12,210,040 (GRCm38) V158A possibly damaging Het
Olfr635 A T 7: 103,980,142 (GRCm38) probably benign Het
Olfr876 T A 9: 37,804,220 (GRCm38) F103Y probably damaging Het
Osmr A G 15: 6,842,028 (GRCm38) Y303H probably damaging Het
Pcdhb8 A T 18: 37,357,578 (GRCm38) I770F probably benign Het
Pde4a C T 9: 21,192,438 (GRCm38) probably benign Het
Prkacb T G 3: 146,751,511 (GRCm38) N79T probably damaging Het
Psd3 A C 8: 67,697,178 (GRCm38) Y1222D probably damaging Het
Rrbp1 T A 2: 143,968,618 (GRCm38) E847D possibly damaging Het
Sbno1 A T 5: 124,391,979 (GRCm38) D912E probably damaging Het
Sgsm3 T A 15: 81,010,852 (GRCm38) probably benign Het
Shcbp1 T C 8: 4,736,372 (GRCm38) T577A probably benign Het
Siglec1 A T 2: 131,083,536 (GRCm38) V335D probably damaging Het
Siglec1 A T 2: 131,075,005 (GRCm38) L1110* probably null Het
Slc4a11 A G 2: 130,687,682 (GRCm38) I335T probably benign Het
Smchd1 A C 17: 71,436,788 (GRCm38) S461A probably benign Het
Spata16 C T 3: 26,914,715 (GRCm38) P415S probably damaging Het
Tdrd12 G A 7: 35,505,034 (GRCm38) S217L possibly damaging Het
Tmem156 C T 5: 65,080,182 (GRCm38) R45H probably benign Het
Vmn2r90 T C 17: 17,733,280 (GRCm38) S569P probably benign Het
Vps13c T A 9: 67,964,108 (GRCm38) V3220E probably damaging Het
Wdr59 T C 8: 111,481,933 (GRCm38) N439S possibly damaging Het
Zfp568 A G 7: 30,022,277 (GRCm38) M215V probably benign Het
Zgrf1 T A 3: 127,584,007 (GRCm38) V967E probably damaging Het
Zkscan16 A G 4: 58,956,483 (GRCm38) D255G possibly damaging Het
Other mutations in Fut9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00919:Fut9 APN 4 25,620,316 (GRCm38) missense possibly damaging 0.71
IGL01134:Fut9 APN 4 25,620,446 (GRCm38) missense probably benign 0.13
IGL01732:Fut9 APN 4 25,619,867 (GRCm38) missense possibly damaging 0.58
IGL02824:Fut9 APN 4 25,620,037 (GRCm38) missense probably damaging 1.00
ANU74:Fut9 UTSW 4 25,620,802 (GRCm38) missense probably benign 0.25
R0280:Fut9 UTSW 4 25,619,852 (GRCm38) missense probably benign 0.00
R0408:Fut9 UTSW 4 25,620,319 (GRCm38) missense possibly damaging 0.69
R0594:Fut9 UTSW 4 25,620,526 (GRCm38) missense possibly damaging 0.94
R0609:Fut9 UTSW 4 25,620,811 (GRCm38) start codon destroyed probably null 0.98
R0709:Fut9 UTSW 4 25,620,359 (GRCm38) missense probably damaging 1.00
R1567:Fut9 UTSW 4 25,620,344 (GRCm38) missense probably damaging 0.99
R1719:Fut9 UTSW 4 25,619,744 (GRCm38) missense possibly damaging 0.62
R1856:Fut9 UTSW 4 25,620,352 (GRCm38) missense probably damaging 1.00
R2036:Fut9 UTSW 4 25,620,322 (GRCm38) missense probably damaging 1.00
R2165:Fut9 UTSW 4 25,619,734 (GRCm38) makesense probably null
R2165:Fut9 UTSW 4 25,619,733 (GRCm38) makesense probably null
R2332:Fut9 UTSW 4 25,619,823 (GRCm38) nonsense probably null
R4539:Fut9 UTSW 4 25,619,793 (GRCm38) missense probably damaging 1.00
R4722:Fut9 UTSW 4 25,799,734 (GRCm38) utr 5 prime probably benign
R4766:Fut9 UTSW 4 25,799,191 (GRCm38) intron probably benign
R4937:Fut9 UTSW 4 25,799,591 (GRCm38) splice site probably benign
R5025:Fut9 UTSW 4 25,620,502 (GRCm38) missense probably damaging 1.00
R5032:Fut9 UTSW 4 25,799,245 (GRCm38) intron probably benign
R5158:Fut9 UTSW 4 25,620,731 (GRCm38) missense probably benign 0.01
R5601:Fut9 UTSW 4 25,620,299 (GRCm38) missense probably benign 0.00
R5974:Fut9 UTSW 4 25,620,090 (GRCm38) nonsense probably null
R6315:Fut9 UTSW 4 25,619,774 (GRCm38) missense probably damaging 1.00
R6385:Fut9 UTSW 4 25,620,328 (GRCm38) missense probably damaging 1.00
R6652:Fut9 UTSW 4 25,620,619 (GRCm38) missense probably benign 0.44
R6809:Fut9 UTSW 4 25,620,647 (GRCm38) missense probably benign
R6825:Fut9 UTSW 4 25,619,925 (GRCm38) missense probably benign
R7145:Fut9 UTSW 4 25,620,507 (GRCm38) missense probably damaging 0.96
R7573:Fut9 UTSW 4 25,620,691 (GRCm38) missense probably benign 0.04
R8933:Fut9 UTSW 4 25,619,861 (GRCm38) missense probably damaging 1.00
R9715:Fut9 UTSW 4 25,620,679 (GRCm38) missense probably benign 0.00
X0057:Fut9 UTSW 4 25,799,686 (GRCm38) start gained probably benign
Posted On 2013-10-07