Incidental Mutation 'IGL01331:Clec4g'
ID74529
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clec4g
Ensembl Gene ENSMUSG00000074491
Gene NameC-type lectin domain family 4, member g
Synonyms4930572L20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #IGL01331
Quality Score
Status
Chromosome8
Chromosomal Location3707064-3720651 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 3717190 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]
Predicted Effect probably benign
Transcript: ENSMUST00000058040
Predicted Effect probably benign
Transcript: ENSMUST00000062037
SMART Domains Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
coiled coil region 98 153 N/A INTRINSIC
CLECT 165 288 8.85e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159612
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160490
Predicted Effect probably benign
Transcript: ENSMUST00000160527
SMART Domains Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
CLECT 2 97 7.75e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clca3a1 G A 3: 144,747,512 T517M probably damaging Het
Cmya5 C T 13: 93,096,946 E545K possibly damaging Het
Cntn6 A T 6: 104,774,523 D380V probably damaging Het
Col9a2 C T 4: 121,045,192 P209S possibly damaging Het
Cyp2b9 T C 7: 26,187,715 V183A probably damaging Het
Dpt T C 1: 164,796,810 Y27H unknown Het
Dusp16 T C 6: 134,718,104 Q588R possibly damaging Het
Dusp27 C A 1: 166,108,180 V150L probably damaging Het
Emg1 A G 6: 124,705,070 S164P probably benign Het
Foxk1 G A 5: 142,453,589 R428Q probably damaging Het
Frmd4a T A 2: 4,602,225 M667K probably benign Het
Gpr55 T A 1: 85,941,193 probably benign Het
Gtpbp8 A G 16: 44,740,131 I162T probably benign Het
Ighv1-59 C T 12: 115,335,372 V21I possibly damaging Het
Ipo11 T A 13: 106,795,746 Y938F possibly damaging Het
Map4 G T 9: 110,034,801 V365L probably benign Het
Mboat1 C A 13: 30,219,701 probably benign Het
Med12 A G X: 101,280,754 E649G possibly damaging Het
Nfkbie T C 17: 45,558,569 V150A probably benign Het
Olfr1054 A C 2: 86,332,704 Y217* probably null Het
Olfr632 A G 7: 103,937,575 Y65C possibly damaging Het
Prdm1 T A 10: 44,441,974 K299N possibly damaging Het
Ribc1 T C X: 152,005,106 T291A probably benign Het
Rps6kc1 G T 1: 190,800,352 N484K possibly damaging Het
Serpina3k C A 12: 104,343,110 A271D probably benign Het
Spata18 G T 5: 73,669,681 R321L probably damaging Het
Syne2 C A 12: 75,929,253 probably benign Het
Syt17 T A 7: 118,408,166 I302F probably damaging Het
Tgm6 A G 2: 130,143,618 probably null Het
Tmc2 A G 2: 130,232,356 Y323C probably damaging Het
Tnc T C 4: 63,982,875 D1452G probably damaging Het
Ttn A G 2: 76,789,678 I7555T probably damaging Het
Ugt2b36 A T 5: 87,090,942 W131R probably damaging Het
Vmn2r75 A T 7: 86,171,662 C21* probably null Het
Zfp592 T A 7: 81,041,548 C1158* probably null Het
Other mutations in Clec4g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Clec4g APN 8 3716410 intron probably benign
IGL01090:Clec4g APN 8 3719482 missense probably damaging 1.00
IGL01593:Clec4g APN 8 3719474 critical splice donor site probably null
IGL02942:Clec4g APN 8 3718356 missense probably damaging 0.96
IGL03176:Clec4g APN 8 3718441 missense possibly damaging 0.90
R0071:Clec4g UTSW 8 3717489 start gained probably benign
R0379:Clec4g UTSW 8 3718440 missense probably benign 0.00
R4571:Clec4g UTSW 8 3718766 critical splice donor site probably null
R4854:Clec4g UTSW 8 3716534 missense probably damaging 1.00
R4856:Clec4g UTSW 8 3716419 intron probably benign
R4886:Clec4g UTSW 8 3716419 intron probably benign
R5370:Clec4g UTSW 8 3718344 missense probably benign 0.13
R5390:Clec4g UTSW 8 3718441 missense probably benign 0.02
R6522:Clec4g UTSW 8 3718803 missense probably benign 0.11
R6737:Clec4g UTSW 8 3707716 utr 3 prime probably benign
R7097:Clec4g UTSW 8 3719518 missense possibly damaging 0.58
R7834:Clec4g UTSW 8 3716500 missense probably damaging 1.00
R7917:Clec4g UTSW 8 3716500 missense probably damaging 1.00
Z1088:Clec4g UTSW 8 3707796 utr 3 prime probably benign
Z1088:Clec4g UTSW 8 3716548 missense probably damaging 1.00
Posted On2013-10-07